HRP20000574A2 - Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists - Google Patents
Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists Download PDFInfo
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- HRP20000574A2 HRP20000574A2 HR20000574A HRP20000574A HRP20000574A2 HR P20000574 A2 HRP20000574 A2 HR P20000574A2 HR 20000574 A HR20000574 A HR 20000574A HR P20000574 A HRP20000574 A HR P20000574A HR P20000574 A2 HRP20000574 A2 HR P20000574A2
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- 108010044426 integrins Proteins 0.000 title claims description 25
- 102000006495 integrins Human genes 0.000 title claims description 25
- 239000005557 antagonist Substances 0.000 title description 11
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- 150000001875 compounds Chemical class 0.000 claims description 90
- 150000003839 salts Chemical class 0.000 claims description 18
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- 208000002780 macular degeneration Diseases 0.000 claims description 6
- 230000015590 smooth muscle cell migration Effects 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 5
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US3427098A | 1998-03-04 | 1998-03-04 | |
PCT/US1999/003281 WO1999044994A1 (en) | 1998-03-04 | 1999-02-22 | Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists |
Publications (1)
Publication Number | Publication Date |
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HRP20000574A2 true HRP20000574A2 (en) | 2001-08-31 |
Family
ID=21875345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20000574A HRP20000574A2 (en) | 1998-03-04 | 2000-09-01 | Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP1060164A1 (zh) |
JP (1) | JP2002505323A (zh) |
KR (1) | KR20010041584A (zh) |
CN (1) | CN1214011C (zh) |
AP (1) | AP1244A (zh) |
AR (1) | AR018139A1 (zh) |
AU (1) | AU753230B2 (zh) |
BG (1) | BG104740A (zh) |
BR (1) | BR9908470A (zh) |
CA (1) | CA2322207A1 (zh) |
EA (1) | EA200000804A1 (zh) |
EE (1) | EE200000506A (zh) |
GE (1) | GEP20033118B (zh) |
HR (1) | HRP20000574A2 (zh) |
HU (1) | HUP0100865A3 (zh) |
ID (1) | ID25591A (zh) |
IL (1) | IL137653A0 (zh) |
IS (1) | IS5582A (zh) |
MY (1) | MY123908A (zh) |
NO (1) | NO315703B1 (zh) |
NZ (1) | NZ506598A (zh) |
OA (1) | OA11530A (zh) |
PL (1) | PL342726A1 (zh) |
SK (1) | SK13002000A3 (zh) |
TR (1) | TR200002542T2 (zh) |
UA (1) | UA71906C2 (zh) |
WO (1) | WO1999044994A1 (zh) |
YU (1) | YU52000A (zh) |
ZA (1) | ZA994406B (zh) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
WO2001079173A2 (en) | 2000-04-17 | 2001-10-25 | Celltech R & D Limited | Enamine derivatives as cell adhesion molecules |
US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
US6921767B2 (en) * | 2000-06-15 | 2005-07-26 | Pharmacia Corporation | Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives |
EP1305291A1 (en) | 2000-08-02 | 2003-05-02 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
AU2003299600A1 (en) * | 2002-12-20 | 2004-07-29 | Pharmacia Corpration | The r-isomer of beta amino acid compounds as integrin receptor antagonists derivatives |
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
CA2612979A1 (en) * | 2005-06-10 | 2006-12-21 | Bipar Sciences, Inc. | Parp modulators and treatment of cancer |
JP2010520238A (ja) | 2007-03-01 | 2010-06-10 | マリンクロット インコーポレイテッド | 統合された光活性低分子および統合された光活性低分子使用 |
JP4792124B1 (ja) * | 2010-11-15 | 2011-10-12 | エフイートレード株式会社 | 車両用保護フィルムの型取り方法、及び、車両用保護フィルムの製造方法 |
US8716226B2 (en) | 2012-07-18 | 2014-05-06 | Saint Louis University | 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists |
CA2878469A1 (en) | 2012-07-18 | 2014-01-23 | Saint Louis University | Beta amino acid derivatives as integrin antagonists |
US10328082B2 (en) | 2014-05-30 | 2019-06-25 | Pfizer Inc. | Methods of use and combinations |
EP3151670B1 (en) * | 2014-06-04 | 2019-10-02 | Monsanto Technology LLC | 3,6-dichlorosalicylic acid compounds and related synthetic processes |
ES2806276T3 (es) | 2015-12-30 | 2021-02-17 | Univ Saint Louis | Derivados de ácido aminobenzoico meta-azaciclicos como antagonistas pan-integrina |
JPWO2021230325A1 (zh) | 2020-05-14 | 2021-11-18 | ||
WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (1)
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CA2230209A1 (en) * | 1995-08-30 | 1997-03-06 | G.D. Searle & Co. | Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid derivatives as integrin antagonists |
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1999
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- 1999-02-22 TR TR2000/02542T patent/TR200002542T2/xx unknown
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- 1999-02-22 PL PL99342726A patent/PL342726A1/xx unknown
- 1999-02-22 CA CA002322207A patent/CA2322207A1/en not_active Abandoned
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2000
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Also Published As
Publication number | Publication date |
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NO315703B1 (no) | 2003-10-13 |
NO20004316L (no) | 2000-11-06 |
JP2002505323A (ja) | 2002-02-19 |
TR200002542T2 (tr) | 2001-05-21 |
EE200000506A (et) | 2002-04-15 |
KR20010041584A (ko) | 2001-05-25 |
MY123908A (en) | 2006-06-30 |
HUP0100865A2 (hu) | 2001-08-28 |
NZ506598A (en) | 2003-07-25 |
IS5582A (is) | 2000-08-04 |
CN1214011C (zh) | 2005-08-10 |
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AR018139A1 (es) | 2001-10-31 |
ID25591A (id) | 2000-10-19 |
BG104740A (en) | 2001-02-28 |
IL137653A0 (en) | 2001-10-31 |
WO1999044994A1 (en) | 1999-09-10 |
AU3294799A (en) | 1999-09-20 |
AU753230B2 (en) | 2002-10-10 |
GEP20033118B (en) | 2003-11-25 |
EA200000804A1 (ru) | 2001-04-23 |
NO20004316D0 (no) | 2000-08-30 |
ZA994406B (en) | 2000-02-11 |
CA2322207A1 (en) | 1999-09-10 |
EP1060164A1 (en) | 2000-12-20 |
BR9908470A (pt) | 2000-12-05 |
AP1244A (en) | 2004-02-04 |
HUP0100865A3 (en) | 2001-11-28 |
AP2000001893A0 (en) | 2000-09-30 |
PL342726A1 (en) | 2001-07-02 |
CN1291978A (zh) | 2001-04-18 |
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YU52000A (sh) | 2003-02-28 |
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