HK1245822A1 - 一種經修飾的dnase及其應用 - Google Patents

一種經修飾的dnase及其應用

Info

Publication number
HK1245822A1
HK1245822A1 HK18104094.7A HK18104094A HK1245822A1 HK 1245822 A1 HK1245822 A1 HK 1245822A1 HK 18104094 A HK18104094 A HK 18104094A HK 1245822 A1 HK1245822 A1 HK 1245822A1
Authority
HK
Hong Kong
Prior art keywords
modified dnase
dnase
modified
Prior art date
Application number
HK18104094.7A
Other languages
English (en)
Inventor
Zeltsburg Lilach Chen
Ilya Ruderfer
Avidor Shulman
Liat Fux
Yulia Ugortsev
Hagit Neta
Sivan Gelley
Laviad Elad Lavee
Yoseph Shaaltiel
Original Assignee
Protalix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protalix Ltd filed Critical Protalix Ltd
Publication of HK1245822A1 publication Critical patent/HK1245822A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21001—Deoxyribonuclease I (3.1.21.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
HK18104094.7A 2015-01-04 2018-03-23 一種經修飾的dnase及其應用 HK1245822A1 (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562099560P 2015-01-04 2015-01-04
US201562099565P 2015-01-04 2015-01-04
US201562163497P 2015-05-19 2015-05-19
US201562169724P 2015-06-02 2015-06-02
US201562247856P 2015-10-29 2015-10-29
PCT/IL2016/050003 WO2016108244A1 (en) 2015-01-04 2016-01-04 Modified dnase and uses thereof

Publications (1)

Publication Number Publication Date
HK1245822A1 true HK1245822A1 (zh) 2018-08-31

Family

ID=55442842

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18104094.7A HK1245822A1 (zh) 2015-01-04 2018-03-23 一種經修飾的dnase及其應用

Country Status (13)

Country Link
US (2) US11225648B2 (zh)
EP (1) EP3240896A1 (zh)
CN (1) CN107406837A (zh)
AU (1) AU2016204793B2 (zh)
BR (1) BR112017014433A2 (zh)
CA (1) CA2970216A1 (zh)
HK (1) HK1245822A1 (zh)
IL (1) IL253208B2 (zh)
MX (1) MX2017008567A (zh)
NZ (1) NZ733912A (zh)
RU (1) RU2017125957A (zh)
WO (1) WO2016108244A1 (zh)
ZA (1) ZA201704903B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016204793B2 (en) 2015-01-04 2021-12-16 Protalix Ltd. Modified DNase and uses thereof
TWI788307B (zh) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
JP7125392B2 (ja) 2016-11-17 2022-08-24 アイオバンス バイオセラピューティクス，インコーポレイテッド レムナント腫瘍浸潤リンパ球並びにそれを調製及び使用する方法
EP3740581A4 (en) * 2018-01-16 2021-10-27 CLS Therapeutics Limited TREATMENT OF DISEASES BY LIVER EXPRESSION OF AN ENZYME WITH DESOXYRIBONUCLEASE (DNASE) ACTIVITY
JP7384906B2 (ja) 2018-07-09 2023-11-21 ジーアールオー・バイオサイエンシズ・インコーポレイテッド 非標準アミノ酸含有組成物とその使用
WO2020106709A1 (en) * 2018-11-19 2020-05-28 Gro Biosciences Inc. Human dnase for lung disease
JP2023545740A (ja) 2020-10-07 2023-10-31 プロタリクス リミテッド 長期活性ＤＮａｓｅ
CA3207134A1 (en) 2021-02-19 2022-08-25 Jeffrey A. Ledbetter Dnase fusion polypeptides and related compositions and methods

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Also Published As

Publication number Publication date
IL253208B (en) 2022-11-01
CA2970216A1 (en) 2016-07-07
IL253208A0 (en) 2017-08-31
MX2017008567A (es) 2018-04-26
CN107406837A (zh) 2017-11-28
NZ733912A (en) 2023-04-28
RU2017125957A (ru) 2019-02-04
AU2016204793A1 (en) 2017-08-10
AU2016204793B2 (en) 2021-12-16
US20180112201A1 (en) 2018-04-26
IL253208B2 (en) 2023-03-01
BR112017014433A2 (pt) 2018-05-15
EP3240896A1 (en) 2017-11-08
ZA201704903B (en) 2023-10-25
US11814657B2 (en) 2023-11-14
US11225648B2 (en) 2022-01-18
WO2016108244A1 (en) 2016-07-07
US20220106578A1 (en) 2022-04-07

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