HK1255567A1 - 苯基丙酰胺類衍生物、其製備方法及其在醫藥上的應用 - Google Patents
苯基丙酰胺類衍生物、其製備方法及其在醫藥上的應用Info
- Publication number
- HK1255567A1 HK1255567A1 HK18114605.8A HK18114605A HK1255567A1 HK 1255567 A1 HK1255567 A1 HK 1255567A1 HK 18114605 A HK18114605 A HK 18114605A HK 1255567 A1 HK1255567 A1 HK 1255567A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- manufacturing
- pharmaceutical application
- phenyl propanamide
- propanamide derivative
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610397516 | 2016-06-07 | ||
PCT/CN2017/087328 WO2017211272A1 (zh) | 2016-06-07 | 2017-06-06 | 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1255567A1 true HK1255567A1 (zh) | 2019-08-23 |
Family
ID=60578399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18114605.8A HK1255567A1 (zh) | 2016-06-07 | 2018-11-15 | 苯基丙酰胺類衍生物、其製備方法及其在醫藥上的應用 |
Country Status (14)
Country | Link |
---|---|
US (1) | US20190144499A1 (zh) |
EP (1) | EP3466962A4 (zh) |
JP (1) | JP7120927B2 (zh) |
KR (1) | KR102401743B1 (zh) |
CN (3) | CN114349820A (zh) |
AU (1) | AU2017277003B2 (zh) |
BR (1) | BR112018074431A2 (zh) |
CA (1) | CA3025710A1 (zh) |
HK (1) | HK1255567A1 (zh) |
MX (1) | MX2018015082A (zh) |
RU (1) | RU2738207C2 (zh) |
TW (1) | TWI781938B (zh) |
UA (1) | UA123737C2 (zh) |
WO (1) | WO2017211272A1 (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2018015082A (es) * | 2016-06-07 | 2019-04-22 | Jiangsu Hengrui Medicine Co | Derivado de fenilpropanamida y metodo de fabricacion y su aplicacion farmaceutica. |
EP3521301B1 (en) | 2016-09-27 | 2024-03-06 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Polyamide compound and use thereof |
JP2021505547A (ja) * | 2017-12-06 | 2021-02-18 | 江蘇恒瑞医薬股▲ふん▼有限公司 | 疼痛を治療するための薬物の製造におけるmorアゴニストと組み合わせたkorアゴニストの使用 |
CN109879934B (zh) * | 2017-12-06 | 2020-12-08 | 江苏恒瑞医药股份有限公司 | 一种苯基丙酰胺类衍生物的盐及其制备方法 |
KR20200096588A (ko) * | 2017-12-06 | 2020-08-12 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 페닐프로피온아마이드 유도체의 염 및 이의 제조 방법 |
BR112020023038A2 (pt) | 2018-05-16 | 2021-02-02 | Jiangsu Hengrui Medicine Co., Ltd. | composição farmacêutica de agonista receptor kor |
CN110790817A (zh) * | 2019-11-12 | 2020-02-14 | 成都诺和晟泰生物科技有限公司 | 一种多肽类化合物、制剂、药物组合物及制备方法、应用 |
CN113493490B (zh) * | 2020-04-03 | 2024-03-12 | 成都诺和晟泰生物科技有限公司 | 一种合成肽酰胺类化合物及其在医药领域的用途 |
JP2023525689A (ja) * | 2020-04-30 | 2023-06-19 | メッドシャイン ディスカバリー インコーポレイテッド | フェニルプロピオンアミド系化合物及びその使用 |
KR20230024419A (ko) | 2020-06-25 | 2023-02-20 | 휴먼웰 파마슈티컬 유에스 | 의학적 장애 치료용 펩티드 |
CN115925699B (zh) * | 2022-02-25 | 2023-10-03 | 南京知和医药科技有限公司 | 具有镇痛活性的稠环化合物及其制备方法与用途 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8236766B2 (en) * | 2006-11-10 | 2012-08-07 | Cara Therapeutics, Inc. | Uses of synthetic peptide amides |
US8906859B2 (en) * | 2006-11-10 | 2014-12-09 | Cera Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
WO2008057608A2 (en) * | 2006-11-10 | 2008-05-15 | Cara Therapeutics, Inc. | Synthetic peptide amides |
JP2011526881A (ja) * | 2008-06-25 | 2011-10-20 | ファイザー・インク | ジアリール化合物およびそれらの使用 |
US8809278B2 (en) * | 2008-07-11 | 2014-08-19 | University Of Kansas | Cyclic tetrapeptides |
MX2011009572A (es) * | 2009-03-17 | 2011-09-28 | United Technologies Ut Ag | Composiciones topicas que comprenden interleucina-1 alfa y peptidos y metodos cosmeticos de las mismas. |
KR101773331B1 (ko) * | 2012-03-05 | 2017-08-31 | 닥터 레디스 레보러터리즈 리미티드 | 카파 오피오이드 수용체(κor) 작용제인 치환된 헤테로시클릭 아세트아미드 |
US20150150935A1 (en) * | 2012-06-05 | 2015-06-04 | Cara Therapeutics, Inc. | Peripheral kappa receptor agonists for reducing pain and inflammation |
WO2014089019A1 (en) * | 2012-12-03 | 2014-06-12 | University Of Washington Through Its Center For Commercialization | Methods and compositions for treating vasomotor symptoms |
WO2014184356A1 (en) * | 2013-05-17 | 2014-11-20 | Dr. August Wolff Gmbh & Co. Kg Arzneimittel | Perhydroquinoxaline derivatives useful as analgesics |
WO2015065867A2 (en) * | 2013-10-28 | 2015-05-07 | Cara Therapeutics, Inc. | Peripheral kappa opioid receptor agonists for preventing, inhibiting or treating nausea and vomiting |
CN105523996B (zh) * | 2014-10-17 | 2020-03-06 | 江苏恒瑞医药股份有限公司 | 酰胺类衍生物、其制备方法及其在医药上的应用 |
MX2018015082A (es) * | 2016-06-07 | 2019-04-22 | Jiangsu Hengrui Medicine Co | Derivado de fenilpropanamida y metodo de fabricacion y su aplicacion farmaceutica. |
-
2017
- 2017-06-06 MX MX2018015082A patent/MX2018015082A/es unknown
- 2017-06-06 CN CN202210043910.2A patent/CN114349820A/zh active Pending
- 2017-06-06 CN CN201780004217.1A patent/CN108290926B/zh active Active
- 2017-06-06 CA CA3025710A patent/CA3025710A1/en active Pending
- 2017-06-06 BR BR112018074431-0A patent/BR112018074431A2/pt not_active IP Right Cessation
- 2017-06-06 KR KR1020187037174A patent/KR102401743B1/ko active IP Right Grant
- 2017-06-06 AU AU2017277003A patent/AU2017277003B2/en not_active Ceased
- 2017-06-06 CN CN202210044042.XA patent/CN114940700A/zh active Pending
- 2017-06-06 JP JP2018563586A patent/JP7120927B2/ja active Active
- 2017-06-06 UA UAA201812607A patent/UA123737C2/uk unknown
- 2017-06-06 US US16/306,950 patent/US20190144499A1/en not_active Abandoned
- 2017-06-06 WO PCT/CN2017/087328 patent/WO2017211272A1/zh unknown
- 2017-06-06 RU RU2018145808A patent/RU2738207C2/ru active
- 2017-06-06 EP EP17809711.9A patent/EP3466962A4/en not_active Withdrawn
- 2017-06-06 TW TW106118675A patent/TWI781938B/zh active
-
2018
- 2018-11-15 HK HK18114605.8A patent/HK1255567A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
RU2738207C2 (ru) | 2020-12-09 |
JP2019517530A (ja) | 2019-06-24 |
AU2017277003A1 (en) | 2018-12-13 |
US20190144499A1 (en) | 2019-05-16 |
RU2018145808A (ru) | 2020-07-09 |
UA123737C2 (uk) | 2021-05-26 |
CA3025710A1 (en) | 2017-12-14 |
TW201742858A (zh) | 2017-12-16 |
CN114349820A (zh) | 2022-04-15 |
EP3466962A4 (en) | 2020-01-08 |
JP7120927B2 (ja) | 2022-08-17 |
TWI781938B (zh) | 2022-11-01 |
CN108290926B (zh) | 2022-02-08 |
EP3466962A1 (en) | 2019-04-10 |
WO2017211272A1 (zh) | 2017-12-14 |
CN108290926A (zh) | 2018-07-17 |
KR20190016516A (ko) | 2019-02-18 |
CN114940700A (zh) | 2022-08-26 |
RU2018145808A3 (zh) | 2020-07-09 |
BR112018074431A2 (pt) | 2019-03-06 |
AU2017277003B2 (en) | 2021-01-07 |
MX2018015082A (es) | 2019-04-22 |
KR102401743B1 (ko) | 2022-05-24 |
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