HK1207078A1 - Inhibition of enzymes - Google Patents

Inhibition of enzymes

Info

Publication number
HK1207078A1
HK1207078A1 HK15107783.9A HK15107783A HK1207078A1 HK 1207078 A1 HK1207078 A1 HK 1207078A1 HK 15107783 A HK15107783 A HK 15107783A HK 1207078 A1 HK1207078 A1 HK 1207078A1
Authority
HK
Hong Kong
Prior art keywords
enzymes
inhibition
Prior art date
Application number
HK15107783.9A
Other languages
English (en)
Chinese (zh)
Inventor
‧卡帕蒂
‧希爾德
‧瑞
‧薩頓
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of HK1207078A1 publication Critical patent/HK1207078A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK15107783.9A 2012-07-12 2015-08-11 Inhibition of enzymes HK1207078A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12176079 2012-07-12
EP13158756 2013-03-12
PCT/EP2013/064603 WO2014009425A1 (en) 2012-07-12 2013-07-10 Inhibition of enzymes

Publications (1)

Publication Number Publication Date
HK1207078A1 true HK1207078A1 (en) 2016-01-22

Family

ID=48953361

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15107783.9A HK1207078A1 (en) 2012-07-12 2015-08-11 Inhibition of enzymes

Country Status (11)

Country Link
US (1) US9199984B2 (xx)
EP (1) EP2872509B1 (xx)
KR (1) KR20150031318A (xx)
CN (1) CN104428300B (xx)
AR (1) AR091737A1 (xx)
BR (1) BR112015000507A2 (xx)
CA (1) CA2878792A1 (xx)
HK (1) HK1207078A1 (xx)
IN (1) IN2015DN00202A (xx)
RU (1) RU2638537C2 (xx)
WO (1) WO2014009425A1 (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2933725A1 (en) 2013-12-16 2015-06-25 Chiesi Farmaceutici S.P.A. Tetrahydrotriazolopyrimidine derivatives as human neutrophil elastase inhibitors
US9487528B2 (en) 2014-06-09 2016-11-08 Chiesi Farmaceutici S.P.A. Compounds
US9475779B2 (en) 2014-07-31 2016-10-25 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9440930B2 (en) 2014-07-31 2016-09-13 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9657015B2 (en) 2014-07-31 2017-05-23 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9409870B2 (en) 2014-12-15 2016-08-09 Chiesi Farmaceutici S.P.A. Compounds
US9862706B2 (en) 2016-05-31 2018-01-09 Chiesi Farmaceutici S.P.A. Compounds
US10172830B2 (en) 2016-05-31 2019-01-08 Chiesi Farmaceutici S.P.A. Pyrazolone compounds having human neutrophil elastase inhibitory properties
MX2018014145A (es) * 2016-05-31 2019-03-11 Chiesi Farm Spa Compuestos de imidazolona como inhibidores de elastasa de neutrofilo humano.
KR20210002380A (ko) 2017-02-27 2021-01-08 게저 발린트 디스플레이된 정보 및/또는 데이터의 동시 다기능 핸들링을 가능하게 하는 디스플레이를 구비한 스마트 장치
BR112022000915A2 (pt) 2019-07-23 2022-05-17 Bayer Ag Compostos de heteroaril-triazol como pesticidas
MX2022000954A (es) 2019-07-23 2022-02-14 Bayer Ag Novedosos compuestos de heteroaril-triazol como plaguicidas.
BR112022004861A2 (pt) 2019-09-17 2022-06-07 Univ Duke Alvelestat para uso no tratamento de rejeição de transplante, síndrome de bronquiolite obliterante e doença de transplante versus hospedeiro
UY38910A (es) 2019-10-09 2021-05-31 Bayer Ag Compuestos de heteroarilo-triazol como pesticidas, formulaciones, usos y métodos de uso de los mismos
KR20220081359A (ko) 2019-10-09 2022-06-15 바이엘 악티엔게젤샤프트 살충제로서의 신규 헤테로아릴-트리아졸 화합물
WO2021087181A1 (en) * 2019-11-01 2021-05-06 Bristol-Myers Squibb Company Substituted pyrazole compounds as toll receptor inhibitors
TW202134226A (zh) 2019-11-18 2021-09-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
IL297211A (en) 2020-04-16 2022-12-01 Mereo Biopharma 4 Ltd Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency
CN113480486B (zh) * 2021-07-30 2022-05-24 赣南师范大学 一种3-胺基-1,2,4-三唑类衍生物及其制备方法和应用
TW202325294A (zh) 2021-10-20 2023-07-01 英商梅瑞奧生物製藥４有限公司 用於治療纖維化之嗜中性球彈性蛋白酶抑制劑

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4259504A (en) 1979-08-27 1981-03-31 American Cyanamid Company Substituted 1H-1,2,4-triazoles
US4451471A (en) 1981-03-18 1984-05-29 Ciba-Geigy Corporation Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same
US4576958A (en) 1984-01-23 1986-03-18 E. I. Du Pont De Nemours And Company Antihypertensive 4,5-diaryl-1H-imidazole-2-methanol derivatives
AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
ES2184633B1 (es) 2001-08-07 2004-08-01 J. URIACH & CIA, S.A. Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida.
US6693116B2 (en) * 2001-10-08 2004-02-17 Hoffmann-La Roche Inc. Adenosine receptor ligands
BRPI0516819A (pt) 2004-10-07 2008-09-23 Warner Lambert Co derivados de triazolopiridina e agentes antibacterianos
US7902374B2 (en) 2005-05-06 2011-03-08 Universal Display Corporation Stability OLED materials and devices
TW200806637A (en) 2006-05-25 2008-02-01 Synta Pharmaceuticals Corp Synthesis of triazole compounds that modulate HSP90 activity
WO2009061271A1 (en) * 2007-11-06 2009-05-14 Astrazeneca Ab Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
PE20091953A1 (es) 2008-05-08 2010-01-09 Du Pont Azoles sustituidos como fungicidas
CN102131805A (zh) * 2008-06-20 2011-07-20 百时美施贵宝公司 用作激酶抑制剂的咪唑并吡啶和咪唑并吡嗪化合物
CN102131806A (zh) * 2008-06-20 2011-07-20 百时美施贵宝公司 用作激酶抑制剂的三唑并吡啶化合物
DE102009004197A1 (de) * 2009-01-09 2010-07-15 Bayer Schering Pharma Aktiengesellschaft Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung
WO2011039528A1 (en) * 2009-10-02 2011-04-07 Astrazeneca Ab 2-pyridone compounds used as inhibitors of neutrophil elastase

Also Published As

Publication number Publication date
RU2015104644A (ru) 2016-08-27
RU2638537C2 (ru) 2017-12-14
US9199984B2 (en) 2015-12-01
KR20150031318A (ko) 2015-03-23
CN104428300A (zh) 2015-03-18
CA2878792A1 (en) 2014-01-16
US20140018345A1 (en) 2014-01-16
EP2872509B1 (en) 2016-09-14
IN2015DN00202A (xx) 2015-06-12
WO2014009425A1 (en) 2014-01-16
CN104428300B (zh) 2016-11-09
AR091737A1 (es) 2015-02-25
EP2872509A1 (en) 2015-05-20
BR112015000507A2 (pt) 2017-06-27

Similar Documents

Publication Publication Date Title
HK1207078A1 (en) Inhibition of enzymes
IL287057A (en) Purified iduronate-2-sulfatase
AP4029A (en) Inhibitors of beta-secretase
ZA201500911B (en) Enzymes
HK1199252A1 (en) Inhibitors of nedd8-activating enzyme nedd8-
HK1203949A1 (en) Inhibitors of iap iap
HK1211024A1 (en) Inhibitors of syk syk
IL236963A0 (en) beta-secretase inhibitors
HK1202053A1 (en) Treatment of liver conditions
HK1201066A1 (en) Pyranopyridone inhibitors of tankyrase
PL2888228T3 (pl) Inhibitory oddziaływania CD40-TRAF6
GB201207018D0 (en) Enzymes
EP2892529A4 (en) USES OF (-) - PERHEXILINE
GB201215883D0 (en) Enzyme inhibition
GB201215856D0 (en) Enzyme inhibition
GB201114748D0 (en) Enzyme inhibition
GB201114751D0 (en) Enzyme inhibition
GB201223308D0 (en) Enzyme inhibitors
IL233740A0 (en) Treatment of liver diseases
GB201211978D0 (en) Enzyme

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20210707