HK1201064A1 - Guanidinyl-substituted polyamides useful for treating human papilloma virus - Google Patents

Guanidinyl-substituted polyamides useful for treating human papilloma virus Download PDF

Info

Publication number
HK1201064A1
HK1201064A1 HK15101532.6A HK15101532A HK1201064A1 HK 1201064 A1 HK1201064 A1 HK 1201064A1 HK 15101532 A HK15101532 A HK 15101532A HK 1201064 A1 HK1201064 A1 HK 1201064A1
Authority
HK
Hong Kong
Prior art keywords
tmg
compound
group
hpv
polyamide
Prior art date
Application number
HK15101532.6A
Other languages
English (en)
Chinese (zh)
Inventor
詹姆士．
詹姆士．K．巴什金
．巴什金
特里．G．爱德华兹
特裡．
克里斯多夫．费舍尔
．愛德華茲
小乔治．D．哈里斯
克裡斯多夫．費舍爾
凯文．J．科勒
小喬治．
．哈裡斯
凱文．
．科勒
Original Assignee
纳诺维尔有限责任公司
密苏里大学学监
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 纳诺维尔有限责任公司, 密苏里大学学监 filed Critical 纳诺维尔有限责任公司
Publication of HK1201064A1 publication Critical patent/HK1201064A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK15101532.6A 2011-10-10 2012-10-10 Guanidinyl-substituted polyamides useful for treating human papilloma virus HK1201064A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161545311P 2011-10-10 2011-10-10
US61/545,311 2011-10-10
PCT/US2012/059604 WO2013055825A2 (en) 2011-10-10 2012-10-10 Guanidinyl-substituted polyamides useful for treating human papilloma virus

Publications (1)

Publication Number Publication Date
HK1201064A1 true HK1201064A1 (en) 2015-08-21

Family

ID=48042465

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15101532.6A HK1201064A1 (en) 2011-10-10 2012-10-10 Guanidinyl-substituted polyamides useful for treating human papilloma virus

Country Status (12)

Country Link
US (1) US9133228B2 (cg-RX-API-DMAC7.html)
EP (1) EP2751096A4 (cg-RX-API-DMAC7.html)
JP (1) JP2015502330A (cg-RX-API-DMAC7.html)
KR (1) KR20140074996A (cg-RX-API-DMAC7.html)
CN (1) CN104024247B (cg-RX-API-DMAC7.html)
AU (1) AU2012322835A1 (cg-RX-API-DMAC7.html)
BR (1) BR112014008464A2 (cg-RX-API-DMAC7.html)
CA (1) CA2851516C (cg-RX-API-DMAC7.html)
HK (1) HK1201064A1 (cg-RX-API-DMAC7.html)
RU (1) RU2014113702A (cg-RX-API-DMAC7.html)
SG (1) SG11201401226YA (cg-RX-API-DMAC7.html)
WO (1) WO2013055825A2 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9982020B2 (en) * 2011-10-10 2018-05-29 Nanovir Llc Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses
WO2016022664A1 (en) 2014-08-05 2016-02-11 Nanovir Llc Antiviral compounds and methods for treating infections caused by double-stranded dna viruses
ES3044861T3 (en) * 2019-03-20 2025-11-27 Juntendo Educational Found Agent targeting double-membrane organelle dna

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004732A1 (en) 1993-08-06 1995-02-16 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
WO1998037066A1 (en) 1996-02-26 1998-08-27 California Institute Of Technology Improved polyamides for binding in the minor groove of double stranded dna
CN1260006A (zh) 1996-02-26 2000-07-12 加利福尼亚州技术学院 双链dna和杂环低聚物之间复合物的形成
EP0973740A1 (en) 1996-02-26 2000-01-26 California Institute Of Technology Design, synthesis and use of specific polyamide dna-binding ligands
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
WO1998035702A1 (en) 1996-08-01 1998-08-20 California Institute Of Technology Inhibition of gene transcription by polyamide dna-binding ligands
AU5910899A (en) 1998-09-11 2000-04-03 California Institute Of Technology Inhibition of oncogene transcription by synthetic polyamides
US6673940B1 (en) 1999-01-08 2004-01-06 California Institute Of Technology Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids
WO2003000683A1 (fr) 2001-06-25 2003-01-03 Japan Science And Technology Agency Procede de synthese en phase solide de polyamides de pyrrole-imidazole
BR0213988A (pt) 2001-11-07 2004-08-31 Pharmacia Corp Moduladores de poliamida de transcrição de cox2
BR0213989A (pt) 2001-11-07 2005-03-01 Pharmacia Corp Métodos para promover a absorção e acúmulo nuclear de poliamidas em células eucarióticas
ATE468147T1 (de) 2003-01-16 2010-06-15 Femmepharma Holding Co Inc Vaginaler oder rektaler applikator und verfahren
EP1599474B1 (en) 2003-03-04 2013-04-24 California Institute Of Technology Heterocyclic oligomeric compounds for DNA recognition
WO2004099131A2 (en) 2003-04-30 2004-11-18 Pharmacia Corporation Compounds having a fused, bicyclic moiety for binding to the minor groove of dsdna
US8399013B2 (en) 2003-06-26 2013-03-19 Poly-Med, Inc. Partially absorbable fiber-reinforced composites for controlled drug delivery
WO2005033282A2 (en) 2003-10-01 2005-04-14 Pharmacia & Upjohn Company Llc Polyamide compositions and therapeutic methods for treatment of human papilloma virus
DE10357677A1 (de) 2003-12-10 2005-07-14 Greiner Bio-One Gmbh Primer und Sonden zum Nachweis genitaler HPV-Genotypen
WO2007045096A1 (en) * 2005-10-21 2007-04-26 University Of Saskatchewan Oligoheteroaromatic luminiscent assemblies as high-affinity dna sequence-directed ligands
WO2007103584A2 (en) * 2006-03-09 2007-09-13 Nanovir, Llc Polyamides for treating human papilloma virus
ATE555108T1 (de) * 2006-05-04 2012-05-15 Nanovir Llc Polyamide zur behandlung des menschlichen papilloma-virus
US8993609B2 (en) 2006-05-04 2015-03-31 Nanovir, Llc Compounds for treating papilloma virus infection

Also Published As

Publication number Publication date
EP2751096A2 (en) 2014-07-09
WO2013055825A2 (en) 2013-04-18
RU2014113702A (ru) 2015-11-20
CA2851516A1 (en) 2013-04-18
SG11201401226YA (en) 2014-05-29
WO2013055825A3 (en) 2013-06-13
AU2012322835A1 (en) 2014-04-17
CN104024247B (zh) 2016-05-25
NZ623292A (en) 2016-02-26
CA2851516C (en) 2016-08-02
JP2015502330A (ja) 2015-01-22
KR20140074996A (ko) 2014-06-18
US20130090362A1 (en) 2013-04-11
US9133228B2 (en) 2015-09-15
CN104024247A (zh) 2014-09-03
BR112014008464A2 (pt) 2017-04-11
EP2751096A4 (en) 2015-04-08

Similar Documents

Publication Publication Date Title
JP5796039B2 (ja) ヒトパピローマウイルスを処置するためのポリアミド類
CN111808136B (zh) 核苷酸类似物
US9066951B2 (en) Drugs to treat HPV infection
CN118477088A (zh) N4-羟基胞苷及衍生物和与其相关的抗病毒用途
WO2007103584A2 (en) Polyamides for treating human papilloma virus
CN104024247B (zh) 有用于治疗人类乳头瘤病毒的被胍基取代的聚酰胺
US9290551B2 (en) Compounds for treating papilloma virus infection
US9982020B2 (en) Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses
JP2016540776A (ja) 分枝鎖非環式ヌクレオシドホスホン酸エステルならびにその合成法および使用
JP2877908B2 (ja) 抗ヘルペスペンタペプチド類
NZ623292B2 (en) Guanidinyl-substituted polyamides useful for treating human papilloma virus
CA3207381A1 (en) 2-s rimantadine and 2-r rimantadine for treating cancer and precancerous papilloma virus lesions
WO2016022664A1 (en) Antiviral compounds and methods for treating infections caused by double-stranded dna viruses
Bashkin et al. Polyamides for treating human papilloma virus
Bashkin et al. Polyamides containing amino butyric acid-based building blocks
WO2015161479A1 (zh) 一种嘧啶类化合物的抗宫颈癌用途
Edwards i, United States Patent (10) Patent No.: US 9.333. 232 B2
Wilson Emerging therapies for human papillomavirus infection
Nanovir Bashkin et al.(43) Pub. Date: Sep. 6, 2012