HK1187369A1 - 用於分泌性蛋白表達的融合蛋白 - Google Patents

用於分泌性蛋白表達的融合蛋白

Info

Publication number
HK1187369A1
HK1187369A1 HK14100350.8A HK14100350A HK1187369A1 HK 1187369 A1 HK1187369 A1 HK 1187369A1 HK 14100350 A HK14100350 A HK 14100350A HK 1187369 A1 HK1187369 A1 HK 1187369A1
Authority
HK
Hong Kong
Prior art keywords
protein
secretory
expression
fusion protein
fusion
Prior art date
Application number
HK14100350.8A
Other languages
English (en)
Inventor
Joen Luirink
Wouter S P Jong
Original Assignee
Abera Bioscience Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abera Bioscience Ab filed Critical Abera Bioscience Ab
Publication of HK1187369A1 publication Critical patent/HK1187369A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK14100350.8A 2010-09-28 2014-01-13 用於分泌性蛋白表達的融合蛋白 HK1187369A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE1051000 2010-09-28
PCT/EP2011/066854 WO2012041899A1 (en) 2010-09-28 2011-09-28 Fusion protein for secretory protein expression

Publications (1)

Publication Number Publication Date
HK1187369A1 true HK1187369A1 (zh) 2014-04-04

Family

ID=44719941

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14100350.8A HK1187369A1 (zh) 2010-09-28 2014-01-13 用於分泌性蛋白表達的融合蛋白

Country Status (8)

Country Link
US (1) US9322011B2 (zh)
EP (1) EP2622078B1 (zh)
CN (1) CN103228787B (zh)
CA (1) CA2811699C (zh)
ES (1) ES2529442T3 (zh)
HK (1) HK1187369A1 (zh)
PL (1) PL2622078T3 (zh)
WO (1) WO2012041899A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201009861D0 (en) * 2010-06-11 2010-07-21 Novartis Ag OMV vaccines
WO2013151706A2 (en) * 2012-04-06 2013-10-10 Cornell University Subunit vaccine delivery platform for robust humoral and cellular immune responses
US10357555B2 (en) * 2012-07-10 2019-07-23 Transgene Sa Mycobacterial antigen vaccine
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
CN117247460A (zh) * 2015-06-02 2023-12-19 Intravacc有限责任公司 革兰氏阴性菌外膜囊泡抗原表面展示
US11059868B2 (en) 2017-10-25 2021-07-13 Abera Bioscience Ab Display of heterologous molecules on bacterial cells and membrane vesicles
GB202009411D0 (en) * 2020-06-19 2020-08-05 Prokarium Ltd Autotransporter systems
EP3981879A1 (en) * 2020-10-09 2022-04-13 Stada Arzneimittel Ag Method of producing a recombinant protein in a host cell which has a disabled rhamnose metabolism as well as expression vectors, host cells and recombinant proteins thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000504928A (ja) * 1996-03-15 2000-04-25 マツクス―プランク―ゲゼルシヤフト ツール フエルデルング デル ヴイツセンシヤフテン エー フアウ 組み換え蛋白質のエクスポート系
ATE346168T1 (de) * 2001-03-02 2006-12-15 Univ Des Saarlandes Wissens Un Funktionelles oberflächendisplay von polypeptiden
GB0220199D0 (en) * 2002-08-30 2002-10-09 Univ Utrecht Mutant protein and refolding method
JP2006500963A (ja) * 2002-08-02 2006-01-12 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン組成物
AU2003901316A0 (en) * 2003-03-21 2003-04-03 The Royal Alexandra Hospital For Children Regulation of cell surface proteins
WO2005032584A2 (en) * 2003-10-02 2005-04-14 Glaxosmithkline Biologicals S.A. Pertussis antigens and use thereof in vaccination
EP1706481A2 (en) * 2003-12-23 2006-10-04 GlaxoSmithKline Biologicals S.A. Vaccine
ES2301262B1 (es) * 2004-01-14 2009-05-29 Consejo Sup. Investig. Cientificas Generacion de adhesion especifica en bacterias gram negativas mediante el anclaje de monodominos de inmunoglobulinas en su superficie con autotransportadores.
US8029777B2 (en) * 2004-08-13 2011-10-04 Marshall Barry J Helicobacter system and uses thereof
EP1981905B1 (en) * 2006-01-16 2016-08-31 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Chlamydia vaccine
US8293685B2 (en) * 2007-07-26 2012-10-23 The Regents Of The University Of California Methods for enhancing bacterial cell display of proteins and peptides
WO2011029881A2 (en) * 2009-09-09 2011-03-17 Autodisplay Biotech Gmbh A method for binding a recombinant polypeptide to a carrier
US8771669B1 (en) * 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
EP2545068B8 (en) * 2010-03-11 2018-03-21 GlaxoSmithKline Biologicals S.A. Immunogenic composition or vaccine against gram-negative bacterial, for example neiserial, infection or disease
WO2012038508A1 (en) * 2010-09-23 2012-03-29 Autodisplay Biotech Gmbh Surface display of polypeptides containing a metal porphyrin or a flavin

Also Published As

Publication number Publication date
WO2012041899A1 (en) 2012-04-05
CN103228787B (zh) 2017-06-23
US9322011B2 (en) 2016-04-26
CA2811699C (en) 2019-07-02
EP2622078B1 (en) 2014-11-05
PL2622078T3 (pl) 2015-05-29
US20130344099A1 (en) 2013-12-26
CA2811699A1 (en) 2012-04-05
ES2529442T3 (es) 2015-02-20
EP2622078A1 (en) 2013-08-07
CN103228787A (zh) 2013-07-31

Similar Documents

Publication Publication Date Title
HRP20150241T1 (en) Anticancer fusion protein
HK1192587A1 (zh) 治療性融合蛋白
IL232743A0 (en) anticancer fusion protein
EP2729488A4 (en) PROCESS FOR PREPARING MULTIMANT POLYPEPTIDES
EP2772230A4 (en) FUSION GRAFT
SG10201500208SA (en) Npp1 fusion proteins
HK1186192A1 (zh) 抗癌融合蛋白
HK1187369A1 (zh) 用於分泌性蛋白表達的融合蛋白
IL232834A0 (en) anticancer fusion protein
IL226205A0 (en) anticancer fusion protein
EP2698386B8 (en) Fusion protein
EP2683742A4 (en) NPP1 FUSION PROTEIN
EP2657337A4 (en) FUSION PROTEIN
ZA201308597B (en) Anticancer fusion protein
ZA201207425B (en) Fusion protein
GB201007955D0 (en) Somatosatin fusion proteins
GB201114701D0 (en) Fusion proteins
GB201107189D0 (en) Fusion proteins
AU2011905145A0 (en) Fusion Protein
GB201104152D0 (en) Fusion Polypeptide
GB201007550D0 (en) Modified receptor fusion proteins
GB201004150D0 (en) Modified receptor fusion proteins
GB201010202D0 (en) Fusion polypeptides
HUP1100282A2 (en) Protein factor