HK1248540A1 - 用於靶向藥物遞送的自組裝分子 - Google Patents
用於靶向藥物遞送的自組裝分子Info
- Publication number
- HK1248540A1 HK1248540A1 HK18108192.9A HK18108192A HK1248540A1 HK 1248540 A1 HK1248540 A1 HK 1248540A1 HK 18108192 A HK18108192 A HK 18108192A HK 1248540 A1 HK1248540 A1 HK 1248540A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- drug delivery
- targeted drug
- self assembling
- assembling molecules
- molecules
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
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- A61K49/0089—Particulate, powder, adsorbate, bead, sphere
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- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
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- A61K51/1268—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules host-guest, closed hollow molecules, inclusion complexes, e.g. with cyclodextrins, clathrates, cavitates, fullerenes
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Radiology & Medical Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562140696P | 2015-03-31 | 2015-03-31 | |
PCT/US2016/025290 WO2016161129A1 (en) | 2015-03-31 | 2016-03-31 | Self assembling molecules for targeted drug delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1248540A1 true HK1248540A1 (zh) | 2018-10-19 |
Family
ID=57007332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK18108192.9A HK1248540A1 (zh) | 2015-03-31 | 2018-06-26 | 用於靶向藥物遞送的自組裝分子 |
Country Status (10)
Country | Link |
---|---|
US (2) | US20180140719A1 (zh) |
EP (2) | EP3277268A4 (zh) |
JP (2) | JP2018513142A (zh) |
CN (1) | CN107613963A (zh) |
AU (1) | AU2016242920B2 (zh) |
CA (1) | CA2980329C (zh) |
HK (1) | HK1248540A1 (zh) |
MA (1) | MA41866A (zh) |
MX (2) | MX2017012187A (zh) |
WO (1) | WO2016161129A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA41866A (fr) * | 2015-03-31 | 2018-02-06 | Massachusetts Gen Hospital | Molécules à auto-assemblage pour l'administration ciblée de médicaments |
US20200338011A1 (en) * | 2017-10-20 | 2020-10-29 | The General Hospital Corporation | Macrophage Targeted Immunotherapeutics |
MX2022009251A (es) * | 2020-01-28 | 2022-09-19 | Nanotomer Inc | Constructos del receptor de anticuerpo quimérico de clatrina para terapia de activación in vivo de células inmunitarias. |
WO2021160873A1 (en) * | 2020-02-13 | 2021-08-19 | Eth Zurich | Nanoparticles encapsulating small molecules |
CN112229887B (zh) * | 2020-09-02 | 2022-07-22 | 中国科学院深圳先进技术研究院 | 一种可精准编辑酶/电极界面及其制备方法 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5679683A (en) | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
US5525625A (en) | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
WO1998037881A1 (en) | 1997-02-28 | 1998-09-03 | Warner Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
IL132840A (en) | 1997-07-01 | 2004-12-15 | Warner Lambert Co | Derivatives 4 - bromo or 4 - benzohydroxamic acid iodine amino iodine and pharmaceutical preparations containing them for use as MEK inhibitors |
KR20010014360A (ko) | 1997-07-01 | 2001-02-26 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 2-(4-브로모 또는 4-요오도 페닐아미노)벤조산 유도체 및mek 억제제로서의 그의 용도 |
AU2482700A (en) | 1999-01-13 | 2000-08-01 | Warner-Lambert Company | 1-heterocycle substituted diarylamines |
BR9916894A (pt) | 1999-01-13 | 2001-11-20 | Warner Lambert Co | ácidos sulfohidroxâmicos e sulfohidroxamatos eseu uso como inibidores de mek |
CA2348236A1 (en) | 1999-01-13 | 2000-07-20 | Stephen Douglas Barrett | 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors |
EP1150950A2 (en) | 1999-01-13 | 2001-11-07 | Warner-Lambert Company | Anthranilic acid derivatives |
CN1177830C (zh) | 1999-01-13 | 2004-12-01 | 沃尼尔·朗伯公司 | 苯并杂环和它们作为mek抑制剂的用途 |
AU2201500A (en) | 1999-01-13 | 2000-08-01 | Warner-Lambert Company | Benzenesulfonamide derivatives and their use as mek inhibitors |
GB9910579D0 (en) | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
GB9910577D0 (en) | 1999-05-08 | 1999-07-07 | Zeneca Ltd | Chemical compounds |
CA2403017A1 (en) | 2000-03-15 | 2001-09-20 | Warner-Lambert Company | 5-amide substituted diarylamines as mex inhibitors |
EP1339702A1 (en) | 2000-03-15 | 2003-09-03 | Warner-Lambert Company | 5-amide substituted diarylamines as mek inhibitors |
NZ524120A (en) | 2000-07-19 | 2005-08-26 | Warner Lambert Co | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids |
DE60122176T2 (de) | 2000-09-15 | 2007-07-05 | Vertex Pharmaceuticals Inc., Cambridge | Isoxazole und ihre verwendung als erk-inhibitoren |
US20030049203A1 (en) * | 2001-08-31 | 2003-03-13 | Elmaleh David R. | Targeted nucleic acid constructs and uses related thereto |
PL401638A1 (pl) | 2002-03-13 | 2013-05-27 | Array Biopharma Inc. | N3 alkilowane pochodne benzimidazolu jako inhibitory MEK |
US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
KR101264570B1 (ko) | 2003-11-19 | 2013-05-14 | 어레이 바이오파마 인크. | Mek의 헤테로시클릭 억제제 및 그의 사용 방법 |
US7393924B2 (en) * | 2004-01-06 | 2008-07-01 | Franco Vitaliano | Smart bio-nanoparticle elements |
US7429667B2 (en) | 2005-01-20 | 2008-09-30 | Ardea Biosciences, Inc. | Phenylamino isothiazole carboxamidines as MEK inhibitors |
WO2006121168A1 (en) * | 2005-05-09 | 2006-11-16 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
RS52243B (en) | 2005-05-18 | 2012-10-31 | Astrazeneca Ab | HETEROCYCLIC MELT INHIBITORS AND PROCEDURES FOR THEIR USE |
US8101799B2 (en) | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
US20070049591A1 (en) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibitors of MAPK/Erk Kinase |
DE102005062440B4 (de) * | 2005-12-27 | 2011-02-24 | Lts Lohmann Therapie-Systeme Ag | Proteinbasiertes Trägersystem zur Resistenzüberwindung von Tumorzellen |
EP2069308B1 (en) | 2006-09-12 | 2017-03-29 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Azonafide derived tumor and cancer targeting compounds |
EP2121620B1 (en) | 2007-01-19 | 2015-06-17 | Ardea Biosciences, Inc. | Inhibitors of mek |
WO2008103920A2 (en) * | 2007-02-23 | 2008-08-28 | Specigen, Inc. | Targeted protein cages |
CL2008003810A1 (es) | 2007-12-19 | 2009-05-22 | Genentech Inc | Compuestos derivados de 5-anilino imidazol[1,5-a]piridina o pirazina, inhibidores de la actividad mek quinasa; composiciones farmaceuticas que los contienen; y su uso para tratar trastornos hiperproliferativos y una enfermedad inflamatoria. |
US11235062B2 (en) | 2009-03-06 | 2022-02-01 | Metaqor Llc | Dynamic bio-nanoparticle elements |
EP2499486A4 (en) | 2009-11-13 | 2013-11-27 | Infinity Pharmaceuticals Inc | COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, EVALUATION, PREVENTION, AND THERAPY OF CANCER |
WO2014141289A1 (en) * | 2013-03-12 | 2014-09-18 | Amrita Vishwa Vidyapeetham University | Photo - chemo composition on the basis of microcapsules with a core -shell structure |
WO2015108783A1 (en) | 2014-01-16 | 2015-07-23 | The Brigham And Women's Hospital, Inc. | Targeted delivery of immunoregulatory drugs |
TWI595006B (zh) * | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | 抗pd-1抗體類和使用彼等之方法 |
MA41866A (fr) | 2015-03-31 | 2018-02-06 | Massachusetts Gen Hospital | Molécules à auto-assemblage pour l'administration ciblée de médicaments |
-
2016
- 2016-03-30 MA MA041866A patent/MA41866A/fr unknown
- 2016-03-31 MX MX2017012187A patent/MX2017012187A/es unknown
- 2016-03-31 AU AU2016242920A patent/AU2016242920B2/en active Active
- 2016-03-31 US US15/563,339 patent/US20180140719A1/en not_active Abandoned
- 2016-03-31 EP EP16774208.9A patent/EP3277268A4/en not_active Withdrawn
- 2016-03-31 JP JP2017551201A patent/JP2018513142A/ja active Pending
- 2016-03-31 EP EP21178644.7A patent/EP3936121A1/en active Pending
- 2016-03-31 CA CA2980329A patent/CA2980329C/en active Active
- 2016-03-31 WO PCT/US2016/025290 patent/WO2016161129A1/en active Application Filing
- 2016-03-31 CN CN201680030763.8A patent/CN107613963A/zh active Pending
-
2017
- 2017-09-25 MX MX2022009027A patent/MX2022009027A/es unknown
-
2018
- 2018-06-26 HK HK18108192.9A patent/HK1248540A1/zh unknown
-
2019
- 2019-11-25 US US16/694,437 patent/US11666664B2/en active Active
-
2021
- 2021-04-01 JP JP2021062630A patent/JP2021113196A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3277268A1 (en) | 2018-02-07 |
EP3277268A4 (en) | 2018-12-05 |
CA2980329C (en) | 2024-01-23 |
US20200078472A1 (en) | 2020-03-12 |
US20180140719A1 (en) | 2018-05-24 |
CA2980329A1 (en) | 2016-10-06 |
AU2016242920B2 (en) | 2021-10-21 |
US11666664B2 (en) | 2023-06-06 |
MA41866A (fr) | 2018-02-06 |
JP2021113196A (ja) | 2021-08-05 |
AU2016242920A1 (en) | 2017-10-12 |
MX2017012187A (es) | 2018-01-09 |
EP3936121A1 (en) | 2022-01-12 |
MX2022009027A (es) | 2022-08-11 |
JP2018513142A (ja) | 2018-05-24 |
WO2016161129A1 (en) | 2016-10-06 |
CN107613963A (zh) | 2018-01-19 |
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