HK1200189A1 - Targeted lysosomal enzyme compounds - Google Patents

Targeted lysosomal enzyme compounds

Info

Publication number
HK1200189A1
HK1200189A1 HK15100520.2A HK15100520A HK1200189A1 HK 1200189 A1 HK1200189 A1 HK 1200189A1 HK 15100520 A HK15100520 A HK 15100520A HK 1200189 A1 HK1200189 A1 HK 1200189A1
Authority
HK
Hong Kong
Prior art keywords
lysosomal enzyme
enzyme compounds
targeted
targeted lysosomal
compounds
Prior art date
Application number
HK15100520.2A
Other languages
English (en)
Chinese (zh)
Inventor
多米尼克．波依溫
讓-保羅．卡斯泰恩
米歇爾．德默勒
薩斯米塔．塔里帕西
讓-克里斯托夫．柯里
西蒙．洛德-杜富爾
Original Assignee
Angiochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angiochem Inc filed Critical Angiochem Inc
Publication of HK1200189A1 publication Critical patent/HK1200189A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/06—Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
HK15100520.2A 2011-12-01 2015-01-16 Targeted lysosomal enzyme compounds HK1200189A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161565764P 2011-12-01 2011-12-01
US201261596515P 2012-02-08 2012-02-08
US201261660564P 2012-06-15 2012-06-15
PCT/CA2012/050867 WO2013078564A2 (fr) 2011-12-01 2012-11-30 Composés d'enzyme lysosomale vectorisée

Publications (1)

Publication Number Publication Date
HK1200189A1 true HK1200189A1 (en) 2015-07-31

Family

ID=48536183

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15100520.2A HK1200189A1 (en) 2011-12-01 2015-01-16 Targeted lysosomal enzyme compounds
HK15104430.3A HK1204002A1 (en) 2011-12-01 2015-05-11 Targeted lysosomal enzyme compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15104430.3A HK1204002A1 (en) 2011-12-01 2015-05-11 Targeted lysosomal enzyme compounds

Country Status (11)

Country Link
US (1) US20150037311A1 (fr)
EP (1) EP2785838A4 (fr)
JP (1) JP2015505824A (fr)
CN (1) CN104145015A (fr)
AU (1) AU2012344702A1 (fr)
BR (1) BR112014013161A2 (fr)
CA (1) CA2857567A1 (fr)
HK (2) HK1200189A1 (fr)
MX (1) MX2014006594A (fr)
RU (1) RU2014126484A (fr)
WO (1) WO2013078564A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1583562B1 (fr) 2003-01-06 2011-06-15 Angiochem Inc. Angiopep-1, composes apparentes, et leurs utilisations
BRPI0613005A8 (pt) 2005-07-15 2017-12-26 Angiochem Inc uso de polipeptídeos de aprotinina como veículos em conjugados farmacêuticos.
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
PT2279008T (pt) 2008-04-18 2019-05-20 Angiochem Inc Composições farmacêuticas de paclitaxel, análogos de paclitaxel ou conjugados de paclitaxel e métodos relacionados de preparação e utilização
RU2531591C2 (ru) 2008-10-15 2014-10-20 Ангиокем Инк. Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
CA2740316A1 (fr) 2008-10-15 2010-04-22 Angiochem Inc. Conjugues d'agonistes de glp-1 et leurs utilisations
CN102307904A (zh) 2008-12-05 2012-01-04 安吉奥开米公司 神经降压素或神经降压素类似物的缀合物及其用途
CN102300987A (zh) 2008-12-17 2011-12-28 安吉奥开米公司 膜型-1基质金属蛋白抑制剂及其用途
US9173891B2 (en) 2009-04-20 2015-11-03 Angiochem, Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
US9161988B2 (en) 2009-07-02 2015-10-20 Angiochem Inc. Multimeric peptide conjugates and uses thereof
BR112014031273A2 (pt) * 2012-06-15 2017-07-25 Angiochem Inc compostos enzima alvejados e seus usos
JP2015526434A (ja) 2012-08-14 2015-09-10 アンジオケム インコーポレーテッド ペプチド−デンドリマーコンジュゲート及びその使用
ES2804594T3 (es) 2013-03-15 2021-02-08 Amicus Therapeutics Inc Reticuladores químicos
WO2014194428A1 (fr) * 2013-06-06 2014-12-11 Angiochem Inc. Composés d'héparane sulfatase ciblés
KR20160040556A (ko) * 2013-07-11 2016-04-14 노파르티스 아게 미생물 트랜스글루타미나제를 사용한 리신-특이적 화학효소적 단백질 변형
SG11201609706VA (en) * 2014-06-23 2017-01-27 Novartis Ag Site specific protein modifications
JP6823055B2 (ja) 2015-06-15 2021-01-27 アンジオケム インコーポレーテッド 軟髄膜癌腫症の治療方法
JOP20190245A1 (ar) 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
JP2021500857A (ja) 2017-10-02 2021-01-14 デナリ セラピューティクス インコーポレイテッドＤｅｎａｌｉ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 酵素補充療法用酵素を含む融合タンパク質
TW202027794A (zh) 2018-10-03 2020-08-01 瑞士商諾華公司 血管生成素樣３多肽之持續遞送

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003032727A1 (fr) * 2001-10-16 2003-04-24 Symbiontics Inc. Techniques et compositions permettant le ciblage de proteines sous-glycosylees a travers la barriere hemato-encephalique
EP1514106A4 (fr) * 2002-05-29 2007-05-09 Zystor Therapeutics Inc Proteines therapeutiques ciblees
WO2004108071A2 (fr) * 2003-06-05 2004-12-16 Salk Institute For Biological Studies Compositions et methodes destinees a cibler un polypeptide sur le systeme nerveux central
JP5137814B2 (ja) * 2005-04-06 2013-02-06 ジェンザイム・コーポレーション 治療ターゲティングのための酸不安定リンカーを介するｐｅｇおよびポリシアルリソソーム酵素のコンジュゲート
EP2235175A4 (fr) * 2007-12-20 2012-04-25 Angiochem Inc Conjugués polypeptide-acide nucléique et leurs utilisations
CN102307904A (zh) * 2008-12-05 2012-01-04 安吉奥开米公司 神经降压素或神经降压素类似物的缀合物及其用途
CA2745499A1 (fr) * 2008-12-05 2010-06-10 Angiochem Inc. Conjugues therapeutiques peptidiques et leurs applications
WO2011041897A1 (fr) * 2009-10-06 2011-04-14 Angiochem Inc. Compositions et procédés pour transporter des agents thérapeutiques
EP2333074A1 (fr) * 2009-12-14 2011-06-15 Robert Steinfeld Substances et procédés pour le traitement de maladies liées au stockage lysosomal
EP2785837A4 (fr) * 2011-12-01 2015-07-01 Angiochem Inc Composés enzymatiques ciblés et leurs utilisations

Also Published As

Publication number Publication date
CA2857567A1 (fr) 2013-06-06
BR112014013161A2 (pt) 2019-09-24
US20150037311A1 (en) 2015-02-05
RU2014126484A (ru) 2016-02-10
MX2014006594A (es) 2015-09-16
CN104145015A (zh) 2014-11-12
WO2013078564A3 (fr) 2013-09-06
EP2785838A2 (fr) 2014-10-08
EP2785838A4 (fr) 2015-07-01
HK1204002A1 (en) 2015-11-06
AU2012344702A1 (en) 2014-06-19
WO2013078564A2 (fr) 2013-06-06
JP2015505824A (ja) 2015-02-26

Similar Documents

Publication Publication Date Title
HK1204002A1 (en) Targeted lysosomal enzyme compounds
HK1200190A1 (en) Targeted enzyme compounds and uses thereof
ZA201400678B (en) Alpha-amylase variants
EP2714970A4 (fr) Quantification d'enzyme
EP2751265A4 (fr) Nouvelles cellobiohydrolases
GB201007384D0 (en) Enzymes
GB201004179D0 (en) Enzyme inhibitors
GB201004178D0 (en) Enzyme inhibitors
HK1207881A1 (en) Improved enzyme variants
ZA201207687B (en) Enzyme granules
EP2748299A4 (fr) Ciblage de microbulles
ZA201500911B (en) Enzymes
EP2730652A4 (fr) Enzyme produite par arthrobacter globiformis
SI2756076T1 (sl) Variante encimov z izboljšanimi lastnostmi
GB201112231D0 (en) Micro-organism
PL2748311T3 (pl) Oksydaza glukozowa
GB201214938D0 (en) Alternative oxidase
EP2655646A4 (fr) Perhydrolases ciblées
EP2734620A4 (fr) Enzymes pour dégrader des organosphosphates
GB201207018D0 (en) Enzymes
ZA201400850B (en) Enzyme system
GB201105987D0 (en) Enzymes
EP2663657A4 (fr) Assemblage génomique
GB201114017D0 (en) Inhibitors against endosomal/ysosomal enzymes
GB201114748D0 (en) Enzyme inhibition