HK1158655A1 - 種含磷取代基的喹啉類化合物及其製備方法、以及含有該化合物的藥物組合物及其應用 - Google Patents

種含磷取代基的喹啉類化合物及其製備方法、以及含有該化合物的藥物組合物及其應用

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Publication number
HK1158655A1
HK1158655A1 HK11112975.1A HK11112975A HK1158655A1 HK 1158655 A1 HK1158655 A1 HK 1158655A1 HK 11112975 A HK11112975 A HK 11112975A HK 1158655 A1 HK1158655 A1 HK 1158655A1
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Hong Kong
Prior art keywords
phosphorus
preparation
application
same
substituent
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HK11112975.1A
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English (en)
Inventor
雲子威
王洪濤
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北京康辰藥業股份有限公司
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Publication of HK1158655A1 publication Critical patent/HK1158655A1/zh

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    • C07—ORGANIC CHEMISTRY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/02—Immunomodulators
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
HK11112975.1A 2011-01-28 2011-11-30 種含磷取代基的喹啉類化合物及其製備方法、以及含有該化合物的藥物組合物及其應用 HK1158655A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201110036623.0A CN102093421B (zh) 2011-01-28 2011-01-28 一种含磷取代基的喹啉类化合物及其制备方法、以及含有该化合物的药物组合物及其应用

Publications (1)

Publication Number Publication Date
HK1158655A1 true HK1158655A1 (zh) 2012-07-20

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Country Link
US (1) US8933230B2 (zh)
EP (1) EP2669289B1 (zh)
JP (1) JP5758504B2 (zh)
KR (1) KR101544098B1 (zh)
CN (1) CN102093421B (zh)
AU (1) AU2011357483B2 (zh)
BR (1) BR112013019124B1 (zh)
CA (1) CA2825858C (zh)
HK (1) HK1158655A1 (zh)
NZ (1) NZ613807A (zh)
RU (1) RU2551274C2 (zh)
SG (1) SG192178A1 (zh)
TW (1) TWI478933B (zh)
WO (1) WO2012100459A1 (zh)

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AU2011357483B2 (en) 2015-08-13
KR20130108454A (ko) 2013-10-02
EP2669289A1 (en) 2013-12-04
RU2551274C2 (ru) 2015-05-20
JP5758504B2 (ja) 2015-08-05
CA2825858C (en) 2016-03-15
EP2669289A4 (en) 2014-06-11
TWI478933B (zh) 2015-04-01
BR112013019124B1 (pt) 2021-10-13
US20130331359A1 (en) 2013-12-12
CN102093421B (zh) 2014-07-02
WO2012100459A1 (zh) 2012-08-02
AU2011357483A1 (en) 2013-08-15
BR112013019124A2 (pt) 2019-01-08
SG192178A1 (en) 2013-08-30
US8933230B2 (en) 2015-01-13
CN102093421A (zh) 2011-06-15
KR101544098B1 (ko) 2015-08-12
EP2669289B1 (en) 2015-11-18
CA2825858A1 (en) 2012-08-02
NZ613807A (en) 2014-09-26
RU2013137653A (ru) 2015-03-10
JP2014511356A (ja) 2014-05-15
TW201300400A (zh) 2013-01-01

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