HK1223654A1 - 用於製備手性 -芳基嗎啉的方法 - Google Patents

用於製備手性 -芳基嗎啉的方法

Info

Publication number
HK1223654A1
HK1223654A1 HK16112040.7A HK16112040A HK1223654A1 HK 1223654 A1 HK1223654 A1 HK 1223654A1 HK 16112040 A HK16112040 A HK 16112040A HK 1223654 A1 HK1223654 A1 HK 1223654A1
Authority
HK
Hong Kong
Prior art keywords
chiral
preparation
morpholines
aryl
aryl morpholines
Prior art date
Application number
HK16112040.7A
Other languages
English (en)
Inventor
Rene Trussardi
Beat Rauber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1223654A1 publication Critical patent/HK1223654A1/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/008Preparation of nitrogen-containing organic compounds containing a N-O bond, e.g. nitro (-NO2), nitroso (-NO)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK16112040.7A 2013-12-11 2016-10-19 用於製備手性 -芳基嗎啉的方法 HK1223654A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13196638 2013-12-11
PCT/EP2014/076831 WO2015086495A1 (en) 2013-12-11 2014-12-08 Process for the preparation of chiral 2-aryl morpholines

Publications (1)

Publication Number Publication Date
HK1223654A1 true HK1223654A1 (zh) 2017-08-04

Family

ID=49759111

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16112040.7A HK1223654A1 (zh) 2013-12-11 2016-10-19 用於製備手性 -芳基嗎啉的方法

Country Status (12)

Country Link
US (1) US10337039B2 (zh)
EP (1) EP3080284B1 (zh)
JP (1) JP6511448B2 (zh)
KR (1) KR20160097291A (zh)
CN (1) CN105793430B (zh)
CA (1) CA2932003A1 (zh)
ES (1) ES2653559T3 (zh)
HK (1) HK1223654A1 (zh)
MX (1) MX2016007140A (zh)
PL (1) PL3080284T3 (zh)
RU (1) RU2677328C1 (zh)
WO (1) WO2015086495A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108570014B (zh) * 2018-04-24 2019-05-21 上海馨远医药科技有限公司 一种手性吗啉化合物的制备方法
EP3997085A1 (en) 2019-07-11 2022-05-18 F. Hoffmann-La Roche AG Process for the preparation of substituted pyrazole derivatives
CN118251382A (zh) 2021-11-08 2024-06-25 豪夫迈·罗氏有限公司 芳硝基化合物的催化氢化
CN114317619A (zh) * 2021-12-31 2022-04-12 山西大学 一种酮还原酶连续化反应制备手性醇的方法
WO2024013383A1 (en) 2022-07-15 2024-01-18 F. Hoffmann-La Roche Ag Mutant ketoreductase with increased ketoreductase activity as well as methods and uses involving the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0605033T3 (da) * 1992-12-21 2000-02-07 Duphar Int Res Enzymatisk fremgangsmåde til stereoselektiv fremstilling af en heterobicyklisk alkoholenantiomer
DE10119274A1 (de) * 2001-04-20 2002-10-31 Juelich Enzyme Products Gmbh Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
RS51442B (en) 2002-12-10 2011-04-30 Pfizer Inc. MORPHOLINE DERIVATIVES USED AS DOPAMINE AGONISTS IN TREATMENT I.A. SEXUAL DYSFUNCTIONS
AT501928B1 (de) 2004-10-27 2010-09-15 Iep Gmbh Verfahren zur herstellung von chiralen alkoholen
KR101502634B1 (ko) 2007-02-08 2015-03-16 코덱시스, 인코포레이티드 케토 환원 효소 및 이의 용도
US8796002B2 (en) 2009-06-22 2014-08-05 Codexis, Inc. Polypeptides for a ketoreductase-mediated stereoselective route to alpha chloroalcohols
US9132136B2 (en) 2010-08-02 2015-09-15 Hoffmann-La Roche Inc. Pharmaceutical combination
US8802673B2 (en) * 2011-03-24 2014-08-12 Hoffmann-La Roche Inc Heterocyclic amine derivatives

Also Published As

Publication number Publication date
EP3080284B1 (en) 2017-10-18
US20160289718A1 (en) 2016-10-06
CA2932003A1 (en) 2015-06-18
CN105793430A (zh) 2016-07-20
ES2653559T3 (es) 2018-02-07
JP2017500308A (ja) 2017-01-05
MX2016007140A (es) 2016-07-21
EP3080284A1 (en) 2016-10-19
CN105793430B (zh) 2020-03-03
KR20160097291A (ko) 2016-08-17
RU2016125459A (ru) 2018-01-23
WO2015086495A1 (en) 2015-06-18
RU2677328C1 (ru) 2019-01-16
US10337039B2 (en) 2019-07-02
PL3080284T3 (pl) 2018-05-30
JP6511448B2 (ja) 2019-05-15

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