HK1204002A1 - Targeted lysosomal enzyme compounds - Google Patents
Targeted lysosomal enzyme compoundsInfo
- Publication number
- HK1204002A1 HK1204002A1 HK15104430.3A HK15104430A HK1204002A1 HK 1204002 A1 HK1204002 A1 HK 1204002A1 HK 15104430 A HK15104430 A HK 15104430A HK 1204002 A1 HK1204002 A1 HK 1204002A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- lysosomal enzyme
- enzyme compounds
- targeted
- targeted lysosomal
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161565764P | 2011-12-01 | 2011-12-01 | |
| US201261596515P | 2012-02-08 | 2012-02-08 | |
| US201261660564P | 2012-06-15 | 2012-06-15 | |
| PCT/CA2012/050867 WO2013078564A2 (en) | 2011-12-01 | 2012-11-30 | Targeted lysosomal enzyme compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1204002A1 true HK1204002A1 (en) | 2015-11-06 |
Family
ID=48536183
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15100520.2A HK1200189A1 (en) | 2011-12-01 | 2015-01-16 | Targeted lysosomal enzyme compounds |
| HK15104430.3A HK1204002A1 (en) | 2011-12-01 | 2015-05-11 | Targeted lysosomal enzyme compounds |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15100520.2A HK1200189A1 (en) | 2011-12-01 | 2015-01-16 | Targeted lysosomal enzyme compounds |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20150037311A1 (xx) |
| EP (1) | EP2785838A4 (xx) |
| JP (1) | JP2015505824A (xx) |
| CN (1) | CN104145015A (xx) |
| AU (1) | AU2012344702A1 (xx) |
| BR (1) | BR112014013161A2 (xx) |
| CA (1) | CA2857567A1 (xx) |
| HK (2) | HK1200189A1 (xx) |
| MX (1) | MX2014006594A (xx) |
| RU (1) | RU2014126484A (xx) |
| WO (1) | WO2013078564A2 (xx) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4903036B2 (ja) | 2003-01-06 | 2012-03-21 | アンジオケム・インコーポレーテッド | 血液脳関門を通過する担体としてのアプロチニンおよび類似体 |
| EP2433653B1 (en) | 2005-07-15 | 2019-06-05 | Angiochem Inc. | Use of aprotinin polypeptides as carriers in pharmaceutical conjugates |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| BRPI0910557A2 (pt) | 2008-04-18 | 2015-09-29 | Angiochem Inc | composições farmacêuticas de paclitaxel, análogos de paclitaxel ou conjugados de paclitaxel e métodos relacionados de preparação e uso. |
| WO2010043047A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
| JP5705118B2 (ja) | 2008-10-15 | 2015-04-22 | アンジオケム インコーポレーテッド | 薬物送達のためのエトポシドおよびドキソルビシン複合体 |
| MX2011005963A (es) | 2008-12-05 | 2011-09-01 | Angiochem Inc | Conjugados de neurotensina o analogos de neurotensina y sus usos. |
| MX2011006685A (es) | 2008-12-17 | 2011-09-27 | Angiochem Inc | Inhibidores de metaloproteinas de matriz de membrana tipo-1 y sus usos. |
| JP2012524030A (ja) | 2009-04-20 | 2012-10-11 | アンジオケム インコーポレーテッド | Ａｎｇｉｏｐｅｐ−２アナログにコンジュゲート化した抗癌剤を用いた卵巣癌の治療 |
| US9161988B2 (en) | 2009-07-02 | 2015-10-20 | Angiochem Inc. | Multimeric peptide conjugates and uses thereof |
| CA2876525A1 (en) * | 2012-06-15 | 2013-12-19 | Angiochem Inc. | Targeted iduromdase compounds |
| AU2013302270A1 (en) | 2012-08-14 | 2015-03-26 | Angiochem Inc. | Peptide-dendrimer conjugates and uses thereof |
| SG11201505936QA (en) * | 2013-03-15 | 2015-09-29 | Amicus Therapeutics Inc | Chemical crosslinkers |
| WO2014194428A1 (en) * | 2013-06-06 | 2014-12-11 | Angiochem Inc. | Targeted heparan sulfatase compounds |
| CA2918076A1 (en) * | 2013-07-11 | 2015-01-15 | Novartis Ag | Site-specific chemoenzymatic protein modifications |
| EP3851445A1 (en) * | 2014-06-23 | 2021-07-21 | Novartis AG | Site specific protein modifications |
| DK3307326T3 (da) | 2015-06-15 | 2020-10-19 | Angiochem Inc | Fremgangsmåder til behandling af leptomeningeal karcinomatose |
| JOP20190245A1 (ar) | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
| CR20200129A (es) | 2017-10-02 | 2020-08-22 | Denali Therapeutics Inc | Proteínas de fusión que comprenden enzimas de terapia de reemplazo de enzimas |
| AR116566A1 (es) | 2018-10-03 | 2021-05-19 | Novartis Ag | Administración sostenida de polipéptidos similares a la angiopoyetina 3 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005506340A (ja) * | 2001-10-16 | 2005-03-03 | シムバイオンティクス インコーポレイテッド | 血液脳関門をわたる過小グリコシル化タンパク質の標的化のための方法および組成物 |
| EP1514106A4 (en) * | 2002-05-29 | 2007-05-09 | Zystor Therapeutics Inc | TARGETED THERAPEUTIC PROTEINS |
| AU2003286870A1 (en) * | 2003-06-05 | 2005-01-04 | Salk Institute For Biological Studies | Targeting polypeptides to the central nervous system |
| PL1877099T3 (pl) * | 2005-04-06 | 2013-02-28 | Genzyme Corp | Terapeutyczne koniugaty zawierające enzym lizosomalny, kwas polisialowy i grupę kierującą |
| US20110039785A1 (en) * | 2007-12-20 | 2011-02-17 | Angiochem Inc. | Polypeptide-nucleic acid conjugates and uses thereof |
| MX2011005963A (es) * | 2008-12-05 | 2011-09-01 | Angiochem Inc | Conjugados de neurotensina o analogos de neurotensina y sus usos. |
| US20110288011A1 (en) * | 2008-12-05 | 2011-11-24 | Jean-Paul Castaigne | Peptide therapeutic conjugates and uses thereof |
| US20120277158A1 (en) * | 2009-10-06 | 2012-11-01 | Angiochem Inc. | Compositions and methods for the transport of therapeutic agents |
| EP2333074A1 (en) * | 2009-12-14 | 2011-06-15 | Robert Steinfeld | Substances and methods for the treatment of lysosmal storage diseases |
| JP2015500800A (ja) * | 2011-12-01 | 2015-01-08 | アンジオケム インコーポレーテッド | 標的化イズロン酸−２−スルファターゼ化合物 |
-
2012
- 2012-11-30 WO PCT/CA2012/050867 patent/WO2013078564A2/en active Application Filing
- 2012-11-30 AU AU2012344702A patent/AU2012344702A1/en not_active Abandoned
- 2012-11-30 BR BR112014013161A patent/BR112014013161A2/pt not_active IP Right Cessation
- 2012-11-30 EP EP12854302.2A patent/EP2785838A4/en not_active Withdrawn
- 2012-11-30 MX MX2014006594A patent/MX2014006594A/es unknown
- 2012-11-30 US US14/362,034 patent/US20150037311A1/en not_active Abandoned
- 2012-11-30 JP JP2014543737A patent/JP2015505824A/ja active Pending
- 2012-11-30 CN CN201280068758.8A patent/CN104145015A/zh active Pending
- 2012-11-30 RU RU2014126484A patent/RU2014126484A/ru not_active Application Discontinuation
- 2012-11-30 CA CA2857567A patent/CA2857567A1/en not_active Abandoned
-
2015
- 2015-01-16 HK HK15100520.2A patent/HK1200189A1/xx unknown
- 2015-05-11 HK HK15104430.3A patent/HK1204002A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2014126484A (ru) | 2016-02-10 |
| JP2015505824A (ja) | 2015-02-26 |
| EP2785838A4 (en) | 2015-07-01 |
| AU2012344702A1 (en) | 2014-06-19 |
| HK1200189A1 (en) | 2015-07-31 |
| CN104145015A (zh) | 2014-11-12 |
| WO2013078564A2 (en) | 2013-06-06 |
| US20150037311A1 (en) | 2015-02-05 |
| MX2014006594A (es) | 2015-09-16 |
| BR112014013161A2 (pt) | 2019-09-24 |
| WO2013078564A3 (en) | 2013-09-06 |
| CA2857567A1 (en) | 2013-06-06 |
| EP2785838A2 (en) | 2014-10-08 |
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