HK1247914A1 - 作為毒蕈鹼性m1受體正向別構調節劑的氟吲哚衍生物 - Google Patents
作為毒蕈鹼性m1受體正向別構調節劑的氟吲哚衍生物Info
- Publication number
- HK1247914A1 HK1247914A1 HK18107271.5A HK18107271A HK1247914A1 HK 1247914 A1 HK1247914 A1 HK 1247914A1 HK 18107271 A HK18107271 A HK 18107271A HK 1247914 A1 HK1247914 A1 HK 1247914A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- muscarinic
- positive allosteric
- receptor positive
- allosteric modulators
- fluoroindole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN4809CH2015 | 2015-09-10 | ||
| PCT/IB2016/054290 WO2017042643A1 (en) | 2015-09-10 | 2016-07-19 | Fluoroindole derivatives as muscarinic m1 receptor positive allosteric modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1247914A1 true HK1247914A1 (zh) | 2018-10-05 |
Family
ID=56618200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18107271.5A HK1247914A1 (zh) | 2015-09-10 | 2018-06-04 | 作為毒蕈鹼性m1受體正向別構調節劑的氟吲哚衍生物 |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US10294217B2 (zh) |
| EP (1) | EP3347349B1 (zh) |
| JP (1) | JP6553811B2 (zh) |
| KR (1) | KR102068237B1 (zh) |
| CN (1) | CN108026073B (zh) |
| AU (1) | AU2016320645B2 (zh) |
| BR (1) | BR112018004719B1 (zh) |
| CA (1) | CA2997956C (zh) |
| CY (1) | CY1122321T1 (zh) |
| DK (1) | DK3347349T3 (zh) |
| EA (1) | EA033826B1 (zh) |
| ES (1) | ES2750868T3 (zh) |
| HK (1) | HK1247914A1 (zh) |
| HR (1) | HRP20191869T1 (zh) |
| HU (1) | HUE047056T2 (zh) |
| IL (1) | IL257869A (zh) |
| LT (1) | LT3347349T (zh) |
| MA (1) | MA42769B1 (zh) |
| MD (1) | MD3347349T2 (zh) |
| ME (1) | ME03571B (zh) |
| MX (1) | MX2018002821A (zh) |
| NZ (1) | NZ740587A (zh) |
| PL (1) | PL3347349T3 (zh) |
| PT (1) | PT3347349T (zh) |
| RS (1) | RS59473B1 (zh) |
| SI (1) | SI3347349T1 (zh) |
| WO (1) | WO2017042643A1 (zh) |
| ZA (1) | ZA201801463B (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11234979B2 (en) * | 2017-10-18 | 2022-02-01 | Suven Life Sciences Limited | Heteroaryl compounds as muscarinic M1 receptor positive allosteric modulators |
| CA3078164C (en) * | 2017-10-27 | 2022-11-15 | Suven Life Sciences Limited | Polycyclic amides as muscarinic m1 receptor positive allosteric modulators |
| AU2021215709A1 (en) | 2020-02-04 | 2022-09-01 | Mindset Pharma Inc. | 3-pyrrolidine-indole derivatives as serotonergic psychedelic agents for the treatment of CNS disorders |
| WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
| CN115385849B (zh) * | 2022-09-14 | 2024-01-26 | 南通瑞合达医药科技有限公司 | 一种N-Boc-3-氟-4-哌啶酮提纯的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60123485A (ja) | 1983-12-08 | 1985-07-02 | Yoshitomi Pharmaceut Ind Ltd | インド−ル−３−カルボキサミド誘導体 |
| CA2399791A1 (en) | 2000-02-11 | 2001-08-16 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases |
| JP5192389B2 (ja) | 2005-12-05 | 2013-05-08 | メルク・シャープ・エンド・ドーム・コーポレイション | キノロンｍ１レセプター陽性アロステリックモジュレータ |
| CA2770480C (en) * | 2009-08-31 | 2014-11-18 | Merck Sharp & Dohme Corp. | Pyranyl aryl methyl benzoquinazolinone m1 receptor positive allosteric modulators |
| DK2512243T3 (en) * | 2009-12-17 | 2016-07-25 | Merck Sharp & Dohme | POSITIVE ALLOSTERIC QUINOLINAMIDE M1 RECEPTOR MODULATORS |
| EP2575454B1 (en) | 2010-05-28 | 2018-08-29 | Merck Sharp & Dohme Corp. | Naphthalene carboxamide m1 receptor positive allosteric modulators |
| TW201512197A (zh) | 2013-08-30 | 2015-04-01 | Hoffmann La Roche | 吡咯并吡啶或吡唑并吡啶衍生物 |
| WO2015044072A1 (en) | 2013-09-27 | 2015-04-02 | F. Hoffmann-La Roche Ag | Indol and indazol derivatives |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| US9708278B2 (en) | 2013-11-27 | 2017-07-18 | Vanderbilt University | Substituted 4-benzyl-3,4-dihydro-2H-benzo[B][1,4]oxazine-2-carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor M1 |
-
2016
- 2016-07-19 CA CA2997956A patent/CA2997956C/en active Active
- 2016-07-19 AU AU2016320645A patent/AU2016320645B2/en active Active
- 2016-07-19 ES ES16750259T patent/ES2750868T3/es active Active
- 2016-07-19 PT PT167502590T patent/PT3347349T/pt unknown
- 2016-07-19 KR KR1020187009938A patent/KR102068237B1/ko active IP Right Grant
- 2016-07-19 HU HUE16750259A patent/HUE047056T2/hu unknown
- 2016-07-19 PL PL16750259T patent/PL3347349T3/pl unknown
- 2016-07-19 US US15/758,313 patent/US10294217B2/en active Active
- 2016-07-19 WO PCT/IB2016/054290 patent/WO2017042643A1/en active Application Filing
- 2016-07-19 MA MA42769A patent/MA42769B1/fr unknown
- 2016-07-19 EP EP16750259.0A patent/EP3347349B1/en active Active
- 2016-07-19 NZ NZ740587A patent/NZ740587A/en unknown
- 2016-07-19 DK DK16750259T patent/DK3347349T3/da active
- 2016-07-19 LT LT16750259T patent/LT3347349T/lt unknown
- 2016-07-19 RS RS20191328A patent/RS59473B1/sr unknown
- 2016-07-19 ME MEP-2019-288A patent/ME03571B/me unknown
- 2016-07-19 CN CN201680052764.2A patent/CN108026073B/zh active Active
- 2016-07-19 SI SI201630447T patent/SI3347349T1/sl unknown
- 2016-07-19 JP JP2018512868A patent/JP6553811B2/ja active Active
- 2016-07-19 MX MX2018002821A patent/MX2018002821A/es unknown
- 2016-07-19 MD MDE20180689 patent/MD3347349T2/ro unknown
- 2016-07-19 EA EA201890684A patent/EA033826B1/ru unknown
- 2016-07-19 BR BR112018004719-8A patent/BR112018004719B1/pt active IP Right Grant
-
2018
- 2018-03-02 ZA ZA2018/01463A patent/ZA201801463B/en unknown
- 2018-03-05 IL IL257869A patent/IL257869A/en active IP Right Grant
- 2018-06-04 HK HK18107271.5A patent/HK1247914A1/zh unknown
-
2019
- 2019-10-15 HR HRP20191869TT patent/HRP20191869T1/hr unknown
- 2019-10-16 CY CY20191101086T patent/CY1122321T1/el unknown
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