HK63090A - 17 beta-substituted-4-aza-5-alpha-androstenones and their use as 5-alpha-reductase inhibitors - Google Patents

17 beta-substituted-4-aza-5-alpha-androstenones and their use as 5-alpha-reductase inhibitors

Info

Publication number
HK63090A
HK63090A HK630/90A HK63090A HK63090A HK 63090 A HK63090 A HK 63090A HK 630/90 A HK630/90 A HK 630/90A HK 63090 A HK63090 A HK 63090A HK 63090 A HK63090 A HK 63090A
Authority
HK
Hong Kong
Prior art keywords
alpha
androstenones
aza
beta
substituted
Prior art date
Application number
HK630/90A
Other languages
English (en)
Inventor
Gary H Rasmusson
Glenn F Reynolds
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27078980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK63090(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HK63090A publication Critical patent/HK63090A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes
HK630/90A 1984-02-27 1990-08-09 17 beta-substituted-4-aza-5-alpha-androstenones and their use as 5-alpha-reductase inhibitors HK63090A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58406184A 1984-02-27 1984-02-27
US58406284A 1984-02-27 1984-02-27

Publications (1)

Publication Number Publication Date
HK63090A true HK63090A (en) 1990-08-17

Family

ID=27078980

Family Applications (1)

Application Number Title Priority Date Filing Date
HK630/90A HK63090A (en) 1984-02-27 1990-08-09 17 beta-substituted-4-aza-5-alpha-androstenones and their use as 5-alpha-reductase inhibitors

Country Status (16)

Country Link
EP (1) EP0155096B1 (xx)
JP (1) JPH0193600A (xx)
KR (1) KR900001206B1 (xx)
AU (4) AU584321B2 (xx)
CA (1) CA1314541C (xx)
CY (1) CY1553A (xx)
DE (2) DE3584172D1 (xx)
DK (1) DK166704B1 (xx)
ES (1) ES8702430A1 (xx)
GR (1) GR850483B (xx)
HK (1) HK63090A (xx)
IE (2) IE922862L (xx)
IL (1) IL74365A (xx)
NL (1) NL930005I2 (xx)
NZ (1) NZ211145A (xx)
PT (1) PT80010B (xx)

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US5098908A (en) * 1990-06-20 1992-03-24 Merck & Co., Inc. 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
US5091380A (en) * 1990-06-28 1992-02-25 Merck & Co., Inc. N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
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US5120847A (en) * 1990-08-27 1992-06-09 Merck & Co., Inc. Process for iodinating or brominating the α-methylenic carbon of a secondary amide
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US5061803A (en) * 1990-09-24 1991-10-29 Merck & Co., Inc. Process for making 17-beta alkanoyl 3-oxo-4-aza-5-α-androst-1-enes
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EP0547687A1 (en) * 1991-12-18 1993-06-23 Merck & Co. Inc. 17B-N-Substituted adamantyl/norbonanyl carbamoyl-4-aza-5a-and-rost-1-en-3-ones and androstan-3 ones
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US5698720A (en) * 1992-04-20 1997-12-16 Sankyo Company, Limited Steroid derivatives
ATE154937T1 (de) * 1992-04-20 1997-07-15 Sankyo Co Steroide zur behandlung von prostatisch- hypertrophe, ihre herstellung und verwendung
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EP0649431B1 (en) * 1992-05-20 1999-08-11 Merck & Co. Inc. 17-amino substituted 4-azasteroid 5-alpha-reductase inhibitors
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EP0641211A1 (en) * 1992-05-21 1995-03-08 Endorecherche Inc. INHIBITORS OF TESTOSTERONE 5$g(a)-REDUCTASE ACTIVITY
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US5278159A (en) * 1992-10-06 1994-01-11 Merck & Co., Inc. Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors
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US5621104A (en) * 1993-03-24 1997-04-15 Merck & Co., Inc. Substituted 3-phenanthridinone derivatives as 5-alpha-reductase inhibitors
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CN1314241C (zh) * 2002-09-27 2007-05-02 华为技术有限公司 在城域网相同虚容器映射通道内传送不同用户数据的方法
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Also Published As

Publication number Publication date
DK85985A (da) 1985-10-22
IL74365A0 (en) 1985-05-31
CY1553A (en) 1991-03-22
AU626293B2 (en) 1992-07-30
DK85985D0 (da) 1985-02-26
IE850476L (en) 1985-08-27
EP0155096A3 (en) 1986-07-02
AU584321B2 (en) 1989-05-25
EP0155096A2 (en) 1985-09-18
IE922862L (en) 1985-08-27
KR850006185A (ko) 1985-10-02
JPH0541638B2 (xx) 1993-06-24
PT80010A (en) 1985-03-01
KR900001206B1 (ko) 1990-02-28
DK166704B1 (da) 1993-06-28
NZ211145A (en) 1988-10-28
IL74365A (en) 1990-07-26
PT80010B (pt) 1987-09-18
ES8702430A1 (es) 1987-01-01
DE3584172D1 (de) 1991-10-24
AU651741B2 (en) 1994-07-28
CA1314541C (en) 1993-03-16
EP0155096B1 (en) 1989-10-04
IE58058B1 (en) 1993-06-16
AU3313589A (en) 1989-08-10
NL930005I2 (nl) 1993-09-16
DE3573429D1 (en) 1989-11-09
NL930005I1 (nl) 1993-04-01
GR850483B (xx) 1985-06-26
AU7083591A (en) 1991-07-11
AU2748192A (en) 1993-03-18
ES540705A0 (es) 1987-01-01
JPH0193600A (ja) 1989-04-12
AU3916785A (en) 1985-09-05

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Effective date: 20050219