HK1203948A1 - Triazolopyrazine derivatives - Google Patents
Triazolopyrazine derivativesInfo
- Publication number
- HK1203948A1 HK1203948A1 HK15104522.2A HK15104522A HK1203948A1 HK 1203948 A1 HK1203948 A1 HK 1203948A1 HK 15104522 A HK15104522 A HK 15104522A HK 1203948 A1 HK1203948 A1 HK 1203948A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- triazolopyrazine derivatives
- triazolopyrazine
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12001568 | 2012-03-07 | ||
PCT/EP2013/000440 WO2013131609A1 (en) | 2012-03-07 | 2013-02-14 | Triazolopyrazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1203948A1 true HK1203948A1 (en) | 2015-11-06 |
Family
ID=47715983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15104522.2A HK1203948A1 (en) | 2012-03-07 | 2015-05-13 | Triazolopyrazine derivatives |
Country Status (12)
Country | Link |
---|---|
US (1) | US20150051202A1 (ja) |
EP (1) | EP2822948B1 (ja) |
JP (1) | JP6049768B2 (ja) |
CN (1) | CN104159901B (ja) |
AR (1) | AR090240A1 (ja) |
AU (1) | AU2013230286B2 (ja) |
CA (1) | CA2866450C (ja) |
ES (1) | ES2579981T3 (ja) |
HK (1) | HK1203948A1 (ja) |
IL (1) | IL234466A (ja) |
TW (1) | TW201341384A (ja) |
WO (1) | WO2013131609A1 (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112015030774A2 (pt) * | 2013-06-10 | 2017-07-25 | Bayer Pharma AG | novos compostos para o tratamento de câncer |
PE20160865A1 (es) * | 2013-12-19 | 2016-09-03 | Novartis Ag | Derivados de [1,2,4] triazolo [1,5-a]pirimidina como inhibidores de proteasoma para el tratamiento de enfermedades parasitarias tales como leishmaniasis |
CN106164066B (zh) | 2014-02-13 | 2020-01-17 | 因赛特公司 | 作为lsd1抑制剂的环丙胺 |
WO2015123424A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
WO2015123437A1 (en) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
EP3392244A1 (en) | 2014-02-13 | 2018-10-24 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
TWI687419B (zh) | 2014-07-10 | 2020-03-11 | 美商英塞特公司 | 作為lsd1抑制劑之咪唑并吡啶及咪唑并吡嗪 |
WO2016007736A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyrazines as lsd1 inhibitors |
US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
US9695167B2 (en) | 2014-07-10 | 2017-07-04 | Incyte Corporation | Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors |
CN107108556B (zh) * | 2014-11-03 | 2020-09-29 | 艾欧米制药有限公司 | 药用化合物 |
ES2757948T3 (es) | 2015-04-03 | 2020-04-30 | Incyte Corp | Compuestos heterocíclicos como inhibidores LSD1 |
CR20180152A (es) | 2015-08-12 | 2018-08-09 | Incyte Corp | Sales de un inhibidor de lsd1 |
KR102664509B1 (ko) | 2016-04-22 | 2024-05-10 | 인사이트 코포레이션 | Lsd1 억제제의 제제 |
RU2748693C2 (ru) * | 2016-08-10 | 2021-05-28 | Такеда Фармасьютикал Компани Лимитед | Гетероциклическое соединение |
SG10201911243WA (en) | 2016-12-22 | 2020-02-27 | Calithera Biosciences Inc | Compositions and methods for inhibiting arginase activity |
KR20200116481A (ko) * | 2018-01-29 | 2020-10-12 | 메르크 파텐트 게엠베하 | Gcn2 억제제 및 이의 용도 |
CN111867581B (zh) * | 2018-01-29 | 2023-12-26 | 默克专利股份有限公司 | Gcn2抑制剂及其用途 |
AU2019297361B2 (en) * | 2018-07-05 | 2024-06-27 | Incyte Corporation | Fused pyrazine derivatives as A2A / A2B inhibitors |
US10968200B2 (en) | 2018-08-31 | 2021-04-06 | Incyte Corporation | Salts of an LSD1 inhibitor and processes for preparing the same |
GB202008749D0 (en) | 2020-06-09 | 2020-07-22 | Ip2Ipo Innovations Ltd | Novel compounds |
CN115819425A (zh) * | 2022-12-22 | 2023-03-21 | 五邑大学 | 一种三唑并六元氮杂环-2-胺类化合物及其制备方法和应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
WO1997030035A1 (en) | 1996-02-13 | 1997-08-21 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
DE69709319T2 (de) | 1996-03-05 | 2002-08-14 | Astrazeneca Ab | 4-anilinochinazolin derivate |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
IL152682A0 (en) | 2000-05-31 | 2003-06-24 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
MXPA02012903A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como inhibidores de angiogenesis. |
WO2002004434A1 (en) | 2000-07-07 | 2002-01-17 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as vascular damaging agents |
NZ545058A (en) | 2003-07-16 | 2008-05-30 | Janssen Pharmaceutica Nv | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors |
CN103251953A (zh) | 2004-07-19 | 2013-08-21 | 约翰·霍普金斯大学 | 供免疫抑制的flt3抑制剂 |
JP2008526926A (ja) | 2005-01-14 | 2008-07-24 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | グリコーゲン合成酵素キナーゼ3阻害剤としてのトリアゾロピリミジン誘導体 |
CN101454326A (zh) * | 2006-05-31 | 2009-06-10 | 加拉帕戈斯股份有限公司 | 用于治疗变性和炎性疾病的三唑并吡嗪化合物 |
TWI453207B (zh) * | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶,其組合物及使用其之治療方法 |
JP5684245B2 (ja) * | 2009-06-05 | 2015-03-11 | セファロン、インク. | 1,2,4−トリアゾロ[1,5a]ピリジン誘導体の調製および使用 |
EP2523949B1 (en) * | 2010-01-15 | 2014-08-20 | Janssen Pharmaceuticals Inc. | Novel substituted triazole derivatives as gamma secretase modulators |
US20110190269A1 (en) * | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
CN103068828B (zh) * | 2010-08-27 | 2015-09-09 | 默克专利股份公司 | 三唑并吡嗪衍生物 |
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2013
- 2013-02-14 AU AU2013230286A patent/AU2013230286B2/en not_active Ceased
- 2013-02-14 ES ES13704368.3T patent/ES2579981T3/es active Active
- 2013-02-14 EP EP13704368.3A patent/EP2822948B1/en not_active Not-in-force
- 2013-02-14 WO PCT/EP2013/000440 patent/WO2013131609A1/en active Application Filing
- 2013-02-14 CA CA2866450A patent/CA2866450C/en not_active Expired - Fee Related
- 2013-02-14 US US14/382,678 patent/US20150051202A1/en not_active Abandoned
- 2013-02-14 JP JP2014560264A patent/JP6049768B2/ja not_active Expired - Fee Related
- 2013-02-14 CN CN201380012661.XA patent/CN104159901B/zh not_active Expired - Fee Related
- 2013-03-05 AR ARP130100705A patent/AR090240A1/es unknown
- 2013-03-06 TW TW102107941A patent/TW201341384A/zh unknown
-
2014
- 2014-09-04 IL IL234466A patent/IL234466A/en active IP Right Grant
-
2015
- 2015-05-13 HK HK15104522.2A patent/HK1203948A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2866450C (en) | 2020-02-18 |
JP2015509512A (ja) | 2015-03-30 |
AU2013230286A1 (en) | 2014-10-16 |
CA2866450A1 (en) | 2013-09-12 |
WO2013131609A1 (en) | 2013-09-12 |
EP2822948B1 (en) | 2016-04-06 |
US20150051202A1 (en) | 2015-02-19 |
EP2822948A1 (en) | 2015-01-14 |
JP6049768B2 (ja) | 2016-12-21 |
AU2013230286B2 (en) | 2016-12-22 |
CN104159901B (zh) | 2016-10-26 |
CN104159901A (zh) | 2014-11-19 |
TW201341384A (zh) | 2013-10-16 |
ES2579981T3 (es) | 2016-08-18 |
IL234466A (en) | 2016-09-29 |
AR090240A1 (es) | 2014-10-29 |
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