HK1219474A1 - -氨基吡啶並 嘧啶- -酮衍生物及其作為 抑制劑的用途 - Google Patents
-氨基吡啶並 嘧啶- -酮衍生物及其作為 抑制劑的用途Info
- Publication number
- HK1219474A1 HK1219474A1 HK16107406.5A HK16107406A HK1219474A1 HK 1219474 A1 HK1219474 A1 HK 1219474A1 HK 16107406 A HK16107406 A HK 16107406A HK 1219474 A1 HK1219474 A1 HK 1219474A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- wee
- aminopyrido
- pyrimidin
- inhibitors
- derivatives
- Prior art date
Links
- GTTIDXWDYUROBU-UHFFFAOYSA-N 2-amino-6H-pyrido[4,3-d]pyrimidin-5-one Chemical class Nc1ncc2c(cc[nH]c2=O)n1 GTTIDXWDYUROBU-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1306610.5A GB201306610D0 (en) | 2013-04-11 | 2013-04-11 | Pharmaceutical compounds |
| PCT/GB2014/051136 WO2014167347A1 (en) | 2013-04-11 | 2014-04-11 | 2-aminopyrido[4,3-d]pyrimidin-5-one derivatives and their use as wee-1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1219474A1 true HK1219474A1 (zh) | 2017-04-07 |
Family
ID=48537110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16107406.5A HK1219474A1 (zh) | 2013-04-11 | 2016-06-24 | -氨基吡啶並 嘧啶- -酮衍生物及其作為 抑制劑的用途 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9714244B2 (zh) |
| EP (1) | EP2984090B1 (zh) |
| JP (1) | JP6412920B2 (zh) |
| KR (1) | KR102250668B1 (zh) |
| CN (1) | CN105209463B (zh) |
| AU (1) | AU2014252828B2 (zh) |
| BR (1) | BR112015026023A2 (zh) |
| CA (1) | CA2909365C (zh) |
| GB (1) | GB201306610D0 (zh) |
| HK (1) | HK1219474A1 (zh) |
| IL (1) | IL242000B (zh) |
| MX (1) | MX362215B (zh) |
| RU (1) | RU2656342C2 (zh) |
| SG (1) | SG11201508405QA (zh) |
| WO (1) | WO2014167347A1 (zh) |
| ZA (1) | ZA201507874B (zh) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104271576A (zh) * | 2012-02-23 | 2015-01-07 | 艾伯维公司 | 激酶的吡啶并嘧啶酮抑制剂 |
| WO2016204429A1 (ko) * | 2015-06-18 | 2016-12-22 | 한국화학연구원 | 헤테로아릴 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 pi3 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물. |
| KR101845931B1 (ko) | 2015-06-18 | 2018-04-05 | 한국화학연구원 | 헤테로아릴 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 pi3 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물 |
| CN107459519A (zh) * | 2016-06-06 | 2017-12-12 | 上海艾力斯医药科技有限公司 | 稠合嘧啶哌啶环衍生物及其制备方法和应用 |
| GB201612095D0 (en) * | 2016-07-12 | 2016-08-24 | Almac Discovery Ltd | Pharmaceutical compounds |
| WO2018133829A1 (zh) | 2017-01-23 | 2018-07-26 | 南京明德新药研发股份有限公司 | 作为Wee1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮衍生物 |
| GB201703881D0 (en) * | 2017-03-10 | 2017-04-26 | Almac Discovery Ltd | Pharmaceutical compounds |
| MX2019011506A (es) | 2017-03-31 | 2019-11-01 | Seattle Genetics Inc | Inhibicion de cinasa 1 de punto de control (chk1) para el tratamiento de cancer. |
| US20200291018A1 (en) * | 2017-07-13 | 2020-09-17 | Syros Pharmaceuticals, Inc. | Tam kinase inhibitors |
| WO2019074981A1 (en) | 2017-10-09 | 2019-04-18 | GiraFpharma LLC | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
| WO2019074979A1 (en) | 2017-10-09 | 2019-04-18 | Girafpharma, Llc | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
| FI3712150T3 (fi) | 2017-11-01 | 2024-07-31 | Wuxi Biocity Biopharmaceutics Co Ltd | Weel-estäjänä toimiva makrosyklinen yhdiste ja sen sovelluksia |
| GB201800378D0 (en) * | 2018-01-10 | 2018-02-21 | Almac Discovery Ltd | Pharmaceutical compounds |
| US20210403451A1 (en) | 2018-10-26 | 2021-12-30 | Wenyuan Qian | Pyrimidopyrazolone derivative as wee1 inhibitor and use thereof |
| KR20200100429A (ko) * | 2019-02-18 | 2020-08-26 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리도[3,4-d]피리미딘-8-온 유도체 및 이를 포함하는 암의 예방, 개선 또는 치료용 약학 조성물 |
| KR102697799B1 (ko) | 2019-03-22 | 2024-08-23 | 쇼우야오 홀딩스 (베이징) 코., 엘티디. | Wee1 억제제 및 이의 제조 및 용도 |
| KR20210150476A (ko) | 2019-04-09 | 2021-12-10 | 누베이션 바이오 인크. | 헤테로시클릭 화합물 및 그의 용도 |
| PT3964510T (pt) | 2019-04-30 | 2024-07-29 | Wuxi Biocity Biopharmaceutics Co Ltd | Forma cristalina do composto inibidor de wee1 e sua utilização |
| CN115698006B (zh) | 2020-06-17 | 2024-03-29 | 微境生物医药科技(上海)有限公司 | 作为Wee-1抑制剂的吡唑并[3，4-d]嘧啶-3-酮衍生物 |
| WO2022228511A1 (zh) | 2021-04-30 | 2022-11-03 | 微境生物医药科技(上海)有限公司 | 作为Wee-1抑制剂的稠环化合物及其制备方法和用途 |
| CA3225152A1 (en) * | 2021-06-04 | 2022-12-08 | Aprea Therapeutics, Inc. | Pyridopyrimidine derivatives useful as wee1 kinase inhibitors |
| CN116462687A (zh) | 2022-01-18 | 2023-07-21 | 江苏天士力帝益药业有限公司 | Wee1抑制剂及其制备和用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2783B1 (en) * | 2005-09-30 | 2014-03-15 | نوفارتيس ايه جي | Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones |
| AR060635A1 (es) * | 2006-04-27 | 2008-07-02 | Banyu Pharma Co Ltd | Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer |
| EP2330909B1 (en) * | 2008-08-12 | 2013-09-18 | GlaxoSmithKline LLC | Chemical compounds |
| RU2011126254A (ru) * | 2008-11-28 | 2013-01-10 | Новартис Аг | Применение ингибтиторов hsp90 для терапевтического лечения |
| JP2012511502A (ja) * | 2008-12-12 | 2012-05-24 | Ｍｓｄ株式会社 | ジヒドロピリミドピリミジン誘導体 |
| AU2009325400A1 (en) | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivatives |
| AR075180A1 (es) * | 2009-01-29 | 2011-03-16 | Novartis Ag | Formulaciones orales solidas de una pirido-pirimidinona |
| JP2014520855A (ja) * | 2011-07-15 | 2014-08-25 | アッヴィ・インコーポレイテッド | 増殖性疾患の治療に有用な三環式キナーゼ阻害薬 |
| US8796289B2 (en) | 2011-07-19 | 2014-08-05 | Abbvie Inc. | Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases |
| CN104271576A (zh) * | 2012-02-23 | 2015-01-07 | 艾伯维公司 | 激酶的吡啶并嘧啶酮抑制剂 |
-
2013
- 2013-04-11 GB GBGB1306610.5A patent/GB201306610D0/en not_active Ceased
-
2014
- 2014-04-11 JP JP2016507063A patent/JP6412920B2/ja active Active
- 2014-04-11 CA CA2909365A patent/CA2909365C/en active Active
- 2014-04-11 RU RU2015148189A patent/RU2656342C2/ru active
- 2014-04-11 EP EP14717827.1A patent/EP2984090B1/en active Active
- 2014-04-11 BR BR112015026023A patent/BR112015026023A2/pt not_active Application Discontinuation
- 2014-04-11 MX MX2015014234A patent/MX362215B/es active IP Right Grant
- 2014-04-11 KR KR1020157032360A patent/KR102250668B1/ko active IP Right Grant
- 2014-04-11 WO PCT/GB2014/051136 patent/WO2014167347A1/en active Application Filing
- 2014-04-11 SG SG11201508405QA patent/SG11201508405QA/en unknown
- 2014-04-11 CN CN201480027198.0A patent/CN105209463B/zh active Active
- 2014-04-11 AU AU2014252828A patent/AU2014252828B2/en active Active
- 2014-04-11 US US14/783,752 patent/US9714244B2/en active Active
-
2015
- 2015-10-11 IL IL242000A patent/IL242000B/en active IP Right Grant
- 2015-10-22 ZA ZA2015/07874A patent/ZA201507874B/en unknown
-
2016
- 2016-06-24 HK HK16107406.5A patent/HK1219474A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2015014234A (es) | 2016-06-16 |
| JP6412920B2 (ja) | 2018-10-24 |
| CN105209463A (zh) | 2015-12-30 |
| BR112015026023A2 (pt) | 2017-07-25 |
| ZA201507874B (en) | 2017-09-27 |
| RU2656342C2 (ru) | 2018-06-05 |
| CA2909365A1 (en) | 2014-10-16 |
| MX362215B (es) | 2019-01-09 |
| AU2014252828A1 (en) | 2015-11-05 |
| EP2984090B1 (en) | 2017-05-31 |
| US9714244B2 (en) | 2017-07-25 |
| IL242000B (en) | 2021-03-25 |
| JP2016516763A (ja) | 2016-06-09 |
| US20160060258A1 (en) | 2016-03-03 |
| EP2984090A1 (en) | 2016-02-17 |
| RU2015148189A (ru) | 2017-05-23 |
| KR102250668B1 (ko) | 2021-05-10 |
| AU2014252828B2 (en) | 2018-07-05 |
| CN105209463B (zh) | 2017-10-13 |
| WO2014167347A1 (en) | 2014-10-16 |
| SG11201508405QA (en) | 2015-11-27 |
| NZ713114A (en) | 2021-01-29 |
| KR20150143668A (ko) | 2015-12-23 |
| GB201306610D0 (en) | 2013-05-29 |
| CA2909365C (en) | 2021-11-09 |
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