HK1199840A1 - Noribogaine salt ansolvates - Google Patents
Noribogaine salt ansolvatesInfo
- Publication number
- HK1199840A1 HK1199840A1 HK15100394.5A HK15100394A HK1199840A1 HK 1199840 A1 HK1199840 A1 HK 1199840A1 HK 15100394 A HK15100394 A HK 15100394A HK 1199840 A1 HK1199840 A1 HK 1199840A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ansolvates
- noribogaine salt
- noribogaine
- salt ansolvates
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161535300P | 2011-09-15 | 2011-09-15 | |
| PCT/US2012/055597 WO2013040471A2 (en) | 2011-09-15 | 2012-09-14 | Noribogaine salt ansolvates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1199840A1 true HK1199840A1 (en) | 2015-07-24 |
Family
ID=47881233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15100394.5A HK1199840A1 (en) | 2011-09-15 | 2015-01-14 | Noribogaine salt ansolvates |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US9040520B2 (es) |
| EP (1) | EP2755658A4 (es) |
| KR (2) | KR102381792B1 (es) |
| CN (2) | CN103857397B (es) |
| AU (1) | AU2012308274B2 (es) |
| BR (1) | BR112014005064A2 (es) |
| CA (1) | CA2845007C (es) |
| CL (1) | CL2014000506A1 (es) |
| CO (1) | CO6970589A2 (es) |
| HK (1) | HK1199840A1 (es) |
| IL (1) | IL230940B (es) |
| MX (1) | MX2014001933A (es) |
| PE (1) | PE20142353A1 (es) |
| RU (1) | RU2014105881A (es) |
| SG (1) | SG2014011811A (es) |
| TW (2) | TWI588145B (es) |
| WO (1) | WO2013040471A2 (es) |
| ZA (1) | ZA201401268B (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8765737B1 (en) * | 2010-05-11 | 2014-07-01 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US9394294B2 (en) * | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| US8741891B1 (en) | 2010-06-22 | 2014-06-03 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| CA2806232A1 (en) | 2010-07-23 | 2012-01-26 | Demerx, Inc. | Noribogaine compositions |
| EP2481740B1 (en) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| KR102381792B1 (ko) | 2011-09-15 | 2022-04-01 | 데메알엑스, 인크. | 노르이보가인 염 무용매화물 |
| EP2788003A4 (en) | 2011-12-09 | 2015-05-27 | Demerx Inc | PHOSPHATESTER OF NORIBOGAIN |
| PL2797416T3 (pl) | 2011-12-28 | 2017-12-29 | Global Blood Therapeutics, Inc. | Podstawione związki benzaldehydowe i sposoby ich zastosowania do zwiększania natlenienia tkanek |
| US9012450B2 (en) | 2011-12-28 | 2015-04-21 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| AU2013212139A1 (en) | 2012-01-25 | 2014-06-26 | Demerx, Inc. | Synthetic voacangine |
| US8940728B2 (en) | 2012-12-20 | 2015-01-27 | Demerx, Inc. | Substituted noribogaine |
| US9045481B2 (en) | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
| US9783535B2 (en) | 2012-12-20 | 2017-10-10 | Demerx, Inc. | Substituted noribogaine |
| WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| KR20190041548A (ko) | 2013-03-15 | 2019-04-22 | 글로벌 블러드 테라퓨틱스, 인크. | 헤모글로빈 조정을 위한 화합물 및 이의 용도 |
| MY191087A (en) | 2013-03-15 | 2022-05-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| EA201591426A1 (ru) | 2013-03-15 | 2016-02-29 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| WO2014143201A1 (en) | 2013-03-15 | 2014-09-18 | Demerx, Inc. | Method for noribogaine treatment of addiction in patients on methadone |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| BR112015032160B1 (pt) * | 2014-02-07 | 2021-11-30 | Global Blood Therapeutics, Inc | Ansolvato cristalino de composto, composição e composição farmacêutica |
| US9345711B2 (en) | 2014-02-18 | 2016-05-24 | Demerx, Inc. | Methods for acute and long-term treatment of drug addiction |
| US9561232B2 (en) | 2014-02-18 | 2017-02-07 | Demerx, Inc. | Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use |
| EP3107545A4 (en) | 2014-02-18 | 2017-10-25 | DemeRx, Inc. | Methods for acute and long-term treatment of drug addiction |
| US9591978B2 (en) | 2014-03-13 | 2017-03-14 | Demerx, Inc. | Methods and compositions for pre-screening patients for treatment with noribogaine |
| US9549935B2 (en) | 2014-07-14 | 2017-01-24 | Demerx, Inc. | Methods and compositions for treating migraines using noribogaine |
| ES2867174T3 (es) | 2014-11-26 | 2021-10-20 | Demerx Inc | Métodos y composiciones para potenciar la acción de analgésicos opioides mediante el uso de alcaloides de iboga |
| MA43373A (fr) | 2015-12-04 | 2018-10-10 | Global Blood Therapeutics Inc | Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde |
| TWI752307B (zh) | 2016-05-12 | 2022-01-11 | 美商全球血液治療公司 | 新穎化合物及製造化合物之方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
| KR20220008824A (ko) | 2019-04-17 | 2022-01-21 | 컴퍼스 패쓰파인더 리미티드 | 실로시빈으로 불안 장애, 두통 장애 및 섭식 장애를 치료하는 방법 |
| WO2023150547A2 (en) * | 2022-02-01 | 2023-08-10 | Caamtech, Inc. | Psychedelic compounds and their therapeutic uses |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2813873A (en) * | 1957-11-19 | Derivatives of the ibogaine alkaloids | ||
| GB789870A (en) | 1955-10-10 | 1958-01-29 | Gobey Lab | Alkaloid derivatives |
| DE69534975T2 (de) * | 1994-07-25 | 2007-01-11 | Nda International, Inc. | Verwendung von noribogain derivaten zur behandlung von chemischer abhängigkeit bei säugern |
| US5591738A (en) | 1994-10-14 | 1997-01-07 | Nda International, Inc. | Method of treating chemical dependency using β-carboline alkaloids, derivatives and salts thereof |
| US7220737B1 (en) | 1997-09-04 | 2007-05-22 | Novoneuron, Inc | Noribogaine in the treatment of pain and drug addiction |
| ES2224430T3 (es) | 1997-09-04 | 2005-03-01 | Novoneuron Inc | Noribogaina en el tratamiento del dolor y de la toxicomania. |
| WO2004043920A1 (en) * | 2002-11-08 | 2004-05-27 | Dov Pharmaceuticals, Inc. | Polymorphs of bicifadine hydrochloride |
| AU2007209992A1 (en) | 2006-01-31 | 2007-08-09 | Thallion Pharmaceuticals Inc. | Crystalline forms of a farnesyl dibenzodiazepinone |
| CA2806232A1 (en) * | 2010-07-23 | 2012-01-26 | Demerx, Inc. | Noribogaine compositions |
| EP2481740B1 (en) * | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| KR102381792B1 (ko) | 2011-09-15 | 2022-04-01 | 데메알엑스, 인크. | 노르이보가인 염 무용매화물 |
-
2012
- 2012-09-14 KR KR1020207027537A patent/KR102381792B1/ko active IP Right Grant
- 2012-09-14 RU RU2014105881/04A patent/RU2014105881A/ru not_active Application Discontinuation
- 2012-09-14 SG SG2014011811A patent/SG2014011811A/en unknown
- 2012-09-14 KR KR1020147004777A patent/KR20140062472A/ko active Application Filing
- 2012-09-14 BR BR112014005064A patent/BR112014005064A2/pt active Search and Examination
- 2012-09-14 EP EP12832208.8A patent/EP2755658A4/en not_active Withdrawn
- 2012-09-14 US US13/619,520 patent/US9040520B2/en active Active
- 2012-09-14 AU AU2012308274A patent/AU2012308274B2/en active Active
- 2012-09-14 CN CN201280039971.6A patent/CN103857397B/zh not_active Expired - Fee Related
- 2012-09-14 MX MX2014001933A patent/MX2014001933A/es unknown
- 2012-09-14 CN CN201610292095.8A patent/CN105949193A/zh active Pending
- 2012-09-14 PE PE2014000301A patent/PE20142353A1/es not_active Application Discontinuation
- 2012-09-14 CA CA2845007A patent/CA2845007C/en active Active
- 2012-09-14 WO PCT/US2012/055597 patent/WO2013040471A2/en active Application Filing
- 2012-09-17 TW TW101133953A patent/TWI588145B/zh active
- 2012-09-17 TW TW106109146A patent/TW201726676A/zh unknown
-
2014
- 2014-02-12 IL IL230940A patent/IL230940B/en unknown
- 2014-02-19 ZA ZA2014/01268A patent/ZA201401268B/en unknown
- 2014-02-28 CL CL2014000506A patent/CL2014000506A1/es unknown
- 2014-03-17 CO CO14057046A patent/CO6970589A2/es unknown
-
2015
- 2015-01-14 HK HK15100394.5A patent/HK1199840A1/xx unknown
- 2015-05-23 US US14/720,753 patent/US9617265B2/en active Active
-
2016
- 2016-10-07 US US15/288,931 patent/US20170022193A1/en not_active Abandoned
- 2016-10-07 US US15/288,945 patent/US20170022194A1/en not_active Abandoned
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