HK1224290A1 - 四氫異喹啉衍生物的鹽類和溶劑化物 - Google Patents
四氫異喹啉衍生物的鹽類和溶劑化物Info
- Publication number
- HK1224290A1 HK1224290A1 HK16112556.3A HK16112556A HK1224290A1 HK 1224290 A1 HK1224290 A1 HK 1224290A1 HK 16112556 A HK16112556 A HK 16112556A HK 1224290 A1 HK1224290 A1 HK 1224290A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- solvates
- salt
- tetrahydroisoquinoline derivative
- tetrahydroisoquinoline
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36636710P | 2010-07-21 | 2010-07-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1224290A1 true HK1224290A1 (zh) | 2017-08-18 |
Family
ID=44386640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16112556.3A HK1224290A1 (zh) | 2010-07-21 | 2013-07-03 | 四氫異喹啉衍生物的鹽類和溶劑化物 |
Country Status (19)
Country | Link |
---|---|
US (3) | US8614227B2 (zh) |
EP (2) | EP3081557A1 (zh) |
JP (3) | JP5948326B2 (zh) |
CN (2) | CN103003244B (zh) |
AU (3) | AU2011281381B2 (zh) |
CA (1) | CA2803699C (zh) |
DK (1) | DK2595960T3 (zh) |
ES (1) | ES2570135T3 (zh) |
HK (1) | HK1224290A1 (zh) |
HR (1) | HRP20160540T1 (zh) |
HU (1) | HUE028620T2 (zh) |
ME (1) | ME02407B (zh) |
NZ (2) | NZ708529A (zh) |
PL (1) | PL2595960T3 (zh) |
PT (1) | PT2595960E (zh) |
SI (1) | SI2595960T1 (zh) |
SM (1) | SMT201600171B (zh) |
WO (1) | WO2012010843A1 (zh) |
ZA (1) | ZA201300169B (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8614227B2 (en) * | 2010-07-21 | 2013-12-24 | Spinifex Pharmaceuticals Pty Ltd | Salt and solvates of a tetrahydroisoquinoline derivative |
US9320530B2 (en) * | 2013-03-13 | 2016-04-26 | The Spectranetics Corporation | Assisted cutting balloon |
PL3019477T3 (pl) * | 2013-07-08 | 2021-11-22 | Novartis Ag | Związki heterocykliczne i sposoby ich stosowania |
PT3245198T (pt) | 2015-01-13 | 2020-06-16 | Novartis Ag | Derivados de pirrolidina como antagonistas de angiotensina ii tipo 2 |
PL3268356T3 (pl) | 2015-03-12 | 2022-01-24 | Novartis Ag | Związki heterocykliczne i sposoby ich stosowania |
CN106478502B (zh) * | 2015-08-29 | 2021-04-27 | 上海翰森生物医药科技有限公司 | 1,2,3,4-四氢异喹啉衍生物、其制备方法和应用 |
EP3475261A1 (en) | 2016-06-27 | 2019-05-01 | ratiopharm GmbH | Crystalline calcium salt of (s)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinoline carboxylic acid |
WO2018172950A1 (en) | 2017-03-23 | 2018-09-27 | Novartis Ag | Anhydrous crystalline forms of sodium (s)-2-(diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylate |
AU2018279669B8 (en) * | 2017-06-09 | 2020-10-15 | Shandong Danhong Pharmaceutical Co., Ltd. | Carboxylic acid derivative as at AT2R receptor antagonist |
JP2021531749A (ja) | 2018-07-12 | 2021-11-25 | コデクシス, インコーポレイテッド | 操作されたフェニルアラニンアンモニアリアーゼポリペプチド |
WO2020012266A1 (en) | 2018-07-12 | 2020-01-16 | Novartis Ag | Biocatalytic synthesis of olodanrigan (ema401) from 3-(2-(benzyloxy)-3-methoxyphenyl)propenoic acid with phenylalanine ammonia lyase |
CN111620816B (zh) * | 2020-05-27 | 2023-06-02 | 上海赛默罗生物科技有限公司 | 螺桨烷类衍生物、其制备方法、药物组合物和用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
US5236934A (en) | 1992-08-26 | 1993-08-17 | E. I. Du Pont De Nemours And Company | 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders |
AU747110B2 (en) * | 1998-02-25 | 2002-05-09 | Merck & Co., Inc. | Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist |
NZ555334A (en) | 2004-12-24 | 2010-05-28 | Spinifex Pharm Pty Ltd | Method of treatment or prophylaxis of a neuropathic condition using AT2 receptor antagonist |
CA2866540A1 (en) | 2006-03-20 | 2007-09-27 | Spinifex Pharmaceuticals Pty Ltd. | Method of treatment or prophylaxis of inflammatory pain |
NZ601383A (en) * | 2010-01-19 | 2014-07-25 | Spinifex Pharm Pty Ltd | Methods and compositions for improved nerve conduction velocity |
US8614227B2 (en) * | 2010-07-21 | 2013-12-24 | Spinifex Pharmaceuticals Pty Ltd | Salt and solvates of a tetrahydroisoquinoline derivative |
-
2011
- 2011-07-21 US US13/187,882 patent/US8614227B2/en not_active Expired - Fee Related
- 2011-07-21 DK DK11740973.0T patent/DK2595960T3/en active
- 2011-07-21 NZ NZ708529A patent/NZ708529A/en not_active IP Right Cessation
- 2011-07-21 WO PCT/GB2011/001096 patent/WO2012010843A1/en active Application Filing
- 2011-07-21 SI SI201130804A patent/SI2595960T1/sl unknown
- 2011-07-21 EP EP15200360.4A patent/EP3081557A1/en not_active Withdrawn
- 2011-07-21 CA CA2803699A patent/CA2803699C/en not_active Expired - Fee Related
- 2011-07-21 EP EP11740973.0A patent/EP2595960B1/en active Active
- 2011-07-21 ES ES11740973T patent/ES2570135T3/es active Active
- 2011-07-21 CN CN201180035468.9A patent/CN103003244B/zh not_active Expired - Fee Related
- 2011-07-21 NZ NZ605444A patent/NZ605444A/en not_active IP Right Cessation
- 2011-07-21 PT PT117409730T patent/PT2595960E/pt unknown
- 2011-07-21 ME MEP-2016-98A patent/ME02407B/me unknown
- 2011-07-21 CN CN201610152658.3A patent/CN105777636A/zh active Pending
- 2011-07-21 HU HUE11740973A patent/HUE028620T2/en unknown
- 2011-07-21 PL PL11740973.0T patent/PL2595960T3/pl unknown
- 2011-07-21 AU AU2011281381A patent/AU2011281381B2/en not_active Ceased
- 2011-07-21 JP JP2013520203A patent/JP5948326B2/ja not_active Expired - Fee Related
-
2013
- 2013-01-08 ZA ZA2013/00169A patent/ZA201300169B/en unknown
- 2013-07-03 HK HK16112556.3A patent/HK1224290A1/zh unknown
- 2013-11-18 US US14/083,391 patent/US8927575B2/en not_active Expired - Fee Related
-
2014
- 2014-12-17 US US14/573,774 patent/US9162985B2/en not_active Expired - Fee Related
-
2015
- 2015-10-06 AU AU2015238774A patent/AU2015238774A1/en not_active Abandoned
-
2016
- 2016-04-11 JP JP2016078656A patent/JP2016164178A/ja active Pending
- 2016-05-20 HR HRP20160540TT patent/HRP20160540T1/hr unknown
- 2016-06-15 SM SM201600171T patent/SMT201600171B/it unknown
-
2017
- 2017-05-15 AU AU2017203236A patent/AU2017203236A1/en not_active Abandoned
- 2017-08-14 JP JP2017156436A patent/JP2017214415A/ja active Pending
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