HK1171739A1 - Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals - Google Patents

Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals

Info

Publication number
HK1171739A1
HK1171739A1 HK12112389.0A HK12112389A HK1171739A1 HK 1171739 A1 HK1171739 A1 HK 1171739A1 HK 12112389 A HK12112389 A HK 12112389A HK 1171739 A1 HK1171739 A1 HK 1171739A1
Authority
HK
Hong Kong
Prior art keywords
indolizinecarboxamides
aza
pharmaceuticals
cyclic
preparation
Prior art date
Application number
HK12112389.0A
Other languages
English (en)
Inventor
Henning Steinhagen
Bodo Scheiper
Hans Matter
Gary Mccort
Guillaume Begis
Pascale Goberville
Berangere Thiers
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of HK1171739A1 publication Critical patent/HK1171739A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK12112389.0A 2009-07-29 2012-11-30 Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals HK1171739A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09290599 2009-07-29
PCT/EP2010/060679 WO2011012538A1 (en) 2009-07-29 2010-07-23 Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals

Publications (1)

Publication Number Publication Date
HK1171739A1 true HK1171739A1 (en) 2013-04-05

Family

ID=41181399

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12112389.0A HK1171739A1 (en) 2009-07-29 2012-11-30 Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals

Country Status (20)

Country Link
US (1) US8415336B2 (he)
EP (1) EP2459557B1 (he)
JP (1) JP5740399B2 (he)
KR (1) KR20120052247A (he)
CN (1) CN102548993B (he)
AR (1) AR077428A1 (he)
AU (1) AU2010277736B2 (he)
BR (1) BR112012008140A2 (he)
CA (1) CA2766535A1 (he)
DK (1) DK2459557T3 (he)
ES (1) ES2431948T3 (he)
HK (1) HK1171739A1 (he)
IL (1) IL217614A (he)
MX (1) MX2012001200A (he)
MY (1) MY153103A (he)
PT (1) PT2459557E (he)
RU (1) RU2539574C2 (he)
SG (1) SG178149A1 (he)
TW (1) TWI469982B (he)
WO (1) WO2011012538A1 (he)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR077428A1 (es) 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos
WO2013149940A1 (en) 2012-04-02 2013-10-10 Basf Se Acrylamide compounds for combating invertebrate pests
US9458164B2 (en) 2013-03-11 2016-10-04 Bristol-Myers Squibb Company Pyrrolopyridazines as potassium ion channel inhibitors
EA031409B1 (ru) * 2014-06-17 2018-12-28 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные индолизина в качестве ингибиторов фосфоинозитид-3-киназ
DK3442977T3 (da) 2016-04-15 2023-10-09 Blueprint Medicines Corp Inhibitorer af activinreceptorlignende kinase
WO2019079649A1 (en) 2017-10-18 2019-04-25 Blueprint Medicines Corporation SUBSTITUTED PYRROLOPYRIDINES AS INHIBITORS OF ACTIVIN RECEPTOR-RELATED KINASE

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278161A (en) * 1990-06-28 1994-01-11 Hoffmann-La Roche Inc. Amino acid derivatives useful as renin inhibitors
EP0820452B1 (en) 1995-04-07 2003-06-04 Schering Corporation Carbonyl-piperazinyl and piperidinil compounds which inhibit farnesyl protein transferase
KR20010034881A (ko) 1998-05-21 2001-04-25 시오노 요시히코 ｓＰＬＡ2 억제 효과를 갖는 피롤로[1,2-ｂ]피리다진 유도체
EP1432709B8 (en) * 2001-09-13 2005-11-02 Synta Pharmaceuticals Corporation 1-glyoxylamide indolizines for treating cancer
US20040116462A1 (en) 2002-12-12 2004-06-17 Mitsunori Ono Indolizine compounds
TW200300681A (en) * 2001-11-12 2003-06-16 Ono Pharmaceutical Co Carboxylic acid derivative compound and medicament containing same as active ingredient
US6900208B2 (en) * 2002-03-28 2005-05-31 Bristol Myers Squibb Company Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
US7030112B2 (en) * 2003-03-25 2006-04-18 Bristol-Myers Squibb Company Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
FR2857966A1 (fr) * 2003-07-24 2005-01-28 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
JP2007505106A (ja) 2003-09-09 2007-03-08 イーライ リリー アンド カンパニー アゼピン、オキサゼピン、およびチアゼピンの置換ピペラジン
TW200529860A (en) 2003-12-22 2005-09-16 Astrazeneca Ab Nicotinic acetylcholine receptor ligands
TW200605867A (en) * 2004-03-17 2006-02-16 Novartis Ag Use of organic compounds
JP4927704B2 (ja) * 2004-03-19 2012-05-09 シュペーデル・エクスペリメンタ・アーゲー 有機化合物
PT1717226E (pt) * 2004-03-19 2009-04-03 Novartis Ag Derivados de 5-amino-4-hidroxi-8-(1h-indol-5-il)-octan amida 2,7-substituída como inibidores da renina para o tratamento da hipertensão
GB0512944D0 (en) 2005-06-24 2005-08-03 Argenta Discovery Ltd Indolizine compounds
AU2006322707B2 (en) 2005-12-07 2011-09-15 Sumitomo Chemical Company, Limited Pyridazine compound and use thereof
AU2009210297B2 (en) * 2008-01-31 2013-11-21 Sanofi Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals
MX2010007661A (es) * 2008-01-31 2010-08-03 Sanofi Aventis Azaindol-3-carboxamidas ciclicas, su preparacion y su uso como productos farmaceuticos.
AR077428A1 (es) 2009-07-29 2011-08-24 Sanofi Aventis (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos

Also Published As

Publication number Publication date
US8415336B2 (en) 2013-04-09
RU2539574C2 (ru) 2015-01-20
MY153103A (en) 2014-12-31
BR112012008140A2 (pt) 2016-09-13
TW201116527A (en) 2011-05-16
PT2459557E (pt) 2013-11-04
EP2459557A1 (en) 2012-06-06
KR20120052247A (ko) 2012-05-23
AR077428A1 (es) 2011-08-24
IL217614A (he) 2015-06-30
CN102548993B (zh) 2014-12-10
ES2431948T3 (es) 2013-11-28
TWI469982B (zh) 2015-01-21
AU2010277736A1 (en) 2012-02-16
JP5740399B2 (ja) 2015-06-24
AU2010277736B2 (en) 2015-04-02
CN102548993A (zh) 2012-07-04
DK2459557T3 (da) 2013-12-16
EP2459557B1 (en) 2013-09-18
WO2011012538A1 (en) 2011-02-03
US20120232081A1 (en) 2012-09-13
SG178149A1 (en) 2012-03-29
JP2013500300A (ja) 2013-01-07
RU2012107484A (ru) 2013-09-10
CA2766535A1 (en) 2011-02-03
MX2012001200A (es) 2012-03-26

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170723