HRP20031055B1 - Novel immunomodulating compounds - Google Patents

Novel immunomodulating compounds

Info

Publication number
HRP20031055B1
HRP20031055B1 HR20031055A HRP20031055A HRP20031055B1 HR P20031055 B1 HRP20031055 B1 HR P20031055B1 HR 20031055 A HR20031055 A HR 20031055A HR P20031055 A HRP20031055 A HR P20031055A HR P20031055 B1 HRP20031055 B1 HR P20031055B1
Authority
HR
Croatia
Prior art keywords
alkyl
halo
lower alkyl
alkoxy
unsaturated
Prior art date
Application number
HR20031055A
Other languages
English (en)
Croatian (hr)
Inventor
Axel Bj�rk Per
Fex Tomas
Olof Lars
Poul Sorensen
Da Graca Thrige Dorthe
Original Assignee
Active Biotech Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Active Biotech Ab filed Critical Active Biotech Ab
Publication of HRP20031055A2 publication Critical patent/HRP20031055A2/hr
Publication of HRP20031055B1 publication Critical patent/HRP20031055B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HR20031055A 2001-07-04 2003-12-17 Novel immunomodulating compounds HRP20031055B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0102404A SE0102404D0 (sv) 2001-07-04 2001-07-04 Novel immunomodulating compounds
PCT/SE2002/001309 WO2003004495A1 (fr) 2001-07-04 2002-07-02 Nouveaux composes immunomodulateurs

Publications (2)

Publication Number Publication Date
HRP20031055A2 HRP20031055A2 (en) 2004-06-30
HRP20031055B1 true HRP20031055B1 (en) 2008-01-31

Family

ID=20284743

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20031055A HRP20031055B1 (en) 2001-07-04 2003-12-17 Novel immunomodulating compounds

Country Status (21)

Country Link
EP (1) EP1409485B1 (fr)
JP (1) JP2005501033A (fr)
CN (1) CN1249063C (fr)
AT (1) ATE324373T1 (fr)
AU (1) AU2002315996B2 (fr)
BR (1) BR0210776A (fr)
CA (1) CA2451749A1 (fr)
DE (1) DE60210977T2 (fr)
ES (1) ES2258150T3 (fr)
HK (1) HK1066809A1 (fr)
HR (1) HRP20031055B1 (fr)
HU (1) HUP0401204A3 (fr)
MX (1) MXPA04000017A (fr)
NO (1) NO20035684L (fr)
NZ (1) NZ530316A (fr)
PL (1) PL367637A1 (fr)
RU (1) RU2004103079A (fr)
SE (1) SE0102404D0 (fr)
WO (1) WO2003004495A1 (fr)
YU (1) YU101603A (fr)
ZA (1) ZA200309806B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE353898T1 (de) 2002-11-22 2007-03-15 Active Biotech Ab Pyrazolochinoline mit immunmodulierenderwirkung
DE60326639D1 (de) 2002-12-16 2009-04-23 Active Biotech Ab Tetrazyklische immunmodulierende verbindungen
GB0305876D0 (en) * 2003-03-14 2003-04-16 Avidex Ltd Immuno inhibitory heterocyclic compounds
DE602004030225D1 (de) * 2003-03-14 2011-01-05 Medigene Ltd Immunmodulierende heterocyclische verbindungen
GB0325644D0 (en) 2003-11-04 2003-12-10 Avidex Ltd Immuno ihibitory pyrazolone compounds
WO2005068467A1 (fr) 2004-01-14 2005-07-28 Ajinomoto Co., Inc. Nouveau compose a cycle fusionne
GB0411770D0 (en) * 2004-05-26 2004-06-30 Avidex Ltd Immuno inhibitory heterocyclic compouds
DE602004017231D1 (de) 2004-08-09 2008-11-27 Medigene Ltd Immunmodulierende oxopyrazolocinnoline als cd80-inhibitoren
CN101863903B (zh) * 2010-06-08 2014-03-12 沈阳药科大学 1,4-二氢噻吩并[3’,2’:5,6]噻喃并[4,3-c]吡唑-3-羧酸衍生物及其应用
JP6625973B2 (ja) * 2013-06-24 2019-12-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｆｓｈｒの調節剤としてのピラゾール化合物及びその使用
EP2883883A1 (fr) 2013-12-16 2015-06-17 Cardio3 Biosciences S.A. Cibles thérapeutiques et agents utiles dans le traitement des lésions ischémiques de reperfusion
NZ728301A (en) 2014-07-08 2017-09-29 Avertana Ltd Extraction of products from titanium-bearing minerals

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268516A (en) * 1978-10-11 1981-05-19 Pfizer Inc. [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents
US4312870A (en) * 1979-06-21 1982-01-26 Ciba-Geigy Corporation Pyrazoloquinolines
EP0354693A1 (fr) * 1988-08-09 1990-02-14 The Boots Company PLC Agents thérapeutiques
EP0354694A1 (fr) * 1988-08-09 1990-02-14 The Boots Company PLC [1]Benzothiopyrano[4,3-c]pyrazoles thérapeutiques
WO1991006298A1 (fr) * 1989-10-26 1991-05-16 Kabi Pharmacia Therapeutics Ab Nouvelle utilisation de composes de quinoleine condensee
WO1991011448A1 (fr) * 1990-02-02 1991-08-08 The Boots Company Plc Agents therapeutiques
WO1997034893A1 (fr) * 1996-03-20 1997-09-25 Astra Pharmaceuticals Ltd. Composes pharmaceutiquement utiles

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268516A (en) * 1978-10-11 1981-05-19 Pfizer Inc. [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents
US4312870A (en) * 1979-06-21 1982-01-26 Ciba-Geigy Corporation Pyrazoloquinolines
EP0354693A1 (fr) * 1988-08-09 1990-02-14 The Boots Company PLC Agents thérapeutiques
EP0354694A1 (fr) * 1988-08-09 1990-02-14 The Boots Company PLC [1]Benzothiopyrano[4,3-c]pyrazoles thérapeutiques
WO1991006298A1 (fr) * 1989-10-26 1991-05-16 Kabi Pharmacia Therapeutics Ab Nouvelle utilisation de composes de quinoleine condensee
WO1991011448A1 (fr) * 1990-02-02 1991-08-08 The Boots Company Plc Agents therapeutiques
WO1997034893A1 (fr) * 1996-03-20 1997-09-25 Astra Pharmaceuticals Ltd. Composes pharmaceutiquement utiles

Also Published As

Publication number Publication date
HUP0401204A2 (hu) 2004-10-28
BR0210776A (pt) 2004-07-20
YU101603A (en) 2006-05-25
SE0102404D0 (sv) 2001-07-04
CA2451749A1 (fr) 2003-01-16
HUP0401204A3 (en) 2008-03-28
AU2002315996B2 (en) 2007-11-29
JP2005501033A (ja) 2005-01-13
NZ530316A (en) 2004-08-27
CN1522254A (zh) 2004-08-18
NO20035684D0 (no) 2003-12-19
EP1409485A1 (fr) 2004-04-21
MXPA04000017A (es) 2004-05-21
DE60210977D1 (de) 2006-06-01
WO2003004495A1 (fr) 2003-01-16
HRP20031055A2 (en) 2004-06-30
ES2258150T3 (es) 2006-08-16
NO20035684L (no) 2004-03-02
DE60210977T2 (de) 2006-09-21
HK1066809A1 (en) 2005-04-01
RU2004103079A (ru) 2005-06-10
ZA200309806B (en) 2004-12-20
ATE324373T1 (de) 2006-05-15
PL367637A1 (en) 2005-03-07
EP1409485B1 (fr) 2006-04-26
CN1249063C (zh) 2006-04-05

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Payment date: 20080624

Year of fee payment: 7

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Effective date: 20090703