HK1225739A1 - 针对肺炎链球菌进行保护的富含脯氨酸的肽 - Google Patents

针对肺炎链球菌进行保护的富含脯氨酸的肽 Download PDF

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Publication number
HK1225739A1
HK1225739A1 HK16113900.4A HK16113900A HK1225739A1 HK 1225739 A1 HK1225739 A1 HK 1225739A1 HK 16113900 A HK16113900 A HK 16113900A HK 1225739 A1 HK1225739 A1 HK 1225739A1
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HK
Hong Kong
Prior art keywords
peptide
proline
building block
lipopeptide
amino acids
Prior art date
Application number
HK16113900.4A
Other languages
English (en)
Chinese (zh)
Inventor
Arin Ghasparian
Armando ZUNIGA
Nina GEIB
Marco TAMBORINI
Maja JUD
Gerd Pluschke
Aniebrys MARRERO NODARSE
John Anthony Robinson
Original Assignee
Virometix Ag
Swiss Tropical And Public Health Institute
Universität Basel
Universität Zürich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virometix Ag, Swiss Tropical And Public Health Institute, Universität Basel, Universität Zürich filed Critical Virometix Ag
Publication of HK1225739A1 publication Critical patent/HK1225739A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018—Lipids, e.g. in lipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16023—Virus like particles [VLP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HK16113900.4A 2013-12-03 2014-12-02 针对肺炎链球菌进行保护的富含脯氨酸的肽 HK1225739A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13195402.6 2013-12-03
EP13195402 2013-12-03

Publications (1)

Publication Number Publication Date
HK1225739A1 true HK1225739A1 (zh) 2017-09-15

Family

ID=49765797

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16113900.4A HK1225739A1 (zh) 2013-12-03 2014-12-02 针对肺炎链球菌进行保护的富含脯氨酸的肽

Country Status (12)

Country Link
US (2) US9943583B2 (https=)
EP (1) EP3077410B1 (https=)
JP (2) JP2017501990A (https=)
KR (1) KR20160088323A (https=)
CN (1) CN105793276A (https=)
AU (1) AU2014359292B2 (https=)
BR (1) BR112016012306A2 (https=)
CA (1) CA2931570A1 (https=)
HK (1) HK1225739A1 (https=)
RU (1) RU2737638C2 (https=)
WO (1) WO2015082501A1 (https=)
ZA (1) ZA201603962B (https=)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
AU2017231108B2 (en) * 2016-03-08 2021-06-17 KeMyth Biotech Co., Ltd. Use of pneumolysin peptides as antagonists against toll-like receptor 4 and methods of treating toll-like receptor 4 related diseases
CN110381992A (zh) * 2016-12-03 2019-10-25 Uab研究基金会 组合了肺炎球菌表面蛋白A的选择的α螺旋结构域和脯氨酸富集结构域的肺炎球菌疫苗
CA3066026A1 (en) 2017-06-14 2018-12-20 Virometix Ag Cyclic peptides for protection against respiratory syncytial virus
CN108559784B (zh) * 2018-07-06 2021-08-20 陕西省动物研究所 一种同时检测三种病原菌的三重pcr检测用引物、探针、试剂盒及检测方法
JP7550762B2 (ja) 2018-12-20 2024-09-13 ヴァイロメティックス アーゲー リポペプチドビルディングブロックおよび合成ウイルス様粒子
CN119306795A (zh) * 2019-03-25 2025-01-14 免疫功坊股份有限公司 带有金属结合区的复合多肽及其分子构建体
US12280098B2 (en) * 2019-03-29 2025-04-22 The University Of Tokyo Pneumococcal surface proteins
WO2021260176A1 (en) 2020-06-25 2021-12-30 Virometix Ag Synthetic epitopes of betacoronaviruses
EP4216992A1 (en) 2020-09-28 2023-08-02 DBV Technologies Particle comprising an rsv-f protein for use in rsv vaccination
CN121693342A (zh) 2023-07-12 2026-03-17 维罗迈科斯股份公司 肺炎球菌抗原的组合物
WO2025242657A1 (en) 2024-05-21 2025-11-27 Shape Biopharmaceuticals Ag Lipopeptide building blocks and aggregates

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US4663160A (en) * 1983-03-14 1987-05-05 Miles Laboratories, Inc. Vaccines for gram-negative bacteria
GB8704647D0 (en) 1987-02-27 1987-04-01 Guy S & St Thomas S Hospitals Vaccine
US6592876B1 (en) * 1993-04-20 2003-07-15 Uab Research Foundation Pneumococcal genes, portions thereof, expression products therefrom, and uses of such genes, portions and products
US5391712A (en) 1991-08-30 1995-02-21 Beckman Instruments, Inc. Non-hemolytic streptolysin O variants
GB9202219D0 (en) * 1992-02-03 1992-03-18 Connaught Lab A synthetic heamophilus influenzae conjugate vaccine
US6251405B1 (en) * 1995-06-07 2001-06-26 Connaught Laboratories, Inc. Immunological combination compositions and methods
WO1997037026A1 (en) 1996-04-02 1997-10-09 Smithkline Beecham Corporation Novel compounds
JP2000512487A (ja) 1996-05-14 2000-09-26 スミスクライン・ビーチャム・コーポレイション 新規化合物
US6096863A (en) 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
JP4469026B2 (ja) 1996-10-31 2010-05-26 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド Ｓｔｒｅｐｔｏｃｏｃｃｕｓ ｐｎｅｕｍｏｎｉａｅの抗原およびワクチン
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6800744B1 (en) 1997-07-02 2004-10-05 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
CA2312900A1 (en) 1997-12-02 1999-06-10 Powderject Vaccines, Inc. Transdermal delivery of particulate vaccine compositions
IT1320157B1 (it) 2000-01-27 2003-11-18 Combistone Italia S P A Piano e/o rivestimento per arredamento e procedimento per la suaproduzione.
CA2881568C (en) 2000-10-27 2019-09-24 Novartis Vaccines And Diagnostics, Inc. Nucleic acids and proteins from streptococcus groups a & b
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BR0208874A (pt) 2001-04-13 2004-06-22 Wyeth Corp Proteìnas superficiais de streptococcus pyogenes
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CA2672052C (en) * 2006-12-09 2018-01-09 Universitaet Zuerich Prorektorat Forschung Coiled-coil lipopeptide helical bundles and synthetic virus-like particles
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Also Published As

Publication number Publication date
US20180256698A1 (en) 2018-09-13
US20160324947A1 (en) 2016-11-10
RU2737638C2 (ru) 2020-12-01
AU2014359292A1 (en) 2016-06-23
EP3077410A1 (en) 2016-10-12
BR112016012306A2 (pt) 2017-09-26
EP3077410B1 (en) 2021-02-03
CN105793276A (zh) 2016-07-20
WO2015082501A1 (en) 2015-06-11
KR20160088323A (ko) 2016-07-25
US9943583B2 (en) 2018-04-17
JP2017501990A (ja) 2017-01-19
AU2014359292B2 (en) 2019-02-28
ZA201603962B (en) 2020-02-26
CA2931570A1 (en) 2015-06-11
JP2020073487A (ja) 2020-05-14

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