HK1220635A1 - 用於癌症靶向治療的小分子配體-藥物軛合物 - Google Patents
用於癌症靶向治療的小分子配體-藥物軛合物Info
- Publication number
- HK1220635A1 HK1220635A1 HK16108809.6A HK16108809A HK1220635A1 HK 1220635 A1 HK1220635 A1 HK 1220635A1 HK 16108809 A HK16108809 A HK 16108809A HK 1220635 A1 HK1220635 A1 HK 1220635A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- small molecule
- cancer therapy
- drug conjugates
- molecule ligand
- ligand drug
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 238000011275 oncology therapy Methods 0.000 title 1
- 150000003384 small molecules Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
- A61K47/546—Porphyrines; Porphyrine with an expanded ring system, e.g. texaphyrine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6134608P | 2008-06-13 | 2008-06-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1220635A1 true HK1220635A1 (zh) | 2017-05-12 |
Family
ID=41417140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16108809.6A HK1220635A1 (zh) | 2008-06-13 | 2016-07-22 | 用於癌症靶向治療的小分子配體-藥物軛合物 |
Country Status (5)
Country | Link |
---|---|
US (3) | US20110085974A1 (zh) |
EP (1) | EP2303337A4 (zh) |
CN (2) | CN105288645A (zh) |
HK (1) | HK1220635A1 (zh) |
WO (1) | WO2009152440A1 (zh) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ569818A (en) * | 2005-12-16 | 2012-07-27 | Catherine M Shachaf | Diagnostic system for the detection and diagnosis of skin cancer |
WO2009012109A2 (en) | 2007-07-13 | 2009-01-22 | Emory University | Cyanine-containing compounds for cancer imaging and treatment |
WO2011116142A1 (en) * | 2010-03-16 | 2011-09-22 | Xiaojian Yang | Method of using near infrared fluorescent dyes for imaging and targeting cancers |
JP5755724B2 (ja) * | 2011-03-10 | 2015-07-29 | 国立大学法人岐阜大学 | 光電変換素子及び色素増感太陽電池 |
US9675620B2 (en) | 2011-07-26 | 2017-06-13 | University Of Southern California | MAO inhibitors and their conjugates as therapeutics for the treatment of brain cancer |
JP2014525914A (ja) * | 2011-07-26 | 2014-10-02 | ユニヴァーシティー オブ サザン カリフォルニア | モノアミンオキシダーゼ阻害剤ならびに前立腺がんを処置および診断するための方法 |
WO2013052776A1 (en) | 2011-10-07 | 2013-04-11 | Cedars-Sinai Medical Center | Compositions and methods for tumor imaging and targeting by a class of organic heptamethine cyanine dyes that possess dual nuclear and near-infrared properties |
WO2013086207A1 (en) * | 2011-12-06 | 2013-06-13 | The Ohio State University | Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease |
US20150223675A1 (en) * | 2012-09-04 | 2015-08-13 | Given Imaging Ltd. | Luminal administration of tag molecules for diagnostic applications |
WO2014065439A1 (en) | 2012-10-26 | 2014-05-01 | Canon Kabushiki Kaisha | Cancer cell inhibitory drug and cancer stem-cell detection probe |
CN110179995A (zh) * | 2012-12-28 | 2019-08-30 | 塔弗达治疗有限公司 | 包封在颗粒中的靶向缀合物及其制剂 |
US9931412B2 (en) * | 2013-02-08 | 2018-04-03 | The Regents Of The University Of Michigan | Targeted theranostics |
EP3035938B1 (en) * | 2013-09-10 | 2020-08-19 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics |
WO2015161192A1 (en) | 2014-04-17 | 2015-10-22 | Memorial Sloan Kettering Cancer Center | Fucoidan nanogels and methods of their use and manufacture |
WO2016106324A1 (en) * | 2014-12-22 | 2016-06-30 | Da Zen Group, Llc | Organic anion transporting peptide-based cancer imaging and therapy |
CN105111773B (zh) * | 2015-08-19 | 2017-06-27 | 大连理工大学 | 一类氨基菁类荧光染料及其制备方法和应用 |
RU2657833C2 (ru) * | 2015-12-01 | 2018-06-15 | Общество С Ограниченной Ответственностью "Остерос Биомедика" | Стабилизированная лекарственная форма конъюгата этидроната с цитарабином и её применение |
US10548881B2 (en) | 2016-02-23 | 2020-02-04 | Tarveda Therapeutics, Inc. | HSP90 targeted conjugates and particles and formulations thereof |
CN109152845B (zh) | 2016-04-14 | 2022-07-12 | 宝力泰锐克斯有限公司 | 含有在环内包含至少两个(-ch2-ch2-o-)单元的接头的缀合物和缀合试剂 |
CN105949112B (zh) * | 2016-05-05 | 2018-07-31 | 中国科学院长春应用化学研究所 | 一种用于光学成像的化合物、制备方法及其键合物 |
GB201608936D0 (en) | 2016-05-20 | 2016-07-06 | Polytherics Ltd | Novel conjugates and novel conjugating reagents |
EA030671B1 (ru) | 2016-07-20 | 2018-09-28 | Общество С Ограниченной Ответственностью "Остерос Биомедика" | Препарат для лечения костных поражений, вызванных злокачественными новообразованиями |
CN110087649B (zh) | 2016-10-21 | 2022-02-18 | 西达赛奈医疗中心 | 用辛伐他汀和化疗药物与七甲川花菁染料偶联体提高肿瘤对激素拮抗剂和药物的敏感性 |
US11207420B2 (en) | 2017-04-19 | 2021-12-28 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Cytotoxin and conjugate, uses of same and preparation method therefor |
KR101973456B1 (ko) * | 2017-10-17 | 2019-04-29 | 울산과학기술원 | 미토콘드리아에 표적화되는 수용성 화합물, 이를 포함하는 조성물 및 이의 제조방법 |
CN109796780A (zh) * | 2017-11-17 | 2019-05-24 | 中国科学院宁波材料技术与工程研究所 | 一种七甲川苯并吲哚花菁染料及其制备方法和应用 |
CN109593052B (zh) * | 2018-11-20 | 2021-04-20 | 首都医科大学 | 用于诊断和治疗的放射性精氨酸衍生物及其制备方法 |
US20200289676A1 (en) * | 2019-03-15 | 2020-09-17 | Lahjavida, Llc | Near-Infrared Dyes And Conjugates For Targeting Tumors |
CN111518545B (zh) * | 2020-04-20 | 2022-03-15 | 苏州大学 | 高稳定性近红外二区纳米荧光探针及其制备方法和应用 |
CN112675305B (zh) * | 2021-01-22 | 2023-05-23 | 中国科学院深圳先进技术研究院 | 用于肿瘤治疗的双亲性分子自组装纳米药物及制备方法和用途 |
CA3223936A1 (en) * | 2021-06-28 | 2023-01-05 | Ronald Christiaan Elgersma | Conjugates comprising phosphoantigens and their use in therapy |
CN113999156A (zh) * | 2021-11-23 | 2022-02-01 | 临沂大学 | 一种近红外荧光小分子探针及其合成方法与应用 |
CN117959457A (zh) * | 2022-10-26 | 2024-05-03 | 深圳先进技术研究院 | 一种用作靶蛋白降解剂的双功能化合物及其在靶蛋白溶酶体降解中的应用 |
EP4360659A1 (en) * | 2022-10-26 | 2024-05-01 | Cyanagen S.r.l. | Fluorescent water-soluble polycationic chitosan polymers as markers for biological 3d imaging |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE68927479T2 (de) * | 1988-05-02 | 1997-04-03 | Phanos Tech Inc | Verbindungen, zusammensetzungen und verfahren zum binden von bio-affektions-substanzen an oberflächenmembranen von bioteilchen |
ZA929179B (en) * | 1991-11-27 | 1993-05-24 | Zynaxis Technologies Inc | Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles. |
US5986086A (en) * | 1997-06-20 | 1999-11-16 | Amersham Pharmacia Biotech Inc. | Non-sulfonated cyanine dyes for labeling nucleosides and nucleotides |
US6214812B1 (en) * | 1998-04-02 | 2001-04-10 | Mbc Research, Inc. | Bisphosphonate conjugates and methods of making and using the same |
CA2362937C (en) * | 1999-02-24 | 2011-03-22 | The Uab Research Foundation | Taxane derivatives for targeted therapy of cancer |
US7790144B2 (en) * | 2000-01-18 | 2010-09-07 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
US6673334B1 (en) * | 2000-10-16 | 2004-01-06 | Mallinkcrodt, Inc. | Light sensitive compounds for instant determination of organ function |
AU2002236683A1 (en) * | 2000-10-27 | 2002-05-21 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
EP1221465A1 (en) * | 2001-01-03 | 2002-07-10 | Innosense S.r.l. | Symmetric, monofunctionalised polymethine dyes labelling reagents |
US6747151B2 (en) * | 2001-05-04 | 2004-06-08 | Mallinckrodt, Inc. | Azo compounds for type I phototherapy |
US7060654B2 (en) * | 2003-10-28 | 2006-06-13 | Hewlett-Packard Development Company | Imaging media and materials used therein |
US6761878B2 (en) * | 2001-10-17 | 2004-07-13 | Mallinckrodt, Inc. | Pathological tissue detection and treatment employing targeted benzoindole optical agents |
US7261875B2 (en) * | 2001-12-21 | 2007-08-28 | Board Of Regents, The University Of Texas System | Dendritic poly (amino acid) carriers and methods of use |
WO2003059149A2 (en) * | 2001-12-21 | 2003-07-24 | Threshold Pharmaceuticals, Inc. | Methods for cancer imaging |
US7344700B2 (en) * | 2002-02-28 | 2008-03-18 | University Of Tennessee Research Corporation | Radiolabeled selective androgen receptor modulators and their use in prostate cancer imaging and therapy |
JP2003261464A (ja) * | 2002-03-07 | 2003-09-16 | Fuji Photo Film Co Ltd | 近赤外蛍光造影剤および蛍光造影法 |
ITMI20022411A1 (it) * | 2002-11-14 | 2004-05-15 | Bracco Imaging Spa | Agenti per la diagnosi e la terapia di tumori che espongono sulla superficie delle cellule proteine alterate. |
US7850946B2 (en) * | 2003-05-31 | 2010-12-14 | Washington University In St. Louis | Macrocyclic cyanine and indocyanine bioconjugates provide improved biomedical applications |
WO2005012579A2 (en) * | 2003-07-31 | 2005-02-10 | Molecular Probes, Inc. | Homodimeric cyanine dye dimer comprising aromatic, heteroaromatic, cyclic or heterocyclic linker moiety in nucleic acid reporter molecules |
NO20034350D0 (no) * | 2003-09-29 | 2003-09-29 | Amersham Health As | Optisk avbilding av kolorektal kreft |
US20050255042A1 (en) * | 2003-11-24 | 2005-11-17 | The Regents Of The University Of California Office Of Technology Transfer, University Of California | On-demand cleavable linkers for radioconjugates for cancer imaging and therapy |
EP1679082A1 (en) * | 2005-01-07 | 2006-07-12 | Schering AG | Use of cyanine dyes for the diagnosis of proliferative diseases |
US8541555B2 (en) * | 2006-04-18 | 2013-09-24 | Solulink Biosciences, Inc. | Hydrazone-based and oxime-based fluorescent and chromophoric/pro-fluorescent and pro-chromophoric reagents and linkers |
WO2008017074A2 (en) * | 2006-08-03 | 2008-02-07 | Beth Israel Deaconess Medical Center, Inc. | Dyes and precursors and conjugates thereof |
WO2009012109A2 (en) * | 2007-07-13 | 2009-01-22 | Emory University | Cyanine-containing compounds for cancer imaging and treatment |
-
2009
- 2009-06-12 CN CN201510644982.2A patent/CN105288645A/zh active Pending
- 2009-06-12 US US12/995,417 patent/US20110085974A1/en not_active Abandoned
- 2009-06-12 CN CN200980126216.XA patent/CN102099059B/zh not_active Expired - Fee Related
- 2009-06-12 WO PCT/US2009/047216 patent/WO2009152440A1/en active Application Filing
- 2009-06-12 EP EP09763728.4A patent/EP2303337A4/en not_active Withdrawn
-
2016
- 2016-01-26 US US15/006,734 patent/US20160310604A1/en not_active Abandoned
- 2016-07-22 HK HK16108809.6A patent/HK1220635A1/zh unknown
-
2023
- 2023-03-17 US US18/123,236 patent/US20230248832A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20160310604A1 (en) | 2016-10-27 |
US20110085974A1 (en) | 2011-04-14 |
EP2303337A4 (en) | 2014-09-03 |
CN105288645A (zh) | 2016-02-03 |
WO2009152440A1 (en) | 2009-12-17 |
CN102099059A (zh) | 2011-06-15 |
EP2303337A1 (en) | 2011-04-06 |
US20230248832A1 (en) | 2023-08-10 |
CN102099059B (zh) | 2015-09-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1220635A1 (zh) | 用於癌症靶向治療的小分子配體-藥物軛合物 | |
HRP20181385T1 (hr) | Ciljanje abcb5 za terapiju raka | |
HK1185414A1 (zh) | 用抗體陣列選擇乳腺癌治療藥物 | |
HK1207976A1 (zh) | 奧里斯他汀藥物連接體軛合物 | |
EP2480230A4 (en) | LIGAND-DRUG CONJUGATES DR5 | |
EP2127671A4 (en) | THERAPEUTIC AGENT AGAINST CANCER | |
ZA201000310B (en) | Drug selection for lung cancer therapy using antibody-based arrays | |
HK1151727A1 (zh) | 用抗體-藥物偶聯物聯合治療 | |
HK1151734A1 (zh) | 肝癌治療劑 | |
IL197316A0 (en) | Buprenophine-wafer for drug substitution therapy | |
HRP20130547T1 (hr) | Konjugati za ciljano dopremanje lijeka kroz krvno-moždanu barijeru | |
EP2190853A4 (en) | HALOGENIDE-FREE COMPLEXES FROM GLUCOSAMINE AND AN ACIDIC ACID | |
IL227009B (en) | Drug selection for malignant cancer therapy using antibody-based arrays | |
EP2454598A4 (en) | ACTIVE SUBSTANCE SELECTION FOR ANTIBODY ARRAYS | |
BRPI0813789A2 (pt) | Potenciação de quimioterapia contra câncer | |
ZA201304462B (en) | Novel conjugates for targeted drug delivery | |
EP2135604A4 (en) | PREPARATION OF INFUSION FOR PATIENT SUFFERING FROM CANCER | |
EP2099303A4 (en) | THERAPEUTIC COMPOSITIONS ON TETRAHYDROISOCHINOLINE BASE FOR CANCER THERAPY | |
GB0707556D0 (en) | Treatment for cancer | |
EP2009007A4 (en) | VEGETABLE THERAPEUTIC AGENT FOR THE TREATMENT OF A MALIGNANT TUMOR | |
PT2305654E (pt) | Agente terapêutico para a dor relacionada com o cancro | |
IL210247A0 (en) | Ccl20 - specific antibodies for cancer therapy | |
GB0706538D0 (en) | Cancer therapeutic | |
GB0606703D0 (en) | Transcutaneous cancer therapeutic | |
GB0612258D0 (en) | Transcutaneous cancer therapeutic |