HK1188774A1 - 以兩步驟製備 -二氧代己酸酯 - Google Patents

以兩步驟製備 -二氧代己酸酯

Info

Publication number
HK1188774A1
HK1188774A1 HK14101753.9A HK14101753A HK1188774A1 HK 1188774 A1 HK1188774 A1 HK 1188774A1 HK 14101753 A HK14101753 A HK 14101753A HK 1188774 A1 HK1188774 A1 HK 1188774A1
Authority
HK
Hong Kong
Prior art keywords
preparation
steps
hexanoate ester
dioxo
dioxo hexanoate
Prior art date
Application number
HK14101753.9A
Other languages
English (en)
Inventor
Christian Noti
Guixian Hu
Barry Jackson
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of HK1188774A1 publication Critical patent/HK1188774A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/04—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides onto unsaturated carbon-to-carbon bonds
    • C07C67/05—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides onto unsaturated carbon-to-carbon bonds with oxidation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/297—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C67/32—Decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
HK14101753.9A 2011-04-01 2014-02-24 以兩步驟製備 -二氧代己酸酯 HK1188774A1 (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201161470548P 2011-04-01 2011-04-01
EP11002723 2011-04-01
US201161472820P 2011-04-07 2011-04-07
EP11002922 2011-04-07
US201161526321P 2011-08-23 2011-08-23
US201161526307P 2011-08-23 2011-08-23
EP11006872 2011-08-23
EP11006862 2011-08-23
EP11007605 2011-09-19
EP11007606 2011-09-19
EP12150868 2012-01-12
EP12150867 2012-01-12
PCT/EP2012/055581 WO2012130919A1 (en) 2011-04-01 2012-03-29 Preparation of 3,5-dioxo hexanoate ester in two steps

Publications (1)

Publication Number Publication Date
HK1188774A1 true HK1188774A1 (zh) 2014-05-16

Family

ID=46929511

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14101753.9A HK1188774A1 (zh) 2011-04-01 2014-02-24 以兩步驟製備 -二氧代己酸酯

Country Status (13)

Country Link
US (2) US8859786B2 (zh)
EP (1) EP2694490B1 (zh)
JP (1) JP5960243B2 (zh)
KR (1) KR101778345B1 (zh)
CN (1) CN103476763B (zh)
CA (2) CA2830134C (zh)
EA (1) EA023490B1 (zh)
ES (1) ES2669574T3 (zh)
HK (1) HK1188774A1 (zh)
IL (1) IL228519A (zh)
MX (1) MX337105B (zh)
TW (2) TW201245171A (zh)
WO (2) WO2012130919A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103476763B (zh) * 2011-04-01 2016-02-03 隆萨有限公司 以两步骤制备3,5-二氧代己酸酯

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH492670A (de) * 1968-04-24 1970-06-30 Lonza Ag Verfahren zur Herstellung von y-Chloracetessigsäureester
IN151753B (zh) * 1980-04-02 1983-07-23 Lonza Ag
DE3741509A1 (de) 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
JPH0484893A (ja) * 1990-07-27 1992-03-18 Chisso Corp 光学活性１，３―ジオキサン誘導体
DE69937374T2 (de) 1998-08-05 2008-07-24 Kaneka Corp. Verfahren zur Herstellung von 3,5-dihydroxy substituierten Estern als Zwischenprodukte zur Herstellung optisch aktiver 2-(6-(Hydroxymethyl)-1,3-dioxan-4-yl)-essigsäure-Derivate
AU2000254249A1 (en) * 2000-03-28 2001-10-08 Biocon India Limited Synthesis of (r-(r*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-
DE10208007A1 (de) 2002-02-26 2003-09-18 Forschungszentrum Juelich Gmbh Verfahren zur Herstellung von Alkoholen aus Substraten mittels Oxidoreduktasen, Zweiphasensystem umfassend eine wässrige Phase und eine organische Phase sowie Vorrichtung zur Durchführung des Verfahrens
JPWO2004085443A1 (ja) * 2003-03-24 2006-06-29 ア・チ・エツセ・ドブフアル・エツセ・ピー・アー ７−［２−（２−アミノチアゾール−４−イル）−２−ヒドロキシイミノアセトアミド−３−ビニル−３−セフェム−４−カルボン酸（シン異性体）の新規結晶およびその製造方法
WO2005054207A1 (en) 2003-12-04 2005-06-16 Glenmark Pharmaceuticals Limited Process for the preparation of pyrimidine derivatives
CN103476763B (zh) * 2011-04-01 2016-02-03 隆萨有限公司 以两步骤制备3,5-二氧代己酸酯

Also Published As

Publication number Publication date
CN103476763B (zh) 2016-02-03
TWI551592B (zh) 2016-10-01
US9296718B2 (en) 2016-03-29
EA201301110A1 (ru) 2014-04-30
CA2830134C (en) 2018-03-06
CA2987775A1 (en) 2012-10-04
US20140024842A1 (en) 2014-01-23
WO2012130919A1 (en) 2012-10-04
JP2014522377A (ja) 2014-09-04
TW201245171A (en) 2012-11-16
EA023490B1 (ru) 2016-06-30
EP2694490B1 (en) 2018-03-21
MX2013011200A (es) 2014-03-12
TW201247640A (en) 2012-12-01
US20140371451A1 (en) 2014-12-18
CN103476763A (zh) 2013-12-25
KR101778345B1 (ko) 2017-09-13
ES2669574T3 (es) 2018-05-28
WO2012130920A1 (en) 2012-10-04
CA2987775C (en) 2019-01-08
CA2830134A1 (en) 2012-10-04
US8859786B2 (en) 2014-10-14
KR20140034175A (ko) 2014-03-19
MX337105B (es) 2016-02-09
EP2694490A1 (en) 2014-02-12
JP5960243B2 (ja) 2016-08-02
IL228519A (en) 2015-08-31
IL228519A0 (en) 2013-12-31

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20200326