HK1173754A1 - Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences - Google Patents

Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences

Info

Publication number
HK1173754A1
HK1173754A1 HK13100880.8A HK13100880A HK1173754A1 HK 1173754 A1 HK1173754 A1 HK 1173754A1 HK 13100880 A HK13100880 A HK 13100880A HK 1173754 A1 HK1173754 A1 HK 1173754A1
Authority
HK
Hong Kong
Prior art keywords
capture
nucleic acid
target
acid sequences
selective hybridization
Prior art date
Application number
HK13100880.8A
Other languages
English (en)
Chinese (zh)
Inventor
Michael M Becker
Kristin W Livezey
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Publication of HK1173754A1 publication Critical patent/HK1173754A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK13100880.8A 2008-05-13 2013-01-21 Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences HK1173754A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5294408P 2008-05-13 2008-05-13

Publications (1)

Publication Number Publication Date
HK1173754A1 true HK1173754A1 (en) 2013-05-24

Family

ID=41316534

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13100880.8A HK1173754A1 (en) 2008-05-13 2013-01-21 Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences

Country Status (7)

Country Link
US (3) US10316352B2 (xx)
EP (3) EP2479287B1 (xx)
JP (2) JP5733796B2 (xx)
AU (1) AU2009246363B2 (xx)
CA (1) CA2723726C (xx)
HK (1) HK1173754A1 (xx)
WO (1) WO2009140374A2 (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5733796B2 (ja) 2008-05-13 2015-06-10 ジェン−プロウブ インコーポレイテッド 標的核酸配列の選択的ハイブリダイゼーションおよび捕捉における使用のため不活化可能型標的捕捉オリゴマー
WO2010078374A1 (en) 2008-12-30 2010-07-08 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of listeria
EP2616555B1 (en) 2010-09-16 2017-11-08 Gen-Probe Incorporated Capture probes immobilizable via l-nucleotide tail
WO2012061412A1 (en) 2010-11-01 2012-05-10 Gen-Probe Incorporated Integrated capture and amplification of target nucleic acid for sequencing
EP2683833B1 (en) 2011-03-10 2018-09-26 Gen-Probe Incorporated Methods for the selection and optimization of oligonucleotide tag sequences
AU2012304537B2 (en) 2011-09-06 2015-08-20 Gen-Probe Incorporated Closed nucleic acid structures
CN103797119B (zh) * 2011-09-14 2017-10-27 日本碍子株式会社 靶核酸的检测方法
WO2013044097A1 (en) 2011-09-21 2013-03-28 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
WO2013049135A1 (en) 2011-09-26 2013-04-04 Gen-Probe Incorporated Algorithms for sequence determinations
US9663830B2 (en) 2012-05-20 2017-05-30 Helixbind Methods and compositions for the diagnosis of sepsis using gamma peptide nucleic acids
DK2890814T3 (da) * 2012-08-30 2019-12-16 Gen Probe Inc Flerfaset nukleinsyreamplificering
ITTO20121154A1 (it) * 2012-12-27 2014-06-28 Fond Istituto Italiano Di Tecnologia Sistema di sonde per rivelare una sequenza nucleotidica bersaglio a singolo filamento
WO2016064887A1 (en) 2014-10-20 2016-04-28 Gen-Probe Incorporated Red blood cell lysis solution
EP3417298B1 (en) 2016-02-19 2023-12-27 Gen-Probe Incorporated Laboratory automated instruments, systems, and methods
WO2017189746A1 (en) 2016-04-27 2017-11-02 Gen-Probe Incorporated Blood cell lysis reagent
GB2570412A (en) * 2016-08-31 2019-07-24 Harvard College Methods of generating libraries of nucleic acid sequences for detection via fluorescent in situ sequencing
US11840721B2 (en) 2017-04-03 2023-12-12 Helixbind, Inc. Methods and devices for identifying microbial infections
WO2019099629A1 (en) * 2017-11-17 2019-05-23 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING C1orf43 NUCLEIC ACID
WO2020076976A1 (en) 2018-10-10 2020-04-16 Readcoor, Inc. Three-dimensional spatial molecular indexing
CN109486808A (zh) * 2018-11-16 2019-03-19 许昌学院 一种适用于可视化环介导等温扩增的动物线粒体dna提取方法
US20230227896A1 (en) * 2020-01-16 2023-07-20 Dnae Diagnostics Limited Compositions, Kits and Methods for Isolating Target Polynucleotides

Family Cites Families (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4174384A (en) 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
FR2422956A1 (fr) 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
FI63596C (fi) 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4556643A (en) 1982-07-26 1985-12-03 Agracetus Assay method and probe for polynucleotide sequences
US5288609A (en) 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
CA1260372A (en) 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
US6221581B1 (en) 1984-04-27 2001-04-24 Enzo Diagnostics, Inc. Processes for detecting polynucleotides, determining genetic mutations or defects in genetic material, separating or isolating nucleic acid of interest from samples, and useful compositions of matter and multihybrid complex compositions
US4766062A (en) 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
US5268266A (en) 1984-05-07 1993-12-07 Genetics Institute, Inc. Process and nucleic acid construct for producing reagent complexes useful in determining target nucleotide sequences
US5503979A (en) * 1984-05-25 1996-04-02 The Trustees Of Columbia University In The City Of New York Method of using replicatable hybridzable recombinant RNA probes
US5367066A (en) * 1984-10-16 1994-11-22 Chiron Corporation Oligonucleotides with selectably cleavable and/or abasic sites
US6060237A (en) 1985-02-26 2000-05-09 Biostar, Inc. Devices and methods for optical detection of nucleic acid hybridization
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
JP2609238B2 (ja) * 1985-05-02 1997-05-14 ジエネテイツクス・インスチチユ−ト・インコ−ポレ−テツド 標的ヌクレオチド配列の検定に有用な試薬複合体を作製するための方法および核酸構築物
US4751177A (en) 1985-06-13 1988-06-14 Amgen Methods and kits for performing nucleic acid hybridization assays
US4824776A (en) 1985-07-25 1989-04-25 Molecular Biosystems, Inc. Method for increasing the sensitivity of nucleic acid hybridization assays
US4725536A (en) 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4752566A (en) 1985-12-17 1988-06-21 Genetics Institute, Inc. Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide
US4818680A (en) 1985-12-18 1989-04-04 Mary Collins Method and kit involving displacement and rehybridization of labeled polynucleotide
DE3785591T2 (de) 1986-01-10 1993-09-02 Amoco Corp Kompetitiver homogener test.
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4782484A (en) 1986-04-18 1988-11-01 Bell Communications Research, Inc. Encoding and decoding signals for transmission over a multi-access medium
US5310652A (en) 1986-08-22 1994-05-10 Hoffman-La Roche Inc. Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
ZA877772B (en) 1986-10-23 1988-04-20 Amoco Corporation Target and background capture methods and apparatus for affinity assays
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US6150517A (en) 1986-11-24 2000-11-21 Gen-Probe Methods for making oligonucleotide probes for the detection and/or quantitation of non-viral organisms
US5599667A (en) 1987-03-02 1997-02-04 Gen-Probe Incorporated Polycationic supports and nucleic acid purification separation and hybridization
US6031091A (en) 1987-09-21 2000-02-29 Gen-Probe Incorporated Non-nucleotide linking reagents for nucleotide probes
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
CA2002076A1 (en) 1988-11-21 1990-05-21 Brent A. Burdick Diagnostic kit and method using a solid phase capture means for detecting nucleic acids
EP0379369B1 (en) 1989-01-19 1996-09-04 BEHRINGWERKE Aktiengesellschaft Nucleic acid amplification using single primer
JP3046837B2 (ja) 1989-03-10 2000-05-29 バイシス・インコーポレーテツド 固定化されたオリゴヌクレオチドのプローブおよびそれらの使用
ATE155821T1 (de) 1989-03-10 1997-08-15 Vysis Inc Interferenzverhinderung mit affinitätseinfangschemas
US5589335A (en) 1989-04-05 1996-12-31 Amoco Corporation Hybridization promotion reagents
DE69032847T2 (de) 1989-06-30 1999-05-12 Chiron Corp., Emeryville, Calif. Hydrophobe Nukleinsäure-Sonde
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5480784A (en) 1989-07-11 1996-01-02 Gen-Probe Incorporated Nucleic acid sequence amplification methods
US5200314A (en) 1990-03-23 1993-04-06 Chiron Corporation Polynucleotide capture assay employing in vitro amplification
US5667976A (en) * 1990-05-11 1997-09-16 Becton Dickinson And Company Solid supports for nucleic acid hybridization assays
US5439793A (en) 1990-07-19 1995-08-08 Syntex (U.S.A.) Inc. Method for producing a polynucleotide having an intramolecularly base-paired structure
US5849481A (en) 1990-07-27 1998-12-15 Chiron Corporation Nucleic acid hybridization assays employing large comb-type branched polynucleotides
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
EP0529070A1 (en) 1991-02-27 1993-03-03 Amoco Corporation Methods for improving the sensitivity of hybridization assays
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5270184A (en) 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
US5364787A (en) * 1992-03-23 1994-11-15 Idaho Research Foundation Genes and enzymes involved in the microbial degradation of pentachlorophenol
US5445933A (en) 1992-09-15 1995-08-29 Boehringer Mannheim Corporation Strand displacement assay and complex useful therefor
EP0601889A2 (en) 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nucleic acid probes
FR2699236B1 (fr) 1992-12-11 1995-02-24 Rapid Sa Ecrou encagé perfectionné.
US5780273A (en) 1993-04-09 1998-07-14 Amoco Corporation Insertion elements and amplifiable nucleic acids
US6576419B1 (en) 1993-07-23 2003-06-10 University Of Utah Research Foundation Assay procedure using fluorogenic tracers
CA2105364A1 (en) 1993-09-01 1995-03-02 Eric T. Kool Stem-loop oligonucleotides containing parallel and antiparallel binding domains
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
KR100230909B1 (ko) 1993-11-29 1999-12-01 다니엘 엘. 캐시앙 광범위의 유기체로부터 핵산 추출 방법
US5681697A (en) 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5631148A (en) 1994-04-22 1997-05-20 Chiron Corporation Ribozymes with product ejection by strand displacement
CA2190998A1 (en) 1994-06-01 1995-12-07 Sudhir Agrawal Branched oligonucleotides as pathogen-inhibitory agents
US20070269799A9 (en) 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
JP3189000B2 (ja) 1994-12-01 2001-07-16 東ソー株式会社 特定核酸配列の検出方法
US5556771A (en) 1995-02-10 1996-09-17 Gen-Probe Incorporated Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification
US5731148A (en) 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US5710029A (en) 1995-06-07 1998-01-20 Gen-Probe Incorporated Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5770365A (en) 1995-08-25 1998-06-23 Tm Technologies, Inc. Nucleic acid capture moieties
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
JP2001517925A (ja) 1995-12-22 2001-10-09 ベーリングウエルケ、アクティエンゲゼルシャフト 核酸の均質増幅および検出
DE69738687D1 (de) 1996-04-12 2008-06-26 Phri Properties Inc Sonden, kits und assays
ES2270467T3 (es) 1996-07-16 2007-04-01 Gen-Probe Incorporated Metodos para detectar y amplificar secuencias de acido nucleico utilizando oligonucleotidos modificados que tienen una tm especifica de la diana mas elevada.
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5965363A (en) 1996-09-19 1999-10-12 Genetrace Systems Inc. Methods of preparing nucleic acids for mass spectrometric analysis
US6060246A (en) 1996-11-15 2000-05-09 Avi Biopharma, Inc. Reagent and method for isolation and detection of selected nucleic acid sequences
ATE348155T1 (de) * 1996-11-20 2007-01-15 Introgen Therapeutics Inc Ein verbessertes verfahren zur produktion und reinigung von adenoviralen vektoren
US6025133A (en) 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
JP4222635B2 (ja) 1997-05-02 2009-02-12 ジェン−プローブ・インコーポレーテッド ２段階ハイブリダイゼーションおよびポリヌクレオチドの捕捉
US6031098A (en) * 1997-08-11 2000-02-29 California Institute Of Technology Detection and treatment of duplex polynucleotide damage
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
EP1025120B1 (en) 1997-10-27 2010-08-18 Boston Probes, Inc. Methods, kits and compositions pertaining to pna molecular beacons
AU9762098A (en) * 1997-11-07 1999-05-31 Chugai Research Institute For Molecular Medicine, Inc. Steroid hormone binding protein
EP1043335A4 (en) 1997-12-25 2005-08-31 Japan Tobacco Inc MONOCLONAL ANTIBODY AGAINST CONNECTIVE TISSUE GROWTH FACTOR AND ITS MEDICAL APPLICATIONS
DE69941333D1 (de) 1998-07-02 2009-10-08 Gen Probe Inc Molekulare fackeln
JP3925586B2 (ja) 1998-07-17 2007-06-06 ソニー株式会社 データ受信装置および方法ならびにデータ送受信システムおよび方法
US6037130A (en) * 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
ES2211222T3 (es) 1998-08-27 2004-07-01 Bayer Corporation Purificacion de oligomeros usando seleccion de final dual.
ATE521718T1 (de) 1998-11-09 2011-09-15 Eiken Chemical Prozess zur synthetisierung von nukleinsäure
CA2361201A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
US6303305B1 (en) 1999-03-30 2001-10-16 Roche Diagnostics, Gmbh Method for quantification of an analyte
US6821770B1 (en) 1999-05-03 2004-11-23 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
EP1055734B1 (en) 1999-05-24 2004-10-13 Tosoh Corporation Method for assaying ribonucleic acid
US8137906B2 (en) * 1999-06-07 2012-03-20 Sloning Biotechnology Gmbh Method for the synthesis of DNA fragments
US7052844B2 (en) 1999-12-21 2006-05-30 Ingeneus, Inc. Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism
AU2001267191A1 (en) 2000-06-06 2001-12-17 Tm Bioscience Corporation Capture moieties for nucleic acids and uses thereof
WO2001098785A2 (en) * 2000-06-19 2001-12-27 Arizona Board Of Regents Rapid flow-based immunoassay microchip
US6451588B1 (en) 2000-06-30 2002-09-17 Pe Corporation (Ny) Multipartite high-affinity nucleic acid probes
US6596490B2 (en) 2000-07-14 2003-07-22 Applied Gene Technologies, Inc. Nucleic acid hairpin probes and uses thereof
US6261785B1 (en) * 2000-07-27 2001-07-17 Becton, Dickinson And Company Amplification and detection of Bordetella pertussis
US20050196785A1 (en) * 2001-03-05 2005-09-08 California Institute Of Technology Combinational array for nucleic acid analysis
US7371580B2 (en) 2001-08-24 2008-05-13 Agilent Technologies, Inc. Use of unstructured nucleic acids in assaying nucleic acid molecules
US7070933B2 (en) * 2001-09-28 2006-07-04 Gen-Probe Incorporated Inversion probes
JP3824309B2 (ja) * 2001-12-28 2006-09-20 住友精密工業株式会社 生化学検体の検出方法と検出チップ
EP1474504A2 (en) * 2002-01-24 2004-11-10 Pointilliste, Inc. Use of collections of binding sites for sample profiling and other applications
AU2003235894A1 (en) 2002-05-08 2003-12-12 Arkray, Inc. Method of detecting target nucleic acid
WO2003095666A2 (en) * 2002-05-13 2003-11-20 Nanocytometry Corporation Oligonucleotide probes for in vitro, in vivo and intracellular detection
EP1539979B1 (en) 2002-09-20 2008-11-19 New England Biolabs, Inc. Helicase dependent amplification of nucleic acids
ES2354068T3 (es) * 2002-10-11 2011-03-09 Erasmus Universiteit Rotterdam Cebadores de amplificación de ácidos nucleicos para estudios de clonalidad basada en pcr.
US7927840B2 (en) * 2006-09-11 2011-04-19 Gen Probe Incorporated Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region
US7851150B2 (en) 2002-12-18 2010-12-14 Third Wave Technologies, Inc. Detection of small nucleic acids
ATE434167T1 (de) 2003-03-07 2009-07-15 Univ New Jersey Med Optisch dekodierbare mikroträger, arrays und verfahren
CA2520811C (en) * 2003-03-28 2013-05-28 Japan As Represented By Director General Of National Rehabilitation Center For Persons With Disabilities Method of cdna synthesis
US20050214789A1 (en) * 2003-04-30 2005-09-29 Moyle William R Sensors for biomolecular detection and cell classification
EP1618215A4 (en) 2003-05-01 2007-12-05 Gen Probe Inc OLIGONUCLEOTIDE AS MOLECULAR SWITCH
US7300755B1 (en) * 2003-05-12 2007-11-27 Fred Hutchinson Cancer Research Center Methods for haplotyping genomic DNA
US7381811B2 (en) * 2003-05-19 2008-06-03 Gen-Probe Incorporated Compositions and methods for detecting Trichomonas vaginalis in a sample
WO2005004794A2 (en) 2003-06-09 2005-01-20 Alnylam Pharmaceuticals Inc. Method of treating neurodegenerative disease
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
EP1692266A4 (en) * 2003-11-06 2009-11-18 Univ Nevada Reno IMPROVED METHODS FOR DETECTING AND MEASURING SPECIFIC NUCLEIC ACID SEQUENCES
US20050250147A1 (en) * 2004-05-10 2005-11-10 Macevicz Stephen C Digital profiling of polynucleotide populations
EP1778867B1 (en) * 2004-07-01 2010-04-28 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
EP1786916B1 (en) 2004-08-27 2013-05-08 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
US7713697B2 (en) 2004-08-27 2010-05-11 Gen-Probe Incorporated Methods and kits for amplifying DNA
US7763426B2 (en) 2004-11-01 2010-07-27 The Regents Of The University Of California Probes and methods for detection of Escheridia coli and antibiotic resistance
US20060223122A1 (en) * 2005-03-08 2006-10-05 Agnes Fogo Classifying and predicting glomerulosclerosis using a proteomics approach
EP2322940B1 (en) 2005-03-10 2014-10-29 Gen-Probe Incorporated Systems amd methods to perform assays for detecting or quantifing analytes within samples
GB2424946A (en) * 2005-04-05 2006-10-11 Stratec Biomedical Systems Ag A detection system for substance binding using up-converting fluorescent probes
ES2381279T3 (es) 2005-05-06 2012-05-24 Gen-Probe Incorporated Métodos y productos para la captura de ácido nucleico diana
WO2006122002A2 (en) 2005-05-09 2006-11-16 Panomics, Inc. Multiplex capture of nucleic acids
US20060292616A1 (en) 2005-06-23 2006-12-28 U.S. Genomics, Inc. Single molecule miRNA-based disease diagnostic methods
US7919239B2 (en) 2005-07-01 2011-04-05 Agilent Technologies, Inc. Increasing hybridization efficiencies
PT1907588E (pt) * 2005-07-26 2013-10-09 Merck Sharp & Dohme Ensaios para determinação da resistência aos medicamentos da classe das equinocandinas
AU2007233270B2 (en) * 2006-04-04 2013-06-20 Fluidigm Corporation Cooperative probes and methods of using them
ATE536424T1 (de) 2006-06-06 2011-12-15 Gen Probe Inc Markierte oligonukleotide und ihre verwendung in nukleinsäureverstärkungsverfahren
US7833716B2 (en) 2006-06-06 2010-11-16 Gen-Probe Incorporated Tagged oligonucleotides and their use in nucleic acid amplification methods
US8242057B2 (en) * 2006-06-26 2012-08-14 Cleveland Biolabs, Inc. Methods for identifying modulators of apoptosis
US9051601B2 (en) 2006-08-01 2015-06-09 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
US8685899B2 (en) 2007-02-14 2014-04-01 Genisphere Inc. Methods, reagents and kits for detection of nucleic acid molecules
JP5759673B2 (ja) * 2007-03-21 2015-08-05 ブルックヘブン サイエンス アソシエイツ，エルエルシー 組み合わされたヘアピン−アンチセンス組成物および発現を調節するための方法
CA2629589C (en) 2007-04-20 2016-03-29 F.Hoffmann-La Roche Ag Isolation and purification of nucleic acid molecules with a solid phase
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
JP5733796B2 (ja) 2008-05-13 2015-06-10 ジェン−プロウブ インコーポレイテッド 標的核酸配列の選択的ハイブリダイゼーションおよび捕捉における使用のため不活化可能型標的捕捉オリゴマー
WO2011091393A1 (en) * 2010-01-25 2011-07-28 Rd Biosciences, Inc. Self-folding amplification of target nucleic acid
US9506112B2 (en) * 2010-02-05 2016-11-29 Siemens Healthcare Diagnostics Inc. Increasing multiplex level by externalization of passive reference in polymerase chain reactions
ES2623859T3 (es) * 2010-03-04 2017-07-12 Miacom Diagnostics Gmbh FISH múltiple mejorada
US20120288857A1 (en) * 2011-02-03 2012-11-15 Fluidigm Corporation Multifunctional probe-primers
WO2012162161A1 (en) * 2011-05-20 2012-11-29 Phthisis Diagnostics Microsporidia detection system and method

Also Published As

Publication number Publication date
US10316352B2 (en) 2019-06-11
EP2479287A1 (en) 2012-07-25
US20090286249A1 (en) 2009-11-19
EP2288726B1 (en) 2012-06-13
EP2806037B1 (en) 2016-09-21
JP2015057075A (ja) 2015-03-26
US20180010172A1 (en) 2018-01-11
JP2011520450A (ja) 2011-07-21
EP2806037A1 (en) 2014-11-26
JP5733796B2 (ja) 2015-06-10
AU2009246363B2 (en) 2013-10-24
WO2009140374A2 (en) 2009-11-19
US20210024982A1 (en) 2021-01-28
WO2009140374A3 (en) 2010-01-07
US12065693B2 (en) 2024-08-20
CA2723726A1 (en) 2009-11-19
CA2723726C (en) 2017-09-12
AU2009246363A1 (en) 2009-11-19
EP2288726A2 (en) 2011-03-02
EP2479287B1 (en) 2014-07-23
JP6014649B2 (ja) 2016-10-25
US10829801B2 (en) 2020-11-10
EP2288726A4 (en) 2011-09-14

Similar Documents

Publication Publication Date Title
HK1173754A1 (en) Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
GB201014134D0 (en) Methods of RNA aplification in the presence of DNA
EP1999276A4 (en) METHOD AND AGENT FOR NUCLEIC ACID SEQUENCING
EP2274449A4 (en) COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING
EP2622064A4 (en) NUCLEOSIDES, NUCLEOTIDES AND MODIFIED NUCLEIC ACIDS AND USES THEREOF
EP2224017A4 (en) PROCESS FOR INCREASING THE NUCLEIC ACID TARGET SEQUENCE AND PROBE USED THEREFOR
EP2391725A4 (en) METHOD AND SYSTEMS FOR CLEANING TRANSMITTING AND / OR MANIPULATING NUCLEIC ACIDS
IL201420A0 (en) Nucleic acid enzymes and complexes and methods for their use
EP2126119A4 (en) APPARATUS AND METHOD FOR NUCLEIC ACID AMPLIFICATION
GB0713143D0 (en) Nucleic acid detection method
IL231460A0 (en) 5 - methoxy, ho - '3, unblocked nucleotides that undergo rapid degradation by light and methods for nucleic acid sequencing
GB0703996D0 (en) Nucleic acid detection
EP2207896A4 (en) AMPLIFICATION OF NUCLEIC ACID
ZA201008749B (en) Isothermal nucleic acid amplification
ZA201104532B (en) Axmi-150 delta-endotoxin gene and methods for its use
EP2362907A4 (en) NUCLEAR ACID EXTRACTION ON DOVED GLASS SURFACES
EP2083843A4 (en) MULTIFUNCTIONAL SUPPORTS FOR THE ADMINISTRATION OF NUCLEIC ACIDS AND METHOD OF USE THEREOF
EP2354226A4 (en) METHOD FOR DETECTING REGULATIONS OF NUCLEIC ACID AMPLIFICATION AND USE THEREOF
GB0603160D0 (en) Nucleic acid
IL206542A0 (en) Method for hybridizing nucleic acids
EP2292798A4 (en) HYBRIDIZATION IN SITU D ARN
EP2333059A4 (en) UNIVERSAL NUCLEIC ACID SET AND APPLICATIONS THEREFOR
EP2421880A4 (en) COMPOSITIONS AND METHODS FOR NUCLEIC ACID DELIVERY
ZA201102807B (en) Primer and amplification method for forming single stranded dna amplicons
EP2319922A4 (en) NUCLEIC ACID PROBE ASSEMBLY AND METHOD OF USE