HK1190708A1 - Substituted pyrimido[1,2-b]indazoles and their use as modulators of the pi3k/akt pathway [12-b] pi3k/akt - Google Patents

Substituted pyrimido[1,2-b]indazoles and their use as modulators of the pi3k/akt pathway [12-b] pi3k/akt

Info

Publication number
HK1190708A1
HK1190708A1 HK14103765.1A HK14103765A HK1190708A1 HK 1190708 A1 HK1190708 A1 HK 1190708A1 HK 14103765 A HK14103765 A HK 14103765A HK 1190708 A1 HK1190708 A1 HK 1190708A1
Authority
HK
Hong Kong
Prior art keywords
pi3k
akt
indazoles
modulators
substituted pyrimido
Prior art date
Application number
HK14103765.1A
Other languages
English (en)
Chinese (zh)
Inventor
．雷溫克爾
．哈格巴爾特
．波利茨
．諾伊豪斯
．伯默
Original Assignee
拜耳知識產權有限責任公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 拜耳知識產權有限責任公司 filed Critical 拜耳知識產權有限責任公司
Publication of HK1190708A1 publication Critical patent/HK1190708A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK14103765.1A 2010-12-16 2014-04-21 Substituted pyrimido[1,2-b]indazoles and their use as modulators of the pi3k/akt pathway [12-b] pi3k/akt HK1190708A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10195397 2010-12-16
PCT/EP2011/072593 WO2012080237A1 (en) 2010-12-16 2011-12-13 Substituted pyrimido[1,2-b]indazoles and their use as modulators of the pi3k/akt pathway

Publications (1)

Publication Number Publication Date
HK1190708A1 true HK1190708A1 (en) 2014-07-11

Family

ID=45349509

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14103765.1A HK1190708A1 (en) 2010-12-16 2014-04-21 Substituted pyrimido[1,2-b]indazoles and their use as modulators of the pi3k/akt pathway [12-b] pi3k/akt

Country Status (8)

Country Link
US (1) US8987286B2 (xx)
EP (1) EP2651949B1 (xx)
JP (1) JP5886868B2 (xx)
CN (1) CN103370321B (xx)
CA (1) CA2821777A1 (xx)
ES (1) ES2549443T3 (xx)
HK (1) HK1190708A1 (xx)
WO (1) WO2012080237A1 (xx)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY35809A (es) 2013-11-05 2015-05-29 Bayer Pharma AG (aza)piridopirazolopirimidinonas e indazolopirimidinonas y sus usos
WO2016173948A1 (en) 2015-04-30 2016-11-03 Bayer Pharma Aktiengesellschaft Indazolopyrimidinones as fibrinolysis inhibitors
CN109912606B (zh) * 2019-04-16 2021-05-04 新乡医学院 一种嘧啶并吲唑类化合物的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101160128B (zh) 2005-04-13 2010-08-18 宇部兴产株式会社 含有吲唑衍生物作为有效成分的视网膜神经细胞保护剂
AR064010A1 (es) * 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt
CA2752105C (en) * 2009-02-13 2017-10-31 Matthias Vennemann Fused pyrimidines
US8614221B2 (en) 2009-03-11 2013-12-24 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
WO2010114780A1 (en) * 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity

Also Published As

Publication number Publication date
US8987286B2 (en) 2015-03-24
WO2012080237A1 (en) 2012-06-21
JP5886868B2 (ja) 2016-03-16
JP2014501234A (ja) 2014-01-20
CN103370321B (zh) 2015-07-29
CA2821777A1 (en) 2012-06-21
CN103370321A (zh) 2013-10-23
EP2651949A1 (en) 2013-10-23
ES2549443T3 (es) 2015-10-28
US20130310405A1 (en) 2013-11-21
EP2651949B1 (en) 2015-07-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20191217