HRP20070393T3 - 4-(aminometil)-piperidin benzamidi kao 5ht4-antagonisti - Google Patents
4-(aminometil)-piperidin benzamidi kao 5ht4-antagonistiInfo
- Publication number
- HRP20070393T3 HRP20070393T3 HR20070393T HRP20070393T HRP20070393T3 HR P20070393 T3 HRP20070393 T3 HR P20070393T3 HR 20070393 T HR20070393 T HR 20070393T HR P20070393 T HRP20070393 T HR P20070393T HR P20070393 T3 HRP20070393 T3 HR P20070393T3
- Authority
- HR
- Croatia
- Prior art keywords
- 6alkyl
- substituted
- hydrogen
- hydroxy
- halo
- Prior art date
Links
- SZVHQUMEPYZZTA-UHFFFAOYSA-N benzamide;piperidin-4-ylmethanamine Chemical class NCC1CCNCC1.NC(=O)C1=CC=CC=C1 SZVHQUMEPYZZTA-UHFFFAOYSA-N 0.000 title 1
- 239000003523 serotonin 4 antagonist Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 20
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 9
- 125000001475 halogen functional group Chemical group 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 125000001424 substituent group Chemical group 0.000 abstract 7
- -1 C1-6alkyloxy Chemical group 0.000 abstract 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical group FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 abstract 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 3
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical group FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 2
- 125000005879 dioxolanyl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 2
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- FUFZNHHSSMCXCZ-UHFFFAOYSA-N 5-piperidin-4-yl-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole Chemical group FC(F)(F)C1=CC=CC(C=2N=C(ON=2)C2CCNCC2)=C1 FUFZNHHSSMCXCZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000532 dioxanyl group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N sulfur dioxide Inorganic materials O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- GEGIENATMYITAP-UHFFFAOYSA-N trifluoro(nitro)methane Chemical compound [O-][N+](=O)C(F)(F)F GEGIENATMYITAP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/06—Anti-spasmodics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Spoj s formulom (I) njegov stereokemijski izomemioblik, njegov N-oksidni oblik ili njegova farmaceutski prihvatljiva kisela ili bazna adicijska sol,naznačen time, da-R1-R2 je dvovalentni radikal s formulom-O-CH2-O- (a-1) -O-CH2-CH2- (a-2) -O-CH2-CH2-O- (a-3) -O-CH2-CH2-CH2- (a-4) -O-CH2-CH2-CH2-O- (a-5) -O-CH2-CH2-CH2-CH2- (a-6) -O-CH2-CH2-CH2-CH2-O- (a-7) -O-CH2-CH2-CH2-CH2-CH2- (a-8), gdje u rečenim dvovalentnim radikalima jedan ili dva vodikova atoma na istom ili različitom ugljikovom atomu ponekad mogu biti zamijenjeni s C1-6alkilom ili hidroksiR3 je vodik, halo, C1-4alkil; R4 je C1-6alkil; C1-6alkil zamijenjen s cijano ili C1-6alkiloksi; C1-6alkilaoki; cijano; amino ili mono ili di(C1-6alkil)amino; R5 je vodik ili C1-6alkil, a -OR5 radikal se nalazi na položaju 3- ili 4-piperidinskog ostatka; L je vodik ili L je radikal s formulom-Alk-R6 (b-1), -Alk-X-R7 (b-2), -Alk-Y-C(=O)-R9 (b-3) ili-Alk-Z-C(=O)-NR11R12 (b-4), gdje svaki Alk je C1-12alkandiil; iR6 je vodik; hidroksi; cijano;C3-6cikloalkil; C1-6alkilsulfonilamino; aril ili Het; R7 je C1-6alkil; C1-6alkil supstituiran s hidroksi; C3-6cikloalkil; aril ili Het; X je O, S, SO2 ili NR8; spomenuti R8 je vodik ili C1-6alkil; R9 je vodik, C1-6alkil, C3-6cikloalkil, hidroksi iliaril; Y je izravna veza ili NR10 gdje R10 je vodik ili C1-6alkil; Z je izravna veza, O, S ili NR10 gdje R10 je vodik ili C1-6alkil; R11 i R12, svaki zasebno su vodici, C1-6alkil, C3-6cikloalkil ili R11 i R12 skupa s dušikovim atomom koji nosi R11 i R12 mogu oblikovati pirolidinilni, piperidinilni, piperazinilni ili 4-morfohalinilni prsten, a pri tome oba mogu biti ponekad supstituirana s C1-6alkilom; Aril predstavlja nesupstituirani fenil ili fenil koji je supstituirani s 1, 2 ili 3 supstituenta svaki neovisno izabran između halo, hidroksi, C1-6alkila, C1-6alkiloksi, C1-6alkilkarbomla, nitro,trifluorometana, amino, aminokarbonila i aminosulfonila; iHet je furanil supstituiran s C1-6alkil ili halo; tetrahidrofuranil; tetrahidrofuranil supstituiran s C1-6alkilom; dioksolanil; dioksolanil supstituiran s C1-6alkilora; dioksanil; dioksanil supstituiran s C1-6alkilom; tetrahidropiranil; tetrahidropiranil supstituiran s C1-6alkilom; 2,3-dihidro-2-okso-1H-imidazolil; 2,3-dihidro-2-okso-1H-imidazolil supstituiran s jednim ili dva supstituenta, svaki neovisno izabran između halo ili C1-6alkila; pirolidinil; pirolidinil supstituiran s jednim ili dva supstituenta, svaki zasebno izabran između halo, hidroksi ili C1-6alkila; piridinil; piridinil supstituiran s jednim ili dva supstituenta, svaki zasebno izabran između halo, hidroksi ili C1-6alkila; pirimidinil; pirimidinil supstituiran s jednim ili dva supstituenta, svaki zasebno izabran između halo, hidroksi ili C1-6alkila; piridazinil;piridazinil supstituiran s jednim ili dva supstituenta, svaki zasebno izabran između hidroksi, C1-6alkiloksi, C1-6alkila ili halo; pirazinil; pirazinil supstituiran s jednim ili dva supstituenta, svaki zasebno izabran između hidroksi, C1-6alkiloksi,C1-6alk
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0350236 | 2003-06-19 | ||
| PCT/EP2004/006285 WO2005000838A1 (en) | 2003-06-19 | 2004-06-10 | 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20070393T3 true HRP20070393T3 (hr) | 2007-10-31 |
Family
ID=33547568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20070393T HRP20070393T3 (hr) | 2003-06-19 | 2007-09-10 | 4-(aminometil)-piperidin benzamidi kao 5ht4-antagonisti |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7638535B2 (hr) |
| EP (1) | EP1641784B1 (hr) |
| JP (1) | JP4688800B2 (hr) |
| KR (1) | KR101151645B1 (hr) |
| CN (1) | CN100537565C (hr) |
| AR (1) | AR044821A1 (hr) |
| AT (1) | ATE364602T1 (hr) |
| AU (1) | AU2004251825B2 (hr) |
| BR (1) | BRPI0411603B1 (hr) |
| CA (1) | CA2528590C (hr) |
| CY (1) | CY1106857T1 (hr) |
| DE (1) | DE602004006997T2 (hr) |
| DK (1) | DK1641784T3 (hr) |
| EA (1) | EA008504B1 (hr) |
| ES (1) | ES2288258T3 (hr) |
| HK (1) | HK1095327A1 (hr) |
| HR (1) | HRP20070393T3 (hr) |
| IL (1) | IL172604A (hr) |
| JO (1) | JO2478B1 (hr) |
| MX (1) | MXPA05013772A (hr) |
| MY (1) | MY139454A (hr) |
| NZ (1) | NZ544592A (hr) |
| PA (1) | PA8605101A1 (hr) |
| PL (1) | PL1641784T3 (hr) |
| PT (1) | PT1641784E (hr) |
| SI (1) | SI1641784T1 (hr) |
| TW (1) | TWI346107B (hr) |
| UA (1) | UA88607C2 (hr) |
| WO (1) | WO2005000838A1 (hr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200533348A (en) | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| US7728006B2 (en) | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| ES2332808T3 (es) | 2004-11-05 | 2010-02-12 | Theravance, Inc. | Compuestos agonistas del receptor 5-ht4. |
| EP1807423B1 (en) | 2004-11-05 | 2009-05-20 | Theravance, Inc. | Quinolinone-carboxamide compounds |
| NZ555180A (en) | 2004-12-22 | 2010-09-30 | Theravance Inc | Indazole-carboxamide compounds useful as 5-HT4 receptor agonists |
| EP1871772B1 (en) | 2005-03-02 | 2014-09-10 | Theravance, Inc. | Quinolinone compounds as 5-ht4 receptor agonists |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| US20100081981A1 (en) * | 2008-10-01 | 2010-04-01 | Cheng Shien-Che | Wrist support |
| GB0901487D0 (en) * | 2009-01-30 | 2009-03-11 | Movetis N V | Asthma Therapy |
| TW201326180A (zh) | 2011-11-30 | 2013-07-01 | Actelion Pharmaceuticals Ltd | ３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素 |
| GB201403093D0 (en) | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| WO2017122722A1 (ja) | 2016-01-15 | 2017-07-20 | 大日本住友製薬株式会社 | ２環性複素環化合物 |
| GB201715194D0 (en) | 2017-09-20 | 2017-11-01 | Carrick Therapeutics Ltd | Compounds and their therapeutic use |
| CN115974856B (zh) * | 2022-12-28 | 2023-08-11 | 北京康立生医药技术开发有限公司 | 一种治疗成人t细胞白血病淋巴瘤药物伐美妥司他的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4186135A (en) * | 1976-08-04 | 1980-01-29 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | Substituted 2,3-alkylene bis (oxy) benzamides and derivatives and method of preparation |
| US5374637A (en) * | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
| TW548103B (en) * | 1997-07-11 | 2003-08-21 | Janssen Pharmaceutica Nv | Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
| TW570920B (en) * | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
-
2004
- 2004-06-09 JO JO200473A patent/JO2478B1/en active
- 2004-06-10 SI SI200430410T patent/SI1641784T1/sl unknown
- 2004-06-10 DE DE602004006997T patent/DE602004006997T2/de not_active Expired - Lifetime
- 2004-06-10 US US10/560,479 patent/US7638535B2/en not_active Expired - Fee Related
- 2004-06-10 MX MXPA05013772A patent/MXPA05013772A/es active IP Right Grant
- 2004-06-10 CA CA2528590A patent/CA2528590C/en not_active Expired - Fee Related
- 2004-06-10 NZ NZ544592A patent/NZ544592A/en unknown
- 2004-06-10 AT AT04739785T patent/ATE364602T1/de active
- 2004-06-10 PT PT04739785T patent/PT1641784E/pt unknown
- 2004-06-10 WO PCT/EP2004/006285 patent/WO2005000838A1/en active IP Right Grant
- 2004-06-10 ES ES04739785T patent/ES2288258T3/es not_active Expired - Lifetime
- 2004-06-10 PL PL04739785T patent/PL1641784T3/pl unknown
- 2004-06-10 DK DK04739785T patent/DK1641784T3/da active
- 2004-06-10 EA EA200600061A patent/EA008504B1/ru not_active IP Right Cessation
- 2004-06-10 BR BRPI0411603-8A patent/BRPI0411603B1/pt not_active IP Right Cessation
- 2004-06-10 JP JP2006515886A patent/JP4688800B2/ja not_active Expired - Fee Related
- 2004-06-10 CN CNB2004800171349A patent/CN100537565C/zh not_active Expired - Fee Related
- 2004-06-10 AU AU2004251825A patent/AU2004251825B2/en not_active Ceased
- 2004-06-10 EP EP04739785A patent/EP1641784B1/en not_active Expired - Lifetime
- 2004-06-15 PA PA20048605101A patent/PA8605101A1/es unknown
- 2004-06-16 MY MYPI20042307A patent/MY139454A/en unknown
- 2004-06-18 AR ARP040102131A patent/AR044821A1/es active IP Right Grant
- 2004-06-18 TW TW093117573A patent/TWI346107B/zh not_active IP Right Cessation
- 2004-10-06 UA UAA200511028A patent/UA88607C2/ru unknown
-
2005
- 2005-12-10 KR KR1020057023794A patent/KR101151645B1/ko active IP Right Grant
- 2005-12-15 IL IL172604A patent/IL172604A/en active IP Right Grant
-
2007
- 2007-01-25 HK HK07100899.5A patent/HK1095327A1/xx not_active IP Right Cessation
- 2007-09-10 HR HR20070393T patent/HRP20070393T3/hr unknown
- 2007-09-11 CY CY20071101169T patent/CY1106857T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20070393T3 (hr) | 4-(aminometil)-piperidin benzamidi kao 5ht4-antagonisti | |
| HRP20000006B1 (hr) | Gastrokinetički biciklički benzamidi derivata 3- ili 4-substituiranog 4-(aminometil)-piperidina | |
| MY153393A (en) | Amino nicotinic and isonicotinic acid derivatives as dhodh as inhibitors | |
| PE20090288A1 (es) | Derivados de quinoxalina como inhibidores de la pi3 quinasa | |
| AR066669A1 (es) | Derivados de imidazolona como inhibidores de bencimidazolona quimasa. composiciones farmaceuticas. | |
| RS52902B (en) | NEW PYRIDINE DERIVATIVES AND PYRIMIDINE DERIVATIVES (3) | |
| AR045587A1 (es) | Derivados de acil piperazinas sustituidas, proceso de obtencion, uso y composiciones farmaceuticas que las contienen | |
| CO5640152A2 (es) | Composiciones farmaceuticas para inhibidores de la proteasa del virus de la hepatitis c | |
| EA200501045A1 (ru) | Адамантилацетамиды как ингибиторы 11-бета гидроксистероиддегидрогеназы | |
| WO2008155668A3 (en) | Heteroarylamide pyrimidone compounds | |
| EA200701245A1 (ru) | Производные 2,4(4,6)-пиримидинов | |
| AR037534A1 (es) | Derivado de adamantano, su uso en la fabricacion de un medicamento para usar en terapia, composicion farmaceutica, proceso para la preparacion de dicho compuesto y dicha composicion y compuestos intermediarios | |
| NO20076006L (no) | Acetylenderivater | |
| RS53588B1 (en) | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | |
| AR051342A1 (es) | Derivados de purina, purinona, deazapurina y deazapurinona como inhibidores de la actividad de la protein quinasa; metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en la elaboracion de un medicamento para el tratamiento de enfermedades mediadas por la protein quina | |
| EA200601177A1 (ru) | Пиридо- и пиримидопиримидиновые производные в качестве антипролиферативных агентов | |
| AR064221A1 (es) | Inhibidores no nucleosidos de transcriptasa inversa | |
| AR056582A1 (es) | COMPUESTOS DE PIRAZOLIL UREA CON ACTIVIDAD INHIBITORIA DE CINASA P38 Y FORMULACIoN FARMACÉUTICA QUE LO COMPRENDE | |
| DK1533304T3 (da) | Amidderivat | |
| DE602005022764D1 (de) | Piperidin- und azetidinderivate als glyt1-inhibitoren | |
| AR067528A1 (es) | Eteres heterociclicos sustituidos y su uso en trastornos del snc | |
| NO20051089L (no) | Bredspektrede 2-amino-benzotiazol-sulfonamid-HIV-proteaseinhibitorer | |
| AR066605A1 (es) | Derivados de heteroarilamida pirimidona | |
| EA200501041A1 (ru) | Замещенные производные 1-пиперидин-4-ил-4-пирролидин-3-илпиперазина и их применение в качестве антагонистов нейрокининов | |
| MX2009003051A (es) | Derivados de quinolinona. |