HK1205105A1 - A process for the preparation of the compound and synthetic intermediates thereof - Google Patents

A process for the preparation of the compound and synthetic intermediates thereof

Info

Publication number
HK1205105A1
HK1205105A1 HK15105438.2A HK15105438A HK1205105A1 HK 1205105 A1 HK1205105 A1 HK 1205105A1 HK 15105438 A HK15105438 A HK 15105438A HK 1205105 A1 HK1205105 A1 HK 1205105A1
Authority
HK
Hong Kong
Prior art keywords
compound
preparation
synthetic intermediates
intermediates
synthetic
Prior art date
Application number
HK15105438.2A
Other languages
English (en)
Chinese (zh)
Inventor
Silvano Spinelli
Valeria Livi
Original Assignee
Clovis Oncology Italy Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clovis Oncology Italy Srl filed Critical Clovis Oncology Italy Srl
Publication of HK1205105A1 publication Critical patent/HK1205105A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/44—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK15105438.2A 2009-03-16 2015-06-08 A process for the preparation of the compound and synthetic intermediates thereof HK1205105A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2009A000397A IT1393351B1 (it) 2009-03-16 2009-03-16 Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi

Publications (1)

Publication Number Publication Date
HK1205105A1 true HK1205105A1 (en) 2015-12-11

Family

ID=41210541

Family Applications (2)

Application Number Title Priority Date Filing Date
HK12107948.4A HK1167136A1 (en) 2009-03-16 2012-08-14 A process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6- methoxyquinolin-4-yloxy)-n-methyl-1-naphthamide and synthetic intermediates thereof 6-(7-((1-))-6--4-)-n--1-
HK15105438.2A HK1205105A1 (en) 2009-03-16 2015-06-08 A process for the preparation of the compound and synthetic intermediates thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK12107948.4A HK1167136A1 (en) 2009-03-16 2012-08-14 A process for the preparation of 6-(7-((1-aminocyclopropyl)methoxy)-6- methoxyquinolin-4-yloxy)-n-methyl-1-naphthamide and synthetic intermediates thereof 6-(7-((1-))-6--4-)-n--1-

Country Status (16)

Country Link
US (3) US8642767B2 (xx)
EP (3) EP2408739B1 (xx)
JP (2) JP5817079B2 (xx)
CN (3) CN104193676B (xx)
CY (2) CY1114503T1 (xx)
DK (2) DK2408739T3 (xx)
ES (2) ES2585221T3 (xx)
HK (2) HK1167136A1 (xx)
HR (2) HRP20130978T1 (xx)
HU (1) HUE029528T2 (xx)
IT (1) IT1393351B1 (xx)
PL (2) PL2641897T3 (xx)
PT (2) PT2641897T (xx)
SI (2) SI2408739T1 (xx)
SM (1) SMT201600356B (xx)
WO (1) WO2010105761A1 (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1393351B1 (it) 2009-03-16 2012-04-20 Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi
CN104936946A (zh) * 2013-01-18 2015-09-23 爱德程制药有限公司 制备抗肿瘤剂6-(7-((1-氨基环丙基)甲氧基)-6-甲氧基喹啉-4-基氧基)-n-甲基-1-萘甲酰胺的方法及其结晶
CN105311030B (zh) 2014-06-06 2020-03-24 正大天晴药业集团股份有限公司 用于抗肿瘤的螺取代化合物
CN105311029A (zh) 2014-06-06 2016-02-10 正大天晴药业集团股份有限公司 抗肿瘤活性的喹啉衍生物
CA2954999C (en) 2014-07-14 2020-01-07 Advenchen Pharmaceuticals, Nanjing Ltd. Fused quinoline compounds as pi3k, mtor inhibitors
US10307412B2 (en) 2014-12-09 2019-06-04 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Quinoline derivative against non-small cell lung cancer
US9751859B2 (en) 2015-05-04 2017-09-05 Advenchen Pharmaceuticals, LLC Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts
AU2016293841B2 (en) 2015-07-11 2020-10-08 Advenchen Pharmaceuticals, LLC Fused quinoline compunds as pi3k/mTor inhibitors
BR112018006873A2 (pt) 2015-10-05 2018-11-06 The Trustees Of Columbia University In The City Of New York ativadores do fluxo autofágico e fosfolipase d e depuração de agregados de proteína incluindo tau e tratamento de proteinopatias
CN107296811B (zh) 2016-04-15 2022-12-30 正大天晴药业集团股份有限公司 一种用于治疗胃癌的喹啉衍生物
CN109748902B (zh) * 2017-11-02 2020-11-06 杭州科巢生物科技有限公司 一种盐酸安罗替尼的制备方法
JP2021517162A (ja) 2018-03-02 2021-07-15 チア タイ チオギン ファーマスーチカル グループ コーポレイテッド，リミテッド Ｃ−ｍｅｔキナーゼ阻害剤としての化合物の結晶及びその調製方法及びその使用
AU2019232437A1 (en) 2018-03-07 2020-10-08 Bayer Aktiengesellschaft Identification and use of ERK5 inhibitors
CN110483393A (zh) * 2018-05-14 2019-11-22 上海海和药物研究开发有限公司 德立替尼的晶型
CN110483392A (zh) * 2018-05-14 2019-11-22 上海海和药物研究开发有限公司 合成n-保护的喹啉-7-基氧基甲基环丙基胺衍生物的方法及合成中间体
CN109705093A (zh) * 2018-12-29 2019-05-03 正大天晴药业集团股份有限公司 喹啉衍生物及其制备方法和用途
CN115160221B (zh) * 2022-07-26 2024-10-18 恩祺生物科技(上海)有限公司 德立替尼晶型化合物和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0956287B1 (en) * 1996-12-23 2003-08-13 Aventis Pharmaceuticals Inc. 3-aryl-2-(1-substituted-4-piperidinyl)-1(1-di)oxo-3h-benzo d]-isothiazole derivatives, their preparation and their use as modulators of neurotransmitter function
AU763618B2 (en) * 1999-02-10 2003-07-31 Astrazeneca Ab Quinazoline derivatives as angiogenesis inhibitors
WO2004018430A1 (ja) * 2002-08-23 2004-03-04 Kirin Beer Kabushiki Kaisha ＴＧＦβ阻害活性を有する化合物およびそれを含んでなる医薬組成物
UA82577C2 (xx) * 2003-12-23 2008-04-25 Пфайзер Инк. Похідні хіноліну$производные хинолина
US8163923B2 (en) * 2007-03-14 2012-04-24 Advenchen Laboratories, Llc Spiro substituted compounds as angiogenesis inhibitors
IT1393351B1 (it) 2009-03-16 2012-04-20 Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi

Also Published As

Publication number Publication date
JP6061158B2 (ja) 2017-01-18
CN102356063B (zh) 2014-09-24
EP2641897B1 (en) 2016-07-13
IT1393351B1 (it) 2012-04-20
JP2012520332A (ja) 2012-09-06
PL2641897T3 (pl) 2017-01-31
CN104193676A8 (zh) 2016-08-17
US9012645B2 (en) 2015-04-21
DK2408739T3 (da) 2013-11-04
US20120010415A1 (en) 2012-01-12
HRP20161163T1 (hr) 2016-11-04
ITMI20090397A1 (it) 2010-09-17
EP3103792A1 (en) 2016-12-14
EP2641897A2 (en) 2013-09-25
CY1117871T1 (el) 2017-05-17
CY1114503T1 (el) 2016-10-05
CN102356063A (zh) 2012-02-15
SI2641897T1 (sl) 2016-10-28
EP2408739B1 (en) 2013-08-14
ES2585221T3 (es) 2016-10-04
SI2408739T1 (sl) 2013-11-29
SMT201600356B (it) 2016-11-10
US20140114075A1 (en) 2014-04-24
US9340508B2 (en) 2016-05-17
ES2431618T3 (es) 2013-11-27
PT2641897T (pt) 2016-08-04
EP2408739A1 (en) 2012-01-25
CN106187882A (zh) 2016-12-07
CN104193676A (zh) 2014-12-10
PT2408739E (pt) 2013-10-21
PL2408739T3 (pl) 2014-01-31
WO2010105761A1 (en) 2010-09-23
JP5817079B2 (ja) 2015-11-18
DK2641897T3 (en) 2016-10-03
US8642767B2 (en) 2014-02-04
JP2015180665A (ja) 2015-10-15
HRP20130978T1 (hr) 2013-11-22
EP2641897A3 (en) 2013-11-20
CN104193676B (zh) 2016-08-17
US20150191429A1 (en) 2015-07-09
HUE029528T2 (en) 2017-03-28
HK1167136A1 (en) 2012-11-23

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220313