HK1251562A1 - 三環稠合吡啶-2-酮衍生物及其作為brd4抑制劑的用途 - Google Patents

三環稠合吡啶-2-酮衍生物及其作為brd4抑制劑的用途

Info

Publication number
HK1251562A1
HK1251562A1 HK18110992.7A HK18110992A HK1251562A1 HK 1251562 A1 HK1251562 A1 HK 1251562A1 HK 18110992 A HK18110992 A HK 18110992A HK 1251562 A1 HK1251562 A1 HK 1251562A1
Authority
HK
Hong Kong
Prior art keywords
derivatives
tricyclic fused
brd4 inhibitors
pyridin
fused pyridin
Prior art date
Application number
HK18110992.7A
Other languages
English (en)
Inventor
Chandrika Mulakala
Payal Kiran Parikh
Pavan Kumar Gondrala
Manjunatha M Ramaiah
Sridharan Rajagopal
Dhanalakshmi Sivanandhan
Saravanan Vadivelu
Murugan Chinnapattu
Original Assignee
朱比蘭特生物系統有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57346000&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1251562(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 朱比蘭特生物系統有限公司 filed Critical 朱比蘭特生物系統有限公司
Publication of HK1251562A1 publication Critical patent/HK1251562A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK18110992.7A 2015-09-09 2018-08-27 三環稠合吡啶-2-酮衍生物及其作為brd4抑制劑的用途 HK1251562A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN4781CH2015 2015-09-09

Publications (1)

Publication Number Publication Date
HK1251562A1 true HK1251562A1 (zh) 2019-02-01

Family

ID=57346000

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18110992.7A HK1251562A1 (zh) 2015-09-09 2018-08-27 三環稠合吡啶-2-酮衍生物及其作為brd4抑制劑的用途

Country Status (22)

Country Link
US (2) US10689395B2 (zh)
EP (1) EP3347356B1 (zh)
JP (1) JP6838052B2 (zh)
KR (1) KR20180049056A (zh)
CN (1) CN108137588B (zh)
AU (1) AU2016319638B2 (zh)
CA (1) CA2997531A1 (zh)
CY (1) CY1124245T1 (zh)
DK (1) DK3347356T3 (zh)
ES (1) ES2866073T3 (zh)
HK (1) HK1251562A1 (zh)
HR (1) HRP20210581T1 (zh)
HU (1) HUE053912T2 (zh)
IL (1) IL257473B (zh)
LT (1) LT3347356T (zh)
MX (1) MX2018002738A (zh)
PL (1) PL3347356T3 (zh)
PT (1) PT3347356T (zh)
RS (1) RS61803B1 (zh)
RU (1) RU2734959C2 (zh)
SI (1) SI3347356T1 (zh)
WO (1) WO2017042834A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3099693A4 (en) 2014-01-31 2017-08-16 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
MX2016009974A (es) 2014-01-31 2016-10-31 Dana Farber Cancer Inst Inc Derivados de diaminopirimidina bencensulfona y sus usos.
BR112018004618A2 (pt) 2015-09-11 2018-09-25 Dana-Farber Cancer Institute, Inc. ciano tienotriazoldiazepinas e usos das mesmas
CN108472299A (zh) * 2015-09-11 2018-08-31 达纳-法伯癌症研究所股份有限公司 乙酰胺噻吩并三唑并二氮杂环庚三烯及其用途
MX2018006499A (es) 2015-11-25 2018-08-01 Dana Farber Cancer Inst Inc Inhibidores de bromodominio bivalentes y usos de los mismos.
JP2019534306A (ja) * 2016-11-10 2019-11-28 羅欣薬業（上海）有限公司Ｌｕｏｘｉｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ（Ｓｈａｎｇｈａｉ） Ｃｏ．， Ｌｔｄ． 窒素含有大員環系化合物、その製造方法、薬物組成物および使用
CN112119065B (zh) * 2018-07-13 2024-01-23 四川科伦博泰生物医药股份有限公司 苯并二氮杂环类化合物、其制备方法及用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2008133288A1 (ja) 2007-04-25 2010-07-29 第一三共株式会社 三環性アリール化合物
SG10201407781SA (en) 2009-09-28 2015-01-29 Hoffmann La Roche Benzoxepin PI3K Inhibitor Compounds And Methods Of Use
AR084070A1 (es) * 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
BR112015022391B1 (pt) * 2013-03-12 2021-12-21 Abbvie Inc Compostos inibidores do domínio bromo tetracíclico, composição farmacêutica que compreende os referidos compostos e usos terapêuticos dos mesmos
KR102588109B1 (ko) * 2015-03-30 2023-10-12 주빌란트 바이오시스 리미티드 암 치료에 유용한 1-(사이클로) 알킬 피리딘-2-온의 트리사이클릭 융합 유도체

Also Published As

Publication number Publication date
MX2018002738A (es) 2018-04-13
RU2734959C2 (ru) 2020-10-26
US20200339595A1 (en) 2020-10-29
RU2018112015A3 (zh) 2019-10-11
CN108137588A (zh) 2018-06-08
AU2016319638B2 (en) 2021-02-11
JP6838052B2 (ja) 2021-03-03
DK3347356T3 (da) 2021-04-26
LT3347356T (lt) 2021-06-10
BR112018004338A2 (pt) 2018-10-09
US11267820B2 (en) 2022-03-08
US10689395B2 (en) 2020-06-23
CA2997531A1 (en) 2017-03-16
US20180237453A1 (en) 2018-08-23
WO2017042834A1 (en) 2017-03-16
HRP20210581T1 (hr) 2021-05-28
IL257473A (en) 2018-04-30
RS61803B1 (sr) 2021-06-30
CN108137588B (zh) 2021-06-18
HUE053912T2 (hu) 2021-07-28
EP3347356A1 (en) 2018-07-18
RU2018112015A (ru) 2019-10-11
IL257473B (en) 2021-12-01
JP2018529673A (ja) 2018-10-11
ES2866073T3 (es) 2021-10-19
SI3347356T1 (sl) 2021-08-31
AU2016319638A1 (en) 2018-03-15
PL3347356T3 (pl) 2021-08-16
EP3347356B1 (en) 2021-03-24
KR20180049056A (ko) 2018-05-10
PT3347356T (pt) 2021-06-28
CY1124245T1 (el) 2022-07-22

Similar Documents

Publication Publication Date Title
HRP20181650T1 (hr) Biciklički heterociklički derivati kao inhibitori bromodomene
IL251441A0 (en) History of imidazo pyridine and pharmaceutical preparations containing them
HK1251562A1 (zh) 三環稠合吡啶-2-酮衍生物及其作為brd4抑制劑的用途
IL253656A0 (en) Mono- and polyazanephthalene modified histories and their use
HK1244486A1 (zh) 三環dlk抑制劑及其用途
HK1254661A1 (zh) 三環化合物以及它們作為磷酸二酯酶抑制劑的用途
IL263172A (en) The history of three-ring heterocycles, their preparation and use
HRP20182064T1 (hr) Derivati tetrahidrokinolina kao inhibitori bromodomene
LT3487851T (lt) Aminopiridino dariniai ir jų naudojimas kaip selektyvių alk-2 inhibitorių
HK1250028A1 (zh) 2-苯基-6-咪唑基-吡啶-4-甲酰胺衍生物及其作為eaat3抑制劑的用途
EP3371192A4 (en) PODOPHYL LOTOXIN DERIVATIVES AND THEIR USE
IL258690A (en) Pyridone derivatives and their use as kinase inhibitors
HUE038944T2 (hu) Tiokromeno[2,3-c]kinolin-12-on származékok és topoizomeráz inhibitorként való alkalmazásuk