HK1232158A1 - 用於治療肝癌的藥物 - Google Patents
用於治療肝癌的藥物Info
- Publication number
- HK1232158A1 HK1232158A1 HK17105969.7A HK17105969A HK1232158A1 HK 1232158 A1 HK1232158 A1 HK 1232158A1 HK 17105969 A HK17105969 A HK 17105969A HK 1232158 A1 HK1232158 A1 HK 1232158A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- medicament
- treatment
- liver cancer
- liver
- cancer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11173379A EP2543372A1 (en) | 2011-07-08 | 2011-07-08 | Medicament for the treatment of liver cancer |
| US201161508368P | 2011-07-15 | 2011-07-15 | |
| EP12161141 | 2012-03-23 | ||
| EP12162905 | 2012-04-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1232158A1 true HK1232158A1 (zh) | 2018-01-05 |
Family
ID=47505540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK17105969.7A HK1232158A1 (zh) | 2011-07-08 | 2017-06-15 | 用於治療肝癌的藥物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10441577B2 (zh) |
| EP (2) | EP3111937B1 (zh) |
| ES (1) | ES2627120T3 (zh) |
| HK (1) | HK1232158A1 (zh) |
| WO (1) | WO2013007708A1 (zh) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| CN104334742A (zh) | 2012-01-27 | 2015-02-04 | 利兰斯坦福青年大学董事会 | 解析和定量无细胞rna的方法 |
| GB201306901D0 (en) * | 2013-04-16 | 2013-05-29 | Chroma Therapeutics Ltd | Combination |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| WO2015006591A1 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | 2,4- or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2015003355A2 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| CN103751221B (zh) * | 2014-01-23 | 2016-08-17 | 中国人民解放军第三军医大学第一附属医院 | Sirt1抑制剂联合索拉菲尼在制备治疗肝癌的药物中的应用 |
| KR20160122850A (ko) * | 2014-02-28 | 2016-10-24 | 미르나 테라퓨틱스 인코포레이티드 | 간암에 대한 소라페닙-마이크로rna 병용 요법 |
| KR102400737B1 (ko) | 2014-03-14 | 2022-05-20 | 아지오스 파마슈티컬스 아이엔씨. | 치료적으로 활성인 화합물의 약제학적 조성물 |
| US10745355B2 (en) * | 2015-01-30 | 2020-08-18 | The University Of Sydney | Anti-cancer compounds |
| ES2789331T3 (es) * | 2015-03-02 | 2020-10-26 | Rigel Pharmaceuticals Inc | Inhibidores de TGF-beta |
| AU2016338557B2 (en) | 2015-10-15 | 2022-05-26 | Celgene Corporation | Combination therapy for treating malignancies |
| EP3362065B1 (en) | 2015-10-15 | 2024-04-03 | Les Laboratoires Servier | Combination therapy comprising ivosidenib, cytarabine and daunorubicin or idarubicin for treating acute myelogenous leukemia |
| WO2018021827A1 (en) * | 2016-07-29 | 2018-02-01 | Chong Kun Dang Pharmaceutical Corp. | Compositions for treating liver cancer comprising a vascular disrupting agent |
| WO2018049191A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridone derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| TW201811799A (zh) | 2016-09-09 | 2018-04-01 | 美商英塞特公司 | 吡唑并嘧啶化合物及其用途 |
| MX2019002750A (es) | 2016-09-09 | 2019-07-04 | Incyte Corp | Derivados de pirazolopiridina como moduladores de cinasa 1 progenitora hematopoyetica (hpk1) y usos de los mismos para tratamiento de cancer. |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| US20180228786A1 (en) | 2017-02-15 | 2018-08-16 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| WO2018153373A1 (zh) * | 2017-02-27 | 2018-08-30 | 贝达药业股份有限公司 | Fgfr抑制剂及其应用 |
| US11229657B2 (en) | 2017-04-21 | 2022-01-25 | Lunella Biotech, Inc. | Targeting hypoxic cancer stem cells (CSCs) with doxycycline: implications for improving anti-angiogenic therapy |
| US11197872B2 (en) | 2017-04-21 | 2021-12-14 | Lunella Biotech, Inc. | Vitamin C and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (CSCs) |
| GB201706806D0 (en) | 2017-04-28 | 2017-06-14 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| CR20190524A (es) | 2017-05-19 | 2020-01-10 | Lunella Biotech Inc | Antimitoscinas: inhibidores específicos de la biogénesis mitocondrial para erradicar células madre cancerosas |
| WO2018214846A1 (zh) * | 2017-05-23 | 2018-11-29 | 成都优赛丽医药科技有限公司 | 咪唑并[1',2'：1,6]吡啶并[2,3-d]嘧啶类化合物作为蛋白激酶抑制剂 |
| JP7397672B2 (ja) | 2017-06-26 | 2023-12-13 | ルネラ・バイオテック・インコーポレーテッド | ミトケトシン：癌細胞におけるケトン代謝を標的とするミトコンドリアに基づく治療薬 |
| US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
| CA3128468A1 (en) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| KR20200105816A (ko) * | 2017-11-14 | 2020-09-09 | 앵스띠뛰 레지오날 뒤 깡세르 드 몽뻴리에 (아이씨엠) | 전립선암 치료를 위한 활성제의 연합 |
| TWI828644B (zh) | 2017-12-06 | 2024-01-11 | 仁新醫藥股份有限公司 | 微管蛋白抑制劑 |
| CA3091517A1 (en) | 2018-02-20 | 2019-08-29 | Incyte Corporation | N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as hpk1 inhibitors for treating cancer |
| US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
| WO2019164847A1 (en) | 2018-02-20 | 2019-08-29 | Incyte Corporation | Indazole compounds and uses thereof |
| US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| MA53726A (fr) | 2018-09-25 | 2022-05-11 | Incyte Corp | Composés pyrazolo[4,3-d]pyrimidine en tant que modulateurs des alk2 et/ou fgfr |
| GB2597379B (en) | 2019-02-14 | 2022-12-28 | Mirvie Inc | Methods and systems for determining a pregnancy-related state of a subject |
| JP2022543155A (ja) | 2019-08-06 | 2022-10-07 | インサイト・コーポレイション | Ｈｐｋ１阻害剤の固体形態 |
| GB201915828D0 (en) * | 2019-10-31 | 2019-12-18 | Cancer Research Tech Ltd | Compounds, compositions and therapeutic uses thereof |
| US11316208B2 (en) | 2020-07-08 | 2022-04-26 | American Hyperform, Inc. | Process for recycling cobalt and nickel from lithium ion batteries |
| US11909016B2 (en) | 2021-08-24 | 2024-02-20 | American Hyperform, Inc. | Recycling process for isolating and recovering rare earth metals and nickel hydroxide from nickel metal hydride batteries |
| IT202200000314A1 (it) * | 2022-01-11 | 2023-07-11 | Universita’ Degli Studi Di Parma | Composto e composizione per il ripristino metabolico e funzionale dei linfociti nk nell’epatocarcinoma e relativo metodo |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000042012A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
| SI1663978T1 (sl) | 2003-07-23 | 2008-02-29 | Bayer Pharmaceuticals Corp | Fluoro substituirana omega-karboksiaril difenil secnina za zdravljenje ali preprecevanje bolezni instanj |
| CN101317832B (zh) * | 2007-06-06 | 2011-08-31 | 周亚伟 | 白藜芦醇口服纳米给药系统 |
| EP2206534A1 (de) * | 2008-10-09 | 2010-07-14 | c-a-i-r biosciences GmbH | Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten |
| FR2945210B1 (fr) | 2009-05-07 | 2011-07-01 | Sanofi Aventis | Combinaison antitumorale comprenant l'ave8062 et le sorafenib |
| WO2011056005A2 (ko) * | 2009-11-04 | 2011-05-12 | 성균관대학교산학협력단 | 안티센스 가닥에 의한 오프-타겟 효과를 최소화한 신규한 ｓｉＲＮＡ 구조 및 그 용도 |
-
2012
- 2012-07-09 WO PCT/EP2012/063445 patent/WO2013007708A1/en active Application Filing
- 2012-07-09 EP EP16183815.6A patent/EP3111937B1/en active Active
- 2012-07-09 EP EP12734932.2A patent/EP2729146B1/en active Active
- 2012-07-09 US US14/131,059 patent/US10441577B2/en not_active Expired - Fee Related
- 2012-07-09 ES ES12734932.2T patent/ES2627120T3/es active Active
-
2017
- 2017-06-15 HK HK17105969.7A patent/HK1232158A1/zh unknown
-
2019
- 2019-09-12 US US16/569,109 patent/US20200000787A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US10441577B2 (en) | 2019-10-15 |
| US20150079154A1 (en) | 2015-03-19 |
| EP2729146B1 (en) | 2017-03-08 |
| WO2013007708A1 (en) | 2013-01-17 |
| EP3111937A1 (en) | 2017-01-04 |
| US20200000787A1 (en) | 2020-01-02 |
| ES2627120T3 (es) | 2017-07-26 |
| EP3111937B1 (en) | 2020-06-17 |
| EP2729146A1 (en) | 2014-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1232158A1 (zh) | 用於治療肝癌的藥物 | |
| HK1254759A1 (zh) | 用於增加folr1癌症治療的功效的方法 | |
| HK1202253A1 (zh) | 癌症的聯合治療 | |
| PT2818482T (pt) | Composição farmacêutica para o tratamento de cancro | |
| HUE045461T2 (hu) | Gyógyászati készítmény rák kezelésére | |
| HK1201256A1 (zh) | 用於治療癌症的吡咯並嘧啶化合物 | |
| IL228738A0 (en) | Antibodies for cancer treatment | |
| EP2542081A4 (en) | COMPOSITIONS FOR CANCER TREATMENT | |
| EP2688594A4 (en) | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | |
| IL232890A0 (en) | Immunogenic therapy for cancer | |
| EP2788378A4 (en) | ASSOCIATION THERAPY FOR THE TREATMENT OF CANCER | |
| IL227558A0 (en) | A therapeutic agent for tumors | |
| IL228430A0 (en) | Cancer treatment | |
| HK1185874A1 (zh) | 用於治療癌症的新的 -氨基- -羥基-苯甲酰胺 | |
| EP2608671A4 (en) | COMPOUNDS USED IN THE TREATMENT OF CANCER | |
| IL275636A (en) | Medical combination for cancer treatment | |
| IL238592B (en) | Compounds for the treatment of liver diseases | |
| PL2663318T3 (pl) | Kompozycja farmaceutyczna do leczenia raka | |
| WO2012106461A9 (en) | Combination therapy for treatment of cancer | |
| EP2750691A4 (en) | SRPX IN THE TREATMENT OF CANCER | |
| GB201121783D0 (en) | Treatment of cancer | |
| GB201121791D0 (en) | Combination treatment of cancer | |
| HK1157189A1 (en) | Pharmaceutical composition for the treatment of tumor diseases |