HRP20000242A2 - Shaped bodies for use as implants in human medicine and method for the production of such shaped bodies - Google Patents
Shaped bodies for use as implants in human medicine and method for the production of such shaped bodies Download PDFInfo
- Publication number
- HRP20000242A2 HRP20000242A2 HR20000242A HRP20000242A HRP20000242A2 HR P20000242 A2 HRP20000242 A2 HR P20000242A2 HR 20000242 A HR20000242 A HR 20000242A HR P20000242 A HRP20000242 A HR P20000242A HR P20000242 A2 HRP20000242 A2 HR P20000242A2
- Authority
- HR
- Croatia
- Prior art keywords
- polyols
- diols
- glycol
- shaped bodies
- groups
- Prior art date
Links
- 239000007943 implant Substances 0.000 title claims description 26
- 238000000034 method Methods 0.000 title claims description 17
- 238000004519 manufacturing process Methods 0.000 title claims description 8
- 239000003814 drug Substances 0.000 title claims description 6
- 229920005862 polyol Polymers 0.000 claims description 30
- 150000003077 polyols Chemical class 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 24
- 150000002009 diols Chemical class 0.000 claims description 21
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 238000004132 cross linking Methods 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 239000003054 catalyst Substances 0.000 claims description 12
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 12
- 125000004185 ester group Chemical group 0.000 claims description 12
- 230000007062 hydrolysis Effects 0.000 claims description 10
- 238000006460 hydrolysis reaction Methods 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 239000012634 fragment Substances 0.000 claims description 9
- 239000004814 polyurethane Substances 0.000 claims description 9
- 229920002635 polyurethane Polymers 0.000 claims description 9
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 125000005442 diisocyanate group Chemical group 0.000 claims description 7
- 229920000728 polyester Polymers 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- 239000007858 starting material Substances 0.000 claims description 7
- 239000010409 thin film Substances 0.000 claims description 7
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 6
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 claims description 6
- 210000000988 bone and bone Anatomy 0.000 claims description 6
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims description 6
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 6
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 229920006037 cross link polymer Polymers 0.000 claims description 5
- 210000003041 ligament Anatomy 0.000 claims description 5
- -1 polytetramethylene Polymers 0.000 claims description 5
- 150000007513 acids Chemical class 0.000 claims description 4
- 239000001361 adipic acid Substances 0.000 claims description 4
- 235000011037 adipic acid Nutrition 0.000 claims description 4
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 claims description 4
- 239000005056 polyisocyanate Substances 0.000 claims description 4
- 229920001228 polyisocyanate Polymers 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 4
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 claims description 3
- LZDXRPVSAKWYDH-UHFFFAOYSA-N 2-ethyl-2-(prop-2-enoxymethyl)propane-1,3-diol Chemical compound CCC(CO)(CO)COCC=C LZDXRPVSAKWYDH-UHFFFAOYSA-N 0.000 claims description 3
- IGDCJKDZZUALAO-UHFFFAOYSA-N 2-prop-2-enoxypropane-1,3-diol Chemical compound OCC(CO)OCC=C IGDCJKDZZUALAO-UHFFFAOYSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 3
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 3
- 239000001530 fumaric acid Substances 0.000 claims description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
- 239000011976 maleic acid Substances 0.000 claims description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 3
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 239000011541 reaction mixture Substances 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 239000000811 xylitol Substances 0.000 claims description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 3
- 235000010447 xylitol Nutrition 0.000 claims description 3
- 229960002675 xylitol Drugs 0.000 claims description 3
- KNGOKMSCODQKMQ-UHFFFAOYSA-N 3,4-dihydroxyhexanedioic acid Chemical compound OC(=O)CC(O)C(O)CC(O)=O KNGOKMSCODQKMQ-UHFFFAOYSA-N 0.000 claims description 2
- NKKKCPCVVQJIAR-UHFFFAOYSA-N C(=O)(O)CC(CC(C)(C)C)(CC(=O)O)CC(=O)O Chemical compound C(=O)(O)CC(CC(C)(C)C)(CC(=O)O)CC(=O)O NKKKCPCVVQJIAR-UHFFFAOYSA-N 0.000 claims description 2
- 150000003512 tertiary amines Chemical class 0.000 claims description 2
- 238000005728 strengthening Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 8
- 239000012948 isocyanate Substances 0.000 description 6
- 150000002513 isocyanates Chemical class 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 5
- 239000008240 homogeneous mixture Substances 0.000 description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229920001610 polycaprolactone Polymers 0.000 description 3
- 239000004632 polycaprolactone Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000010936 titanium Substances 0.000 description 3
- 229910052719 titanium Inorganic materials 0.000 description 3
- JCTXTXVFAPKQBD-UHFFFAOYSA-N 3,4,5-trihydroxyheptanedioic acid Chemical compound OC(=O)CC(O)C(O)C(O)CC(O)=O JCTXTXVFAPKQBD-UHFFFAOYSA-N 0.000 description 2
- UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- KORSJDCBLAPZEQ-UHFFFAOYSA-N dicyclohexylmethane-4,4'-diisocyanate Chemical compound C1CC(N=C=O)CCC1CC1CCC(N=C=O)CC1 KORSJDCBLAPZEQ-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- NKKHZOWXTLEOLJ-UHFFFAOYSA-N 3-(carboxymethyl)-3-[3-hydroxy-2,2-bis(hydroxymethyl)propyl]pentanedioic acid Chemical compound C(=O)(O)CC(CC(CO)(CO)CO)(CC(=O)O)CC(=O)O NKKHZOWXTLEOLJ-UHFFFAOYSA-N 0.000 description 1
- RCXHRHWRRACBTK-UHFFFAOYSA-N 3-(oxiran-2-ylmethoxy)propane-1,2-diol Chemical compound OCC(O)COCC1CO1 RCXHRHWRRACBTK-UHFFFAOYSA-N 0.000 description 1
- HVCNXQOWACZAFN-UHFFFAOYSA-N 4-ethylmorpholine Chemical compound CCN1CCOCC1 HVCNXQOWACZAFN-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- UKLDJPRMSDWDSL-UHFFFAOYSA-L [dibutyl(dodecanoyloxy)stannyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[Sn](CCCC)(CCCC)OC(=O)CCCCCCCCCCC UKLDJPRMSDWDSL-UHFFFAOYSA-L 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 150000008049 diazo compounds Chemical class 0.000 description 1
- 239000012975 dibutyltin dilaurate Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000002902 organometallic compounds Chemical class 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229920005906 polyester polyol Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 150000007519 polyprotic acids Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011265 semifinished product Substances 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003351 stiffener Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
- C08G18/4236—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups
- C08G18/4238—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups derived from dicarboxylic acids and dialcohols
- C08G18/4241—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups derived from dicarboxylic acids and dialcohols from dicarboxylic acids and dialcohols in combination with polycarboxylic acids and/or polyhydroxy compounds which are at least trifunctional
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
- C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
- C08G18/4269—Lactones
- C08G18/4277—Caprolactone and/or substituted caprolactone
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9704003A SE510868C2 (sv) | 1997-11-03 | 1997-11-03 | Formkroppar för användning som implantat i humanmedicin samt förfarande för framställning av sådana formkroppar |
| PCT/SE1998/001869 WO1999022780A1 (en) | 1997-11-03 | 1998-10-19 | Shaped bodies for use as implants in human medicine and method for the production of such shaped bodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20000242A2 true HRP20000242A2 (en) | 2001-02-28 |
Family
ID=20408832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20000242A HRP20000242A2 (en) | 1997-11-03 | 2000-04-25 | Shaped bodies for use as implants in human medicine and method for the production of such shaped bodies |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6436136B1 (sv) |
| EP (1) | EP1027086B1 (sv) |
| JP (1) | JP2001521788A (sv) |
| KR (1) | KR20010031738A (sv) |
| AR (1) | AR009698A1 (sv) |
| AT (1) | ATE216271T1 (sv) |
| AU (1) | AU740604B2 (sv) |
| BR (1) | BR9812774A (sv) |
| CA (1) | CA2308190A1 (sv) |
| DE (1) | DE69804989T2 (sv) |
| DK (1) | DK1027086T3 (sv) |
| EE (1) | EE200000760A (sv) |
| ES (1) | ES2175795T3 (sv) |
| HK (1) | HK1030168A1 (sv) |
| HR (1) | HRP20000242A2 (sv) |
| HU (1) | HUP0004017A3 (sv) |
| IL (1) | IL135935A0 (sv) |
| NO (1) | NO20002292L (sv) |
| NZ (1) | NZ504190A (sv) |
| PL (1) | PL343839A1 (sv) |
| PT (1) | PT1027086E (sv) |
| SE (1) | SE510868C2 (sv) |
| SK (1) | SK6532000A3 (sv) |
| TR (1) | TR200001223T2 (sv) |
| TW (1) | TW501933B (sv) |
| WO (1) | WO1999022780A1 (sv) |
| YU (1) | YU24100A (sv) |
| ZA (1) | ZA989694B (sv) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL140049A0 (en) * | 1998-06-05 | 2002-02-10 | Polyganics Bv | Biomedical polyurethane, its preparation and use |
| GB0116341D0 (en) * | 2001-07-04 | 2001-08-29 | Smith & Nephew | Biodegradable polymer systems |
| GB0202233D0 (en) * | 2002-01-31 | 2002-03-20 | Smith & Nephew | Bioresorbable polymers |
| US8025685B2 (en) * | 2003-08-06 | 2011-09-27 | Kenneth Stewart | Bone instrumentation cover or shield |
| DE10340392A1 (de) * | 2003-09-02 | 2005-04-07 | Mnemoscience Gmbh | Amorphe Polyesterurethan-Netzwerke mit Form-Gedächtnis-Eigenschaften |
| US7141354B2 (en) * | 2003-09-30 | 2006-11-28 | Dai Nippon Printing Co., Ltd. | Photo radical generator, photo sensitive resin composition and article |
| GB0329654D0 (en) | 2003-12-23 | 2004-01-28 | Smith & Nephew | Tunable segmented polyacetal |
| DE102004057699A1 (de) * | 2004-11-30 | 2006-06-01 | Henkel Kgaa | Zwei-Komponenten-Polyurethanklebstoffe, Additive für Zwei-Komponenten-Polyurethanklebstoffe und Verwendung der Additive |
| WO2007103276A2 (en) | 2006-03-03 | 2007-09-13 | Smith & Nephew, Inc. | Systems and methods for delivering a medicament |
| CN101594831B (zh) | 2006-11-30 | 2011-09-14 | 史密夫和内修有限公司 | 纤维增强的复合材料 |
| JP5416090B2 (ja) | 2007-04-18 | 2014-02-12 | スミス アンド ネフュー ピーエルシー | 形状記憶ポリマーの膨張成形 |
| EP2142227B1 (en) | 2007-04-19 | 2012-02-29 | Smith & Nephew, Inc. | Multi-modal shape memory polymers |
| DE602008006181D1 (de) | 2007-04-19 | 2011-05-26 | Smith & Nephew Inc | Graft-fixierung |
| EP2385960B1 (en) | 2009-01-12 | 2020-03-11 | University Of Massachusetts Lowell | Polyisobutylene-based polyurethanes |
| JP6581303B2 (ja) * | 2015-12-17 | 2019-09-25 | カーディアック ペースメイカーズ， インコーポレイテッド | ポリイソブチレン−ポリウレタンを含むポリマー材料およびそれを含む医療デバイス並びに同ポリマー材料を製造する方法 |
| WO2018165273A1 (en) | 2017-03-07 | 2018-09-13 | Cardiac Pacemakers, Inc. | Hydroboration/oxidation of allyl-terminated polyisobutylene |
| US11472911B2 (en) | 2018-01-17 | 2022-10-18 | Cardiac Pacemakers, Inc. | End-capped polyisobutylene polyurethane |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE505703C2 (sv) | 1995-12-15 | 1997-09-29 | Polyrand Ab | Linjär blockpolymer innefattande urea- och uretangrupper, förfarande för framställning av linjära blockpolymerer samt användning av blockpolymererna som implantat |
| DE3689650T2 (de) * | 1985-12-17 | 1994-05-26 | United States Surgical Corp | Bioresorbierbare Polymere von hohem Molekulargewicht und Implantate davon. |
| NL8703115A (nl) * | 1987-12-23 | 1989-07-17 | Groningen Science Park | Biodegradeerbare polyurethanen, daarop gebaseerde voortbrengselen, en polyesterpolyol prepolymeren. |
| US5502158A (en) * | 1988-08-08 | 1996-03-26 | Ecopol, Llc | Degradable polymer composition |
| WO1994009048A1 (en) * | 1992-10-13 | 1994-04-28 | Rijksuniversiteit Te Groningen | Polyurethane network for biomedical use |
| US6221997B1 (en) * | 1997-04-28 | 2001-04-24 | Kimberly Ann Woodhouse | Biodegradable polyurethanes |
-
1997
- 1997-11-03 SE SE9704003A patent/SE510868C2/sv not_active IP Right Cessation
-
1998
- 1998-10-19 NZ NZ504190A patent/NZ504190A/xx not_active Application Discontinuation
- 1998-10-19 DK DK98949293T patent/DK1027086T3/da active
- 1998-10-19 ES ES98949293T patent/ES2175795T3/es not_active Expired - Lifetime
- 1998-10-19 BR BR9812774-8A patent/BR9812774A/pt not_active IP Right Cessation
- 1998-10-19 TR TR2000/01223T patent/TR200001223T2/xx unknown
- 1998-10-19 WO PCT/SE1998/001869 patent/WO1999022780A1/en not_active Application Discontinuation
- 1998-10-19 US US09/530,160 patent/US6436136B1/en not_active Expired - Fee Related
- 1998-10-19 KR KR1020007004802A patent/KR20010031738A/ko not_active Application Discontinuation
- 1998-10-19 HU HU0004017A patent/HUP0004017A3/hu unknown
- 1998-10-19 YU YU24100A patent/YU24100A/sh unknown
- 1998-10-19 PL PL98343839A patent/PL343839A1/xx unknown
- 1998-10-19 CA CA002308190A patent/CA2308190A1/en not_active Abandoned
- 1998-10-19 SK SK653-2000A patent/SK6532000A3/sk unknown
- 1998-10-19 PT PT98949293T patent/PT1027086E/pt unknown
- 1998-10-19 EE EEP200000760A patent/EE200000760A/xx unknown
- 1998-10-19 AT AT98949293T patent/ATE216271T1/de not_active IP Right Cessation
- 1998-10-19 JP JP2000518710A patent/JP2001521788A/ja active Pending
- 1998-10-19 DE DE69804989T patent/DE69804989T2/de not_active Expired - Fee Related
- 1998-10-19 IL IL13593598A patent/IL135935A0/xx unknown
- 1998-10-19 AU AU95643/98A patent/AU740604B2/en not_active Ceased
- 1998-10-19 EP EP98949293A patent/EP1027086B1/en not_active Expired - Lifetime
- 1998-10-20 AR ARP980105229A patent/AR009698A1/es not_active Application Discontinuation
- 1998-10-23 ZA ZA989694A patent/ZA989694B/xx unknown
- 1998-10-30 TW TW087118084A patent/TW501933B/zh active
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2000
- 2000-04-25 HR HR20000242A patent/HRP20000242A2/hr not_active Application Discontinuation
- 2000-04-28 NO NO20002292A patent/NO20002292L/no not_active Application Discontinuation
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2001
- 2001-02-14 HK HK01101087A patent/HK1030168A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL135935A0 (en) | 2001-05-20 |
| SE510868C2 (sv) | 1999-07-05 |
| PL343839A1 (en) | 2001-09-10 |
| ZA989694B (en) | 1999-04-29 |
| PT1027086E (pt) | 2002-09-30 |
| JP2001521788A (ja) | 2001-11-13 |
| BR9812774A (pt) | 2000-10-10 |
| HUP0004017A2 (en) | 2001-03-28 |
| ATE216271T1 (de) | 2002-05-15 |
| TW501933B (en) | 2002-09-11 |
| YU24100A (sh) | 2001-09-28 |
| DE69804989T2 (de) | 2002-11-21 |
| ES2175795T3 (es) | 2002-11-16 |
| SE9704003D0 (sv) | 1997-11-03 |
| NO20002292D0 (no) | 2000-04-28 |
| EP1027086A1 (en) | 2000-08-16 |
| NZ504190A (en) | 2002-09-27 |
| TR200001223T2 (tr) | 2002-01-21 |
| SK6532000A3 (en) | 2000-09-12 |
| WO1999022780A1 (en) | 1999-05-14 |
| CA2308190A1 (en) | 1999-05-14 |
| NO20002292L (no) | 2000-06-23 |
| SE9704003L (sv) | 1999-05-04 |
| AU740604B2 (en) | 2001-11-08 |
| HK1030168A1 (en) | 2001-04-27 |
| KR20010031738A (ko) | 2001-04-16 |
| DK1027086T3 (da) | 2002-08-12 |
| US6436136B1 (en) | 2002-08-20 |
| HUP0004017A3 (en) | 2003-10-28 |
| AR009698A1 (es) | 2000-04-26 |
| EP1027086B1 (en) | 2002-04-17 |
| EE200000760A (et) | 2002-04-15 |
| DE69804989D1 (de) | 2002-05-23 |
| AU9564398A (en) | 1999-05-24 |
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