HK1248708A1 - 用來製備均一低聚物的手性試劑 - Google Patents

用來製備均一低聚物的手性試劑

Info

Publication number
HK1248708A1
HK1248708A1 HK18108188.5A HK18108188A HK1248708A1 HK 1248708 A1 HK1248708 A1 HK 1248708A1 HK 18108188 A HK18108188 A HK 18108188A HK 1248708 A1 HK1248708 A1 HK 1248708A1
Authority
HK
Hong Kong
Prior art keywords
preparation
chiral reagents
homogeneous oligomers
oligomers
homogeneous
Prior art date
Application number
HK18108188.5A
Other languages
English (en)
Inventor
Atsushi Endo
Robert T Yu
Francis Fang
Hyeong Wook Choi
Mingde Shan
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of HK1248708A1 publication Critical patent/HK1248708A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK18108188.5A 2015-08-05 2018-06-26 用來製備均一低聚物的手性試劑 HK1248708A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562201510P 2015-08-05 2015-08-05
PCT/US2016/045876 WO2017024264A2 (en) 2015-08-05 2016-08-05 Chiral reagents for preparation of homogeneous oligomers

Publications (1)

Publication Number Publication Date
HK1248708A1 true HK1248708A1 (zh) 2018-10-19

Family

ID=56943909

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18108188.5A HK1248708A1 (zh) 2015-08-05 2018-06-26 用來製備均一低聚物的手性試劑

Country Status (30)

Country Link
US (3) US10457698B2 (zh)
EP (2) EP4039690A1 (zh)
JP (3) JP6978406B2 (zh)
KR (1) KR20180044303A (zh)
CN (3) CN108350005B (zh)
AU (3) AU2016302009B2 (zh)
BR (2) BR112018002430A2 (zh)
CA (1) CA2994842A1 (zh)
CL (1) CL2018000322A1 (zh)
CO (1) CO2018001615A2 (zh)
DK (1) DK3331891T3 (zh)
ES (1) ES2907629T3 (zh)
HK (1) HK1248708A1 (zh)
HR (1) HRP20220129T1 (zh)
HU (1) HUE057593T2 (zh)
IL (3) IL293066A (zh)
LT (1) LT3331891T (zh)
MA (1) MA44209B1 (zh)
MD (1) MD3331891T2 (zh)
MX (2) MX2018001557A (zh)
MY (1) MY196627A (zh)
PE (1) PE20180687A1 (zh)
PH (1) PH12018500265A1 (zh)
PL (1) PL3331891T3 (zh)
PT (1) PT3331891T (zh)
RS (1) RS62930B1 (zh)
SI (1) SI3331891T1 (zh)
UA (1) UA123995C2 (zh)
WO (1) WO2017024264A2 (zh)
ZA (2) ZA201801518B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108350005B (zh) * 2015-08-05 2024-02-06 卫材R&D管理有限公司 用于制备均一低聚物的手性试剂
WO2018057430A1 (en) 2016-09-20 2018-03-29 The Regents Of The University Of Colorado, A Body Corporate Synthesis of backbone modified morpholino oligonucleotides and chimeras using phosphoramidite chemistry
IL294271A (en) 2019-12-26 2022-08-01 Nippon Shinyaku Co Ltd Antisense nucleic acids that cause splicing on exon 50
JPWO2021172498A1 (zh) 2020-02-28 2021-09-02
US20240060068A1 (en) 2020-12-11 2024-02-22 Eisai R&D Management Co., Ltd. Poly-morpholino oligonucleotide gapmers
AR124302A1 (es) 2020-12-11 2023-03-15 Eisai R&D Man Co Ltd Gápmeros de oligonucleótidos de objetivo tau
IL307787A (en) 2021-04-28 2023-12-01 Eisai R&D Man Co Ltd ANTISENSE OLIGONUCLEOTIDES and their use for the treatment of neurodegenerative disorders
WO2024010870A2 (en) * 2022-07-07 2024-01-11 Eisai R&D Management Co., Ltd. Crystalline monomers for preparing antisense oligonucleotides and methods of their preparation and use
WO2024092256A2 (en) 2022-10-27 2024-05-02 Eisai R&D Management Co., Ltd. Peptide-antisense oligonucleotides and their use for treatment of neurodegenerative disorders

Family Cites Families (22)

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US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US6117993A (en) * 1995-05-23 2000-09-12 Hybridon, Inc. Synthons for oligonucleotide synthesis
US5922695A (en) 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
US5874554A (en) 1996-12-13 1999-02-23 Incyte Pharmaceuticals, Inc. Methods and solvent vehicles for reagent delivery in oligonucleotide synthesis using automated pulse jetting devices
US6306599B1 (en) * 1999-07-16 2001-10-23 Agilent Technologies Inc. Biopolymer arrays and their fabrication
EP1176151B1 (en) * 2000-07-28 2014-08-20 Agilent Technologies, Inc. Synthesis of polynucleotides using combined oxidation/deprotection chemistry
AR036122A1 (es) 2001-07-03 2004-08-11 Avecia Biotechnology Inc Un complejo de sal que comprende un n-alquilimidazol y una 1,1-dioxo-1,2-dihidro-1l6-benzo [d]-isotiazol-3-ona y un metodo para sintetizar oligonucleotidos utilizando la quimica de fosforamidita
CA2884340C (en) * 2007-11-15 2017-07-25 Sarepta Therapeutics, Inc. Method of synthesis of morpholino oligomers
US8076476B2 (en) 2007-11-15 2011-12-13 Avi Biopharma, Inc. Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits
WO2011018798A2 (en) 2009-08-14 2011-02-17 Indian Association For The Cultivation Of Science Morpholino-based antisense agent
CA2799501C (en) * 2010-05-28 2022-02-15 Sarepta Therapeutics, Inc. Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
RS55610B1 (sr) * 2010-09-30 2017-06-30 Nippon Shinyaku Co Ltd Derivat morfolino nukleinske kiseline
US9161948B2 (en) 2011-05-05 2015-10-20 Sarepta Therapeutics, Inc. Peptide oligonucleotide conjugates
KR102183273B1 (ko) * 2011-05-05 2020-11-27 사렙타 쎄러퓨틱스, 인코퍼레이티드 펩타이드 올리고뉴클레오타이드 접합체
TWI689513B (zh) 2011-10-07 2020-04-01 美商基利科學股份有限公司 抗病毒核苷酸類似物的製備方法
EA035030B1 (ru) 2011-11-18 2020-04-20 Сарепта Терапьютикс, Инк. Модифицированные морфолиновые аналоги олигонуклеотидов
ES2832531T3 (es) 2011-11-30 2021-06-10 Sarepta Therapeutics Inc Oligonucleótidos para el tratamiento de enfermedades por expansión de repeticiones
CN102702265A (zh) * 2012-05-14 2012-10-03 天津特安化学科技有限公司 一种固相合成磷酰二胺吗啉代寡核苷酸及方法
DE102015214943A1 (de) 2015-08-05 2017-02-09 Siemens Aktiengesellschaft Verfahren und Anlage für eine chemische Synthese
MY188405A (en) 2015-08-05 2021-12-08 Janssen Biotech Inc Anti-cd154 antibodies and methods of using them
GB201513921D0 (en) 2015-08-05 2015-09-23 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers
CN108350005B (zh) * 2015-08-05 2024-02-06 卫材R&D管理有限公司 用于制备均一低聚物的手性试剂

Also Published As

Publication number Publication date
UA123995C2 (uk) 2021-07-07
JP6978406B2 (ja) 2021-12-08
JP2022003067A (ja) 2022-01-11
RU2018107663A3 (zh) 2020-05-21
MY196627A (en) 2023-04-23
AU2023226763A1 (en) 2023-09-28
IL284611B1 (en) 2023-07-01
RS62930B1 (sr) 2022-03-31
BR122023025447A2 (pt) 2024-01-16
HUE057593T2 (hu) 2022-05-28
JP7254869B2 (ja) 2023-04-10
RU2018107663A (ru) 2019-09-05
LT3331891T (lt) 2022-02-25
EP3331891A2 (en) 2018-06-13
MD3331891T2 (ro) 2022-04-30
AU2016302009B2 (en) 2021-09-30
CN113461733A (zh) 2021-10-01
IL257353A (en) 2018-04-30
PL3331891T3 (pl) 2022-03-28
EP3331891B1 (en) 2021-12-15
MX2022000124A (es) 2022-02-16
ZA201801518B (en) 2020-10-28
US20210171555A1 (en) 2021-06-10
US10457698B2 (en) 2019-10-29
IL293066A (en) 2022-07-01
ZA201905394B (en) 2022-07-27
DK3331891T3 (da) 2022-02-28
BR112018002430A2 (pt) 2018-09-18
CA2994842A1 (en) 2017-02-09
IL257353B2 (en) 2023-02-01
WO2017024264A2 (en) 2017-02-09
PT3331891T (pt) 2022-02-28
MA44209A (fr) 2021-04-28
AU2016302009A1 (en) 2018-03-29
MA44209B1 (fr) 2022-03-31
WO2017024264A8 (en) 2018-04-12
IL284611B2 (en) 2023-11-01
PE20180687A1 (es) 2018-04-23
EP4039690A1 (en) 2022-08-10
US20200115405A1 (en) 2020-04-16
WO2017024264A3 (en) 2017-03-30
ES2907629T3 (es) 2022-04-25
IL257353B (en) 2022-10-01
HRP20220129T1 (hr) 2022-04-15
JP2018525380A (ja) 2018-09-06
CN108350005B (zh) 2024-02-06
AU2021290235A1 (en) 2022-01-20
CN108350005A (zh) 2018-07-31
JP2023085402A (ja) 2023-06-20
MX2018001557A (es) 2018-05-02
CO2018001615A2 (es) 2018-07-19
US20180222932A1 (en) 2018-08-09
KR20180044303A (ko) 2018-05-02
IL284611A (en) 2021-08-31
PH12018500265A1 (en) 2018-08-13
SI3331891T1 (sl) 2022-04-29
US10836784B2 (en) 2020-11-17
CN117924364A (zh) 2024-04-26
CL2018000322A1 (es) 2018-05-18
AU2021290235B2 (en) 2023-06-08

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