HK1255567A1 - 苯基丙酰胺類衍生物、其製備方法及其在醫藥上的應用 - Google Patents

苯基丙酰胺類衍生物、其製備方法及其在醫藥上的應用

Info

Publication number
HK1255567A1
HK1255567A1 HK18114605.8A HK18114605A HK1255567A1 HK 1255567 A1 HK1255567 A1 HK 1255567A1 HK 18114605 A HK18114605 A HK 18114605A HK 1255567 A1 HK1255567 A1 HK 1255567A1
Authority
HK
Hong Kong
Prior art keywords
manufacturing
pharmaceutical application
phenyl propanamide
propanamide derivative
derivative
Prior art date
Application number
HK18114605.8A
Other languages
English (en)
Inventor
李心
王斌
錢文建
陳陽
賀峰
陶維康
Original Assignee
江蘇恒瑞醫藥股份有限公司
上海恒瑞醫藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江蘇恒瑞醫藥股份有限公司, 上海恒瑞醫藥有限公司 filed Critical 江蘇恒瑞醫藥股份有限公司
Publication of HK1255567A1 publication Critical patent/HK1255567A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
HK18114605.8A 2016-06-07 2018-11-15 苯基丙酰胺類衍生物、其製備方法及其在醫藥上的應用 HK1255567A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610397516 2016-06-07
PCT/CN2017/087328 WO2017211272A1 (zh) 2016-06-07 2017-06-06 苯基丙酰胺类衍生物、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
HK1255567A1 true HK1255567A1 (zh) 2019-08-23

Family

ID=60578399

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18114605.8A HK1255567A1 (zh) 2016-06-07 2018-11-15 苯基丙酰胺類衍生物、其製備方法及其在醫藥上的應用

Country Status (14)

Country Link
US (1) US20190144499A1 (zh)
EP (1) EP3466962A4 (zh)
JP (1) JP7120927B2 (zh)
KR (1) KR102401743B1 (zh)
CN (3) CN114349820A (zh)
AU (1) AU2017277003B2 (zh)
BR (1) BR112018074431A2 (zh)
CA (1) CA3025710A1 (zh)
HK (1) HK1255567A1 (zh)
MX (1) MX2018015082A (zh)
RU (1) RU2738207C2 (zh)
TW (1) TWI781938B (zh)
UA (1) UA123737C2 (zh)
WO (1) WO2017211272A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018015082A (es) * 2016-06-07 2019-04-22 Jiangsu Hengrui Medicine Co Derivado de fenilpropanamida y metodo de fabricacion y su aplicacion farmaceutica.
EP3521301B1 (en) 2016-09-27 2024-03-06 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Polyamide compound and use thereof
JP2021505547A (ja) * 2017-12-06 2021-02-18 江蘇恒瑞医薬股▲ふん▼有限公司 疼痛を治療するための薬物の製造におけるｍｏｒアゴニストと組み合わせたｋｏｒアゴニストの使用
CN109879934B (zh) * 2017-12-06 2020-12-08 江苏恒瑞医药股份有限公司 一种苯基丙酰胺类衍生物的盐及其制备方法
KR20200096588A (ko) * 2017-12-06 2020-08-12 지앙수 헨그루이 메디슨 컴퍼니 리미티드 페닐프로피온아마이드 유도체의 염 및 이의 제조 방법
BR112020023038A2 (pt) 2018-05-16 2021-02-02 Jiangsu Hengrui Medicine Co., Ltd. composição farmacêutica de agonista receptor kor
CN110790817A (zh) * 2019-11-12 2020-02-14 成都诺和晟泰生物科技有限公司 一种多肽类化合物、制剂、药物组合物及制备方法、应用
CN113493490B (zh) * 2020-04-03 2024-03-12 成都诺和晟泰生物科技有限公司 一种合成肽酰胺类化合物及其在医药领域的用途
JP2023525689A (ja) * 2020-04-30 2023-06-19 メッドシャイン ディスカバリー インコーポレイテッド フェニルプロピオンアミド系化合物及びその使用
KR20230024419A (ko) 2020-06-25 2023-02-20 휴먼웰 파마슈티컬 유에스 의학적 장애 치료용 펩티드
CN115925699B (zh) * 2022-02-25 2023-10-03 南京知和医药科技有限公司 具有镇痛活性的稠环化合物及其制备方法与用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US8906859B2 (en) * 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
WO2008057608A2 (en) * 2006-11-10 2008-05-15 Cara Therapeutics, Inc. Synthetic peptide amides
JP2011526881A (ja) * 2008-06-25 2011-10-20 ファイザー・インク ジアリール化合物およびそれらの使用
US8809278B2 (en) * 2008-07-11 2014-08-19 University Of Kansas Cyclic tetrapeptides
MX2011009572A (es) * 2009-03-17 2011-09-28 United Technologies Ut Ag Composiciones topicas que comprenden interleucina-1 alfa y peptidos y metodos cosmeticos de las mismas.
KR101773331B1 (ko) * 2012-03-05 2017-08-31 닥터 레디스 레보러터리즈 리미티드 카파 오피오이드 수용체(κor) 작용제인 치환된 헤테로시클릭 아세트아미드
US20150150935A1 (en) * 2012-06-05 2015-06-04 Cara Therapeutics, Inc. Peripheral kappa receptor agonists for reducing pain and inflammation
WO2014089019A1 (en) * 2012-12-03 2014-06-12 University Of Washington Through Its Center For Commercialization Methods and compositions for treating vasomotor symptoms
WO2014184356A1 (en) * 2013-05-17 2014-11-20 Dr. August Wolff Gmbh & Co. Kg Arzneimittel Perhydroquinoxaline derivatives useful as analgesics
WO2015065867A2 (en) * 2013-10-28 2015-05-07 Cara Therapeutics, Inc. Peripheral kappa opioid receptor agonists for preventing, inhibiting or treating nausea and vomiting
CN105523996B (zh) * 2014-10-17 2020-03-06 江苏恒瑞医药股份有限公司 酰胺类衍生物、其制备方法及其在医药上的应用
MX2018015082A (es) * 2016-06-07 2019-04-22 Jiangsu Hengrui Medicine Co Derivado de fenilpropanamida y metodo de fabricacion y su aplicacion farmaceutica.

Also Published As

Publication number Publication date
RU2738207C2 (ru) 2020-12-09
JP2019517530A (ja) 2019-06-24
AU2017277003A1 (en) 2018-12-13
US20190144499A1 (en) 2019-05-16
RU2018145808A (ru) 2020-07-09
UA123737C2 (uk) 2021-05-26
CA3025710A1 (en) 2017-12-14
TW201742858A (zh) 2017-12-16
CN114349820A (zh) 2022-04-15
EP3466962A4 (en) 2020-01-08
JP7120927B2 (ja) 2022-08-17
TWI781938B (zh) 2022-11-01
CN108290926B (zh) 2022-02-08
EP3466962A1 (en) 2019-04-10
WO2017211272A1 (zh) 2017-12-14
CN108290926A (zh) 2018-07-17
KR20190016516A (ko) 2019-02-18
CN114940700A (zh) 2022-08-26
RU2018145808A3 (zh) 2020-07-09
BR112018074431A2 (pt) 2019-03-06
AU2017277003B2 (en) 2021-01-07
MX2018015082A (es) 2019-04-22
KR102401743B1 (ko) 2022-05-24

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