HRP20040416A2 - Benzimidazoles useful as protein kinase inhibitors - Google Patents
Benzimidazoles useful as protein kinase inhibitors Download PDFInfo
- Publication number
- HRP20040416A2 HRP20040416A2 HR20040416A HRP20040416A HRP20040416A2 HR P20040416 A2 HRP20040416 A2 HR P20040416A2 HR 20040416 A HR20040416 A HR 20040416A HR P20040416 A HRP20040416 A HR P20040416A HR P20040416 A2 HRP20040416 A2 HR P20040416A2
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- group
- optionally substituted
- heteroaryl
- phenyl
- Prior art date
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- 150000001556 benzimidazoles Chemical class 0.000 title description 2
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 94
- 238000000034 method Methods 0.000 claims description 33
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 31
- -1 sulfonylamino, aminosulfonyl Chemical group 0.000 claims description 31
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims description 24
- 239000002904 solvent Substances 0.000 claims description 24
- 125000001072 heteroaryl group Chemical group 0.000 claims description 22
- 125000000217 alkyl group Chemical group 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 125000002541 furyl group Chemical group 0.000 claims description 17
- 125000001544 thienyl group Chemical group 0.000 claims description 17
- 125000003118 aryl group Chemical group 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- 238000011282 treatment Methods 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 15
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- 239000001257 hydrogen Substances 0.000 claims description 14
- 125000000623 heterocyclic group Chemical group 0.000 claims description 13
- 125000002883 imidazolyl group Chemical group 0.000 claims description 13
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Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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| US34463601P | 2001-11-09 | 2001-11-09 | |
| PCT/US2002/035494 WO2003041708A1 (fr) | 2001-11-09 | 2002-11-05 | Benzimidazoles utilises en tant qu'inhibiteurs de la proteine kinase |
Publications (1)
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| HRP20040416A2 true HRP20040416A2 (en) | 2005-04-30 |
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Country Status (18)
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| US (1) | US6825219B2 (fr) |
| EP (1) | EP1448199A1 (fr) |
| JP (1) | JP2005509003A (fr) |
| KR (1) | KR20040063144A (fr) |
| CN (1) | CN1612733A (fr) |
| BR (1) | BR0214019A (fr) |
| CA (1) | CA2464419A1 (fr) |
| CO (1) | CO5580788A2 (fr) |
| EA (1) | EA200400595A1 (fr) |
| HR (1) | HRP20040416A2 (fr) |
| IL (1) | IL161516A0 (fr) |
| MX (1) | MXPA04004301A (fr) |
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| FR2851563B1 (fr) * | 2003-02-26 | 2005-04-22 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
| FR2862971B1 (fr) * | 2003-11-28 | 2006-03-24 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et d'imidazo-pyridine et leur utilisation en tant que medicament |
| US20050176792A1 (en) * | 2004-01-14 | 2005-08-11 | Boehringer Ingelheim Pharmaceuticals, Inc. | Ketone substituted benzimidazole compounds |
| WO2005079791A1 (fr) * | 2004-02-12 | 2005-09-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derives d'acide thiophene-2-carboxylique (1h-benzimidazol-2 yl)-amide et composes associes utilises comme inhibiteurs de la tec kinase itk (kinase des lymphocites inductibles par l'interleukine -2) pour traiter une inflammation et des troubles immunologiques et allergiques |
| US8003806B2 (en) | 2004-11-12 | 2011-08-23 | OSI Pharmaceuticals, LLC | Integrin antagonists useful as anticancer agents |
| WO2006068105A1 (fr) * | 2004-12-20 | 2006-06-29 | Santen Pharmaceutical Co., Ltd. | Agent thérapeutique pour un trouble kératoconjonctif |
| CN101142194B (zh) * | 2005-03-14 | 2012-10-10 | 顶点制药有限责任公司 | 吲哚衍生物，组合物及用作β-分泌酶抑制剂的方法 |
| US20060235028A1 (en) * | 2005-04-14 | 2006-10-19 | Li James J | Inhibitors of 11-beta hydroxysteroid dehydrogenase type I |
| GB0515025D0 (en) * | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
| WO2007058832A2 (fr) * | 2005-11-12 | 2007-05-24 | Boehringer Ingelheim International Gmbh | INHIBITEURS DES KINASES Tec |
| US20110071130A1 (en) * | 2006-05-08 | 2011-03-24 | Pharmacopeia, Inc. | 2-aminobenzimidazoles for treating neurodegenerative diseases |
| NZ587051A (en) | 2008-01-04 | 2012-12-21 | Intellikine Llc | Isoquinolinone derivatives, compositions and methods of inhibiting phosphatidyl inositol-3 kinase (pi3 kinase) |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| WO2009106203A1 (fr) * | 2008-02-25 | 2009-09-03 | Merck Patent Gmbh | Activateurs de la glucokinase |
| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
| JP2012525389A (ja) | 2009-04-27 | 2012-10-22 | ハイ ポイント ファーマシューティカルズ，リミティド ライアビリティ カンパニー | 置換イソキノリン誘導体、医薬組成物、及びβ−セクレターゼ阻害剤としての使用方法 |
| EP2549874A4 (fr) | 2010-03-23 | 2013-10-02 | High Point Pharmaceuticals Llc | Dérivés d'imidazole[1,2-b]pyridazine substitués, compositions pharmaceutiques et procédés d'utilisation en tant qu'inhibiteurs de bêta-sécrétase |
| EP2611784A4 (fr) | 2010-08-05 | 2014-01-08 | Amgen Inc | Composés benzimidazole et azabenzimidazole qui inhibent la kinase des lymphomes anaplasiques |
| CN103648499B (zh) | 2011-01-10 | 2017-02-15 | 无限药品股份有限公司 | 用于制备异喹啉酮的方法及异喹啉酮的固体形式 |
| WO2013153539A1 (fr) | 2012-04-13 | 2013-10-17 | Glenmark Pharmaceuticals S.A. | Composés tricycliques à titre d'inhibiteurs de kinases tec |
| JO3300B1 (ar) * | 2012-06-06 | 2018-09-16 | Novartis Ag | مركبات وتركيبات لتعديل نشاط egfr |
| WO2013184766A1 (fr) * | 2012-06-06 | 2013-12-12 | Irm Llc | Composés et compositions destinés à la modulation de l'activité de l'egfr |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| JP2015526520A (ja) * | 2012-08-31 | 2015-09-10 | プリンシピア バイオファーマ インコーポレイテッド | Ｉｔｋ阻害剤としてのベンズイミダゾール誘導体 |
| WO2015081463A1 (fr) * | 2013-12-02 | 2015-06-11 | Novartis Ag | Formes d'inhibiteurs du recepteur du facteur de croissance epidermique (egfr) |
| WO2015083059A1 (fr) * | 2013-12-02 | 2015-06-11 | Novartis Ag | Formes de l'inhibiteur du récepteur du facteur de croissance épidermique (egfr) |
| WO2015148714A1 (fr) * | 2014-03-25 | 2015-10-01 | Duke University | Ligands de récepteurs de la protéine de choc thermique 70 (hsp-70) |
| WO2015160975A2 (fr) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Polythérapies |
| KR101560338B1 (ko) | 2014-04-21 | 2015-10-19 | 건국대학교 산학협력단 | 야누스 키나아제 1의 활성을 선택적으로 저해하는 벤조이미다졸 유도체 |
| EP3440072B1 (fr) * | 2016-04-07 | 2020-01-29 | GlaxoSmithKline Intellectual Property Development Ltd | Amides hétérocycliques utiles en tant que modulateurs de protéine |
| WO2017223422A1 (fr) | 2016-06-24 | 2017-12-28 | Infinity Pharmaceuticals, Inc. | Polythérapies |
| US11174245B2 (en) | 2018-02-21 | 2021-11-16 | Boehringer Ingelheim International Gmbh | Benzimidazole compounds and derivatives as EGFR inhibitors |
| US20230085408A1 (en) * | 2019-04-05 | 2023-03-16 | STORM Therapeutics Ltd. | Mettl3 inhibitory compounds |
| WO2020260252A1 (fr) | 2019-06-24 | 2020-12-30 | Boehringer Ingelheim International Gmbh | Nouveaux composés macrocycliques et leurs dérivés utilisés en tant qu'inhibiteurs d'egfr |
| CN114591333B (zh) * | 2020-12-04 | 2023-08-01 | 广州嘉越医药科技有限公司 | 一种吡咯并嘧啶类化合物的制备方法 |
| CN116444544A (zh) * | 2022-01-10 | 2023-07-18 | 中国科学院上海药物研究所 | 苯并咪唑类化合物及其医药用途 |
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| US3401171A (en) * | 1966-03-11 | 1968-09-10 | Smithkline Corp | 2-amidobenzimidazoles |
| CA1094061A (fr) | 1976-03-19 | 1981-01-20 | Colin C. Beard | Traduction non-disponible |
| US4191764A (en) | 1976-03-19 | 1980-03-04 | Syntex (U.S.A.) Inc. | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
| US4139626A (en) | 1976-03-19 | 1979-02-13 | Syntex (U.S.A.) Inc. | Anthelmintic 5(6)-benzene ring substituted benzimidazole-2-carbamates |
| US4312873A (en) | 1978-09-29 | 1982-01-26 | Syntex (U.S.A.) Inc. | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity |
| AU632288B2 (en) | 1988-09-12 | 1992-12-24 | Pharmacia & Upjohn Company | Novel cc-1065 analogs having two cpi subunits |
| JPH06759B2 (ja) | 1989-09-22 | 1994-01-05 | ファイザー製薬株式会社 | 新規なベンゾイミダゾール化合物 |
| GB9107398D0 (en) | 1991-04-09 | 1991-05-22 | British Bio Technology | Compounds |
| JP2729545B2 (ja) | 1991-06-05 | 1998-03-18 | 富士写真フイルム株式会社 | ハロゲン化銀カラー写真感光材料用の処理液及びそれを用いた処理方法 |
| US5616537A (en) | 1992-07-03 | 1997-04-01 | Kumiai Chemical Industry Co., Ltd. | Condensed heterocyclic derivatives and herbicides |
| CA2144763A1 (fr) | 1992-10-14 | 1994-04-28 | George D. Hartman | Antagonistes des recepteurs du fibrinogene |
| DE4304650A1 (de) | 1993-02-16 | 1994-08-18 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| IL135176A0 (en) | 1997-11-10 | 2001-05-20 | Bristol Myers Squibb Co | Benzothiazole derivatives and pharmaceutical compositions containing the same |
| WO2001021634A1 (fr) | 1999-09-21 | 2001-03-29 | Lion Bioscience Ag | Derives de benzimidazole et bibliotheques combinatoires contenant ces derives |
| EP1222187B1 (fr) * | 1999-10-06 | 2004-09-22 | Boehringer Ingelheim Pharmaceuticals Inc. | Composes heterocycliques utiles comme inhibiteurs de tyrosine kinases |
| AU2001219185A1 (en) | 2000-03-17 | 2001-10-03 | Alcon, Inc. | 2-acylaminobenzimidazole derivatives for treating glaucoma |
| US6903126B2 (en) | 2001-07-09 | 2005-06-07 | Schering Ag | 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives |
| WO2003030902A1 (fr) | 2001-10-09 | 2003-04-17 | Tularik Inc. | Derives d'imidazole comme agents anti-inflammatoires |
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2002
- 2002-11-05 YU YU37904A patent/YU37904A/sh unknown
- 2002-11-05 JP JP2003543595A patent/JP2005509003A/ja active Pending
- 2002-11-05 MX MXPA04004301A patent/MXPA04004301A/es unknown
- 2002-11-05 US US10/288,362 patent/US6825219B2/en not_active Expired - Lifetime
- 2002-11-05 EP EP02789445A patent/EP1448199A1/fr not_active Withdrawn
- 2002-11-05 KR KR10-2004-7007023A patent/KR20040063144A/ko not_active Application Discontinuation
- 2002-11-05 NZ NZ533310A patent/NZ533310A/xx unknown
- 2002-11-05 EA EA200400595A patent/EA200400595A1/ru unknown
- 2002-11-05 IL IL16151602A patent/IL161516A0/xx unknown
- 2002-11-05 PL PL02369771A patent/PL369771A1/xx not_active Application Discontinuation
- 2002-11-05 CA CA002464419A patent/CA2464419A1/fr not_active Abandoned
- 2002-11-05 WO PCT/US2002/035494 patent/WO2003041708A1/fr active IP Right Grant
- 2002-11-05 BR BR0214019-5A patent/BR0214019A/pt not_active Application Discontinuation
- 2002-11-05 CN CNA028270002A patent/CN1612733A/zh active Pending
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2004
- 2004-04-19 ZA ZA200402947A patent/ZA200402947B/en unknown
- 2004-05-07 NO NO20041887A patent/NO20041887L/no unknown
- 2004-05-07 HR HR20040416A patent/HRP20040416A2/hr not_active Application Discontinuation
- 2004-06-01 CO CO04051014A patent/CO5580788A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003041708A1 (fr) | 2003-05-22 |
| US20030144281A1 (en) | 2003-07-31 |
| YU37904A (sh) | 2006-08-17 |
| CA2464419A1 (fr) | 2003-05-22 |
| US6825219B2 (en) | 2004-11-30 |
| BR0214019A (pt) | 2004-10-13 |
| ZA200402947B (en) | 2005-01-24 |
| MXPA04004301A (es) | 2004-08-11 |
| IL161516A0 (en) | 2004-09-27 |
| CO5580788A2 (es) | 2005-11-30 |
| NO20041887L (no) | 2004-05-07 |
| PL369771A1 (en) | 2005-05-02 |
| EP1448199A1 (fr) | 2004-08-25 |
| EA200400595A1 (ru) | 2004-10-28 |
| JP2005509003A (ja) | 2005-04-07 |
| KR20040063144A (ko) | 2004-07-12 |
| CN1612733A (zh) | 2005-05-04 |
| NZ533310A (en) | 2004-12-24 |
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