HK1248235A1 - 具有作為吲哚胺2，3-二加氧酶抑制劑活性的苯並咪唑和咪唑並吡啶亞氨代甲酰胺化合物 - Google Patents

具有作為吲哚胺2，3-二加氧酶抑制劑活性的苯並咪唑和咪唑並吡啶亞氨代甲酰胺化合物

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HK1248235A1
HK1248235A1 HK18107798.9A HK18107798A HK1248235A1 HK 1248235 A1 HK1248235 A1 HK 1248235A1 HK 18107798 A HK18107798 A HK 18107798A HK 1248235 A1 HK1248235 A1 HK 1248235A1
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HK
Hong Kong
Prior art keywords
imadazopyridine
indoleamine
dioxygenase
benzimidazole
inhibitors
Prior art date
Application number
HK18107798.9A
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English (en)
Inventor
Mark J Bartlett
Julian Andrew Codelli
Britton Kenneth Corkey
Jennifer Leigh Cosman
Kristyna Elbel
Jennifer Alissa Loyer-Drew
David Sperandio
Veldhuizen Joshua Van
Hai Yang
Suet Chung Yeung
Original Assignee
吉利德科學公司
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Application filed by 吉利德科學公司 filed Critical 吉利德科學公司
Publication of HK1248235A1 publication Critical patent/HK1248235A1/zh

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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Families Citing this family (24)

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CN106905256A (zh) * 2017-03-06 2017-06-30 中国药科大学 苯并五元杂环类ido1抑制剂、其制备方法及应用
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EP3661909B1 (en) * 2017-08-02 2023-08-16 Merck Sharp & Dohme LLC Novel substituted phenyl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
WO2019027856A1 (en) 2017-08-02 2019-02-07 Merck Sharp & Dohme Corp. NOVEL SUBSTITUTED PYRIDINE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE (IDO)
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EP3747875B1 (en) * 2018-02-02 2022-12-07 Hinova Pharmaceuticals Inc. Indoleamine-2,3-dioxygenase inhibitor, preparation method therefor and use thereof
PL3752501T3 (pl) 2018-02-13 2023-08-21 Gilead Sciences, Inc. Inhibitory pd-1/pd-l1
EP3781556A1 (en) 2018-04-19 2021-02-24 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
UA125163C2 (uk) 2018-05-14 2022-01-19 Гіліад Сайєнсіз, Інк. Інгібітори mcl-1
JP7199502B2 (ja) * 2018-07-06 2023-01-05 ギリアード サイエンシーズ， インコーポレイテッド 治療用複素環式化合物
PT3820572T (pt) 2018-07-13 2023-11-10 Gilead Sciences Inc Inibidores pd-1/pd-l1
US11987579B2 (en) * 2018-07-30 2024-05-21 Duke University Niclosamide analogues and therapeutic use thereof
US11236085B2 (en) 2018-10-24 2022-02-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
CN110054627B (zh) * 2019-01-10 2020-06-30 北京华氏开元医药科技有限公司 一类新型的ido抑制剂、制备方法、药物组合物及其用途
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PE20231744A1 (es) * 2020-08-07 2023-10-31 Italfarmaco Spa Nuevos inhibidores selectivos de hdac6 basados en oxadiazol
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BR112023017582A2 (pt) 2021-03-05 2023-12-05 Univ Basel Composições para o tratamento de doenças ou condições associadas ao ebv
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CN117794920A (zh) 2021-06-04 2024-03-29 沃泰克斯药物股份有限公司 N-(羟烷基(杂)芳基)四氢呋喃甲酰胺作为钠通道调节剂

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US5643935A (en) * 1995-06-07 1997-07-01 The University Of North Carolina At Chapel Hill Method of combatting infectious diseases using dicationic bis-benzimidazoles
CA2634198C (en) * 2005-12-20 2014-06-03 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CN101415702B (zh) * 2006-04-03 2011-08-10 安斯泰来制药有限公司 杂环化合物
US20080119491A1 (en) * 2006-09-19 2008-05-22 Incyte Corporation Amidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
EP2139478A4 (en) * 2007-03-30 2010-05-05 Cytokinetics Inc CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
JP2016028016A (ja) * 2012-12-12 2016-02-25 大日本住友製薬株式会社 オキサジアゾール誘導体とその医薬用途
US9617272B2 (en) * 2013-03-14 2017-04-11 Newlink Genetics Corporation Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
TWI527811B (zh) * 2013-05-09 2016-04-01 吉李德科學股份有限公司 作爲溴結構域抑制劑的苯並咪唑衍生物
ES2719327T3 (es) * 2013-07-01 2019-07-09 Bristol Myers Squibb Co Inhibidores de IDO

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