HK1179619A1 - -甲基-吡咯烷- -基 甲基-吡啶基醚衍生物及它們作為 受體拮抗劑的用途 - Google Patents
-甲基-吡咯烷- -基 甲基-吡啶基醚衍生物及它們作為 受體拮抗劑的用途Info
- Publication number
- HK1179619A1 HK1179619A1 HK13106772.6A HK13106772A HK1179619A1 HK 1179619 A1 HK1179619 A1 HK 1179619A1 HK 13106772 A HK13106772 A HK 13106772A HK 1179619 A1 HK1179619 A1 HK 1179619A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methylpyrrolidin
- receptor antagonists
- ether derivatives
- methyl pyridinyl
- pyridinyl ether
- Prior art date
Links
- WQZMBSPAIOEJKF-UHFFFAOYSA-N 2-[(3-methylpyrrolidin-3-yl)methoxy]pyridine Chemical class CC1(COc2ccccn2)CCNC1 WQZMBSPAIOEJKF-UHFFFAOYSA-N 0.000 title 1
- 102000002003 Neurokinin-3 Receptors Human genes 0.000 title 1
- 108010040716 Neurokinin-3 Receptors Proteins 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10168688 | 2010-07-07 | ||
| PCT/EP2011/061168 WO2012004207A1 (en) | 2010-07-07 | 2011-07-04 | (3 -methylpyrrolidin- 3 - yl) methyl pyridinyl ether derivatives and their use as nk-3 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1179619A1 true HK1179619A1 (zh) | 2013-10-04 |
Family
ID=44276056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK13106772.6A HK1179619A1 (zh) | 2010-07-07 | 2013-06-07 | -甲基-吡咯烷- -基 甲基-吡啶基醚衍生物及它們作為 受體拮抗劑的用途 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8507535B2 (zh) |
| EP (1) | EP2590963B1 (zh) |
| JP (1) | JP5717154B2 (zh) |
| KR (1) | KR101485272B1 (zh) |
| CN (1) | CN102971310B (zh) |
| BR (1) | BR112013000253B1 (zh) |
| CA (1) | CA2803717C (zh) |
| ES (1) | ES2528370T3 (zh) |
| HK (1) | HK1179619A1 (zh) |
| MX (1) | MX2012015268A (zh) |
| RU (1) | RU2625798C2 (zh) |
| WO (1) | WO2012004207A1 (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013526546A (ja) * | 2010-05-13 | 2013-06-24 | アムジエン・インコーポレーテツド | Ｐｄｅ１０阻害剤としてのヘテロアリ−ルオキシヘテロシクリル化合物 |
| CN107108581B (zh) | 2014-08-21 | 2020-06-23 | 百时美施贵宝公司 | 作为强效rock抑制剂的回接苯甲酰胺衍生物 |
| CN114773318A (zh) | 2015-09-02 | 2022-07-22 | 特维娜有限公司 | 含有六元氮杂杂环的δ阿片受体调节化合物、其使用和制备方法 |
| AU2018221148B2 (en) | 2017-02-17 | 2022-05-05 | Trevena, Inc. | 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| BR112019016775A2 (pt) | 2017-02-17 | 2020-03-31 | Trevena, Inc. | Compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 7 membros, métodos de uso e produção dos mesmos |
| WO2021030335A1 (en) * | 2019-08-12 | 2021-02-18 | Millendo Therapeutics, Inc. | A stereoisomerically pure nk-3 receptor antagonist and crystalline forms thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2696B1 (en) * | 2002-12-23 | 2013-03-03 | شركة جانسين فارماسوتيكا ان. في | Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists |
| US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
| CA2682506C (en) | 2007-04-20 | 2016-05-24 | F. Hoffmann-La Roche Ag | Pyrrolidine derivatives as dual nk1/nk3 receptor antagonists |
| ATE517100T1 (de) | 2007-08-07 | 2011-08-15 | Hoffmann La Roche | Pyrrolidinarylether als nk3-rezeptorantagonisten |
| JP2010536818A (ja) | 2007-08-22 | 2010-12-02 | エフ．ホフマン−ラ ロシュ アーゲー | Ｎｋ３受容体アンタゴニストとしてのピロリジンアリール−エーテル |
| US8063075B2 (en) | 2008-06-10 | 2011-11-22 | Hoffmann-La Roche Inc. | Pyrrolidine ether derivatives as NK3 receptor antagonists |
-
2011
- 2011-06-29 US US13/171,507 patent/US8507535B2/en active Active
- 2011-07-04 BR BR112013000253-0A patent/BR112013000253B1/pt active IP Right Grant
- 2011-07-04 RU RU2013102399A patent/RU2625798C2/ru active
- 2011-07-04 EP EP11728862.1A patent/EP2590963B1/en active Active
- 2011-07-04 WO PCT/EP2011/061168 patent/WO2012004207A1/en active Application Filing
- 2011-07-04 ES ES11728862.1T patent/ES2528370T3/es active Active
- 2011-07-04 CN CN201180033350.2A patent/CN102971310B/zh active Active
- 2011-07-04 JP JP2013517325A patent/JP5717154B2/ja active Active
- 2011-07-04 KR KR1020137003090A patent/KR101485272B1/ko active IP Right Grant
- 2011-07-04 MX MX2012015268A patent/MX2012015268A/es active IP Right Grant
- 2011-07-04 CA CA2803717A patent/CA2803717C/en active Active
-
2013
- 2013-06-07 HK HK13106772.6A patent/HK1179619A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130051474A (ko) | 2013-05-20 |
| JP2013531668A (ja) | 2013-08-08 |
| CN102971310A (zh) | 2013-03-13 |
| KR101485272B1 (ko) | 2015-01-21 |
| RU2013102399A (ru) | 2014-08-20 |
| BR112013000253B1 (pt) | 2021-10-13 |
| JP5717154B2 (ja) | 2015-05-13 |
| BR112013000253A2 (pt) | 2016-05-24 |
| EP2590963B1 (en) | 2014-12-03 |
| WO2012004207A1 (en) | 2012-01-12 |
| US20120010212A1 (en) | 2012-01-12 |
| MX2012015268A (es) | 2013-02-07 |
| CN102971310B (zh) | 2015-06-03 |
| ES2528370T3 (es) | 2015-02-09 |
| US8507535B2 (en) | 2013-08-13 |
| CA2803717C (en) | 2018-01-30 |
| CA2803717A1 (en) | 2012-01-12 |
| RU2625798C2 (ru) | 2017-07-19 |
| EP2590963A1 (en) | 2013-05-15 |
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