HK1207366A1 - 作為 抑制劑的塞二唑啉酮二酮 - Google Patents
作為 抑制劑的塞二唑啉酮二酮Info
- Publication number
- HK1207366A1 HK1207366A1 HK15107867.8A HK15107867A HK1207366A1 HK 1207366 A1 HK1207366 A1 HK 1207366A1 HK 15107867 A HK15107867 A HK 15107867A HK 1207366 A1 HK1207366 A1 HK 1207366A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- gsk
- thiadiazolidinediones
- inhibitors
- inhibitors gsk
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12382066 | 2012-02-24 | ||
| PCT/EP2013/053554 WO2013124413A1 (en) | 2012-02-24 | 2013-02-22 | Thiadiazolidinediones as gsk-3 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1207366A1 true HK1207366A1 (zh) | 2016-01-29 |
Family
ID=47747639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15107867.8A HK1207366A1 (zh) | 2012-02-24 | 2015-08-14 | 作為 抑制劑的塞二唑啉酮二酮 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9371299B2 (zh) |
| EP (1) | EP2838888B1 (zh) |
| JP (2) | JP6073377B2 (zh) |
| AU (2) | AU2013224041B2 (zh) |
| CA (1) | CA2865351C (zh) |
| CY (1) | CY1119231T1 (zh) |
| DK (1) | DK2838888T3 (zh) |
| ES (1) | ES2632428T3 (zh) |
| HK (1) | HK1207366A1 (zh) |
| HR (1) | HRP20170964T1 (zh) |
| HU (1) | HUE035089T2 (zh) |
| IN (1) | IN2014DN07885A (zh) |
| LT (1) | LT2838888T (zh) |
| NZ (1) | NZ630615A (zh) |
| PL (1) | PL2838888T3 (zh) |
| PT (1) | PT2838888T (zh) |
| SI (1) | SI2838888T1 (zh) |
| WO (1) | WO2013124413A1 (zh) |
| ZA (1) | ZA201406225B (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2838888T3 (en) | 2012-02-24 | 2017-07-17 | Asd Therapeutics Partners Llc | THIADIAZOLIDINEDIONS AS GSK-3 INHIBITORS |
| NZ713219A (en) | 2013-03-14 | 2017-04-28 | Massachusetts Inst Technology | Compositions and methods for epithelial stem cell expansion and culture |
| JP6663863B2 (ja) * | 2014-06-12 | 2020-03-13 | シーダーズ−サイナイ メディカル センター | がん治療のための組成物及び方法 |
| KR102493376B1 (ko) | 2014-09-03 | 2023-01-27 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 청력 손실의 치료를 위해 내이 털세포를 생성하기 위한 조성물, 시스템, 및 방법 |
| CN108779437A (zh) | 2016-01-08 | 2018-11-09 | 麻省理工学院 | 分化的肠内分泌细胞和胰岛素产生细胞的制备 |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| US11066419B2 (en) | 2016-12-30 | 2021-07-20 | Frequency Therapeutics, Inc. | 1H-pyrrole-2,5-dione compounds and methods of using same |
| WO2020037326A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
| AU2019321641A1 (en) | 2018-08-17 | 2021-04-15 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by upregulating Jag-1 |
| BR112021007208A2 (pt) * | 2018-10-16 | 2021-08-10 | Italia Technology Alliance S.R.L. | máquina de enrolamento com um sistema de avaliação do material de manta sendo processado e método |
| AU2020218366A1 (en) | 2019-02-08 | 2021-09-16 | Frequency Therapeutics, Inc. | Valproic acid compounds and Wnt agonists for treating ear disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2166328B1 (es) * | 2000-05-11 | 2003-09-16 | Consejo Superior Investigacion | Inhibidores heterociclicos del enzima gsk 3 utiles en el tratamiento de procesos neurodegenerativos e hiperproliferativos |
| HUP0302002A3 (en) | 2000-05-11 | 2007-02-28 | Consejo Superior Investigacion | Heterocyclic inhibitors of glycogen synthase kinase gsk-3, their use and pharmaceutical compositions containing them |
| EP1586318A1 (en) | 2004-04-05 | 2005-10-19 | Neuropharma S.A.U. | Thiadiazolidinones as GSK-3 inhibitors |
| KR100837785B1 (ko) * | 2007-01-17 | 2008-06-13 | 한국화학연구원 | 1,2,4-티아다이아졸리딘-3,5-다이온 화합물을 포함하는염증관련 질환의 치료 및 예방을 위한 약제학적 조성물 |
| DK2838888T3 (en) | 2012-02-24 | 2017-07-17 | Asd Therapeutics Partners Llc | THIADIAZOLIDINEDIONS AS GSK-3 INHIBITORS |
-
2013
- 2013-02-22 DK DK13705492.0T patent/DK2838888T3/en active
- 2013-02-22 HU HUE13705492A patent/HUE035089T2/hu unknown
- 2013-02-22 SI SI201330704T patent/SI2838888T1/sl unknown
- 2013-02-22 US US14/380,623 patent/US9371299B2/en active Active
- 2013-02-22 AU AU2013224041A patent/AU2013224041B2/en active Active
- 2013-02-22 EP EP13705492.0A patent/EP2838888B1/en active Active
- 2013-02-22 JP JP2014558118A patent/JP6073377B2/ja active Active
- 2013-02-22 CA CA2865351A patent/CA2865351C/en active Active
- 2013-02-22 ES ES13705492.0T patent/ES2632428T3/es active Active
- 2013-02-22 PL PL13705492T patent/PL2838888T3/pl unknown
- 2013-02-22 IN IN7885DEN2014 patent/IN2014DN07885A/en unknown
- 2013-02-22 LT LTEP13705492.0T patent/LT2838888T/lt unknown
- 2013-02-22 NZ NZ630615A patent/NZ630615A/en unknown
- 2013-02-22 PT PT137054920T patent/PT2838888T/pt unknown
- 2013-02-22 WO PCT/EP2013/053554 patent/WO2013124413A1/en active Application Filing
-
2014
- 2014-08-25 ZA ZA2014/06225A patent/ZA201406225B/en unknown
-
2015
- 2015-08-14 HK HK15107867.8A patent/HK1207366A1/zh unknown
-
2016
- 2016-05-16 US US15/155,437 patent/US9469618B2/en active Active
-
2017
- 2017-01-04 JP JP2017000211A patent/JP6518270B2/ja active Active
- 2017-06-26 HR HRP20170964TT patent/HRP20170964T1/hr unknown
- 2017-07-12 CY CY20171100737T patent/CY1119231T1/el unknown
- 2017-10-20 AU AU2017248556A patent/AU2017248556B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2632428T3 (es) | 2017-09-13 |
| AU2017248556B2 (en) | 2018-08-09 |
| US20160257660A1 (en) | 2016-09-08 |
| EP2838888B1 (en) | 2017-04-12 |
| HRP20170964T1 (hr) | 2017-10-06 |
| JP6518270B2 (ja) | 2019-05-22 |
| JP2017081974A (ja) | 2017-05-18 |
| CA2865351C (en) | 2019-08-20 |
| AU2013224041A1 (en) | 2014-09-25 |
| JP6073377B2 (ja) | 2017-02-01 |
| NZ630615A (en) | 2015-09-25 |
| EP2838888A1 (en) | 2015-02-25 |
| ZA201406225B (en) | 2016-05-25 |
| IN2014DN07885A (zh) | 2015-04-24 |
| HUE035089T2 (hu) | 2018-05-02 |
| PT2838888T (pt) | 2017-07-18 |
| JP2015508092A (ja) | 2015-03-16 |
| SI2838888T1 (sl) | 2017-09-29 |
| US9371299B2 (en) | 2016-06-21 |
| LT2838888T (lt) | 2017-08-10 |
| US9469618B2 (en) | 2016-10-18 |
| DK2838888T3 (en) | 2017-07-17 |
| CA2865351A1 (en) | 2013-08-29 |
| US20150038538A1 (en) | 2015-02-05 |
| CY1119231T1 (el) | 2018-02-14 |
| WO2013124413A1 (en) | 2013-08-29 |
| AU2017248556A1 (en) | 2017-11-09 |
| PL2838888T3 (pl) | 2017-12-29 |
| AU2013224041B2 (en) | 2017-08-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1210775A1 (zh) | 作為激酶抑制劑的咪唑並三嗪甲腈 | |
| HK1212348A1 (zh) | 自分泌運動因子抑制劑 | |
| HK1208442A1 (zh) | 作為 激酶抑制劑的取代的吡咯並嘧啶基氨基－苯並噻唑酮 | |
| HK1211921A1 (zh) | 抑制劑化合物 | |
| HK1201200A1 (zh) | 取代的吡咯烷- -甲酰胺 | |
| LT2920149T (lt) | 3-aminocikloalkilo junginiai, kaip ror-gama-t inhibitoriai, ir jų panaudojimas | |
| HK1200830A1 (zh) | 取代的吡咯烷- -甲酰胺 | |
| HK1207366A1 (zh) | 作為 抑制劑的塞二唑啉酮二酮 | |
| SG11201501173SA (en) | PI3Kδ INHIBITOR | |
| HK1206724A1 (zh) | 取代的苯並噻吩並嘧啶 | |
| SG11201500973WA (en) | Amino-quinolines as kinase inhibitors | |
| HK1209422A1 (zh) | 抑制劑 | |
| HK1209105A1 (zh) | 抑制劑 | |
| HK1209104A1 (zh) | 抑制劑 | |
| EP2934541A4 (en) | NORIBOGAINE SUBSTITUTE | |
| HK1206022A1 (zh) | 取代的咪唑並噠嗪 | |
| GB201211019D0 (en) | Inhibitor compounds | |
| ZA201504305B (en) | Autotaxin inhibitors | |
| AP2015008541A0 (en) | Autotaxin inhibitors | |
| GB201216008D0 (en) | Novel use of GSK-3 inhibitors |