HK1218935A1 - 靶細胞內治療性蛋白的靶向產生的系統和方法 - Google Patents

靶細胞內治療性蛋白的靶向產生的系統和方法

Info

Publication number
HK1218935A1
HK1218935A1 HK16106874.0A HK16106874A HK1218935A1 HK 1218935 A1 HK1218935 A1 HK 1218935A1 HK 16106874 A HK16106874 A HK 16106874A HK 1218935 A1 HK1218935 A1 HK 1218935A1
Authority
HK
Hong Kong
Prior art keywords
systems
methods
target cell
therapeutic protein
targeted production
Prior art date
Application number
HK16106874.0A
Other languages
English (en)
Inventor
Matthew R Scholz
Original Assignee
Oisin Biotechnologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oisin Biotechnologies filed Critical Oisin Biotechnologies
Publication of HK1218935A1 publication Critical patent/HK1218935A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK16106874.0A 2013-03-24 2016-06-15 靶細胞內治療性蛋白的靶向產生的系統和方法 HK1218935A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361804716P 2013-03-24 2013-03-24
PCT/US2014/031638 WO2014160661A2 (en) 2013-03-24 2014-03-24 Systems and methods for the targeted production of a therapeutic protein within a target cell

Publications (1)

Publication Number Publication Date
HK1218935A1 true HK1218935A1 (zh) 2017-03-17

Family

ID=51625661

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16106874.0A HK1218935A1 (zh) 2013-03-24 2016-06-15 靶細胞內治療性蛋白的靶向產生的系統和方法

Country Status (10)

Country Link
US (3) US20160051700A1 (zh)
EP (1) EP2978854A4 (zh)
KR (3) KR20180118259A (zh)
CN (1) CN105518149A (zh)
AU (3) AU2014241622A1 (zh)
BR (1) BR112015024605A2 (zh)
CA (1) CA2940123C (zh)
HK (1) HK1218935A1 (zh)
MX (2) MX2015013590A (zh)
WO (1) WO2014160661A2 (zh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US10835560B2 (en) 2013-12-20 2020-11-17 Joseph E. Kovarik Reducing the likelihood of skin cancer in an individual human being
US10940169B2 (en) 2015-11-30 2021-03-09 Joseph E. Kovarik Method for reducing the likelihood of developing cancer in an individual human being
WO2012177927A1 (en) 2011-06-21 2012-12-27 Mayo Foundation For Medical Education And Research Transgenic animals capable of being induced to delete senescent cells
WO2013158664A2 (en) 2012-04-17 2013-10-24 Kythera Biopharmaceuticals, Inc. Use of engineered viruses to specifically kill senescent cells
US9901080B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells
US9901081B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse for determining the role of senescent cells in cancer
WO2014089124A1 (en) 2012-12-03 2014-06-12 Cenexys, Inc. Immunogenic compositions for inducing an immune response for elimination of senescent cells
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11672835B2 (en) 2013-12-20 2023-06-13 Seed Health, Inc. Method for treating individuals having cancer and who are receiving cancer immunotherapy
US11213552B2 (en) 2015-11-30 2022-01-04 Joseph E. Kovarik Method for treating an individual suffering from a chronic infectious disease and cancer
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11026982B2 (en) 2015-11-30 2021-06-08 Joseph E. Kovarik Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US11642382B2 (en) 2013-12-20 2023-05-09 Seed Health, Inc. Method for treating an individual suffering from bladder cancer
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11529379B2 (en) 2013-12-20 2022-12-20 Seed Health, Inc. Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
WO2017223107A1 (en) * 2016-06-20 2017-12-28 Unity Biotechnology, Inc. Genome modifying enzyme therapy for diseases modulated by senescent cells
CA3047140A1 (en) * 2017-01-09 2018-07-12 Oisin Biotechnologies Constructs for expression of therapeutic proteins in target cells
AU2019210698B2 (en) * 2018-01-23 2020-08-20 Ascend Biopharmaceuticals Ltd Enhanced viral delivery formulation
US11603543B2 (en) 2018-04-18 2023-03-14 Oisin Biotechnologies, Inc. Fusogenic lipid nanoparticles for target cell-specific production of a therapeutic protein
WO2020023183A1 (en) * 2018-07-24 2020-01-30 So Young Life Sciences Corporation Use of liposomes to deliver a protein and a gene encoding the protein to a live cell
EP3653716A1 (en) * 2018-11-19 2020-05-20 HSF Pharmaceuticals Replication-competent controlled alpha-herpesvirus virus vectors and uses therefore
CN112521511B (zh) * 2020-12-07 2023-03-14 中山大学 一种含EB病毒gB蛋白的自组装纳米颗粒及其制备方法与应用
WO2022245984A1 (en) * 2021-05-19 2022-11-24 Shape Therapeutics Inc. Compositions and methods for modulating payload expression at a transcriptional level
KR20230136406A (ko) 2022-03-18 2023-09-26 단국대학교 천안캠퍼스 산학협력단 Fast 유전자를 포함하는 레트로바이러스 벡터 및 암 유전자치료제로서의 용도
WO2024073370A2 (en) * 2022-09-27 2024-04-04 The Regents Of The University Of California Methods to rejuvenate human cells through transcriptional reprogramming

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0571390B1 (en) 1990-11-23 2000-03-08 Peptech Limited The delay, prevention and/or reversal of cell senescence
CA2325088A1 (en) 2000-12-01 2002-06-01 Fusogenix Inc. Novel membrane fusion proteins derived from poikilothermic reovirus
WO2002101076A2 (en) * 2001-06-13 2002-12-19 Eastern Virginia Medical School Methods for targeted expression of therapeutic nucleic acid
CN100361710C (zh) * 2004-06-07 2008-01-16 成都康弘生物科技有限公司 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用
WO2008154644A1 (en) 2007-06-12 2008-12-18 Case Western Reserve University Targeted cell death
AU2009248945B2 (en) 2008-05-23 2014-02-13 Siwa Corporation Methods, compositions and apparatuses for facilitating regeneration
US9089520B2 (en) 2010-05-21 2015-07-28 Baylor College Of Medicine Methods for inducing selective apoptosis
CA2813300A1 (en) 2010-09-29 2012-04-05 Innovascreen Inc. Recombinant polypeptides for membrane fusion and uses thereof
WO2012177927A1 (en) * 2011-06-21 2012-12-27 Mayo Foundation For Medical Education And Research Transgenic animals capable of being induced to delete senescent cells
CA3047140A1 (en) * 2017-01-09 2018-07-12 Oisin Biotechnologies Constructs for expression of therapeutic proteins in target cells

Also Published As

Publication number Publication date
MX2015013590A (es) 2016-06-06
BR112015024605A2 (pt) 2017-07-18
AU2021200496A1 (en) 2021-02-25
CA2940123A1 (en) 2014-10-02
MX2019010735A (es) 2019-11-05
KR20180118259A (ko) 2018-10-30
CN105518149A (zh) 2016-04-20
CA2940123C (en) 2023-10-10
WO2014160661A2 (en) 2014-10-02
AU2018220160A1 (en) 2018-09-13
WO2014160661A3 (en) 2014-12-31
US20160010110A1 (en) 2016-01-14
US20160051700A1 (en) 2016-02-25
US20200009268A1 (en) 2020-01-09
EP2978854A4 (en) 2017-01-11
EP2978854A2 (en) 2016-02-03
KR20160002848A (ko) 2016-01-08
KR20200074283A (ko) 2020-06-24
AU2018220160B2 (en) 2021-05-20
AU2014241622A1 (en) 2015-11-12

Similar Documents

Publication Publication Date Title
HK1218935A1 (zh) 靶細胞內治療性蛋白的靶向產生的系統和方法
EP3069313A4 (en) Automated physical therapy systems and methods
EP3060173A4 (en) Methods and systems for heart valve therapy
EP2961475A4 (en) SYSTEMS AND METHOD FOR WIRELESS CONTROL TO NON-INVASIVE ELECTROTHERAPY
EP3071291A4 (en) Systems and methods for electrical stimulation of biological systems
EP2895120A4 (en) SYSTEMS AND METHOD FOR HAPTIC STIMULATION
ZA201507315B (en) Selective gene therapy expression system
GB201302447D0 (en) Therapeutic and diagnostic target
EP2952225A4 (en) PARTICLE BEAM THERAPY SYSTEM
HK1216159A1 (zh) 治療性融合蛋白
EP3025674A4 (en) Therapeutic manipulator and manipulator system
GB202012079D0 (en) Process control systems and methods
SG11201602431SA (en) Sputtering target and production method
SG11201510401VA (en) Medical pendant system
HK1217538A1 (zh) 治療的系統生物學方法
GB201303308D0 (en) Therapeutic and diagnostic target
EP2983469A4 (en) INSECTICIDAL FEEDING GRAINS, GRAIN COMPRISING SYSTEMS, AND GRAIN MANUFACTURING METHOD
EP2996684A4 (en) THERAPEUTIC PROCEDURES
GB201804143D0 (en) Human target II
GB201302274D0 (en) Therapeutic and diagnositic target
GB201303408D0 (en) Therapeutic and diagnostic target
GB201303415D0 (en) Therapeutic and diagnostic target
GB201303404D0 (en) Therapeutic and diagnostic target
GB201303395D0 (en) Therapeutic and diagnostic target
GB201303389D0 (en) Therapeutic and diagnostic target