HK1201830A1 - 作為 激酶抑制劑的取代的咪唑並吡嗪 - Google Patents
作為 激酶抑制劑的取代的咪唑並吡嗪Info
- Publication number
- HK1201830A1 HK1201830A1 HK15102318.4A HK15102318A HK1201830A1 HK 1201830 A1 HK1201830 A1 HK 1201830A1 HK 15102318 A HK15102318 A HK 15102318A HK 1201830 A1 HK1201830 A1 HK 1201830A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- akt
- kinase inhibitors
- substituted imidazopyrazines
- imidazopyrazines
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12150558 | 2012-01-10 | ||
PCT/EP2013/050196 WO2013104610A1 (en) | 2012-01-10 | 2013-01-08 | Substituted imidazopyrazines as akt kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1201830A1 true HK1201830A1 (zh) | 2015-09-11 |
Family
ID=47553056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15102318.4A HK1201830A1 (zh) | 2012-01-10 | 2015-03-06 | 作為 激酶抑制劑的取代的咪唑並吡嗪 |
Country Status (8)
Country | Link |
---|---|
US (1) | US9260435B2 (zh) |
EP (1) | EP2802586B1 (zh) |
JP (1) | JP6088542B2 (zh) |
CN (1) | CN104066735B (zh) |
CA (1) | CA2860723A1 (zh) |
ES (1) | ES2588186T3 (zh) |
HK (1) | HK1201830A1 (zh) |
WO (1) | WO2013104610A1 (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3012327T (pt) | 2013-06-20 | 2021-01-22 | Taiho Pharmaceutical Co Ltd | Método para prever a eficácia terapêutica do inibidor de pi3k/akt/mtor com base na expressão de phlda1 ou pik3c2b |
WO2015154064A2 (en) | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
US10214537B2 (en) | 2014-10-22 | 2019-02-26 | Bristol-Myers Squibb Company | Bicyclic heteroaryl amine compounds |
EP3209665B1 (en) | 2014-10-22 | 2019-08-14 | Bristol-Myers Squibb Company | Substituted pyrrolotriazine amine compounds as pi3k inhibitors |
US10323044B2 (en) | 2015-02-27 | 2019-06-18 | Taiho Pharmaceutical Co., Ltd. | Crystal of imidazo-oxazine, pharmaceutical composition containing said crystal, and method for producing said crystal |
US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
TW202233190A (zh) * | 2016-12-07 | 2022-09-01 | 英屬開曼群島商百濟神州有限公司 | 作為PI3Kδ抑制劑的咪唑並[1,5-A]吡衍生物 |
HUE061898T2 (hu) * | 2017-09-08 | 2023-08-28 | Beigene Ltd | Imidazo[1,5-a]pirazin-származékok mint PI3Kdelta inhibitorok |
RS62818B1 (sr) | 2017-10-18 | 2022-02-28 | Incyte Corp | Kondenzovani derivati imidazola zamenjeni tercijarnim hidroksi grupama kao inhibitorima pi3k-gamma |
SG11202102224UA (en) * | 2018-09-05 | 2021-04-29 | Incyte Corp | Crystalline forms of a phosphoinositide 3-kinase (pi3k) inhibitor |
JP2022512706A (ja) * | 2018-10-16 | 2022-02-07 | エフ.ホフマン-ラ ロシュ アーゲー | 眼科におけるAkt阻害剤の使用 |
WO2021050744A2 (en) * | 2019-09-10 | 2021-03-18 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Treatment methods for eye disorders |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007096764A2 (en) | 2006-02-27 | 2007-08-30 | Glenmark Pharmaceuticals S.A. | Bicyclic heteroaryl derivatives as cannabinoid receptor modulators |
AR064010A1 (es) | 2006-12-06 | 2009-03-04 | Merck & Co Inc | Inhibidores de la actividad de la akt |
PE20090596A1 (es) | 2007-08-14 | 2009-06-07 | Bayer Schering Pharma Ag | Imidazoles biciclicos fusionados |
US20110288090A1 (en) | 2009-02-02 | 2011-11-24 | Armstrong Donna J | Inhibitors of AKT Activity |
EP2405756B1 (en) | 2009-03-12 | 2013-07-03 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
WO2011033265A1 (en) | 2009-09-18 | 2011-03-24 | Almac Discovery Limited | Pharmaceutical compounds |
GB0919380D0 (en) * | 2009-11-04 | 2009-12-23 | Almac Discovery Ltd | Pharmaceutical compouds |
JP5830094B2 (ja) * | 2010-07-12 | 2015-12-09 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 置換イミダゾ[1,2−a]ピリミジンおよび−ピリジン |
JO3068B1 (ar) * | 2011-04-07 | 2017-03-15 | Bayer Ip Gmbh | إيميدازوبيريميدينات كمثبطات كيناز akt |
-
2013
- 2013-01-08 WO PCT/EP2013/050196 patent/WO2013104610A1/en active Application Filing
- 2013-01-08 JP JP2014551591A patent/JP6088542B2/ja not_active Expired - Fee Related
- 2013-01-08 US US14/370,831 patent/US9260435B2/en not_active Expired - Fee Related
- 2013-01-08 ES ES13700139.2T patent/ES2588186T3/es active Active
- 2013-01-08 EP EP13700139.2A patent/EP2802586B1/en not_active Not-in-force
- 2013-01-08 CA CA2860723A patent/CA2860723A1/en not_active Abandoned
- 2013-01-08 CN CN201380006342.8A patent/CN104066735B/zh not_active Expired - Fee Related
-
2015
- 2015-03-06 HK HK15102318.4A patent/HK1201830A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP6088542B2 (ja) | 2017-03-01 |
EP2802586A1 (en) | 2014-11-19 |
ES2588186T3 (es) | 2016-10-31 |
CN104066735B (zh) | 2016-08-31 |
WO2013104610A1 (en) | 2013-07-18 |
CA2860723A1 (en) | 2013-07-18 |
CN104066735A (zh) | 2014-09-24 |
JP2015503601A (ja) | 2015-02-02 |
US9260435B2 (en) | 2016-02-16 |
EP2802586B1 (en) | 2016-05-25 |
US20150005309A1 (en) | 2015-01-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CHRG | Changes in the register |
Free format text: ADDITION OF INVENTOR: INCE, STUART S |
|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20220108 |