CN104193676A8 - 制备化合物的方法及其合成中间体 - Google Patents

制备化合物的方法及其合成中间体 Download PDF

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Publication number
CN104193676A8
CN104193676A8 CN201410380387.8A CN201410380387A CN104193676A8 CN 104193676 A8 CN104193676 A8 CN 104193676A8 CN 201410380387 A CN201410380387 A CN 201410380387A CN 104193676 A8 CN104193676 A8 CN 104193676A8
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China
Prior art keywords
compound
synthetic intermediate
prepare method
present
prepare
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CN201410380387.8A
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English (en)
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CN104193676B (zh
CN104193676A (zh
Inventor
S·斯皮纳利
V·利维
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Eos Ethics Oncology Co "eos Co
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Eos Ethics Oncology Co "eos Co
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Publication of CN104193676A publication Critical patent/CN104193676A/zh
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Publication of CN104193676A8 publication Critical patent/CN104193676A8/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/44—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

本发明涉及制备式(I)化合物6-(7-((1-氨基环丙基)甲氧基)-6-甲氧基喹啉-4-基氧基)-N-甲基-1-萘甲酰胺的方法及其合成中间体。本发明的方法与以前描述的那些方法相比具有各种优点，尤其是它避免使用酰叠氮中间体及其Curtius重排。
CN201410380387.8A 2009-03-16 2010-03-11 制备化合物的方法及其合成中间体 Expired - Fee Related CN104193676B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI2009A000397A IT1393351B1 (it) 2009-03-16 2009-03-16 Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi
IT2009A000397 2009-03-16
ITMI2009A000397 2009-03-16
CN201080011948.7A CN102356063B (zh) 2009-03-16 2010-03-11 制备6-(7-((1-氨基环丙基)甲氧基)-6-甲氧基喹啉-4-基氧基)-n-甲基-1-萘甲酰胺的方法及其合成中间体

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201080011948.7A Division CN102356063B (zh) 2009-03-16 2010-03-11 制备6-(7-((1-氨基环丙基)甲氧基)-6-甲氧基喹啉-4-基氧基)-n-甲基-1-萘甲酰胺的方法及其合成中间体

Publications (3)

Publication Number Publication Date
CN104193676A CN104193676A (zh) 2014-12-10
CN104193676B CN104193676B (zh) 2016-08-17
CN104193676A8 true CN104193676A8 (zh) 2016-08-17

Family

ID=41210541

Family Applications (3)

Application Number Title Priority Date Filing Date
CN201410380387.8A Expired - Fee Related CN104193676B (zh) 2009-03-16 2010-03-11 制备化合物的方法及其合成中间体
CN201080011948.7A Expired - Fee Related CN102356063B (zh) 2009-03-16 2010-03-11 制备6-(7-((1-氨基环丙基)甲氧基)-6-甲氧基喹啉-4-基氧基)-n-甲基-1-萘甲酰胺的方法及其合成中间体
CN201610565855.8A Pending CN106187882A (zh) 2009-03-16 2010-03-11 制备化合物的方法及其合成中间体

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201080011948.7A Expired - Fee Related CN102356063B (zh) 2009-03-16 2010-03-11 制备6-(7-((1-氨基环丙基)甲氧基)-6-甲氧基喹啉-4-基氧基)-n-甲基-1-萘甲酰胺的方法及其合成中间体
CN201610565855.8A Pending CN106187882A (zh) 2009-03-16 2010-03-11 制备化合物的方法及其合成中间体

Country Status (16)

Country Link
US (3) US8642767B2 (zh)
EP (3) EP2641897B1 (zh)
JP (2) JP5817079B2 (zh)
CN (3) CN104193676B (zh)
CY (2) CY1114503T1 (zh)
DK (2) DK2641897T3 (zh)
ES (2) ES2431618T3 (zh)
HK (2) HK1167136A1 (zh)
HR (2) HRP20130978T1 (zh)
HU (1) HUE029528T2 (zh)
IT (1) IT1393351B1 (zh)
PL (2) PL2641897T3 (zh)
PT (2) PT2641897T (zh)
SI (2) SI2408739T1 (zh)
SM (1) SMT201600356B (zh)
WO (1) WO2010105761A1 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1393351B1 (it) 2009-03-16 2012-04-20 Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi
EA201591205A1 (ru) * 2013-01-18 2015-12-30 Адвенчен Фармасьютикалс, Ллс Способ получения противоопухолевого агента 6-(7-((1-аминоциклопропил)-метокси)-6-метоксихинолин-4-илокси)-n-метил-1-нафтамида и его кристаллической структуры
CN105311030B (zh) 2014-06-06 2020-03-24 正大天晴药业集团股份有限公司 用于抗肿瘤的螺取代化合物
CN105311029A (zh) 2014-06-06 2016-02-10 正大天晴药业集团股份有限公司 抗肿瘤活性的喹啉衍生物
EP3169687B1 (en) 2014-07-14 2019-01-02 Advenchen Pharmaceuticals, Nanjing Ltd. FUSED QUINOLINE COMPUNDS AS PI3K, mTOR INHIBITORS
JP6865684B2 (ja) 2014-12-09 2021-04-28 チア タイ チオギン ファーマスーチカル グループ コーポレイテッド，リミテッド 非小細胞肺癌に対するキノリン誘導体
US9751859B2 (en) 2015-05-04 2017-09-05 Advenchen Pharmaceuticals, LLC Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts
AU2016293841B2 (en) 2015-07-11 2020-10-08 Advenchen Pharmaceuticals, LLC Fused quinoline compunds as pi3k/mTor inhibitors
CA3000988A1 (en) 2015-10-05 2017-04-13 The Trustees Of Columbia University In The City Of New York Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies
CN107296811B (zh) 2016-04-15 2022-12-30 正大天晴药业集团股份有限公司 一种用于治疗胃癌的喹啉衍生物
CN109748902B (zh) * 2017-11-02 2020-11-06 杭州科巢生物科技有限公司 一种盐酸安罗替尼的制备方法
JP2021517162A (ja) 2018-03-02 2021-07-15 チア タイ チオギン ファーマスーチカル グループ コーポレイテッド，リミテッド Ｃ−ｍｅｔキナーゼ阻害剤としての化合物の結晶及びその調製方法及びその使用
AU2019232437A1 (en) 2018-03-07 2020-10-08 Bayer Aktiengesellschaft Identification and use of ERK5 inhibitors
CN110483393A (zh) * 2018-05-14 2019-11-22 上海海和药物研究开发有限公司 德立替尼的晶型
CN110483392A (zh) * 2018-05-14 2019-11-22 上海海和药物研究开发有限公司 合成n-保护的喹啉-7-基氧基甲基环丙基胺衍生物的方法及合成中间体
CN116444489A (zh) * 2018-12-29 2023-07-18 正大天晴药业集团股份有限公司 喹啉衍生物及其制备方法和用途
CN115160221A (zh) * 2022-07-26 2022-10-11 上海歆贻医药科技有限公司 德立替尼晶型化合物和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0956287T3 (da) * 1996-12-23 2003-11-24 Aventis Pharma Inc 3-Aryl-2-(1-substituerede-4-piperidinyl)-1(1-di)oxo-3H-benzo[D]-isothiazol-derivater, deres fremstilling og deres anvendelse som modulatorer af neurotransmitterfunktion
ATE482946T1 (de) * 1999-02-10 2010-10-15 Astrazeneca Ab Chinazolinderivate als angiogenesehemmer und zwischenprodukte dafür
EP1548008A4 (en) * 2002-08-23 2008-08-06 Kirin Pharma Kk COMPOUND HAVING BETA-TRANSFORMING GROWTH FACTOR INHIBITORY ACTIVITY AND DRUG CONTAINING COMPOSITION
CA2551508C (en) * 2003-12-23 2011-08-09 Pfizer Inc. Novel quinoline derivatives
US8163923B2 (en) 2007-03-14 2012-04-24 Advenchen Laboratories, Llc Spiro substituted compounds as angiogenesis inhibitors
IT1393351B1 (it) 2009-03-16 2012-04-20 Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi

Also Published As

Publication number Publication date
DK2408739T3 (da) 2013-11-04
SI2641897T1 (sl) 2016-10-28
US20150191429A1 (en) 2015-07-09
PL2641897T3 (pl) 2017-01-31
JP5817079B2 (ja) 2015-11-18
CN102356063B (zh) 2014-09-24
CN104193676B (zh) 2016-08-17
CN102356063A (zh) 2012-02-15
US9012645B2 (en) 2015-04-21
ES2585221T3 (es) 2016-10-04
ES2431618T3 (es) 2013-11-27
SMT201600356B (it) 2016-11-10
PT2641897T (pt) 2016-08-04
PT2408739E (pt) 2013-10-21
EP2641897B1 (en) 2016-07-13
PL2408739T3 (pl) 2014-01-31
EP2408739A1 (en) 2012-01-25
US20120010415A1 (en) 2012-01-12
HUE029528T2 (en) 2017-03-28
CY1114503T1 (el) 2016-10-05
EP2408739B1 (en) 2013-08-14
DK2641897T3 (en) 2016-10-03
WO2010105761A1 (en) 2010-09-23
US8642767B2 (en) 2014-02-04
CN106187882A (zh) 2016-12-07
EP2641897A2 (en) 2013-09-25
HRP20161163T1 (hr) 2016-11-04
IT1393351B1 (it) 2012-04-20
US20140114075A1 (en) 2014-04-24
EP3103792A1 (en) 2016-12-14
US9340508B2 (en) 2016-05-17
CN104193676A (zh) 2014-12-10
JP6061158B2 (ja) 2017-01-18
ITMI20090397A1 (it) 2010-09-17
HK1205105A1 (zh) 2015-12-11
HRP20130978T1 (hr) 2013-11-22
HK1167136A1 (zh) 2012-11-23
JP2012520332A (ja) 2012-09-06
EP2641897A3 (en) 2013-11-20
SI2408739T1 (sl) 2013-11-29
JP2015180665A (ja) 2015-10-15
CY1117871T1 (el) 2017-05-17

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