HK1203853A1 - 精氨酸酶抑制劑和其治療應用 - Google Patents

精氨酸酶抑制劑和其治療應用

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Publication number
HK1203853A1
HK1203853A1 HK15104761.2A HK15104761A HK1203853A1 HK 1203853 A1 HK1203853 A1 HK 1203853A1 HK 15104761 A HK15104761 A HK 15104761A HK 1203853 A1 HK1203853 A1 HK 1203853A1
Authority
HK
Hong Kong
Prior art keywords
arginase
inhibitors
therapeutic applications
therapeutic
applications
Prior art date
Application number
HK15104761.2A
Other languages
English (en)
Inventor
邁克爾‧范贊特
亞當‧戈文比奧夫斯基
池民邱
達倫‧懷特豪斯
托德‧賴德
雷蒙德‧保羅‧貝克特
Original Assignee
Mars Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mars Inc filed Critical Mars Inc
Publication of HK1203853A1 publication Critical patent/HK1203853A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P33/00—Antiparasitic agents
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
HK15104761.2A 2011-10-19 2015-05-19 精氨酸酶抑制劑和其治療應用 HK1203853A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161548939P 2011-10-19 2011-10-19
PCT/US2012/060789 WO2013059437A1 (en) 2011-10-19 2012-10-18 Inhibitors of arginase and their therapeutic applications

Publications (1)

Publication Number Publication Date
HK1203853A1 true HK1203853A1 (zh) 2015-11-06

Family

ID=47116482

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15104761.2A HK1203853A1 (zh) 2011-10-19 2015-05-19 精氨酸酶抑制劑和其治療應用

Country Status (11)

Country Link
US (1) US9266908B2 (zh)
EP (1) EP2768491B1 (zh)
JP (1) JP5993459B2 (zh)
CN (1) CN104244932B (zh)
AU (1) AU2012326109A1 (zh)
BR (1) BR112014009415B1 (zh)
CA (1) CA2852685C (zh)
HK (1) HK1203853A1 (zh)
IL (1) IL232113A (zh)
MX (1) MX343534B (zh)
WO (1) WO2013059437A1 (zh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103068830B (zh) 2010-04-22 2016-06-29 马尔斯公司 精氨酸酶抑制剂及其治疗应用
PL2632927T3 (pl) 2010-10-26 2016-09-30 Boroniany jako inhibitory arginazy
US9266908B2 (en) 2011-10-19 2016-02-23 Mars, Incorporated Inhibitors of arginase and their therapeutic applications
US10800751B2 (en) * 2013-08-23 2020-10-13 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
RU2574025C2 (ru) * 2014-04-15 2016-01-27 Государственное Научное Учреждение Научно-исследовательский институт ветеринарии Восточной Сибири Россельхозакадемии Препарат для лечения острых желудочно-кишечных болезней новорожденных ягнят
PL410665A1 (pl) 2014-12-29 2016-07-04 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Inhibitory arginazy oraz ich zastosowania terapeutyczne
WO2016210106A1 (en) 2015-06-23 2016-12-29 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
CA3000996A1 (en) * 2015-10-05 2017-04-13 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors and immuno-oncology agents
SI3368541T1 (sl) 2015-10-30 2020-10-30 Calithera Biosciences, Inc. Sestavki in postopki za zaviranje arginazne dejavnosti
PL417066A1 (pl) 2016-05-04 2017-11-06 Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością Inhibitory arginazy oraz ich zastosowania terapeutyczne
WO2018089490A1 (en) 2016-11-08 2018-05-17 Calithera Biosciences, Inc. Arginase inhibitor combination therapies
PT3559009T (pt) 2016-12-22 2021-05-04 Calithera Biosciences Inc Composições e métodos para inibir a atividade da arginase
CN108794517B (zh) * 2017-04-27 2021-03-30 南京谷睿生物科技有限公司 一种精氨酸酶抑制剂及其制备方法与用途
EA201992695A1 (ru) 2017-05-12 2020-05-15 Калитера Байосайнсиз, Инк. Способ получения (3r,4s)-3-ацетамидо-4-аллил-n-(трет-бутил)пирролидин-3-карбоксамида
TW201910513A (zh) * 2017-08-16 2019-03-16 香港商鎧耀波麗堂（香港）有限公司 胺基酸耗竭治療的組合物及方法
AU2019211067A1 (en) 2018-01-28 2020-08-13 Universite De Geneve Arginase suppression for cancer treatment
EA202092086A1 (ru) 2018-03-05 2021-02-09 Аркус Байосайенсиз, Инк. Ингибиторы аргиназы
CA3094939A1 (en) 2018-03-29 2019-10-03 Oncoarendi Therapeutics S.A. Dipeptide piperidine derivatives
EP3810615A4 (en) * 2018-06-20 2022-03-30 Merck Sharp & Dohme Corp. ARGINASE INHIBITORS AND METHODS OF USE
CN109053496B (zh) * 2018-08-09 2020-10-20 吉尔生化（上海）有限公司 一种3-Boc-氨甲基环丁酮的合成方法
US20220017541A1 (en) * 2018-11-21 2022-01-20 Black Belt Tx Ltd Inhibitors of arginase
MA56324B1 (fr) * 2019-02-08 2023-10-31 Astrazeneca Ab 151 85 Soedertaelje Inhibiteurs de l'arginase et leurs procédés d'utilisation
CN111848423B (zh) * 2019-04-30 2022-10-14 尚科生物医药（上海）有限公司 3-氧代环丁基氨基甲酸叔丁酯的制备方法
CN112110944B (zh) * 2019-06-21 2022-02-11 南京谷睿生物科技有限公司 一种化合物及其制备方法和应用
TW202228720A (zh) 2020-12-22 2022-08-01 波蘭商昂科艾倫迪治療法股份公司 精胺酸酶抑制劑及其使用方法
CN112645971B (zh) * 2021-01-20 2021-12-24 中国科学院兰州化学物理研究所 一种烷基卤代物直接制备烷基硼酸酯类化合物的方法

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Publication number Priority date Publication date Assignee Title
CA2305703A1 (en) 1997-10-10 1999-04-22 David W. Christianson Compositions and methods for inhibiting arginase activity
US20040063666A1 (en) 1998-10-09 2004-04-01 David Christianson Compositions for inhibiting arginase activity
EP1915143A4 (en) 2005-07-01 2009-11-11 Univ Johns Hopkins ARGINASE II: TARGET TREATMENT FOR THE AGING HEART AND HEART FAILURE
EP2172655B1 (en) 2007-07-12 2018-10-24 Sanyo Denki Co., Ltd. Dual reversal-rotating type axial blower
JP2012515799A (ja) 2009-01-26 2012-07-12 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア アルギナーゼ阻害剤および使用方法
CN103068830B (zh) * 2010-04-22 2016-06-29 马尔斯公司 精氨酸酶抑制剂及其治疗应用
RU2019121905A (ru) * 2010-12-31 2019-09-03 Астразенека Юкей Лимитед Ингибиторы аргиназы и способы их применения
US9266908B2 (en) 2011-10-19 2016-02-23 Mars, Incorporated Inhibitors of arginase and their therapeutic applications

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JP5993459B2 (ja) 2016-09-14
BR112014009415B1 (pt) 2021-11-23
US9266908B2 (en) 2016-02-23
JP2014530866A (ja) 2014-11-20
EP2768491B1 (en) 2016-12-21
AU2012326109A1 (en) 2014-05-29
CN104244932B (zh) 2017-02-22
WO2013059437A1 (en) 2013-04-25
EP2768491A1 (en) 2014-08-27
MX2014004766A (es) 2014-05-28
US20140343019A1 (en) 2014-11-20
IL232113A0 (en) 2014-05-28
IL232113A (en) 2017-05-29
CN104244932A (zh) 2014-12-24
BR112014009415A2 (pt) 2017-06-13
CA2852685A1 (en) 2013-04-25
MX343534B (es) 2016-11-09
CA2852685C (en) 2019-02-26

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