HK1191330A1 - Ethynyl derivatives as positive allosteric modulators of the mglur5 mglur5 - Google Patents

Ethynyl derivatives as positive allosteric modulators of the mglur5 mglur5

Info

Publication number
HK1191330A1
HK1191330A1 HK14104405.5A HK14104405A HK1191330A1 HK 1191330 A1 HK1191330 A1 HK 1191330A1 HK 14104405 A HK14104405 A HK 14104405A HK 1191330 A1 HK1191330 A1 HK 1191330A1
Authority
HK
Hong Kong
Prior art keywords
mglur5
positive allosteric
allosteric modulators
ethynyl derivatives
ethynyl
Prior art date
Application number
HK14104405.5A
Other languages
English (en)
Chinese (zh)
Inventor
喬治.耶施克
西内塞.若利多
洛塔爾.林德曼
海因茨.施塔德勒
埃里克.維埃拉
Original Assignee
霍夫曼-拉羅奇有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 霍夫曼-拉羅奇有限公司 filed Critical 霍夫曼-拉羅奇有限公司
Publication of HK1191330A1 publication Critical patent/HK1191330A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P70/00Climate change mitigation technologies in the production process for final industrial or consumer products
    • Y02P70/50Manufacturing or production processes characterised by the final manufactured product
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02TCLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO TRANSPORTATION
    • Y02T10/00Road transport of goods or passengers
    • Y02T10/60Other road transportation technologies with climate change mitigation effect
    • Y02T10/70Energy storage systems for electromobility, e.g. batteries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Secondary Cells (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Liquid Crystal Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK14104405.5A 2011-04-26 2014-05-09 Ethynyl derivatives as positive allosteric modulators of the mglur5 mglur5 HK1191330A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11163683 2011-04-26
PCT/EP2012/057335 WO2012146551A1 (en) 2011-04-26 2012-04-23 Ethynyl derivatives as positive allosteric modulators of the mglur5

Publications (1)

Publication Number Publication Date
HK1191330A1 true HK1191330A1 (en) 2014-07-25

Family

ID=46025665

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14104405.5A HK1191330A1 (en) 2011-04-26 2014-05-09 Ethynyl derivatives as positive allosteric modulators of the mglur5 mglur5

Country Status (33)

Country Link
US (2) US8957213B2 (es)
EP (1) EP2702051B1 (es)
JP (1) JP5753627B2 (es)
KR (1) KR101554803B1 (es)
CN (1) CN103492373B (es)
AR (1) AR086036A1 (es)
AU (1) AU2012247653B2 (es)
BR (1) BR112013026116A2 (es)
CA (1) CA2829170C (es)
CL (1) CL2013003056A1 (es)
CO (1) CO6801734A2 (es)
CR (1) CR20130475A (es)
CY (1) CY1116391T1 (es)
DK (1) DK2702051T3 (es)
EA (1) EA022019B1 (es)
ES (1) ES2534090T3 (es)
HK (1) HK1191330A1 (es)
HR (1) HRP20150555T1 (es)
HU (1) HUE025031T2 (es)
IL (1) IL228835A (es)
MA (1) MA35133B1 (es)
MX (1) MX337443B (es)
MY (1) MY163164A (es)
PE (1) PE20141169A1 (es)
PL (1) PL2702051T3 (es)
PT (1) PT2702051E (es)
RS (1) RS53903B1 (es)
SG (1) SG194120A1 (es)
SI (1) SI2702051T1 (es)
TW (2) TW201306355A (es)
UA (1) UA110378C2 (es)
WO (1) WO2012146551A1 (es)
ZA (1) ZA201306586B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8957213B2 (en) * 2011-04-26 2015-02-17 Hoffman-La Roche Inc. Ethynyl compounds
UA110862C2 (uk) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
DK2875000T3 (en) * 2012-07-17 2016-10-24 Hoffmann La Roche ARYLETHYNYL DERIVATIVES
PE20150733A1 (es) * 2012-10-18 2015-05-17 Hoffmann La Roche Derivados de etinilo como moduladores de la actividad del receptor mglur5
UA116023C2 (uk) * 2013-07-08 2018-01-25 Ф. Хоффманн-Ля Рош Аг Етинільні похідні як антагоністи метаботропного глутаматного рецептора
KR102035048B1 (ko) * 2015-06-03 2019-10-22 에프. 호프만-라 로슈 아게 에틴일 유도체
LT3322701T (lt) 2015-07-15 2019-07-10 F. Hoffmann-La Roche Ag Etinilo dariniai kaip metabotropinių glutamato receptorių moduliatoriai
US10423423B2 (en) 2015-09-29 2019-09-24 International Business Machines Corporation Efficiently managing speculative finish tracking and error handling for load instructions
DK3484889T3 (da) 2016-07-18 2020-10-26 Hoffmann La Roche Ethynylderivater
SG11202002707VA (en) * 2017-10-10 2020-04-29 Biogen Inc Process for preparing spiro derivatives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI292318B (en) 2003-03-10 2008-01-11 Hoffmann La Roche Imidazol-4-yl-ethynyl-pyridine derivatives
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
JP5635727B2 (ja) * 2004-10-07 2014-12-03 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. チアゾリルmglur5アンタゴニスト及びそれらの使用のための方法
EP1809620B1 (en) 2004-11-04 2010-12-29 Addex Pharma SA Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
ES2328185T3 (es) 2006-05-31 2009-11-10 F. Hoffmann-La Roche Ag Derivados de aril-4-etinil-isoxazol.
SG185285A1 (en) 2007-06-03 2012-11-29 Univ Vanderbilt Benzamide mglur5 positive allosteric modulators and methods of making and using same
US8034806B2 (en) 2007-11-02 2011-10-11 Vanderbilt University Bicyclic mGluR5 positive allosteric modulators and methods of making and using same
CA2734487A1 (en) 2008-08-20 2010-02-25 Southern Research Institute Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections
US8586581B2 (en) 2009-12-17 2013-11-19 Hoffmann-La Roche Inc Ethynyl compounds useful for treatment of CNS disorders
US8420661B2 (en) * 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
US8957213B2 (en) * 2011-04-26 2015-02-17 Hoffman-La Roche Inc. Ethynyl compounds

Also Published As

Publication number Publication date
AR086036A1 (es) 2013-11-13
EP2702051A1 (en) 2014-03-05
SG194120A1 (en) 2013-11-29
CL2013003056A1 (es) 2014-07-25
US20150119384A1 (en) 2015-04-30
HUE025031T2 (en) 2016-02-29
CA2829170A1 (en) 2012-11-01
KR101554803B1 (ko) 2015-09-21
EA022019B1 (ru) 2015-10-30
WO2012146551A1 (en) 2012-11-01
EA201391537A1 (ru) 2014-04-30
MA35133B1 (fr) 2014-05-02
EP2702051B1 (en) 2015-03-04
IL228835A0 (en) 2013-12-31
JP2014512401A (ja) 2014-05-22
CN103492373B (zh) 2015-09-16
CY1116391T1 (el) 2017-02-08
BR112013026116A2 (pt) 2016-12-27
HRP20150555T1 (hr) 2015-07-03
DK2702051T3 (en) 2015-03-16
JP5753627B2 (ja) 2015-07-22
TW201311657A (zh) 2013-03-16
PL2702051T3 (pl) 2015-08-31
IL228835A (en) 2016-02-29
CR20130475A (es) 2013-11-11
PT2702051E (pt) 2015-05-20
CN103492373A (zh) 2014-01-01
ZA201306586B (en) 2014-05-28
MX2013011105A (es) 2013-10-17
KR20140014256A (ko) 2014-02-05
MY163164A (en) 2017-08-15
AU2012247653A1 (en) 2013-09-26
TW201306355A (zh) 2013-02-01
RS53903B1 (en) 2015-08-31
CA2829170C (en) 2019-02-26
NZ614688A (en) 2015-09-25
SI2702051T1 (sl) 2015-06-30
US20120277213A1 (en) 2012-11-01
AU2012247653B2 (en) 2016-05-26
TWI436993B (zh) 2014-05-11
PE20141169A1 (es) 2014-09-22
ES2534090T3 (es) 2015-04-17
US8957213B2 (en) 2015-02-17
CO6801734A2 (es) 2013-11-29
UA110378C2 (en) 2015-12-25
MX337443B (es) 2016-03-07
US9212171B2 (en) 2015-12-15

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