HK1201553A1 - 克服工程 結合域對 化學修飾的敏感性的方法 - Google Patents

克服工程 結合域對 化學修飾的敏感性的方法

Info

Publication number
HK1201553A1
HK1201553A1 HK15101925.1A HK15101925A HK1201553A1 HK 1201553 A1 HK1201553 A1 HK 1201553A1 HK 15101925 A HK15101925 A HK 15101925A HK 1201553 A1 HK1201553 A1 HK 1201553A1
Authority
HK
Hong Kong
Prior art keywords
dna
tale
sensitivity
overcome
binding domains
Prior art date
Application number
HK15101925.1A
Other languages
English (en)
Inventor
Philippe Duchateau
Julien Valton
Original Assignee
Cellectis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellectis filed Critical Cellectis
Publication of HK1201553A1 publication Critical patent/HK1201553A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
HK15101925.1A 2012-03-23 2015-02-26 克服工程 結合域對 化學修飾的敏感性的方法 HK1201553A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261615011P 2012-03-23 2012-03-23
US201261674083P 2012-07-20 2012-07-20
PCT/IB2013/000721 WO2013140250A1 (en) 2012-03-23 2013-03-15 Method to overcome dna chemical modifications sensitivity of engineered tale dna binding domains

Publications (1)

Publication Number Publication Date
HK1201553A1 true HK1201553A1 (zh) 2015-09-04

Family

ID=48471035

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15101925.1A HK1201553A1 (zh) 2012-03-23 2015-02-26 克服工程 結合域對 化學修飾的敏感性的方法

Country Status (10)

Country Link
US (2) US10301614B2 (zh)
EP (1) EP2828384B1 (zh)
JP (1) JP6212535B2 (zh)
CA (1) CA2868055C (zh)
DK (1) DK2828384T3 (zh)
ES (1) ES2683072T3 (zh)
HK (1) HK1201553A1 (zh)
IL (1) IL234797B (zh)
SG (2) SG11201405956SA (zh)
WO (1) WO2013140250A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2828384B1 (en) * 2012-03-23 2018-05-09 Cellectis Method to overcome dna chemical modifications sensitivity of engineered tale dna binding domains
CN111471675A (zh) 2014-03-05 2020-07-31 国立大学法人神户大学 特异性转变靶向dna序列的核酸碱基的基因组序列的修饰方法、及其使用的分子复合体
ES2938623T3 (es) 2015-09-09 2023-04-13 Univ Kobe Nat Univ Corp Método para convertir una secuencia del genoma de una bacteria gram-positiva mediante una conversión específica de una base de ácido nucleico de una secuencia de ADN seleccionada como diana y el complejo molecular utilizado en el mismo
EP3382019B1 (en) 2015-11-27 2022-05-04 National University Corporation Kobe University Method for converting monocot plant genome sequence in which nucleic acid base in targeted dna sequence is specifically converted, and molecular complex used therein
EP3214183B1 (en) * 2016-03-01 2018-11-21 Universität Konstanz Transcription activator-like effector (tale)-based decoding of cytosine nucleobases by selective modification response
CN111278848B (zh) * 2017-08-04 2023-06-27 北京大学 特异性识别甲基化修饰dna碱基的tale rvd及其应用
EP3666898A4 (en) 2017-08-08 2021-03-24 Peking University GENE INACTIVATION PROCESS
EP4149252A2 (en) * 2020-05-12 2023-03-22 Factor Bioscience Inc. Engineered gene-editing proteins
CN117083389A (zh) * 2021-02-17 2023-11-17 密苏里大学管委会 植物叶绿体胞嘧啶碱基编辑器与线粒体胞嘧啶碱基编辑器
IL311782A (en) * 2021-10-04 2024-05-01 Poseida Therapeutics Inc Transposases and their uses
EP4276174A1 (en) 2022-05-09 2023-11-15 Cellectis S.A. Gene therapy for the treatment of activated pi3kinase delta syndrome type 1 (apds1)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
EP2559759A1 (en) 2003-01-28 2013-02-20 Cellectis Custom-made meganuclease and use thereof
EP2206723A1 (en) * 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
US20110239315A1 (en) * 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
PT2816112T (pt) 2009-12-10 2018-11-20 Univ Iowa State Res Found Inc Modificação do adn modificada pelo efector tal
WO2012158986A2 (en) * 2011-05-17 2012-11-22 Transposagen Biopharmaceuticals, Inc. Methods for site-specific genetic modification in stem cells using xanthomonas tal nucleases (xtn) for the creation of model organisms
EP2828384B1 (en) * 2012-03-23 2018-05-09 Cellectis Method to overcome dna chemical modifications sensitivity of engineered tale dna binding domains

Also Published As

Publication number Publication date
US20150037809A1 (en) 2015-02-05
CA2868055C (en) 2020-06-30
US11220683B2 (en) 2022-01-11
JP2015510772A (ja) 2015-04-13
JP6212535B2 (ja) 2017-10-11
EP2828384B1 (en) 2018-05-09
SG11201405956SA (en) 2014-11-27
SG10201607943RA (en) 2016-11-29
US10301614B2 (en) 2019-05-28
ES2683072T3 (es) 2018-09-24
WO2013140250A1 (en) 2013-09-26
CA2868055A1 (en) 2013-09-26
WO2013140250A8 (en) 2014-11-06
IL234797B (en) 2019-02-28
DK2828384T3 (en) 2018-07-16
US20190338273A1 (en) 2019-11-07
EP2828384A1 (en) 2015-01-28

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