HRP20070435A9 - Tricyclic-nucleoside compounds for treating viral infections - Google Patents

Tricyclic-nucleoside compounds for treating viral infections

Info

Publication number
HRP20070435A9
HRP20070435A9 HR20070435A HRP20070435A HRP20070435A9 HR P20070435 A9 HRP20070435 A9 HR P20070435A9 HR 20070435 A HR20070435 A HR 20070435A HR P20070435 A HRP20070435 A HR P20070435A HR P20070435 A9 HRP20070435 A9 HR P20070435A9
Authority
HR
Croatia
Prior art keywords
viral infections
tricyclic
nucleoside compounds
treating viral
compounds
Prior art date
Application number
HR20070435A
Other languages
English (en)
Croatian (hr)
Inventor
D. Keicher Jesse
Don Roberts Christopher
Johannes Reinhard Liehr Sebastian
Zheng Xiaoling
Prhavc Marija
Kumar Rajwanshi Vivek
Original Assignee
Genelabs Technologies
Gilead Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genelabs Technologies, Gilead Sciences filed Critical Genelabs Technologies
Publication of HRP20070435A2 publication Critical patent/HRP20070435A2/xx
Publication of HRP20070435A9 publication Critical patent/HRP20070435A9/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22Pteridine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20070435A 2005-02-28 2006-02-28 Tricyclic-nucleoside compounds for treating viral infections HRP20070435A9 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65746305P 2005-02-28 2005-02-28
PCT/US2006/007132 WO2006093987A1 (en) 2005-02-28 2006-02-28 Tricyclic-nucleoside compounds for treating viral infections

Publications (2)

Publication Number Publication Date
HRP20070435A2 HRP20070435A2 (hr) 2008-02-29
HRP20070435A9 true HRP20070435A9 (en) 2008-09-30

Family

ID=36570903

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20070436A HRP20070436A2 (hr) 2005-02-28 2006-02-28 Triciklički nukleozidni predlijekovi za liječenjevirusnih infekcija
HR20070435A HRP20070435A9 (en) 2005-02-28 2006-02-28 Tricyclic-nucleoside compounds for treating viral infections

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HR20070436A HRP20070436A2 (hr) 2005-02-28 2006-02-28 Triciklički nukleozidni predlijekovi za liječenjevirusnih infekcija

Country Status (18)

Country Link
US (4) US7524825B2 (OSRAM)
EP (2) EP1853617A1 (OSRAM)
JP (2) JP2008531704A (OSRAM)
KR (2) KR20070106781A (OSRAM)
CN (2) CN101142226A (OSRAM)
AP (2) AP2007004128A0 (OSRAM)
AR (1) AR058419A1 (OSRAM)
AU (2) AU2006218704A1 (OSRAM)
BR (2) BRPI0607769A2 (OSRAM)
CA (2) CA2597685A1 (OSRAM)
EA (2) EA200701849A1 (OSRAM)
HR (2) HRP20070436A2 (OSRAM)
IL (2) IL184954A0 (OSRAM)
MX (2) MX2007010463A (OSRAM)
NO (2) NO20074613L (OSRAM)
TW (1) TW200640474A (OSRAM)
WO (2) WO2006093986A1 (OSRAM)
ZA (1) ZA200707410B (OSRAM)

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US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
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PT3042910T (pt) 2010-11-30 2019-04-16 Gilead Pharmasset Llc 2'-espiro-nucleósidos para utilização na terapia da hepatite c
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
JP2014520772A (ja) 2011-06-30 2014-08-25 ステラ・アンパルトセルスカブ Hcv併用療法
WO2013033093A1 (en) * 2011-08-29 2013-03-07 Biocryst Pharmaceuticals, Inc. Heterocyclic compounds as janus kinase inhibitors
AR088441A1 (es) 2011-09-12 2014-06-11 Idenix Pharmaceuticals Inc Compuestos de carboniloximetilfosforamidato sustituido y composiciones farmaceuticas para el tratamiento de infecciones virales
EP2709613B2 (en) 2011-09-16 2020-08-12 Gilead Pharmasset LLC Methods for treating hcv
WO2013056046A1 (en) 2011-10-14 2013-04-18 Idenix Pharmaceuticals, Inc. Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
EP2639238A1 (en) * 2012-03-15 2013-09-18 Universität Bern Tricyclic nucleosides and oligomeric compounds prepared therefrom
AR090699A1 (es) 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
JP6165848B2 (ja) 2012-05-22 2017-07-19 イデニク ファーマシューティカルズ エルエルシー 肝疾患のためのd−アミノ酸化合物
US9296778B2 (en) 2012-05-22 2016-03-29 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphate prodrugs for HCV infection
WO2013177188A1 (en) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. 3',5'-cyclic phosphoramidate prodrugs for hcv infection
HUE029038T2 (en) 2012-05-25 2017-01-30 Janssen Sciences Ireland Uc Uracil spirooxetan nucleosides
EP2900682A1 (en) 2012-09-27 2015-08-05 IDENIX Pharmaceuticals, Inc. Esters and malonates of sate prodrugs
NZ706985A (en) 2012-10-08 2018-08-31 Centre Nat Rech Scient 2’-chloro nucleoside analogs for hcv infection
EP2909222B1 (en) 2012-10-22 2021-05-26 Idenix Pharmaceuticals LLC 2',4'-bridged nucleosides for hcv infection
EP2935304A1 (en) 2012-12-19 2015-10-28 IDENIX Pharmaceuticals, Inc. 4'-fluoro nucleosides for the treatment of hcv
PL2950786T3 (pl) 2013-01-31 2020-05-18 Gilead Pharmasset Llc Formulacja skojarzona dwóch związków przeciwwirusowych
WO2014137930A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. Thiophosphate nucleosides for the treatment of hcv
EP2970358B1 (en) 2013-03-04 2021-06-30 Idenix Pharmaceuticals LLC 3'-deoxy nucleosides for the treatment of hcv
US20140271547A1 (en) 2013-03-13 2014-09-18 Idenix Pharmaceuticals, Inc. Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
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Also Published As

Publication number Publication date
WO2006093987A1 (en) 2006-09-08
TW200640474A (en) 2006-12-01
WO2006093986A1 (en) 2006-09-08
US20060194749A1 (en) 2006-08-31
MX2007010460A (es) 2007-11-08
JP2008531703A (ja) 2008-08-14
NO20074915L (no) 2007-11-20
MX2007010463A (es) 2007-11-08
HRP20070436A2 (hr) 2008-02-29
NO20074613L (no) 2007-11-27
CN101128474A (zh) 2008-02-20
EA200701849A1 (ru) 2008-02-28
KR20070106781A (ko) 2007-11-05
CA2597685A1 (en) 2006-09-08
US20060252715A1 (en) 2006-11-09
HRP20070435A2 (hr) 2008-02-29
ZA200707410B (en) 2008-10-29
BRPI0607770A2 (pt) 2009-06-13
CA2597683A1 (en) 2006-09-08
EP1853618A1 (en) 2007-11-14
AU2006218704A1 (en) 2006-09-08
AU2006218705A1 (en) 2006-09-08
US20090208457A1 (en) 2009-08-20
KR20070106767A (ko) 2007-11-05
IL184955A0 (en) 2007-12-03
JP2008531704A (ja) 2008-08-14
AR058419A1 (es) 2008-02-06
CN101142226A (zh) 2008-03-12
EA200701850A1 (ru) 2008-02-28
US7524825B2 (en) 2009-04-28
IL184954A0 (en) 2007-12-03
US7534771B2 (en) 2009-05-19
BRPI0607769A2 (pt) 2009-10-06
AP2007004128A0 (en) 2007-08-31
AP2007004118A0 (en) 2007-08-31
US20090253648A1 (en) 2009-10-08
EP1853617A1 (en) 2007-11-14

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