HRP20060022A2 - Semi-solid systems containing azetidine derivatives - Google Patents
Semi-solid systems containing azetidine derivatives Download PDFInfo
- Publication number
- HRP20060022A2 HRP20060022A2 HR20060022A HRP20060022A HRP20060022A2 HR P20060022 A2 HRP20060022 A2 HR P20060022A2 HR 20060022 A HR20060022 A HR 20060022A HR P20060022 A HRP20060022 A HR P20060022A HR P20060022 A2 HRP20060022 A2 HR P20060022A2
- Authority
- HR
- Croatia
- Prior art keywords
- azetidine
- active ingredient
- preparation
- enhance
- general formula
- Prior art date
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- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 239000002159 nanocrystal Substances 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229940113116 polyethylene glycol 1000 Drugs 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 229960003089 pramipexole Drugs 0.000 description 1
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 1
- 229940066675 ricinoleate Drugs 0.000 description 1
- 229960001879 ropinirole Drugs 0.000 description 1
- UHSKFQJFRQCDBE-UHFFFAOYSA-N ropinirole Chemical compound CCCN(CCC)CCC1=CC=CC2=C1CC(=O)N2 UHSKFQJFRQCDBE-UHFFFAOYSA-N 0.000 description 1
- 229960003179 rotigotine Drugs 0.000 description 1
- KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 150000004666 short chain fatty acids Chemical class 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- RKZSNTNMEFVBDT-MRVPVSSYSA-N sumanirole Chemical compound C([C@H](C1)NC)C2=CC=CC3=C2N1C(=O)N3 RKZSNTNMEFVBDT-MRVPVSSYSA-N 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- VUYXVWGKCKTUMF-UHFFFAOYSA-N tetratriacontaethylene glycol monomethyl ether Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO VUYXVWGKCKTUMF-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03291796A EP1498122A1 (en) | 2003-07-18 | 2003-07-18 | Semi-solid systems containing azetidine derivatives |
| PCT/EP2004/008553 WO2005013973A1 (en) | 2003-07-18 | 2004-07-08 | Semi-solid systems containing azetidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20060022A2 true HRP20060022A2 (en) | 2006-02-28 |
Family
ID=33462259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20060022A HRP20060022A2 (en) | 2003-07-18 | 2006-01-17 | Semi-solid systems containing azetidine derivatives |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US20050026898A1 (es) |
| EP (2) | EP1498122A1 (es) |
| JP (1) | JP2009513560A (es) |
| KR (1) | KR20060040691A (es) |
| CN (1) | CN1822831A (es) |
| AR (1) | AR045997A1 (es) |
| AU (1) | AU2004262498B2 (es) |
| BR (1) | BRPI0412737A (es) |
| CA (1) | CA2532669A1 (es) |
| CR (1) | CR8179A (es) |
| EC (1) | ECSP066292A (es) |
| GT (1) | GT200400135A (es) |
| HR (1) | HRP20060022A2 (es) |
| IL (1) | IL173111A0 (es) |
| MA (1) | MA27922A1 (es) |
| MX (1) | MXPA06000483A (es) |
| MY (1) | MY142077A (es) |
| NO (1) | NO20060509L (es) |
| OA (1) | OA13191A (es) |
| PA (1) | PA8606701A1 (es) |
| PE (1) | PE20050287A1 (es) |
| RS (1) | RS20060016A (es) |
| RU (1) | RU2343915C2 (es) |
| SG (1) | SG144141A1 (es) |
| TN (1) | TNSN06013A1 (es) |
| TW (1) | TW200522945A (es) |
| UA (1) | UA80633C2 (es) |
| UY (1) | UY28421A1 (es) |
| WO (1) | WO2005013973A1 (es) |
| ZA (1) | ZA200600490B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2007123366A (ru) * | 2004-11-24 | 2008-12-27 | Мерк Энд Ко. | Жидкие и полутвердые фармацевтические препаративные формы для перорального введения замещенного амида |
| FR2923719B1 (fr) * | 2007-11-15 | 2009-11-20 | Sanofi Aventis | Compositions pharmaceutiques a base de derives d'azetidine |
| CN101926757B (zh) * | 2010-09-01 | 2013-01-02 | 北京大学 | 一种难溶性药物的液体组合物及其制备方法 |
| JP5868414B2 (ja) * | 2010-11-08 | 2016-02-24 | カディラ ファーマシューティカルズ リミテッド | タキソイドの医薬組成物 |
| CN105848643A (zh) * | 2013-12-23 | 2016-08-10 | 强生消费者公司 | 消旋卡多曲组合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996036316A1 (en) * | 1995-05-19 | 1996-11-21 | Abbott Laboratories | Self-emulsifying formulations of lipophilic drugs |
| EP1015046A2 (en) * | 1998-07-14 | 2000-07-05 | Em Industries, Inc. | Microdisperse drug delivery systems |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| US6355631B1 (en) * | 2000-03-03 | 2002-03-12 | Aventis Pharma S.A. | Pharmaceutical compositions containing azetidine derivatives, novel azetidine derivatives and their preparation |
| FR2814678B1 (fr) * | 2000-10-04 | 2002-12-20 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite |
| FR2829027A1 (fr) * | 2001-08-29 | 2003-03-07 | Aventis Pharma Sa | Association avec un antagoniste du recepteur cb1, les compositions pharmaceutiques les contenant et leur utilisation pour le traitement de la maladie de parkinson |
| FR2833842B1 (fr) * | 2001-12-21 | 2004-02-13 | Aventis Pharma Sa | Compositions pharmaceutiques a base de derives d'azetidine |
| EP1498123A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Emulsifying systems containing azetidine derivatives |
-
2003
- 2003-07-18 EP EP03291796A patent/EP1498122A1/en not_active Withdrawn
-
2004
- 2004-07-01 PE PE2004000634A patent/PE20050287A1/es not_active Application Discontinuation
- 2004-07-08 MX MXPA06000483A patent/MXPA06000483A/es not_active Application Discontinuation
- 2004-07-08 AU AU2004262498A patent/AU2004262498B2/en not_active Ceased
- 2004-07-08 EP EP04763639A patent/EP1648442A1/en not_active Withdrawn
- 2004-07-08 KR KR1020067001148A patent/KR20060040691A/ko not_active Application Discontinuation
- 2004-07-08 CN CNA2004800206441A patent/CN1822831A/zh active Pending
- 2004-07-08 RU RU2006105011/15A patent/RU2343915C2/ru not_active IP Right Cessation
- 2004-07-08 JP JP2006519901A patent/JP2009513560A/ja active Pending
- 2004-07-08 SG SG200804303-6A patent/SG144141A1/en unknown
- 2004-07-08 RS YUP-2006/0016A patent/RS20060016A/sr unknown
- 2004-07-08 WO PCT/EP2004/008553 patent/WO2005013973A1/en active Application Filing
- 2004-07-08 OA OA1200600018A patent/OA13191A/en unknown
- 2004-07-08 CA CA002532669A patent/CA2532669A1/en not_active Abandoned
- 2004-07-08 BR BRPI0412737-4A patent/BRPI0412737A/pt not_active IP Right Cessation
- 2004-07-13 US US10/889,713 patent/US20050026898A1/en not_active Abandoned
- 2004-07-14 PA PA20048606701A patent/PA8606701A1/es unknown
- 2004-07-15 AR ARP040102495A patent/AR045997A1/es not_active Application Discontinuation
- 2004-07-16 UY UY28421A patent/UY28421A1/es unknown
- 2004-07-16 MY MYPI20042869A patent/MY142077A/en unknown
- 2004-07-16 GT GT200400135A patent/GT200400135A/es unknown
- 2004-07-16 TW TW093121229A patent/TW200522945A/zh unknown
- 2004-08-07 UA UAA200601708A patent/UA80633C2/uk unknown
-
2006
- 2006-01-06 CR CR8179A patent/CR8179A/es not_active Application Discontinuation
- 2006-01-12 IL IL173111A patent/IL173111A0/en unknown
- 2006-01-16 MA MA28726A patent/MA27922A1/fr unknown
- 2006-01-17 ZA ZA200600490A patent/ZA200600490B/en unknown
- 2006-01-17 HR HR20060022A patent/HRP20060022A2/hr not_active Application Discontinuation
- 2006-01-17 TN TNP2006000013A patent/TNSN06013A1/en unknown
- 2006-01-17 EC EC2006006292A patent/ECSP066292A/es unknown
- 2006-01-31 NO NO20060509A patent/NO20060509L/no not_active Application Discontinuation
-
2008
- 2008-07-28 US US12/180,691 patent/US20080293686A1/en not_active Abandoned
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