HK1217730A1 - 衣殼修飾的 載體組合物及用於人肝癌基因治療中的應用方法 - Google Patents
衣殼修飾的 載體組合物及用於人肝癌基因治療中的應用方法Info
- Publication number
- HK1217730A1 HK1217730A1 HK16105737.9A HK16105737A HK1217730A1 HK 1217730 A1 HK1217730 A1 HK 1217730A1 HK 16105737 A HK16105737 A HK 16105737A HK 1217730 A1 HK1217730 A1 HK 1217730A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- raav3
- capsid
- modified
- methods
- gene therapy
- Prior art date
Links
- 238000001415 gene therapy Methods 0.000 title 1
- 201000007270 liver cancer Diseases 0.000 title 1
- 208000014018 liver neoplasm Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/86—Viral vectors
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- A61K39/4615—Dendritic cells
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/899,481 US9920097B2 (en) | 2007-04-09 | 2013-05-21 | Capsid-modified rAAV vector compositions having improved transduction efficiencies, and methods of use |
PCT/US2014/039015 WO2014193716A2 (en) | 2013-05-21 | 2014-05-21 | Capsid-modified, raav3 vector compositions and methods of use in gene therapy of human liver cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1217730A1 true HK1217730A1 (zh) | 2017-01-20 |
Family
ID=51023068
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16105737.9A HK1217730A1 (zh) | 2013-05-21 | 2016-05-18 | 衣殼修飾的 載體組合物及用於人肝癌基因治療中的應用方法 |
Country Status (10)
Country | Link |
---|---|
EP (2) | EP2999791B1 (zh) |
JP (3) | JP6628286B2 (zh) |
KR (4) | KR102234672B1 (zh) |
CN (3) | CN111763690A (zh) |
AU (3) | AU2014274457B2 (zh) |
CA (1) | CA2917018A1 (zh) |
DK (1) | DK2999791T3 (zh) |
HK (1) | HK1217730A1 (zh) |
SG (2) | SG10201709552XA (zh) |
WO (1) | WO2014193716A2 (zh) |
Families Citing this family (43)
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US5410017A (en) * | 1993-05-21 | 1995-04-25 | Rohm And Haas Company | Continuous thermal polycondensation process for preparing polypeptide polymers |
US9725485B2 (en) | 2012-05-15 | 2017-08-08 | University Of Florida Research Foundation, Inc. | AAV vectors with high transduction efficiency and uses thereof for gene therapy |
US10294281B2 (en) | 2012-05-15 | 2019-05-21 | University Of Florida Research Foundation, Incorporated | High-transduction-efficiency rAAV vectors, compositions, and methods of use |
WO2015048534A1 (en) | 2013-09-26 | 2015-04-02 | University Of Florida Research Foundation, Inc. | Synthetic combinatorial aav capsid library for targeted gene therapy |
US10577627B2 (en) | 2014-06-09 | 2020-03-03 | Voyager Therapeutics, Inc. | Chimeric capsids |
GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
WO2016126857A1 (en) | 2015-02-03 | 2016-08-11 | University Of Florida Research Foundation, Inc. | Recombinant aav1, aav5, and aav6 capsid mutants and uses thereof |
GB201508026D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
WO2017058892A2 (en) | 2015-09-28 | 2017-04-06 | The University Of North Carolina At Chapel Hill | Methods and compositions for antibody-evading virus vectors |
WO2017070476A2 (en) * | 2015-10-22 | 2017-04-27 | University Of Florida Research Foundation, Inc. | Synthetic combinatorial aav3 capsid library |
BR112018011881A2 (pt) * | 2015-12-14 | 2018-12-04 | The University Of North Carolina At Chapel Hill | proteínas capsidiais modificadas para liberação aumentada de vetores de parvovírus |
CA3033125A1 (en) * | 2016-08-16 | 2018-02-22 | The University Of North Carolina At Chapel Hill | Methods and compositions for targeted gene transfer |
WO2018035503A1 (en) * | 2016-08-18 | 2018-02-22 | The Regents Of The University Of California | Crispr-cas genome engineering via a modular aav delivery system |
EP3585883A4 (en) | 2017-02-21 | 2021-04-14 | University of Florida Research Foundation, Incorporated | PROTEINS OF MODIFIED AAV CAPSIDES AND THEIR USES |
PL3645551T3 (pl) * | 2017-06-27 | 2024-07-01 | Regeneron Pharmaceuticals, Inc. | Zrekombinowane wektory wirusowe o zmodyfikowanym tropizmie i ich zastosowania do celowanego wprowadzania materiału genetycznego do komórek ludzkich |
SG11202000765PA (en) * | 2017-09-08 | 2020-03-30 | Generation Bio Co | Lipid nanoparticle formulations of non-viral, capsid-free dna vectors |
WO2019143272A1 (en) * | 2018-01-16 | 2019-07-25 | Cls Therapeutics Limited | Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (dnase) activity |
US10610606B2 (en) | 2018-02-01 | 2020-04-07 | Homology Medicines, Inc. | Adeno-associated virus compositions for PAH gene transfer and methods of use thereof |
EP3755795A4 (en) | 2018-02-19 | 2022-07-20 | Homology Medicines, Inc. | ADENO-ASSOCIATED VIRUS COMPOSITIONS FOR RECOVERING F8 GENE FUNCTION AND METHODS OF USE THEREOF |
US20210032660A1 (en) * | 2018-03-29 | 2021-02-04 | Asklepios Biopharmaceutical, Inc. | Liver tropic recombinant aav6 vectors that evade neutralization |
EP3773743A1 (en) | 2018-04-03 | 2021-02-17 | Stridebio, Inc. | Virus vectors for targeting ophthalmic tissues |
MX2020010466A (es) | 2018-04-03 | 2021-01-08 | Vectores de virus que evitan anticuerpos. | |
BR112020020266A2 (pt) | 2018-04-03 | 2021-01-19 | Stridebio, Inc. | Vetores de vírus com evasão de anticorpos |
WO2019210267A2 (en) * | 2018-04-27 | 2019-10-31 | Spark Therapeutics, Inc. | Engineered aav capsids with increased tropism and aav vectors comprising the engineered capsids and methods of making and using same |
JP7142815B2 (ja) * | 2018-06-21 | 2022-09-28 | 株式会社遺伝子治療研究所 | ヒト肝臓への遺伝子導入のためのアデノ随伴ウイルスビリオン |
US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
WO2020079256A1 (en) * | 2018-10-19 | 2020-04-23 | Genethon | Modulation, monitoring and prediction of the immune response directed against aav gene therapy vectors |
WO2020148458A1 (en) * | 2019-01-18 | 2020-07-23 | Institut Pasteur | Aav-mediated gene therapy restoring the otoferlin gene |
KR20220011616A (ko) | 2019-03-21 | 2022-01-28 | 스트라이드바이오 인코포레이티드 | 재조합 아데노 관련 바이러스 벡터 |
EP3736330A1 (en) * | 2019-05-08 | 2020-11-11 | European Molecular Biology Laboratory | Modified adeno-associated virus (aav) particles for gene therapy |
EP3999120A4 (en) * | 2019-07-04 | 2024-02-21 | Children's Medical Research Institute | METHODS AND ADENO-ASSOCIATED VIRUS VECTORS FOR IN VIVO TRANSDUCTION |
FI3997214T3 (fi) * | 2019-07-11 | 2023-11-02 | Centre Nat Rech Scient | Kemiallisesti modifioitu adeno-associated virus |
AU2020367532A1 (en) | 2019-10-17 | 2022-05-12 | Ginkgo Bioworks, Inc. | Adeno-associated viral vectors for treatment of Niemann-Pick disease type C |
US20230340526A1 (en) * | 2019-11-25 | 2023-10-26 | University Of Florida Research Foundation, Incorporated | Novel aav3b variants that target hepatocytes and evade the humoral immune response |
US20230049066A1 (en) * | 2019-11-25 | 2023-02-16 | University Of Florida Research Foundation, Incorporated | Novel aav3b variants that target human hepatocytes in the liver of humanized mice |
TW202140791A (zh) | 2020-01-13 | 2021-11-01 | 美商霍蒙拉奇醫藥公司 | 治療苯酮尿症之方法 |
AU2021267856A1 (en) * | 2020-05-05 | 2022-12-01 | The University Of North Carolina At Chapel Hill | Modified adeno-associated virus 5 capsids and uses thereof |
TW202208632A (zh) | 2020-05-27 | 2022-03-01 | 美商同源醫藥公司 | 用於恢復pah基因功能的腺相關病毒組成物及其使用方法 |
KR20230068444A (ko) | 2020-08-19 | 2023-05-17 | 사렙타 쎄러퓨틱스 인코퍼레이티드 | 레트 증후군의 치료를 위한 아데노 관련 바이러스 벡터 |
CN116648448A (zh) | 2020-11-11 | 2023-08-25 | 欧洲分子生物学实验室 | 用于基因治疗的修饰病毒粒子 |
CN113647359A (zh) * | 2021-08-15 | 2021-11-16 | 芜湖职业技术学院 | 注射衣霉素诱导急性肝损伤小鼠模型的构建方法 |
CN118201947A (zh) * | 2021-10-28 | 2024-06-14 | 上海天泽云泰生物医药有限公司 | 腺相关病毒衣壳 |
WO2023201368A2 (en) * | 2022-04-15 | 2023-10-19 | Dyno Therapeutics, Inc. | Capsid variants and methods of using the same |
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US8999678B2 (en) * | 2005-04-07 | 2015-04-07 | The Trustees Of The University Of Pennsylvania | Method of increasing the function of an AAV vector |
US9725485B2 (en) * | 2012-05-15 | 2017-08-08 | University Of Florida Research Foundation, Inc. | AAV vectors with high transduction efficiency and uses thereof for gene therapy |
ES2714007T3 (es) * | 2007-04-09 | 2019-05-24 | Univ Florida | Composiciones de vectores rAAV que tienen proteínas de la cápside modificadas en tirosina y métodos para su uso |
CA2762118A1 (en) * | 2008-05-20 | 2010-01-28 | Eos Neuroscience, Inc. | Vectors for delivery of light-sensitive proteins and methods of use |
EP4234571A3 (en) * | 2011-02-10 | 2023-09-27 | The University of North Carolina at Chapel Hill | Viral vectors with modified transduction profiles and methods of making and using the same |
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EP2999791B1 (en) | 2018-12-05 |
CN111763690A (zh) | 2020-10-13 |
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DK2999791T3 (en) | 2019-03-18 |
CN111411125A (zh) | 2020-07-14 |
EP3492597A3 (en) | 2019-08-28 |
KR20160010617A (ko) | 2016-01-27 |
CN105408486B (zh) | 2020-07-14 |
JP7021786B2 (ja) | 2022-02-17 |
JP6628286B2 (ja) | 2020-01-08 |
JP2016520311A (ja) | 2016-07-14 |
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AU2014274457B2 (en) | 2019-10-24 |
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WO2014193716A2 (en) | 2014-12-04 |
AU2022204246A1 (en) | 2022-07-21 |
KR20220136477A (ko) | 2022-10-07 |
KR102234672B1 (ko) | 2021-04-06 |
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