HK92292A - Analogues of antibiotic cc-1065 - Google Patents
Analogues of antibiotic cc-1065Info
- Publication number
- HK92292A HK92292A HK922/92A HK92292A HK92292A HK 92292 A HK92292 A HK 92292A HK 922/92 A HK922/92 A HK 922/92A HK 92292 A HK92292 A HK 92292A HK 92292 A HK92292 A HK 92292A
- Authority
- HK
- Hong Kong
- Prior art keywords
- analogues
- antibiotic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58183684A | 1984-02-21 | 1984-02-21 | |
US69436385A | 1985-01-24 | 1985-01-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK92292A true HK92292A (en) | 1992-11-27 |
Family
ID=27078429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK922/92A HK92292A (en) | 1984-02-21 | 1992-11-19 | Analogues of antibiotic cc-1065 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0154445B1 (fr) |
JP (2) | JP2545060B2 (fr) |
CA (2) | CA1238907A (fr) |
DE (1) | DE3570670D1 (fr) |
HK (1) | HK92292A (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3783588T2 (de) * | 1986-04-17 | 1993-06-09 | Kyowa Hakko Kogyo Kk | Neue verbindungen dc-88a und dc-89a1 und deren herstellungsverfahren. |
JP2598819B2 (ja) * | 1986-12-19 | 1997-04-09 | ジ・アップジョン・カンパニー | 新規なcc‐1065同族体 |
US5332837A (en) * | 1986-12-19 | 1994-07-26 | The Upjohn Company | CC-1065 analogs |
US4994578A (en) * | 1987-11-27 | 1991-02-19 | Meiji Seika Kaisha, Ltd. | Certain anti-tumor duocarmycin antibiotics from streptomyces |
EP0318056A3 (fr) * | 1987-11-27 | 1990-12-19 | Meiji Seika Kaisha Ltd. | Antibiotiques et procédé pour leur production |
JP2562935B2 (ja) * | 1988-04-28 | 1996-12-11 | 明治製菓株式会社 | 抗腫瘍性物質sf2582誘導体 |
JP2642165B2 (ja) * | 1988-07-22 | 1997-08-20 | 協和醗酵工業株式会社 | 新規dc−89化合物およびその製造法 |
US5084468A (en) * | 1988-08-11 | 1992-01-28 | Kyowa Hakko Kogyo Co., Ltd. | Dc-88a derivatives |
KR0137959B1 (ko) * | 1988-09-12 | 1998-05-15 | 로버트 에이. 아미테이지 | 2개의 cpi 소단위를 갖는 신규한 cc-1065 유사화합물 |
MX9203460A (es) * | 1988-09-12 | 1992-09-01 | Upjohn Co | Nuevos analogos cc-1065 que tienen dos subunidades cpi. |
US5008271A (en) * | 1988-10-21 | 1991-04-16 | Kyowa Hakko Kogyo Co., Ltd. | DC-88A derivatives |
JP2598116B2 (ja) * | 1988-12-28 | 1997-04-09 | 協和醗酵工業株式会社 | 新規物質dc113 |
JP2510335B2 (ja) * | 1989-07-03 | 1996-06-26 | 協和醗酵工業株式会社 | Dc―88a誘導体 |
US5187186A (en) * | 1989-07-03 | 1993-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Pyrroloindole derivatives |
EP0527189A1 (fr) * | 1990-04-25 | 1993-02-17 | PHARMACIA & UPJOHN COMPANY | Nouveaux analogues de cc-1065 |
US5214065A (en) * | 1990-06-11 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Dc-89 derivatives |
US5248692A (en) * | 1990-06-11 | 1993-09-28 | Kyowa Hakko Kogyo Co., Ltd. | DC-89 derivatives as anti-tumor agents |
US5258383A (en) * | 1991-06-28 | 1993-11-02 | Kyowa Hakko Kogyo Co., Ltd. | DC-89 derivatives |
CA2076465C (fr) * | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Conjugues agents de liaison cellulaire d'analogues et de derives de cc-1065 |
US5248691A (en) * | 1992-09-03 | 1993-09-28 | Eli Lilly And Company | Furanoindolines |
WO1995026964A1 (fr) * | 1994-04-01 | 1995-10-12 | Kyowa Hakko Kogyo Co., Ltd. | Derive dc-89 |
CA2165819C (fr) * | 1994-04-22 | 2005-12-27 | Nobuyoshi Amishiro | Derives de dc-89 |
HUT77654A (hu) * | 1994-11-29 | 1998-07-28 | Kyorin Pharmaceutical Co.,Ltd. | Bisz[(1,2,3,6-tetrahidro-pirrolo[3,2-e]indol-3-il)-akrilamid]-származékok és eljárás előállításukra |
GB9625913D0 (en) * | 1996-12-13 | 1997-01-29 | Cancer Soc Auckland Div Nz Inc | Novel cyclopropylindoles and their seco precursors,and their use as prodrugs |
US6251933B1 (en) | 1996-12-13 | 2001-06-26 | The Cancer Research Campaign Technology Limited | Seco precursors of cyclopropylindolines and their use as prodrugs |
WO1998052925A1 (fr) * | 1997-05-22 | 1998-11-26 | The Scripps Research Institute | Analogues de duocarmycine et de cc-1065 |
EP2266986A1 (fr) | 2001-05-31 | 2010-12-29 | Medarex, Inc. | Cytotoxines, promedicaments, lieurs et stabilisateurs utiles pour ceux-ci |
US7691962B2 (en) | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
WO2007059404A2 (fr) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Composes et conjugues cytotoxiques |
RU2489423C2 (ru) * | 2006-02-02 | 2013-08-10 | Синтарга Б.В. | Водорастворимые аналоги сс-1065 и их конъюгаты |
US8664407B2 (en) | 2007-02-21 | 2014-03-04 | Medarex, LLC | Chemical linkers with single amino acids and conjugates thereof |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
NO2344478T3 (fr) | 2008-11-03 | 2018-02-24 | ||
DK3056203T3 (da) | 2010-04-21 | 2018-01-29 | Syntarga Bv | Konjugater af cc-1065-analoger og bifunktionelle linkere. |
ES2755719T3 (es) * | 2012-04-05 | 2020-04-23 | Nerviano Medical Sciences Srl | Nuevos agentes alquilantes |
ES2738657T3 (es) * | 2013-09-25 | 2020-01-24 | Nerviano Medical Sciences Srl | Derivados de tieno[2,3-e]indol como nuevos antitumorales |
WO2015104373A2 (fr) | 2014-01-10 | 2015-07-16 | Synthon Biopharmaceuticals B.V. | Conjugués anticorps-médicaments à base de duocarmycine utilisables dans le cadre du traitement du cancer de l'endomètre |
JP6342517B2 (ja) | 2014-01-10 | 2018-06-13 | シントン・バイオファーマシューティカルズ・ビー.ブイ.Synthon Biopharmaceuticals B.V. | 改善されたインビボ抗腫瘍活性を示すデュオカルマイシンadc |
US10266606B2 (en) | 2014-01-10 | 2019-04-23 | Synthon Biopharmaceuticals B.V. | Method for purifying Cys-linked antibody-drug conjugates |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4423229A (en) * | 1980-11-18 | 1983-12-27 | The Upjohn Company | Composition of matter and process |
-
1985
- 1985-02-08 CA CA000473917A patent/CA1238907A/fr not_active Expired
- 1985-02-20 EP EP85301125A patent/EP0154445B1/fr not_active Expired
- 1985-02-20 DE DE8585301125T patent/DE3570670D1/de not_active Expired
- 1985-02-21 JP JP60031662A patent/JP2545060B2/ja not_active Expired - Lifetime
-
1987
- 1987-11-23 CA CA000552543A patent/CA1293248C/fr not_active Expired - Fee Related
-
1992
- 1992-11-19 HK HK922/92A patent/HK92292A/xx not_active IP Right Cessation
-
1995
- 1995-12-20 JP JP7331640A patent/JPH08225573A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA1293248C (fr) | 1991-12-17 |
DE3570670D1 (en) | 1989-07-06 |
EP0154445B1 (fr) | 1989-05-31 |
JP2545060B2 (ja) | 1996-10-16 |
JPH08225573A (ja) | 1996-09-03 |
CA1238907A (fr) | 1988-07-05 |
EP0154445A1 (fr) | 1985-09-11 |
JPS60193989A (ja) | 1985-10-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |