HK1206342A1 - N-alkyltriazole compounds as lpar antagonists - Google Patents

N-alkyltriazole compounds as lpar antagonists Download PDF

Info

Publication number
HK1206342A1
HK1206342A1 HK15106927.8A HK15106927A HK1206342A1 HK 1206342 A1 HK1206342 A1 HK 1206342A1 HK 15106927 A HK15106927 A HK 15106927A HK 1206342 A1 HK1206342 A1 HK 1206342A1
Authority
HK
Hong Kong
Prior art keywords
phenyl
methyl
triazol
acid
biphenyl
Prior art date
Application number
HK15106927.8A
Other languages
English (en)
Chinese (zh)
Inventor
斯蒂芬．迪姆斯．加布里埃爾
斯蒂芬．迪姆斯．加布里埃尔
馬修．邁克爾．漢密爾頓
马修．迈克尔．汉密尔顿
馬修．
马修．C．卢卡斯
．盧卡斯
钱义民
錢義民
阿奇尤特哈拉.西杜瑞
Original Assignee
霍夫曼-拉罗奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48628667&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1206342(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 霍夫曼-拉罗奇有限公司 filed Critical 霍夫曼-拉罗奇有限公司
Publication of HK1206342A1 publication Critical patent/HK1206342A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HK15106927.8A 2012-06-20 2013-06-17 N-alkyltriazole compounds as lpar antagonists HK1206342A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261661961P 2012-06-20 2012-06-20
US61/661,961 2012-06-20
PCT/EP2013/062461 WO2013189864A1 (en) 2012-06-20 2013-06-17 N-alkyltriazole compounds as lpar antagonists

Publications (1)

Publication Number Publication Date
HK1206342A1 true HK1206342A1 (en) 2016-01-08

Family

ID=48628667

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15106927.8A HK1206342A1 (en) 2012-06-20 2013-06-17 N-alkyltriazole compounds as lpar antagonists

Country Status (22)

Country Link
US (1) US9321738B2 (OSRAM)
EP (1) EP2864300A1 (OSRAM)
JP (1) JP2015520202A (OSRAM)
KR (1) KR20150021057A (OSRAM)
CN (1) CN104411692A (OSRAM)
AU (1) AU2013279512A1 (OSRAM)
BR (1) BR112014030685A2 (OSRAM)
CA (1) CA2869541A1 (OSRAM)
CL (1) CL2014003243A1 (OSRAM)
CO (1) CO7131358A2 (OSRAM)
CR (1) CR20140525A (OSRAM)
EA (1) EA201492285A1 (OSRAM)
HK (1) HK1206342A1 (OSRAM)
IL (1) IL236088A0 (OSRAM)
IN (1) IN2014DN09348A (OSRAM)
MA (1) MA37764A1 (OSRAM)
MX (1) MX2014014710A (OSRAM)
PE (1) PE20142448A1 (OSRAM)
PH (1) PH12014502789A1 (OSRAM)
SG (1) SG11201407220YA (OSRAM)
UA (1) UA109868C2 (OSRAM)
WO (1) WO2013189864A1 (OSRAM)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG2014011555A (en) 2011-08-15 2014-08-28 Intermune Inc Lysophosphatidic acid receptor antagonists
MA37762B1 (fr) * 2012-06-20 2018-04-30 Hoffmann La Roche Composés n-aryltriazole utilisés comme antagonistes de lpar
CN105142635B (zh) 2013-03-15 2021-07-27 艾匹根生物技术有限公司 有用于治疗疾病的杂环化合物
MX370408B (es) 2014-06-27 2019-12-11 Ube Industries Sal de compuesto heterociclico sustituido con halogeno.
AR108838A1 (es) 2016-06-21 2018-10-03 Bristol Myers Squibb Co Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa
WO2019126085A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Pyrazole n-linked carbamoyl cyclohexyl acids as lpa antagonists
JP7212047B2 (ja) 2017-12-19 2023-01-24 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのシクロヘキシル酸ピラゾールアゾール
SG11202005699QA (en) * 2017-12-19 2020-07-29 Bristol Myers Squibb Co Triazole n-linked carbamoyl cyclohexyl acids as lpa antagonists
EP3728209B1 (en) 2017-12-19 2025-12-24 Bristol-Myers Squibb Company Cyclohexyl acid isoxazole azines as lpa antagonists
KR102777148B1 (ko) * 2017-12-19 2025-03-05 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로헥실 산 트리아졸 아진
ES2942767T3 (es) * 2017-12-19 2023-06-06 Bristol Myers Squibb Co Isoxazol azoles del ácido ciclohexílico como antagonistas del LPA
WO2019126098A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Pyrazole o-linked carbamoyl cyclohexyl acids as lpa antagonists
CN112055710B (zh) 2017-12-19 2025-01-28 百时美施贵宝公司 作为lpa拮抗剂的环己基酸吡唑吖嗪
ES2925626T3 (es) 2017-12-19 2022-10-19 Bristol Myers Squibb Co Acidos isoxazol-O-carbamoilciclohexílicos como antagonistas de LPA
EP3728210A1 (en) 2017-12-19 2020-10-28 Bristol-Myers Squibb Company Isoxazole n-linked carbamoyl cyclohexyl acids as lpa antagonists
US11319315B2 (en) * 2017-12-19 2022-05-03 Bristol-Myers Squibb Company Cyclohexyl acid triazole azoles as LPA antagonists
CN117024420A (zh) * 2017-12-29 2023-11-10 生物马林药物股份有限公司 用于疾病治疗的乙醇酸氧化酶抑制剂
JP7427658B2 (ja) * 2018-09-18 2024-02-05 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのシクロペンチル酸
US12428430B2 (en) 2018-09-18 2025-09-30 Bristol-Myers Squibb Company Oxabicyclo acids as LPA antagonists
EP3852747B1 (en) * 2018-09-18 2023-05-31 Bristol-Myers Squibb Company Cycloheptyl acids as lpa antagonists
JP7431961B2 (ja) * 2019-11-15 2024-02-15 ギリアード サイエンシーズ， インコーポレイテッド Ｌｐａ受容体アンタゴニストとしてのトリアゾールカルバメートピリジルスルホンアミド及びその使用
TWI838626B (zh) 2020-06-03 2024-04-11 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
CA3185689A1 (en) 2020-06-03 2021-12-09 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
CN117295717A (zh) 2021-05-11 2023-12-26 吉利德科学公司 Lpa受体拮抗剂及其用途
EP4337654A1 (en) * 2021-05-13 2024-03-20 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
JP7709612B2 (ja) 2021-12-08 2025-07-16 ギリアード サイエンシーズ， インコーポレイテッド Ｌｐａ受容体アンタゴニスト及びそれらの使用
AR128613A1 (es) 2022-02-25 2024-05-29 Lhotse Bio Inc Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor de lpa

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
GB2466121B (en) * 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
GB2470833B (en) * 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
US20110065695A1 (en) 2009-09-11 2011-03-17 Jeremy Beauchamp Use of aminodihydrothiazines for the treatment or prevention of diabetes
GB2474748B (en) * 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
WO2011159550A2 (en) * 2010-06-14 2011-12-22 Amidra Pharmaceuticals, Inc. Lysophosphatidic acid receptor antagonist and uses thereof
WO2011159633A1 (en) 2010-06-15 2011-12-22 Amira Pharmaceuticals, Inc. Inhalable formulations of lysophosphatdic acid receptor antagonists
EA201390821A1 (ru) * 2010-12-07 2013-10-30 Амира Фармасьютикалс, Инк. Антагонисты рецепторов лизофосфатидной кислоты и их применение
WO2012138648A1 (en) * 2011-04-06 2012-10-11 Irm Llc Compositions and methods for modulating lpa receptors
SG2014011555A (en) * 2011-08-15 2014-08-28 Intermune Inc Lysophosphatidic acid receptor antagonists

Also Published As

Publication number Publication date
JP2015520202A (ja) 2015-07-16
CR20140525A (es) 2015-01-12
EP2864300A1 (en) 2015-04-29
PH12014502789A1 (en) 2015-02-09
SG11201407220YA (en) 2014-12-30
MX2014014710A (es) 2015-03-04
CL2014003243A1 (es) 2015-03-20
EA201492285A1 (ru) 2015-04-30
CN104411692A (zh) 2015-03-11
KR20150021057A (ko) 2015-02-27
CO7131358A2 (es) 2014-12-01
CA2869541A1 (en) 2013-12-27
AU2013279512A1 (en) 2014-10-16
MA37764A1 (fr) 2016-01-29
WO2013189864A1 (en) 2013-12-27
UA109868C2 (ru) 2015-10-12
US20150133511A1 (en) 2015-05-14
US9321738B2 (en) 2016-04-26
IN2014DN09348A (OSRAM) 2015-07-17
IL236088A0 (en) 2015-02-01
BR112014030685A2 (pt) 2017-06-27
PE20142448A1 (es) 2015-01-28

Similar Documents

Publication Publication Date Title
HK1206342A1 (en) N-alkyltriazole compounds as lpar antagonists
US8247401B2 (en) P2X3 receptor antagonists for treatment of pain
HK1206339A1 (en) N-aryltriazole compounds as lpar antagonists
HK1206341A1 (en) Substituted pyrazole compounds as lpar antagonists
CN104395309B (zh) 环状桥头醚dgat1抑制剂
CN104080767A (zh) 新的glp-1受体调节剂
US11530213B2 (en) Naphthyridinone derivatives and their use in the treatment of arrhythmia
EA035606B1 (ru) Аналоги тиадиазола и способы лечения состояний, связанных с дефицитом smn
US11020380B2 (en) Therapeutic compounds
JP4585522B2 (ja) ブラジキニン拮抗物質又は逆作用物質としてのアルファ−ヒドロキシアミド
GB2513403A (en) WNT pathway modulators
JP5963025B2 (ja) ２−ピリドン化合物
CN107428682B (zh) 酰胺类衍生物、其制备方法及其在医药上的用途
JP6048533B2 (ja) ２−ピリドン化合物を含有する医薬