HK1207624A1 - 3-o-heteroaryl-ingenol 3-o-- - Google Patents
3-o-heteroaryl-ingenol 3-o--Info
- Publication number
- HK1207624A1 HK1207624A1 HK15108129.0A HK15108129A HK1207624A1 HK 1207624 A1 HK1207624 A1 HK 1207624A1 HK 15108129 A HK15108129 A HK 15108129A HK 1207624 A1 HK1207624 A1 HK 1207624A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ingenol
- heteroaryl
- Prior art date
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Classifications
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201261664398P | 2012-06-26 | 2012-06-26 | |
US201361763206P | 2013-02-11 | 2013-02-11 | |
PCT/EP2013/062995 WO2014001215A2 (fr) | 2012-06-26 | 2013-06-21 | 3-o-hétéroaryl-ingénol |
Publications (1)
Publication Number | Publication Date |
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HK1207624A1 true HK1207624A1 (en) | 2016-02-05 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HK15108129.0A HK1207624A1 (en) | 2012-06-26 | 2015-08-21 | 3-o-heteroaryl-ingenol 3-o-- |
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Country | Link |
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US (1) | US9422309B2 (fr) |
EP (1) | EP2864290B1 (fr) |
JP (1) | JP6216781B2 (fr) |
KR (1) | KR20150024928A (fr) |
CN (1) | CN104411685B (fr) |
AU (1) | AU2013283511B2 (fr) |
BR (1) | BR112014032244A2 (fr) |
CA (1) | CA2875461A1 (fr) |
DK (1) | DK2864290T3 (fr) |
ES (1) | ES2640612T3 (fr) |
HK (1) | HK1207624A1 (fr) |
IL (1) | IL235925A0 (fr) |
IN (1) | IN2014DN11023A (fr) |
MX (1) | MX2014015497A (fr) |
MY (1) | MY169215A (fr) |
NZ (1) | NZ702835A (fr) |
PL (1) | PL2864290T3 (fr) |
PT (1) | PT2864290T (fr) |
RU (1) | RU2015102095A (fr) |
SG (1) | SG11201408016XA (fr) |
WO (1) | WO2014001215A2 (fr) |
ZA (1) | ZA201409022B (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015059577A1 (fr) | 2013-10-25 | 2015-04-30 | Leo Laboratories Limited | Méthode de traitement topique de kératose actinique sur la calvitie totale à l'aide d'ingénol 3-(3,5-diéthylisoxazole-4-carboxylate) |
WO2016191835A1 (fr) * | 2015-06-03 | 2016-12-08 | Amazônia Fitomedicamentos Ltda. | Procédé de préparation d'ingénol-5,20-acétonide, procédé de préparation de 3-éthynyl-3-hydroxy-4.7.7-triméthylbicyclo[4.1.0]heptane-2-carbaldéhyde, procédé de préparation du composé 2,2-diméthyl-4-éthynyl-5-triphénylphosphoranylidène-1,3-dioxane, et composé intermédiaire |
WO2017089300A1 (fr) * | 2015-11-27 | 2017-06-01 | Leo Laboratories Limited | 3-alkylamido-3-désoxy-ingénols |
WO2017130156A1 (fr) | 2016-01-27 | 2017-08-03 | Glaxosmithkline Intellectual Property (No.2) Limited | Analogues d'igénol, compositions pharmaceutiques et méthodes d'utilisation de ces derniers |
US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
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DE2902506A1 (de) * | 1979-01-23 | 1980-07-24 | Deutsches Krebsforsch | Verwendung von nicht oder nur gering irritierenden und/oder promovierenden diterpenalkoholen und von derivaten davon als antineoplastische mittel |
AUPO864097A0 (en) | 1997-08-19 | 1997-09-11 | Peplin Pty Ltd | Anti-cancer compounds |
US8106092B2 (en) * | 2004-12-13 | 2012-01-31 | Leo Laboratories Limited | Treatment of solid cancers |
CA2629899A1 (fr) * | 2005-11-25 | 2007-05-31 | Peplin Research Pty Ltd | Methodes pour cicatriser des blessures |
GB0525680D0 (en) | 2005-12-16 | 2006-01-25 | Peplin Ltd | Therapeutic compositions |
MX2009011865A (es) * | 2007-04-30 | 2009-12-04 | Peplin Research Pty Ltd | Tratamiento de lesiones viralmente inducidas. |
JP2010526824A (ja) | 2007-05-11 | 2010-08-05 | ソネボーン インコーポレイテッド | シリコーン類似の特性を有するワセリン |
EP2655323B1 (fr) | 2010-12-22 | 2017-12-20 | Leo Laboratories Limited | Ingénol-3-acylates iii et ingénol-3-carbamates |
EP2655312A1 (fr) | 2010-12-22 | 2013-10-30 | Leo Laboratories Limited | 3-acyl-ingénols ii |
US9388124B2 (en) | 2010-12-22 | 2016-07-12 | Leo Laboratories Limited | Ingenol-3-acylates I |
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2013
- 2013-06-21 US US14/409,374 patent/US9422309B2/en not_active Expired - Fee Related
- 2013-06-21 AU AU2013283511A patent/AU2013283511B2/en not_active Ceased
- 2013-06-21 JP JP2015518999A patent/JP6216781B2/ja not_active Expired - Fee Related
- 2013-06-21 NZ NZ702835A patent/NZ702835A/en not_active IP Right Cessation
- 2013-06-21 DK DK13741681.4T patent/DK2864290T3/en active
- 2013-06-21 MY MYPI2014703954A patent/MY169215A/en unknown
- 2013-06-21 SG SG11201408016XA patent/SG11201408016XA/en unknown
- 2013-06-21 EP EP13741681.4A patent/EP2864290B1/fr not_active Not-in-force
- 2013-06-21 KR KR1020157002108A patent/KR20150024928A/ko not_active Application Discontinuation
- 2013-06-21 CN CN201380033726.9A patent/CN104411685B/zh not_active Expired - Fee Related
- 2013-06-21 PL PL13741681T patent/PL2864290T3/pl unknown
- 2013-06-21 WO PCT/EP2013/062995 patent/WO2014001215A2/fr active Application Filing
- 2013-06-21 BR BR112014032244A patent/BR112014032244A2/pt not_active IP Right Cessation
- 2013-06-21 PT PT137416814T patent/PT2864290T/pt unknown
- 2013-06-21 IN IN11023DEN2014 patent/IN2014DN11023A/en unknown
- 2013-06-21 ES ES13741681.4T patent/ES2640612T3/es active Active
- 2013-06-21 MX MX2014015497A patent/MX2014015497A/es unknown
- 2013-06-21 CA CA2875461A patent/CA2875461A1/fr not_active Abandoned
- 2013-06-21 RU RU2015102095A patent/RU2015102095A/ru not_active Application Discontinuation
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2014
- 2014-11-26 IL IL235925A patent/IL235925A0/en unknown
- 2014-12-09 ZA ZA2014/09022A patent/ZA201409022B/en unknown
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2015
- 2015-08-21 HK HK15108129.0A patent/HK1207624A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2640612T3 (es) | 2017-11-03 |
KR20150024928A (ko) | 2015-03-09 |
BR112014032244A2 (pt) | 2017-06-27 |
US9422309B2 (en) | 2016-08-23 |
MX2014015497A (es) | 2015-03-06 |
EP2864290A2 (fr) | 2015-04-29 |
EP2864290B1 (fr) | 2017-06-14 |
US20150175622A1 (en) | 2015-06-25 |
WO2014001215A2 (fr) | 2014-01-03 |
CN104411685B (zh) | 2017-03-29 |
PT2864290T (pt) | 2017-09-19 |
CN104411685A (zh) | 2015-03-11 |
JP2015521639A (ja) | 2015-07-30 |
NZ702835A (en) | 2017-05-26 |
IL235925A0 (en) | 2015-02-01 |
PL2864290T3 (pl) | 2017-11-30 |
CA2875461A1 (fr) | 2014-01-03 |
WO2014001215A3 (fr) | 2014-02-27 |
RU2015102095A (ru) | 2016-08-10 |
ZA201409022B (en) | 2016-03-30 |
IN2014DN11023A (fr) | 2015-09-25 |
AU2013283511B2 (en) | 2017-10-26 |
DK2864290T3 (en) | 2017-10-02 |
JP6216781B2 (ja) | 2017-10-18 |
MY169215A (en) | 2019-03-18 |
AU2013283511A1 (en) | 2014-12-18 |
SG11201408016XA (en) | 2015-03-30 |
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PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20210617 |