HRP20070331T3 - Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation - Google Patents
Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidationInfo
- Publication number
- HRP20070331T3 HRP20070331T3 HR20070331T HRP20070331T HRP20070331T3 HR P20070331 T3 HRP20070331 T3 HR P20070331T3 HR 20070331 T HR20070331 T HR 20070331T HR P20070331 T HRP20070331 T HR P20070331T HR P20070331 T3 HRP20070331 T3 HR P20070331T3
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- nr6r7
- aryl
- formula
- different
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- YFGHCGITMMYXAQ-UHFFFAOYSA-N 2-[(diphenylmethyl)sulfinyl]acetamide Chemical compound C=1C=CC=CC=1C(S(=O)CC(=O)N)C1=CC=CC=C1 YFGHCGITMMYXAQ-UHFFFAOYSA-N 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229960001165 modafinil Drugs 0.000 title 1
- 230000003647 oxidation Effects 0.000 title 1
- 238000007254 oxidation reaction Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 abstract 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 abstract 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052748 manganese Inorganic materials 0.000 abstract 1
- 239000011572 manganese Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- -1 sulfoxide compound Chemical class 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
- 229910052719 titanium Inorganic materials 0.000 abstract 1
- 239000010936 titanium Substances 0.000 abstract 1
- 229910052720 vanadium Inorganic materials 0.000 abstract 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052726 zirconium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03292312A EP1516869A1 (en) | 2003-09-19 | 2003-09-19 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation |
| US50708903P | 2003-10-01 | 2003-10-01 | |
| PCT/IB2004/003026 WO2005028428A1 (en) | 2003-09-19 | 2004-09-17 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20070331T3 true HRP20070331T3 (en) | 2007-09-30 |
Family
ID=34379393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20070331T HRP20070331T3 (en) | 2003-09-19 | 2007-07-19 | Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation |
Country Status (6)
| Country | Link |
|---|---|
| CY (1) | CY1107734T1 (xx) |
| HK (1) | HK1084381A1 (xx) |
| HR (1) | HRP20070331T3 (xx) |
| IL (1) | IL174153A (xx) |
| IS (1) | IS2466B (xx) |
| NO (1) | NO335815B1 (xx) |
-
2006
- 2006-03-07 IL IL174153A patent/IL174153A/en active IP Right Grant
- 2006-03-24 NO NO20061350A patent/NO335815B1/no not_active IP Right Cessation
- 2006-04-12 IS IS8411A patent/IS2466B/is unknown
- 2006-06-09 HK HK06106631A patent/HK1084381A1/xx not_active IP Right Cessation
-
2007
- 2007-07-19 HR HR20070331T patent/HRP20070331T3/xx unknown
- 2007-09-12 CY CY20071101180T patent/CY1107734T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IS2466B (is) | 2008-11-15 |
| HK1084381A1 (en) | 2006-07-28 |
| IL174153A (en) | 2011-01-31 |
| NO20061350L (no) | 2006-04-05 |
| IL174153A0 (en) | 2006-08-01 |
| CY1107734T1 (el) | 2013-04-18 |
| NO335815B1 (no) | 2015-02-23 |
| IS8411A (is) | 2006-04-12 |
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