HK1250392A1 - 子癇前期檢測和治療的方法和組合物 - Google Patents
子癇前期檢測和治療的方法和組合物Info
- Publication number
- HK1250392A1 HK1250392A1 HK18109766.3A HK18109766A HK1250392A1 HK 1250392 A1 HK1250392 A1 HK 1250392A1 HK 18109766 A HK18109766 A HK 18109766A HK 1250392 A1 HK1250392 A1 HK 1250392A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- preeclampsia
- compositions
- detection
- treatment
- methods
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8121—Serpins
- G01N2333/8125—Alpha-1-antitrypsin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90287—Oxidoreductases (1.) oxidising metal ions (1.16)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/36—Gynecology or obstetrics
- G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19791408P | 2008-10-31 | 2008-10-31 | |
US20653409P | 2009-01-29 | 2009-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1250392A1 true HK1250392A1 (zh) | 2018-12-14 |
Family
ID=42125890
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18109541.5A HK1250061A1 (zh) | 2008-10-31 | 2018-07-23 | 子癇前期檢測和治療的方法和組合物 |
HK18109766.3A HK1250392A1 (zh) | 2008-10-31 | 2018-07-27 | 子癇前期檢測和治療的方法和組合物 |
HK18109769.0A HK1250393A1 (zh) | 2008-10-31 | 2018-07-27 | 子癇前期檢測和治療的方法和組合物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18109541.5A HK1250061A1 (zh) | 2008-10-31 | 2018-07-23 | 子癇前期檢測和治療的方法和組合物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18109769.0A HK1250393A1 (zh) | 2008-10-31 | 2018-07-27 | 子癇前期檢測和治療的方法和組合物 |
Country Status (4)
Country | Link |
---|---|
US (4) | US9229009B2 (zh) |
CN (12) | CN105021821B (zh) |
HK (3) | HK1250061A1 (zh) |
WO (1) | WO2010062377A2 (zh) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105021821B (zh) * | 2008-10-31 | 2018-05-11 | 耶鲁大学 | 先兆子痫检测和治疗的方法和组合物 |
EP2496947A1 (en) * | 2009-11-04 | 2012-09-12 | Novartis AG | Positively charged species as binding reagents in the separation of protein aggregates from monomers |
CA2886489A1 (en) | 2011-10-14 | 2013-04-18 | Aarhus Universitet | Diagnostic and prognostic use of prombp-complexes |
US9340784B2 (en) | 2012-03-19 | 2016-05-17 | Ionis Pharmaceuticals, Inc. | Methods and compositions for modulating alpha-1-antitrypsin expression |
ES2681238T3 (es) | 2012-06-27 | 2018-09-12 | F. Hoffmann-La Roche Ag | Medios y métodos de aplicación de la relación sFlt-1/PIGF o Endoglina/PIGF para descartar la aparición de preeclampsia en un cierto periodo de tiempo |
US9950014B2 (en) * | 2012-09-04 | 2018-04-24 | Pluristem Ltd. | Methods for prevention and treatment of preeclampsia |
MX366272B (es) * | 2013-03-14 | 2019-07-04 | Immucor Gti Diagnostics Inc | Metodos y composiciones para diagnosticar preeclampsia. |
CN103513042A (zh) * | 2013-09-23 | 2014-01-15 | 中国科学院动物研究所 | 用于预测或早期诊断妊娠高血压疾病的试剂盒 |
CA2943284A1 (en) * | 2014-03-21 | 2015-11-05 | Igenomix S.L. | Early detection of preeclampsia |
CN116027043A (zh) * | 2014-04-10 | 2023-04-28 | 耶鲁大学 | 检测错误折叠蛋白的方法和组合物 |
CN105092854A (zh) * | 2014-05-07 | 2015-11-25 | 湖州数问生物技术有限公司 | 体外诊断装置和试剂盒 |
US20160025737A1 (en) * | 2014-07-25 | 2016-01-28 | Diabetomics, Llc | Biomarkers for assessment of preeclampsia |
WO2016176859A1 (zh) * | 2015-05-07 | 2016-11-10 | 浙江数问生物技术有限公司 | 体外诊断装置和试剂盒 |
CA2932204A1 (en) * | 2015-06-25 | 2016-12-25 | Alaya Care Inc. | Method for predicting adverse events for home healthcare of remotely monitored patients |
EP3322985B1 (en) * | 2015-07-15 | 2021-10-13 | Gestvision, Inc. | Device for detecting misfolded proteins and methods of use thereof |
US20160324920A1 (en) * | 2016-06-24 | 2016-11-10 | Ian Gill Bemis | Cellular Specific Therapeutic Prion |
CN110770552B (zh) * | 2017-06-14 | 2023-09-12 | 陈敬红 | 高灵敏度光学检测系统 |
WO2019128506A1 (zh) * | 2017-12-28 | 2019-07-04 | 浙江数问生物技术有限公司 | 一种检测错误折叠蛋白质的装置、试剂盒和方法 |
CN110305954B (zh) * | 2019-07-19 | 2022-10-04 | 广州市达瑞生物技术股份有限公司 | 一种早期准确检测先兆子痫的预测模型 |
WO2021178448A1 (en) * | 2020-03-02 | 2021-09-10 | Motor Life Sciences, Llc | Compositions and methods for diagnosing, preventing, and treating amyotrophic lateral sclerosis in patients with hypofunctional anti-trypsin activity |
EP4173696A4 (en) * | 2020-06-24 | 2023-12-20 | Asahi Kasei Medical Co., Ltd. | METHOD FOR ASSESSING A SOLUTION CONTAINING PROTEIN |
US20240003909A1 (en) * | 2020-11-21 | 2024-01-04 | Xingmin Li | Apparatus and method for detecting misfolded protein in biological sample |
CN112582068B (zh) * | 2020-12-31 | 2022-09-20 | 山东省妇幼保健院 | 一种用于妊娠期子痫症状的安全装置 |
WO2024073597A1 (en) * | 2022-09-30 | 2024-04-04 | The Board Of Trustees Of The Leland Stanford Junior University | Pathology modifying neuromodulation therapy design |
CN116832160A (zh) * | 2023-03-15 | 2023-10-03 | 上海市宝山区吴淞中心医院 | Aβ1-42在制备子痫前期治疗药物或诊断试剂盒中的用途 |
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US6642055B1 (en) * | 2000-03-31 | 2003-11-04 | Arbogast Pharmaceuticals, Inc. | Method for the prediction of preeclampsia and other diseases |
KR100425525B1 (ko) * | 2000-11-21 | 2004-03-30 | 재단법인서울대학교산학협력재단 | 조산과 태아감염 및 태아손상을 산전 진단하기 위한진단시약 및 진단키트 |
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US20070003552A1 (en) * | 2002-07-09 | 2007-01-04 | Gebbink Martijn F B | Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation |
US7435419B2 (en) * | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
EA200500232A1 (ru) | 2002-07-19 | 2005-12-29 | Бет Изрейэл Диконисс Медикал Сентер | Способы диагностики и лечения преэклампсии или эклампсии |
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WO2004024090A2 (en) | 2002-09-12 | 2004-03-25 | The Regents Of The University Of California | Immunogens and corresponding antibodies specific for high molecular weight aggregation intermediates common to amyloids formed from proteins of differing sequence |
CN100379882C (zh) * | 2003-01-17 | 2008-04-09 | 香港中文大学 | 作为妊娠相关病症的诊断标志物的循环mRNA |
US20050255114A1 (en) * | 2003-04-07 | 2005-11-17 | Nuvelo, Inc. | Methods and diagnosis for the treatment of preeclampsia |
CN1838950A (zh) * | 2003-06-23 | 2006-09-27 | 神经化学(国际)有限公司 | 治疗蛋白质聚集疾病的方法 |
EP1524523A1 (en) * | 2003-10-17 | 2005-04-20 | Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts | Use of ADAM 12 for diagnosis and therapy of preeclampsia |
DE102004007462A1 (de) * | 2004-02-13 | 2005-09-15 | Heinrich-Heine-Universität Düsseldorf | Antikörper sowie Verfahren zur Diagnose und Behandlung von Schizophrenie |
WO2005093413A2 (en) * | 2004-03-22 | 2005-10-06 | Yale University | Diagnosis and treatment of preeclampsia |
WO2005111626A2 (en) * | 2004-05-19 | 2005-11-24 | Københavns Universitet | Adam12, a novel marker for abnormal cell function |
CN101263154A (zh) * | 2004-11-04 | 2008-09-10 | 华盛顿大学 | 用于治疗蛋白质错折叠及蛋白质聚集疾病的组合物和方法 |
CN101299962A (zh) | 2004-12-15 | 2008-11-05 | 貝丝以色列女执事医疗中心 | 可用于诊断和治疗妊娠并发症的核酸和多肽 |
ES2371084T3 (es) | 2004-12-21 | 2011-12-27 | Yale University | Diagnóstico de la preeclampsia. |
JP5048522B2 (ja) * | 2005-02-15 | 2012-10-17 | エイディーライフ インコーポレイティッド | 誤って折り畳まれたタンパク質およびプリオンを検出する方法 |
EP1733762A1 (en) | 2005-05-25 | 2006-12-20 | 3M Espe AG | Dental composition for detection of carious tissue, detection method |
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US8263342B2 (en) | 2005-10-27 | 2012-09-11 | Yale University | Urinary proteomic biomarker patterns in preeclampsia |
CA2657847A1 (en) * | 2006-08-04 | 2008-02-07 | Lonza Biologics Plc | Method for predicting protein aggregation and designing aggregation inhibitors |
US20080118938A1 (en) * | 2006-09-06 | 2008-05-22 | Lisbell Estrada | Methods and Compositions for the Detection of Protein Folding Disorders |
EP1944611A1 (en) * | 2007-01-11 | 2008-07-16 | Université de la Méditerranée | Biomarker for the medicine and the biology of the reproduction |
EP2217613A1 (en) * | 2007-04-18 | 2010-08-18 | BioChromix AB | Binding of pathological forms of proteins using conjugated polyelectrolytes |
CN101224207A (zh) * | 2007-10-12 | 2008-07-23 | 中国科学院上海有机化学研究所 | 具有诱导自吞噬治疗错误折叠蛋白聚集所致疾病的药物及其筛选方法 |
US20110065139A1 (en) | 2007-11-27 | 2011-03-17 | Jacob Mullerad | diagnostic device for identifying rupture of membrane during pregnancy |
CN105021821B (zh) * | 2008-10-31 | 2018-05-11 | 耶鲁大学 | 先兆子痫检测和治疗的方法和组合物 |
CN103012599B (zh) | 2012-11-28 | 2015-04-29 | 龙岩九健生物芯片技术研究所 | 一种调节硝酸纤维素硝化取代度的方法 |
CN116027043A (zh) | 2014-04-10 | 2023-04-28 | 耶鲁大学 | 检测错误折叠蛋白的方法和组合物 |
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2009
- 2009-11-02 CN CN201410747896.XA patent/CN105021821B/zh active Active
- 2009-11-02 WO PCT/US2009/005957 patent/WO2010062377A2/en active Application Filing
- 2009-11-02 CN CN201910197437.1A patent/CN110187121B/zh active Active
- 2009-11-02 CN CN201410747937.5A patent/CN104777307B/zh active Active
- 2009-11-02 CN CN201910197424.4A patent/CN110208540B/zh active Active
- 2009-11-02 CN CN201710343422.2A patent/CN107677829A/zh active Pending
- 2009-11-02 CN CN201410748445.8A patent/CN104777308B/zh active Active
- 2009-11-02 CN CN201410747689.4A patent/CN105044347B/zh active Active
- 2009-11-02 CN CN201710342959.7A patent/CN107677828A/zh active Pending
- 2009-11-02 CN CN200980153533.0A patent/CN102483418B/zh active Active
- 2009-11-02 CN CN201910197163.6A patent/CN110187119B/zh active Active
- 2009-11-02 US US13/126,757 patent/US9229009B2/en active Active
- 2009-11-02 CN CN201710343423.7A patent/CN107677830A/zh active Pending
- 2009-11-02 CN CN201910197165.5A patent/CN110187120B/zh active Active
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2015
- 2015-09-10 US US14/849,670 patent/US10048276B2/en active Active
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2017
- 2017-08-17 US US15/679,285 patent/US11125758B2/en active Active
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2018
- 2018-07-23 HK HK18109541.5A patent/HK1250061A1/zh unknown
- 2018-07-27 HK HK18109766.3A patent/HK1250392A1/zh unknown
- 2018-07-27 HK HK18109769.0A patent/HK1250393A1/zh unknown
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2021
- 2021-03-02 US US17/189,411 patent/US20210255192A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN104777308B (zh) | 2017-04-12 |
CN104777307A (zh) | 2015-07-15 |
CN105021821B (zh) | 2018-05-11 |
US10048276B2 (en) | 2018-08-14 |
CN110187121B (zh) | 2022-07-01 |
US20170356920A1 (en) | 2017-12-14 |
US11125758B2 (en) | 2021-09-21 |
CN110208540A (zh) | 2019-09-06 |
US20160097775A1 (en) | 2016-04-07 |
CN110187120A (zh) | 2019-08-30 |
CN107677829A (zh) | 2018-02-09 |
CN110187120B (zh) | 2022-07-01 |
CN110187119A (zh) | 2019-08-30 |
CN105044347A (zh) | 2015-11-11 |
CN110187119B (zh) | 2022-07-29 |
WO2010062377A3 (en) | 2010-08-05 |
CN102483418B (zh) | 2015-01-07 |
CN110208540B (zh) | 2024-02-09 |
CN104777307B (zh) | 2019-10-18 |
CN104777308A (zh) | 2015-07-15 |
CN110187121A (zh) | 2019-08-30 |
CN107677828A (zh) | 2018-02-09 |
HK1250061A1 (zh) | 2018-11-23 |
US9229009B2 (en) | 2016-01-05 |
CN102483418A (zh) | 2012-05-30 |
WO2010062377A2 (en) | 2010-06-03 |
CN105021821A (zh) | 2015-11-04 |
US20210255192A1 (en) | 2021-08-19 |
CN105044347B (zh) | 2017-06-09 |
US20110280863A1 (en) | 2011-11-17 |
HK1250393A1 (zh) | 2018-12-14 |
CN107677830A (zh) | 2018-02-09 |
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