HRP20031055B1 - Novi imunomodulirajući spojevi - Google Patents
Novi imunomodulirajući spojeviInfo
- Publication number
- HRP20031055B1 HRP20031055B1 HR20031055A HRP20031055A HRP20031055B1 HR P20031055 B1 HRP20031055 B1 HR P20031055B1 HR 20031055 A HR20031055 A HR 20031055A HR P20031055 A HRP20031055 A HR P20031055A HR P20031055 B1 HRP20031055 B1 HR P20031055B1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- halo
- lower alkyl
- alkoxy
- unsaturated
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000002519 immonomodulatory effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000006165 cyclic alkyl group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Spoj opće formule (I) naznačen time, da X predstavlja vezu ili skupinu odabranu od supstituiranih ili nesupstituiranih C1-3-alkila, NH-C(O)-C1-3-alkil, NH-C(O)-CH2-O-CH2 ili C(O)-NH-(amino kiselinskiostatak); Y predstavlja NR4, O ili S; R1 predstavlja H, halo, CF3, niži alkil ili niži alkoksi; R2 i R4 predstavljaju neovisno H ili niži alkil; iR3 predstavlja H, halo, niži alkil ili niži alkoksi, pri čemu halo je F, Cl, ili Br; gdje niži alkil predstavlja zasićene ili nezasićene, ravnolančane, razgranate ili cikličke alkil skupine s 1-6 atoma ugljika; igdje niži alkoksi predstavlja zasićene ili nezasićene, ravnolančane, razgranate ili cikličke alkoksi skupine s 1-6 atoma ugljika, pod uvjetomda R2 nije vodik, kada X je veza, Y je NH i R3 jevodik, ili njihove farmaceutski prihvatljive soli. Patent sadrži još 11 patentnih zahtjeva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0102404A SE0102404D0 (sv) | 2001-07-04 | 2001-07-04 | Novel immunomodulating compounds |
| PCT/SE2002/001309 WO2003004495A1 (en) | 2001-07-04 | 2002-07-02 | Novel immunomodulating compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20031055A2 HRP20031055A2 (en) | 2004-06-30 |
| HRP20031055B1 true HRP20031055B1 (hr) | 2008-01-31 |
Family
ID=20284743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20031055A HRP20031055B1 (hr) | 2001-07-04 | 2003-12-17 | Novi imunomodulirajući spojevi |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1409485B1 (hr) |
| JP (1) | JP2005501033A (hr) |
| CN (1) | CN1249063C (hr) |
| AT (1) | ATE324373T1 (hr) |
| AU (1) | AU2002315996B2 (hr) |
| BR (1) | BR0210776A (hr) |
| CA (1) | CA2451749A1 (hr) |
| DE (1) | DE60210977T2 (hr) |
| ES (1) | ES2258150T3 (hr) |
| HK (1) | HK1066809A1 (hr) |
| HR (1) | HRP20031055B1 (hr) |
| HU (1) | HUP0401204A3 (hr) |
| MX (1) | MXPA04000017A (hr) |
| NO (1) | NO20035684L (hr) |
| NZ (1) | NZ530316A (hr) |
| PL (1) | PL367637A1 (hr) |
| RU (1) | RU2004103079A (hr) |
| SE (1) | SE0102404D0 (hr) |
| WO (1) | WO2003004495A1 (hr) |
| YU (1) | YU101603A (hr) |
| ZA (1) | ZA200309806B (hr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2282693T3 (es) * | 2002-11-22 | 2007-10-16 | Active Biotech Ab | Pirazoloquinolinas con actividad inmunomodulante. |
| EP1572689B1 (en) | 2002-12-16 | 2009-03-11 | Active Biotech AB | Tetracyclic immunomodulatory compounds |
| GB0305876D0 (en) * | 2003-03-14 | 2003-04-16 | Avidex Ltd | Immuno inhibitory heterocyclic compounds |
| EP1603917B1 (en) * | 2003-03-14 | 2010-11-24 | MediGene Ltd. | Immunomodulating heterocyclic compounds |
| GB0325644D0 (en) * | 2003-11-04 | 2003-12-10 | Avidex Ltd | Immuno ihibitory pyrazolone compounds |
| EP1707567A4 (en) * | 2004-01-14 | 2009-08-19 | Ajinomoto Kk | NEW FUSED CYCLE COMPOUND |
| GB0411770D0 (en) | 2004-05-26 | 2004-06-30 | Avidex Ltd | Immuno inhibitory heterocyclic compouds |
| EP1776366B1 (en) * | 2004-08-09 | 2008-10-15 | MediGene Ltd. | Immunomodulating oxopyrrazolocinnolines as cd80 inhibitors |
| CN101863903B (zh) * | 2010-06-08 | 2014-03-12 | 沈阳药科大学 | 1,4-二氢噻吩并[3’,2’:5,6]噻喃并[4,3-c]吡唑-3-羧酸衍生物及其应用 |
| KR102318498B1 (ko) * | 2013-06-24 | 2021-10-27 | 메르크 파텐트 게엠베하 | Fshr의 조절인자로서의 피라졸 화합물 및 이의 용도 |
| EP2883883A1 (en) | 2013-12-16 | 2015-06-17 | Cardio3 Biosciences S.A. | Therapeutic targets and agents useful in treating ischemia reperfusion injury |
| US10287176B2 (en) | 2014-07-08 | 2019-05-14 | Avertana Limited | Extraction of products from titanium-bearing minerals |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4268516A (en) * | 1978-10-11 | 1981-05-19 | Pfizer Inc. | [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents |
| US4312870A (en) * | 1979-06-21 | 1982-01-26 | Ciba-Geigy Corporation | Pyrazoloquinolines |
| EP0354693A1 (en) * | 1988-08-09 | 1990-02-14 | The Boots Company PLC | Therapeutic agents |
| EP0354694A1 (en) * | 1988-08-09 | 1990-02-14 | The Boots Company PLC | Therapeutic [1]benzothiopyrano[4,3-c]pyrazoles |
| WO1991006298A1 (en) * | 1989-10-26 | 1991-05-16 | Kabi Pharmacia Therapeutics Ab | New use of condensed quinoline compound |
| WO1991011448A1 (en) * | 1990-02-02 | 1991-08-08 | The Boots Company Plc | Therapeutic agents |
| WO1997034893A1 (en) * | 1996-03-20 | 1997-09-25 | Astra Pharmaceuticals Ltd. | Pharmaceutically useful compounds |
-
2001
- 2001-07-04 SE SE0102404A patent/SE0102404D0/xx unknown
-
2002
- 2002-07-02 PL PL02367637A patent/PL367637A1/xx not_active Application Discontinuation
- 2002-07-02 JP JP2003510662A patent/JP2005501033A/ja not_active Withdrawn
- 2002-07-02 BR BR0210776-7A patent/BR0210776A/pt not_active IP Right Cessation
- 2002-07-02 CN CNB028132890A patent/CN1249063C/zh not_active Expired - Fee Related
- 2002-07-02 NZ NZ530316A patent/NZ530316A/en unknown
- 2002-07-02 MX MXPA04000017A patent/MXPA04000017A/es active IP Right Grant
- 2002-07-02 AT AT02746260T patent/ATE324373T1/de not_active IP Right Cessation
- 2002-07-02 YU YU101603A patent/YU101603A/sh unknown
- 2002-07-02 RU RU2004103079/04A patent/RU2004103079A/ru not_active Application Discontinuation
- 2002-07-02 AU AU2002315996A patent/AU2002315996B2/en not_active Ceased
- 2002-07-02 CA CA002451749A patent/CA2451749A1/en not_active Abandoned
- 2002-07-02 ES ES02746260T patent/ES2258150T3/es not_active Expired - Lifetime
- 2002-07-02 EP EP02746260A patent/EP1409485B1/en not_active Expired - Lifetime
- 2002-07-02 WO PCT/SE2002/001309 patent/WO2003004495A1/en active IP Right Grant
- 2002-07-02 DE DE60210977T patent/DE60210977T2/de not_active Expired - Lifetime
- 2002-07-02 HU HU0401204A patent/HUP0401204A3/hu unknown
-
2003
- 2003-12-17 HR HR20031055A patent/HRP20031055B1/hr not_active IP Right Cessation
- 2003-12-19 NO NO20035684A patent/NO20035684L/no not_active Application Discontinuation
- 2003-12-19 ZA ZA200309806A patent/ZA200309806B/en unknown
-
2004
- 2004-12-14 HK HK04109875A patent/HK1066809A1/xx not_active IP Right Cessation
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4268516A (en) * | 1978-10-11 | 1981-05-19 | Pfizer Inc. | [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents |
| US4312870A (en) * | 1979-06-21 | 1982-01-26 | Ciba-Geigy Corporation | Pyrazoloquinolines |
| EP0354693A1 (en) * | 1988-08-09 | 1990-02-14 | The Boots Company PLC | Therapeutic agents |
| EP0354694A1 (en) * | 1988-08-09 | 1990-02-14 | The Boots Company PLC | Therapeutic [1]benzothiopyrano[4,3-c]pyrazoles |
| WO1991006298A1 (en) * | 1989-10-26 | 1991-05-16 | Kabi Pharmacia Therapeutics Ab | New use of condensed quinoline compound |
| WO1991011448A1 (en) * | 1990-02-02 | 1991-08-08 | The Boots Company Plc | Therapeutic agents |
| WO1997034893A1 (en) * | 1996-03-20 | 1997-09-25 | Astra Pharmaceuticals Ltd. | Pharmaceutically useful compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1409485A1 (en) | 2004-04-21 |
| DE60210977D1 (de) | 2006-06-01 |
| HUP0401204A3 (en) | 2008-03-28 |
| ES2258150T3 (es) | 2006-08-16 |
| ATE324373T1 (de) | 2006-05-15 |
| HK1066809A1 (en) | 2005-04-01 |
| NZ530316A (en) | 2004-08-27 |
| BR0210776A (pt) | 2004-07-20 |
| PL367637A1 (en) | 2005-03-07 |
| WO2003004495A1 (en) | 2003-01-16 |
| NO20035684L (no) | 2004-03-02 |
| AU2002315996B2 (en) | 2007-11-29 |
| HRP20031055A2 (en) | 2004-06-30 |
| CN1249063C (zh) | 2006-04-05 |
| CN1522254A (zh) | 2004-08-18 |
| JP2005501033A (ja) | 2005-01-13 |
| SE0102404D0 (sv) | 2001-07-04 |
| EP1409485B1 (en) | 2006-04-26 |
| DE60210977T2 (de) | 2006-09-21 |
| MXPA04000017A (es) | 2004-05-21 |
| RU2004103079A (ru) | 2005-06-10 |
| CA2451749A1 (en) | 2003-01-16 |
| NO20035684D0 (no) | 2003-12-19 |
| ZA200309806B (en) | 2004-12-20 |
| YU101603A (en) | 2006-05-25 |
| HUP0401204A2 (hu) | 2004-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| B1PR | Patent granted | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20080624 Year of fee payment: 7 |
|
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20090703 |