HK1204984A1 - Procaspase activation by combination therapy - Google Patents

Procaspase activation by combination therapy

Info

Publication number
HK1204984A1
HK1204984A1 HK15105884.1A HK15105884A HK1204984A1 HK 1204984 A1 HK1204984 A1 HK 1204984A1 HK 15105884 A HK15105884 A HK 15105884A HK 1204984 A1 HK1204984 A1 HK 1204984A1
Authority
HK
Hong Kong
Prior art keywords
combination therapy
procaspase activation
procaspase
activation
therapy
Prior art date
Application number
HK15105884.1A
Other languages
English (en)
Chinese (zh)
Inventor
Paul J Hergenrother
Rachel C Botham
Timothy M Fan
Mark J Gilbert
Michael K Handley
Howard S Roth
Theodore M Tarasow
Original Assignee
Trustees Of The Universityof Illinois Board Of
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Of The Universityof Illinois Board Of filed Critical Trustees Of The Universityof Illinois Board Of
Publication of HK1204984A1 publication Critical patent/HK1204984A1/xx

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • A61K9/2004—Excipients; Inactive ingredients
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    • A61K33/24—Heavy metals; Compounds thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK15105884.1A 2012-03-06 2015-06-19 Procaspase activation by combination therapy HK1204984A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261607098P 2012-03-06 2012-03-06
PCT/US2013/029405 WO2013134407A2 (en) 2012-03-06 2013-03-06 Procaspase 3 activation by combination therapy

Publications (1)

Publication Number Publication Date
HK1204984A1 true HK1204984A1 (en) 2015-12-11

Family

ID=49117502

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15105884.1A HK1204984A1 (en) 2012-03-06 2015-06-19 Procaspase activation by combination therapy

Country Status (15)

Country Link
US (4) US9399035B2 (ja)
EP (2) EP2822558B1 (ja)
JP (1) JP6172865B2 (ja)
KR (1) KR102074530B1 (ja)
CN (1) CN104507479B (ja)
AU (1) AU2016213862B2 (ja)
BR (1) BR112014022103B1 (ja)
CA (1) CA2866021C (ja)
DK (1) DK2822558T3 (ja)
ES (1) ES2774930T3 (ja)
HK (1) HK1204984A1 (ja)
IN (1) IN2014MN01945A (ja)
MX (2) MX359210B (ja)
RU (1) RU2659936C2 (ja)
WO (2) WO2013134407A2 (ja)

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JP2017538699A (ja) 2014-12-05 2017-12-28 エーエヌ２エイチ ディスカバリー リミテッド パーキンリガーゼ活性化の方法及び組成物
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CN111491927A (zh) * 2017-11-17 2020-08-04 伊利诺伊大学董事会 通过降解双mek信号传导的癌症疗法
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JP2022504184A (ja) * 2018-10-05 2022-01-13 ザ ボード オブ トラスティーズ オブ ザ ユニバーシテイ オブ イリノイ ブドウ膜黒色腫の治療のための併用療法
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CA2866021A1 (en) 2013-09-12
IN2014MN01945A (ja) 2015-07-10
RU2659936C2 (ru) 2018-07-04
EP2822558A4 (en) 2015-08-05
MX2014010713A (es) 2015-03-10
BR112014022103B1 (pt) 2022-04-19
US20160346277A1 (en) 2016-12-01
KR20140143166A (ko) 2014-12-15
AU2016213862A1 (en) 2016-09-01
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EP2822558B1 (en) 2020-02-19
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EP2822558A2 (en) 2015-01-14
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